Lupulone, a hop phytochemical, activates different apoptotic pathways in human colon tumor cells and in their derived metastatic cells

Acta Horticulturae

Volumn 848, Issue , 2009, Pages 215-220

  Lamy, V ^a   Gosse F ^a   Raul, F ^a   Chaabi, M ^b   Lobstein, A ^b  

^a IRCAD   (France)

^b CNRS   (France)

Author keywords

Apoptosis; Caspases; Colon cancer; DR4 DR5; Lupulone; Mitochondria; TRAIL

Indexed keywords

HUMULUS;

EID: 75649120793     PISSN: 05677572     EISSN: None     Source Type: Book Series    
DOI: 10.17660/ActaHortic.2009.848.23     Document Type: Conference Paper

References (6)

1. Dzieran, J., Beck, J. F. and Sonnemann, J. 2008. Differential responsiveness of human hepatoma cells versus normal hepatocytes to TRAIL in combination with either histone deacetylase inhibitors or conventional cytostatics. Cancer. Sci. 99(8):1685-92.
2. Falschlehner, C., Emmerich, C. H., Gerlach, B. and Walczak, H. 2007. TRAIL signalling: decisions between life and death. Int. J. Biochem. Cell. Biol. 39:1462-1475.
3. Janakiram, N. B. and Rao, C. V. 2008. Molecular markers and targets for colorectal cancer prevention. Acta. Pharmacol. Sin. 29:1-20.
4. Lamy, V., Roussi, S., Chaabi, M. et al. 2007. Chemopreventive effects of lupulone, a hopacid, on human conlon cancer-derived metastatic SW620 cells and in rat model of colon carcinogenesis. Carcinogenesis 28:1575-1581.
5. Lee, J. C., Kundu, J. K., Hwang, D. M. et al. 2007. Humulone inhibits phorbol esterinduced COX-2 expression in mouse skin by blocking activation of NF-kappa B and AP-1:Ikappa B kinase and c-Jun-N-terminal kinase as respective potential upstream targets. Carcinogenesis 28(7):1491-8.
6. Roussi, S., Gossé, F., Aoudé-Werner, D. et al. 2007. Mitochondrial perturbation, oxidative stress and lysosomal destabilization are involved in 7beta-hydroxysitosterol triggered apoptosis in human colon cancer cells. Apoptosis 12(1):87-96.