Preservation of memory CD4+ T lymphocytes in breast milk of lactating rhesus monkeys during acute simian immunodeficiency virus infection

Journal of Infectious Diseases

Volumn 201, Issue 2, 2010, Pages 302-310

  Permar, Sallia R ^a,b   Kang, Helen H ^a   Carville, Angela ^c   Wilks, Andrew B ^a   Mansfield, Keith G ^c   Rao, Srinivas S ^d   Letvin, Norman L ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR5;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST MILK; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; FEMALE; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MEMORY T LYMPHOCYTE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RHESUS MONKEY; SIMIAN IMMUNODEFICIENCY VIRUS; T CELL DEPLETION; VIREMIA; VIRUS INFECTION; VIRUS REPLICATION; ANIMAL; CD4 LYMPHOCYTE COUNT; DISEASE MODEL; FLOW CYTOMETRY; IMMUNOLOGY; ISOLATION AND PURIFICATION; MACACA; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; VIROLOGY; VIRUS LOAD;

ANIMALS; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; DISEASE MODELS, ANIMAL; FEMALE; FLOW CYTOMETRY; MACACA MULATTA; MILK, HUMAN; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; SIMIAN IMMUNODEFICIENCY VIRUS; VIRAL LOAD; VIREMIA;

EID: 75649087431     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/649229     Document Type: Article

References (19)

1. Veazey RS, DeMaria M, Chalifoux LV, et al. Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection. Science 1998;280:427-431 (Pubitemid 28208163)
2. Mattapallil JJ, Douek DC, Hill B, Nishimura Y, Martin M, Roederer M. Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection. Nature 2005;434:1093-7.
3. Brenchley JM, Schacker TW, Ruff LE, et al. CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract. J Exp Med 2004; 200:749-759
4. Veazey RS, Marx PA, Lackner AA. Vaginal CD4+ T cells express high levels of CCR5 and are rapidly depleted in simian immunodeficiency virus infection. J Infect Dis 2003; 187:769-776
5. Picker LJ, Hagen SI, Lum R, et al. Insufficient production and tissue delivery of CD4+ memory T cells in rapidly progressive simian immunodeficiency virus infection. J Exp Med 2004;200:1299-1314
6. Li Q, Duan L, Estes JD, et al. Peak SIV replication in resting memory CD4+ T cells depletes gut lamina propria CD4+ T cells. Nature 2005;434:1148-1152 (Pubitemid 40663495)
7. Haase AT. Perils at mucosal front lines for HIV and SIV and their hosts. Nat Rev Immunol 2005; 5:783-792
8. Kourtis AP, Ibegbu CC, Theiler R, et al. Breast milk CD4+ T cells express high levels of C chemokine receptor 5 and CXC chemokine receptor 4 and are preserved in HIV-infected mothers receiving highly active antiretroviral therapy. J Infect Dis 2007; 195:965-972 (Pubitemid 46452101)
9. Permar SR, Kang HH, Carville A, et al. Potent simian immunodeficiency virus-specific cellular immune responses in the breast milk of simian immunodeficiency virus-infected, lactating rhesus monkeys. J Immunol 2008; 181:3643-3650
10. Keele BF, Li H, Learn GH, et al. Low-dose rectal inoculation of rhesus macaques by SIVsmE660 or SIVmac251 recapitulates human mucosal infection by HIV-I. J Exp Med 2009;206:1117-1134
11. Institute for Laboratory Animal Research. Guide for the care and use of laboratory animals. Washington, DC: National Academies Press, 1996.
12. Kaufman DR, Liu J, Carville A, et al. Trafficking of antigen-specific CD8+ T lymphocytes to mucosal surfaces following intramuscular vaccination. J Immunol 2008; 181:4188-4198
13. Veazey RS, Lifson JD, Schmitz JE, et al. Dynamics of simian immunodeficiency virus-specific cytotoxic T-cell responses in tissues. J Med Primatol 2003;32:194-200.
14. Goldblum RM, Ahlstedt S, Carlsson B, et al. Antibody-forming cells in human colostrum after oral immunisation. Nature 1975; 257:797-798
15. Parmely MJ, Beer AE, Billingham RE. In vitro studies on the T-lymphocyte population of human milk. J Exp Med 1976; 144:358-370
16. Chase AJ, Sedaghat AR, German JR, et al. Severe depletion of CD4+ CD25+ regulatory T cells from the intestinal lamina propria but not peripheral blood or lymph nodes during acute simian immunodeficiency virus infection. J Virol 2007;81:12748-12757
17. Mehandru S, Poles MA, Tenner-Racz K, et al. Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tract. J Exp Med 2004; 200:761-770 (Pubitemid 39299462)
18. - T cells in the intestines of macaques during primary infection. J Virol 2001; 75:10515-10519
19. Reynolds MR, Rakasz E, Skinner PJ, et al. CD8+ T-lymphocyte response to major immunodominant epitopes after vaginal exposure to simian immunodeficiency virus: too late and too little. J Virol 2005; 79: 9228-9235 (Pubitemid 40934834)