Micronized Flavonoids in Pain Control after Hemorrhoidectomy: A Prospective Randomized Controlled Study

Surgery Today

Volumn 33, Issue 11, 2003, Pages 828-832

  Colak, Tahsin ^a   Akca, Tamer ^a   Dirlik, Musa ^a   Kanik, Arzu ^a   Dag, Ahmet ^a   Aydin, Suha ^a  

^a MERSIN UNIVERSITY   (Turkey)

Author keywords

Daflon; Hemorrhoids; Micronized flavonoid; Pain control

Indexed keywords

ANALGESIC AGENT; DAFLON; DICLOFENAC; DIPYRONE; FLAVONOID; MICRONIZED FLAVONOID FRACTION; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG COST; DRUG INDICATION; FEMALE; HEMORRHOID; HEMORRHOIDECTOMY; HUMAN; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; PAIN ASSESSMENT; PATIENT SATISFACTION; POSTOPERATIVE ANALGESIA; POSTOPERATIVE PAIN; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL;

ADULT; AGED; AGED, 80 AND OVER; ANALGESICS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; FEMALE; FLAVONOIDS; FOLLOW-UP STUDIES; HEMORRHOIDS; HUMANS; MALE; MIDDLE AGED; PAIN MEASUREMENT; PAIN, POSTOPERATIVE; PROBABILITY; PROSPECTIVE STUDIES; REFERENCE VALUES; SEVERITY OF ILLNESS INDEX; STATISTICS, NONPARAMETRIC; TREATMENT OUTCOME;

EID: 0242383171     PISSN: 09411291     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00595-003-2604-5     Document Type: Article

References (39)

1. Patel N, O'Connor T. Suture hemorrhoidectomy: a day-only alternative. Aust NZ J Surg 1996;66:830-1.
2. Eu K-W, Seow-Choen F, Goh HS. Comparison of emergency and elective haemorrhoidectomy. Br J Surg 1994;81:308-10.
3. Ganio E, Altomare DF, Gabrielli F, Milito G, Canuti S. Prospective randomized multicentre trial comparing stapled with open haemorrhoidectomy. Br J Surg 2001;88:669-74.
4. Haas PA. Fox TA Jr, Haas GP. The pathogenesis of hemorrhoids. Dis Colon Rectum 1984;27:442-50.
5. Lawrence MB, Mclntire LV, Eskin SG. Effect of flow on polymorphonuclear/endothelial cell adhesion. Blood 1987;70:1284-90.
6. Weissmann G, Smolen JE. Korchak HM. Release of inflammatory mediators from stimulated neutrophils. N Engl J Med 1980;303:27-34.
7. Shami SK, Shields DA, Scurr JH, Coleridge Smith PD. Leg ulceration in venous disease. Postgrad Med J 1992;68:779-85.
8. Labrid C, Duhault J, Vix C. Pharmacological properties of Daflon 500mg. J Intern Med 1987;85(suppl):30-6.
9. Di Perri T, Auteri A. Action of s 5682 on the complement system. In vitro and in vivo study. Int Angiol 1988;7(suppl 2):11-5.
10. Labrid CL, Perdrix L. Mechanisms of oedema: activity of Daflon 500 mg. Phlebology 1992:7(suppl 2):30-6.
11. Moroney MA, Alcaraz MJ, Forder RA, Carey F, Hoult JR. Selectivity of neutrophil 5-lipoxygenase and cyclo-oxygenase inhibition by an anti-inflammatory flavonoid glycoside and related aglycone flavonoids. J Pharmacol 1988;40:787-92.
12. Baumann J, Von Bruchhausen F, Wurm G. Flavonoids and related compounds as inhibitors of arachidonic acid peroxidation. Prostaglandins 1980;20:627-39.
13. Godeberge P. Daflon 500mg in treatment of hemorrhoidal disease: a demonstrated efficacy in comparison with placebo. Angiology 1994;45:574-8.
14. Misra MC, Parshad R. Randomized clinical trial of micronized flavonoids in the early control of bleeding from acute internal haemorrhoids. Br J Surg 2000;87:868-72.
15. Ho YH, Foo CL, Seow-Choen F, Goh HS. Prospective randomized controlled trial of micronized flavonidic fraction to reduce bleeding after haemorrhoidectomy. Br J Surg 1995;82:1034-5.
16. Khalil KH, O'Bichere A, Sellu D. Randomized clinical trial of sutured versus stapled closed haemorrhoidectomy. Br J Surg 2000;87:1352-5.
17. Pocock SJ. Clinical trials: a practical approach. Chichester: J Wiley; 1983. p. 231.
18. Andrews BT, Layer GT, Jackson BT, Nichollas RJ. Randomized trial comparing diathermy hemorrhoidectomy with the scissor dissection Milligan-Morgan operation. Dis Colon Rectum 1993;36:295-6.
19. Arbman G, Krook H, Haapaniemi S. Closed vs. open hemorrhoidectomy - is there any difference? Dis Colon Rectum 2000;43:31-4.
20. Mikuni N, Oya M, Komatsu J, Yamana T. A prospective randomized comparison between an open hemorrhoidectomy and a semi-closed (semi-open) hemorrhoidectomy. Surg Today 2002;32: 40-7.
21. Tan JJY, Seow-Choen F. Prospective, randomized trial comparing diathermy and harmonic scalpel hemorrhoidectomy. Dis Colon Rectum 2001;44:677-9.
22. Lin JK. Anal manometric studies in hemorrhoids and anal fissures. Dis Colon Rectum 1989;32:839-42.
23. Mathai V, Ong BC, Ho YH. Randomized controlled trial of lateral internal sphincterotomy with haemorrhoidectomy. Br J Surg 1996;83:380-2.
24. Ho YH, Seow-Choen F, Low JY, Tan M, Leong APKF. Randomized controlled trial of trimebutine (anal sphincter relaxant) for pain after haemorrhoidectomy. Br J Surg 1997;84:377-9.
25. Wasvary HJ, Hain J, Vogel MM, Bendick P, Barkel DC, Klein SN. Randomized, prospective, double blind, placebo-controlled trial of effect of nitroglycerin ointment on pain after hemorrhoidectomy. Dis Colon Rectum 2001;44:1069-73.
26. Balfour L, Stojkovic SG, Botterill ID. Burke DA, Finan PJ, Sagar PM. A randomized, double-blind trial of the effect of metronidazole on pain after closed hemorrhoidectomy. Dis Colon Rectum 2002;45:1186-90.
27. Brisida G, Civello IM, Maria G. Haemorrhoidectomy: painful choice. Lancet 2000;355:2253.
28. Morisaki H, Masuda J, Kazuaki F, Iwao Y, Suzuki K, Matsushima M. Wound infiltration with lidocaine prolongs postoperative analgesia after haemorrhoidectomy with spinal anesthesia. Can J Anaesth 1996;43:914-8.
29. Vinson-Bonnet B, Coltat JC, Fingerhut A, Bonnet F. Local infiltration with ropivacaine improves immediate postoperative pain control after hemorrhoidal surgery. Dis Colon Rectum 2002; 45:104-8.
30. O'Donovan S, Ferrara A, Larach S, Williamson P. Intraoperative use of Toradol facilitates outpatient hemorrhoidectomy. Dis Colon Rectum 1994;37:793-9.
31. Place RJ, Coloma M, White PF, Huber PJ, Van Vlymen J, Simmang CL. Ketorolac improves recovery after outpatient anorectal surgery. Dis Colon Rectum 2000;43:804-8.
32. Lee TP, Matteliano ML, Middleton E Jr. Effect of quercetin on human polymorphonuclear leukocyte lysosomal enzyme release and phospholipid metabolism. Life Sci 1982;31:2765-74.
33. Vane JR. Inhibition of prostaglandin synthesis as mechanism of action for aspirin-like drugs. Nat New Biol 1971;231:232-5.
34. Sekiya F, Okuda H. Selective inhibition platelet lipoxygenase by baicalein. Biochem Biophys Res Commun 1982;105:1090-5.
35. 1. Biochem Pharmacol 1983;32:2813-7.
36. Lim LK, Hunt NH, Weidemann MJ. Reactive oxygen production, arachidonate metabolism and cyclic AMP in macrophages. Biochem Biophys Res Commun 1.983;114:549-55.
37. Cospite M. Double-blind, placebo-controlled evaluation of clinical activity and safety of Daflon 500mg in treatment of acute hemorrhoids. Angiology 1994;45:566-73.
38. Bleday R, Pena JP, Rothenberger DA. Goldberg SM, Buls JG. symptomatic hemorrhoids: current incidence and complications of operative therapy. Dis Colon Rectum 1992;35:477-81.
39. Carapetti EA, Kamm MA, McDonald PJ, Chadwick SJ, Phillips RK. Randomized trial of open versus closed day case haemorrhoidectomy. Br J Surg 1999;86:612-3.