Magnetic resonance imaging signal reduction may precede volume loss in the pituitary gland of transfusion-dependent beta-thalassemic patients

Acta Radiologica

Volumn 51, Issue 1, 2010, Pages 71-77

  Hekmatnia, Ali ^a   Radmard, Amir Reza ^b   Rahmani, Ali Asghar ^a   Adibi, Atoosa ^a   Khademi, Hooman ^b  

^a ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Beta thalassemia; Delayed puberty; Iron overload; Magnetic resonance imaging; Pituitary gland

Indexed keywords

BETA-THALASSEMIA; DECREASE IN VOLUME; HEALTHY CONTROLS; IRON CONCENTRATIONS; MEAN VALUES; PARAMAGNETIC EFFECT; PITUITARY GLAND; SIGNAL INTENSITIES; VOLUME LOSS;

BRAIN; MAGNETIC RESONANCE IMAGING;

MAGNETIC RESONANCE;

ADOLESCENT; ADULT; ARTICLE; BETA THALASSEMIA; BLOOD TRANSFUSION; CASE CONTROL STUDY; FEMALE; HUMAN; HYPOPHYSIS; IRON OVERLOAD; MALE; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; PROSPECTIVE STUDY; PUBERTY;

ADOLESCENT; BETA-THALASSEMIA; BLOOD TRANSFUSION; CASE-CONTROL STUDIES; FEMALE; HUMANS; IRON OVERLOAD; MAGNETIC RESONANCE IMAGING; MALE; PITUITARY GLAND; PROSPECTIVE STUDIES; PUBERTY; YOUNG ADULT;

EID: 75649124518     PISSN: 02841851     EISSN: 16000455     Source Type: Journal    
DOI: 10.3109/02841850903292743     Document Type: Article

References (23)

1. Schnall SF, Benz JEJ. Abnormalities of hemoglobin. In: Mazza JJ, editor. Manual of clinical hematology. Philadelphia: Lippincott Williams & Wilkins; 2002. p. 138-154
2. Angastiniotis M, Modell B. Global epidemiology of hemoglobin disorders. Ann N Y Acad Sci 1998; 850: 251-269 .
3. Brittenham GM, Griffith PM, Nienhuis AW, McLaren CE, Young NS, Tucker EE, et al. Efficacy of deferoxamine in preventing complications of iron overload in patients with thalassemia major. N Engl J Med. 1994; 331: 567-573 .
4. Rund D, Rachmilewitz E. Beta-thalassemia. N Engl J Med. 2005; 353: 1135-1146 .
5. Shamshirsaz AA, Bekheirnia MR, Kamgar M, Pourzahedgilani N, Bouzari N, Habibzadeh M, et al. Metabolic and endocrinologic complications in beta-thalassemia major: a multicenter study in Tehran. BMC Endocr Disord. 2003; 3: 4 .
6. Jensen CE, Tuck SM, Old J, Morris RW, Yardumian A, De Sanctis V, et al. Incidence of endocrine complications and clinical disease severity related to genotype analysis and iron overload in patients with beta-thalassaemia. Eur J Haematol. 1997; 59: 76-81 .
7. Ambrosetto P, Zucchini S, Cicognani A, Cacciari E. MR findings in pituitary haemosiderosis. Pediatr Radiol. 1998; 28: 288-289 .
8. Fujisawa I, Morikawa M, Nakano Y, Konishi J. Hemochromatosis of the pituitary gland: MR imaging. Radiology. 1988; 168: 213-214 .
9. Lau KY, Chan YL, Lam WW, Li CK, Metreweli C. Magnetic resonance imaging evaluation of the pituitary gland and hypothalamus in thalassaemic children with elevated serum ferritin levels. J Paediatr Child Health. 1998; 34: 463-466 .
10. Argyropoulou MI, Kiortsis DN, Metafratzi Z, Bitsis S, Tsatoulis A, Efremidis SC. Pituitary gland height evaluated by MR in patients with beta-thalassemia major: a marker of pituitary gland function. Neuroradiology. 2001; 43: 1056-1058 .
11. Chatterjee R, Katz M, Oatridge A, Bydder GM, Porter JB. Selective loss of anterior pituitary volume with severe pituitary- gonadal insufficiency in poorly compliant male thalassemic patients with pubertal arrest. Ann N Y Acad Sci. 1998; 850: 479-482 .
12. Fink AM, Vidmar S, Kumbla S, Pedreira CC, Kanumakala S, Williams C, et al. Age-related pituitary volumes in prepubertal children with normal endocrine function: volumetric magnetic resonance data. J Clin Endocrinol Metab. 2005; 90: 3274-3278 .
13. Alba M, Hall CM, Whatmore AJ, Clayton PE, Price DA, Salvatori R. Variability in anterior pituitary size within members of a family with GH deficiency due to a new splice mutation in the GHRH receptor gene. Clin Endocrinol (Oxf). 2004; 60: 470-475 .
14. Lurie SN, Doraiswamy PM, Husain MM, Boyko OB, Ellinwood Jr EH, Figiel GS, et al. In vivo assessment of pituitary gland volume with magnetic resonance imaging: the effect of age. J Clin Endocrinol Metab. 1990; 71: 505-508 .
15. Gossuin Y, Muller RN, Gillis P. Relaxation induced by ferritin: a better understanding for an improved MRI iron quantification. NMR Biomed. 2004; 17: 427-432 .
16. Soliman AT, el Zalabany MM, Ragab M, Abdel FM, Hassab H, Rogol AD, et al. Spontaneous and GnRHprovoked gonadotropin secretion and testosterone response to human chorionic gonadotropin in adolescent boys with thalassaemia major and delayed puberty. J Trop Pediatr. 2000; 46: 79-85 .
17. Arslanoglu I, Kutlu H, Isguven P, Tokus F, Isik K. Diagnostic value of pituitary MRI in differentiation of children with normal growth hormone secretion, isolated growth hormone deficiency and multiple pituitary hormone defi - ciency. J Pediatr Endocrinol Metab. 2001; 14: 517-523 .
18. Vymazal J, Urgosik D, Bulte JW. Differentiation between hemosiderin- and ferritin-bound brain iron using nuclear magnetic resonance and magnetic resonance imaging. Cell Mol Biol (Noisy-le-grand). 2000; 46: 835-842 .
19. Sparacia G, Banco A, Midiri M, Iaia A. MR imaging technique for the diagnosis of pituitary iron overload in patients with transfusion-dependent beta-thalassemia major. Am J Neuroradiol. 1998; 19: 1905-1907 .
20. 2 relaxation rate as an index of pituitary iron overload in patients with beta-thalassemia major. Am J Roentgenol. 2000; 175: 1567-1569 .
21. Sparacia G, Iaia A, Banco A, D'Angelo P, Lagalla R. Transfusional hemochromatosis: quantitative relation of MR imaging pituitary signal intensity reduction to hypogonadotropic hypogonadism. Radiology. 2000; 215: 818-823 .
22. Lam WW, Au WY, Chu WC, Tam S, Ha SY, Pennell DJ. One-stop measurement of iron deposition in the anterior pituitary, liver, and heart in thalassemia patients. J Magn Reson Imaging. 2008; 28: 29-33 .
23. Christoforidis A, Haritandi A, Perifanis V, Tsatra I, Athanassiou-Metaxa M, Dimitriadis AS. MRI for the determination of pituitary iron overload in children and young adults with beta-thalassaemia major. Eur J Radiol. 2007; 62: 138-142