DNA damage after intracerebroventricular injection of ouabain in rats

Neuroscience Letters

Volumn 471, Issue 1, 2010, Pages 6-9

  Jornada, Luciano K ^a   Valvassori, Samira S ^a   Arent, Camila O ^a   Leffa, Daniela ^a   Damiani, Adriani A ^a   Hainzenreder, Giana ^a   Ferreira, Camila L ^a   Moretti, Morgana ^a   Andrade, Vanessa M ^a   Quevedo, João ^a  

^a UNIVERSITY OF SOUTHERN SANTA CATARINA   (Brazil)

Author keywords

Bipolar disorder; DNA damage; Na+K+ ATPase; Ouabain

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); OUABAIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIPOLAR DISORDER; BLOOD SAMPLING; CEREBROSPINAL FLUID; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; HIPPOCAMPUS; HYPERACTIVITY; LOCOMOTION; MALE; MICRONUCLEUS TEST; MOTOR PERFORMANCE; NONHUMAN; OPEN FIELD BEHAVIOR; PRIORITY JOURNAL; RAT; TASK PERFORMANCE;

ANIMALS; BIPOLAR DISORDER; COMET ASSAY; DISEASE MODELS, ANIMAL; DNA; DNA DAMAGE; HIPPOCAMPUS; INJECTIONS, INTRAVENTRICULAR; MALE; MICRONUCLEUS TESTS; MOTOR ACTIVITY; OUABAIN; RATS; RATS, WISTAR;

EID: 75749104155     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2009.12.072     Document Type: Article

References (41)

1. Andreazza A.C., Cassini C., Rosa A.R., Leite M.C., de Almeida L.M., Nardin P., Cunha A.B., Cereser K.M., Santin A., Gottfried C., Salvador M., Kapczinski F., and Gonçalves C.A. Serum S100B and antioxidant enzymes in bipolar patients. J. Psychiatr. Res. 41 (2007) 523-529
2. Andreazza A.C., Frey B.N., Erdtmann B., Salvador M., Goncalves C.A., and Kapczinski F. DNA damage in bipolar disorder. Psychiatry Res. 153 (2007) 27-32
3. Andreazza A.C., Kauer-Sant'Anna M., Frey B.N., Stertz L., Zanotto C., Ribeiro L., Giasson K., Valvassori S.S., Réus G.Z., Salvador M., Quevedo J., Gonçalves C.A., and Kapczinski F. Effects of mood stabilizers on DNA damage in an animal model of mania. J. Psychiatry Neurosci. 33 (2008) 516-524
4. Buttner N., Bhattacharyya S., Walsh J., and Benes F.M. DNA fragmentation is increased in non-GABAergic neurons in bipolar disorder but not in schizophrenia. Schizophr. Res. 93 (2007) 33-34
5. Collins A.R., Mitchell D.L., Zunino A., de Wit J., and Busch D. UV-sensitive rodent mutant cell lines of complementation groups 6 and 8 differ phenotypically from their human counterparts. Environ. Mol. Mutagen. 29 (1997) 152-160
6. Cooke M.S., Evans M.D., Dove R., Rozalski R., Gackowski D., Siomek A., Lunec J., and Olinski R. DNA repair is responsible for the presence of oxidatively damaged DNA lesions in urine. Mutat. Res. 574 (2005) 58-66
7. Culmsee C., and Mattson M.P. p53 in neuronal apoptosis. Biochem. Biophys. Res. Commun. 331 (2005) 761-777
8. Davis J.L., Masuoka D.T., Gerbrandt L.K., and Cherkin A. Autoradiographic distribution of L-proline in chicks after intracerebral injection. Physiol. Behav. 22 (1979) 693-695
9. Decker S., Grider G., and Cobb M. Open field is more sensitive that automated activity monitor in documenting ouabain-induced hyperlocomotion in the development of an animal model for bipolar illness. Prog. Neuropsychopharmacol. Biol. Psychiatry 24 (2000) 455-462
10. El-Khamisy S.F., and Caldecott K.W. TDP1-dependent DNA single-strand break repair and neurodegeneration. Mutagenesis 21 (2006) 219-224
11. El-Mallakh R.S. The Na,K-ATPase hypothesis for manic-depression. I. General considerations. Med. Hypotheses 12 (1983) 253-268
12. El-Mallakh R.S., Hedges S., and Casey D. Digoxin encephalopathy presenting as mood disturbance. J. Clin. Psychopharmacol. 15 (1995) 82-83
13. Emerit I. Reactive oxygen species, chromosome mutation, and cancer: possible role of clastogenic factors in carcinogenesis. Free Radical Biol. Med. 16 (1994) 99-109
14. Evan G., and Littlewood T. A matter of life and cell death. Science 281 (1998) 1317-1322
15. Fenech M., and Morley A.A. Cytokinesis-block micronucleus method in human lymphocytes: effect of in vivo ageing and low dose X-irradiation. Mutat. Res. 161 (1986) 193-198
16. Fortunato J.J., Agostinho F.R., Réus G.Z., Petronilho F.C., Dal-Pizzol F., and Quevedo J. Lipid peroxidative damage on malathion exposure in rats. Neurotox. Res. 9 (2006) 23-28
17. Frey B.N., Andreazza A.C., Kunz M., Gomes F.A., Quevedo J., Salvador M., Gonçalves C.A., and Kapczinski F. Increased oxidative stress and DNA damage in bipolar disorder: a twin-case report. Prog. Neuropsychopharmacol. Biol. Psychiatry 31 (2007) 283-285
18. Frey B.N., Andreazza A.C., Nery F.G., Martins M.R., Quevedo J., Soares J.C., and Kapczinski F. The role of hippocampus in the pathophysiology of bipolar disorder. Behav. Pharmacol. 18 (2007) 419-430
19. Frey B.N., Valvassori S.S., Réus G.Z., Martins M.R., Petronilho F.C., Bardini K., Dal-Pizzol F., Kapczinski F., and Quevedo J. Effects of lithium and valproate on amphetamine-induced oxidative stress generation in an animal model of mania. J. Psychiatry Neurosci. 31 (2006) 326-332
20. L.K. Jornada, M. Moretti, S.S. Valvassori, C.L. Ferreira, P.T. Padilha, C.O. Arent, G.R. Fries, F. Kapczinski, J. Quevedo, Effects of mood stabilizers on hippocampus and amygdala BDNF levels in an animal model of mania induced by ouabain, J. Psychiatr. Res., in press.
21. Kapczinski F., Frey B.N., Andreazza A.C., Kauer-Sant'Anna M., Cunha A.B., and Post R.M. Increased oxidative stress as a mechanism for decreased BDNF levels in acute manic episodes. Rev. Bras. Psiquiatr. 30 (2008) 243-245
22. Krishna G., and Hayashi M. In vivo rodent micronucleus assay protocol; conduct and data interpretation. Mutat. Res. 455 (2000) 155-166
23. Kunz M., Gama C.S., Andreazza A.C., Salvador M., Ceresér K.M., Gomes F.A., Belmonte-de-Abreu P.S., Berk M., and Kapczinski F. Elevated serum superoxide dismutase and thiobarbituric acid reactive substances in different phases of bipolar disorder and in schizophrenia. Prog. Neuropsychopharmacol. Biol. Psychiatry 32 (2008) 1677-1681
24. Li R., el-Mallakh R.S., Harrison L., Changaris D.G., and Levy R.S. Lithium prevents ouabain-induced behavioral changes. Toward an animal model for manic depression. Mol. Chem. Neuropathol. 31 (1997) 65-72
25. Machado-Vieira R., Andreazza A.C., Viale C.I., Zanatto V., Cereser Jr. V., da Silva Vargas R., Kapczinski F., Portela L.V., Souza D.O., Salvador M., and Gentil V. Oxidative stress parameters in unmedicated and treated bipolar subjects during initial manic episode: a possible role for lithium antioxidant effects. Neurosci. Lett. 421 (2007) 33-36
26. Maluf S.W., and Erdtmann B. Follow-up study of the genetic damage in lymphocytes of pharmacists and nurses handling antineoplastic drugs evaluated by cytokinesis-block micronuclei analysis and single cell gel electrophoresis assay. Mutat. Res. 471 (2000) 21-27
27. McCarren M., and Alger B.E. Sodium-potassium pump inhibitors increase neuronal excitability in the rat hippocampal slice: role of a Ca2+-dependant conductance. J. Neurophysiol. 57 (1989) 496-509
28. Mynett-Johnson L., Murphy V., McCormack J., Shields D.C., Claffey E., Manley P., and McKeon P. Evidence for an allelic association between bipolar disorder and a Na+, K+ adenosine triphosphatase alpha subunit gene (ATP1A3). Biol. Psychiatry 44 (1998) 47-51
29. Myung N.H., Zhu X., Kruman I.I., Castellani R.J., Petersen R.B., Siedlak S.L., Perry G., Smith M.A., and Lee H.G. Evidence of DNA damage in Alzheimer disease: phosphorylation of histone H2AX in astrocytes. Age (Dordr). 30 (2008) 209-215
30. Picada J.N., Flores D.G., Zettler C.G., Marroni N.P., Roesler R., and Henriques J.A. DNA damage in brain cells of mice treated with an oxidized form of apomorphine. Brain Res. Mol. Brain Res. 114 (2003) 80-85
31. Plata-Salamán C.R. Immunoregulators in the nervous system. Neurosci. Biobehav. Rev. 5 (1991) 185-215
32. Ranjekar P.K., Hinge A., Hegde M.V., Ghate M., Kale A., Sitasawad S., Wagh U.V., Debsikdar V.B., and Mahadik S.P. Decreased antioxidant enzymes and membrane essential polyunsaturated fatty acids in schizophrenic and bipolar mood disorder patients. Psychiatry Res. 121 (2003) 109-122
33. Rose A.M., Mellett B.J., Valdes Jr. R., Kleinman J.E., Herman M.M., Li R., and El-Mallakh R.S. Alpha 2 isoform of the Na,K-adenosine triphosphatase is reduced in temporal cortex of bipolar individuals. Biol. Psychiatry 44 (1998) 892-897
34. Ruktanonchai D.J., El-Mallakh R.S., Li R., and Levy R.S. Persistent hyperactivity following a single intracerebroventricular dose of ouabain. Physiol. Behav. 63 (1998) 63403-66406
35. Scibior-Bentkowska D., and Czeczot H. Cancer cells and oxidative stress. Postepy Hig. Med. Dosw. (Online) 63 (2009) 58-72
36. Tice R.R., Agurell E., Anderson D., Burlinson B., Hartmann A., Kobayashi H., Miyamae Y., Rojas E., Ryu J.C., and Sasaki Y.F. Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ. Mol. Mutagen. 35 (2000) 206-221
37. Valvassori S.S., Petronilho F.C., Réus G.Z., Steckert A.V., Oliveira V.B., Boeck C.R., Kapczinski F., Dal-Pizzol F., and Quevedo J. Effect of N-acetylcysteine and/or deferoxamine on oxidative stress and hyperactivity in an animal model of mania. Prog. Neuropsychopharmacol. Biol. Psychiatry 32 (2008) 1064-1068
38. Villela I.V., Oliveira I.M., Silva J., and Henriques J.A.P. DNA damage and repair in haemolymph cells of golden mussel (Limnoperna fortunei) exposed to environmental contaminants. Mutat. Res. 697 (2006) 78-86
39. Wang D., Kreutzer D.A., and Essigmann J.M. Mutagenicity and repair of oxidative DNA damage: insights from studies using defined lesions. Mutat. Res. 400 (1998) 99-115
40. Watt N.T., Routledge M.N., Wild C.P., and Hooper N.M. Cellular prion protein protects against reactive-oxygen-species-induced DNA damage. Free Radical Biol. Med. 43 (2007) 959-967
41. Xie Z., Kometiani P., Liu J., Shapiro J.I., and Askari A. Intracellular reactive oxygen species mediate the linkage of Na+/K+-ATPase to hypertrophy and its marker genes in cardiac myocytes. J. Biol. Chem. 274 (1999) 19323-19328