Base-functionalized carbocyclic nucleosides: Design, synthesis, and mechanism of antiviral activity

Nucleosides, Nucleotides and Nucleic Acids

Volumn 28, Issue 5-7, 2009, Pages 408-423

  Nair, Vasu ^a   Zhang, Fan ^a   Ma, Xiaohui ^a   Bonsu, Eric ^a  

^a UNIVERSITY OF GEORGIA   (United States)

Author keywords

Antiviral; Carbocyclic nucleosides; IMPDH inhibitor; Synthesis

Indexed keywords

2 VINYLINOSINE; 3 DEAZAGUANOSINE; 9 [2',3' DIHYDROXY 4' (HYDROXYMETHYL)CYCLOPENTYL] 1H PURIN 6(9H)ONE; 9 [2',3' DIHYDROXY 4' (HYDROXYMETHYL)CYCLOPENTYL] 2 (3 OXOBUTENYL) 1H PURIN 6(9H)ONE; 9 [2',3' DIHYDROXY 4' (HYDROXYMETHYL)CYCLOPENTYL] 2 (3 OXOCYCLOHEX 1 ENYL) 1H PURIN 6(9H)ONE; 9 [2',3' DIHYDROXY 4' (HYDROXYMETHYL)CYCLOPENTYL] 2 (3 OXOCYCLOPENTENYL) 1H PURIN 6(9H)ONE; 9 [2',3' DIHYDROXY 4' (HYDROXYMETHYL)CYCLOPENTYL] 2 ETHYNYL 1H PURIN 6(9H)ONE; 9 [2',3' DIHYDROXY 4' (HYDROXYMETHYL)CYCLOPENTYL] 2 VINYL 1H PURIN 6(9H)ONE; CARBOCYCLIC NUCLEOSIDE; INOSINATE DEHYDROGENASE INHIBITOR; NUCLEIC ACID BASE; NUCLEOSIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME INHIBITION; IN VITRO STUDY; METHODOLOGY; NONHUMAN; NUCLEOTIDE SEQUENCE;

ANTIVIRAL AGENTS; ESCHERICHIA COLI; IMP DEHYDROGENASE; MICROBIAL SENSITIVITY TESTS; RIBONUCLEOSIDES; RNA VIRUS INFECTIONS; RNA VIRUSES;

EID: 75749108222     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1080/15257770903044465     Document Type: Article

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