Emergence and kinetics of simian immunodeficiency virus-specific CD8+ T cells in the intestines of macaques during primary infection

Journal of Virology

Volumn 75, Issue 21, 2001, Pages 10515-10519

  Veazey, R S ^a   Gauduin, M C ^a   Mansfield, K G ^a   Tham, I C ^a   Altman, J D ^a   Lifson, J D ^a   Lackner, A A ^a   Johnson, R P ^a  

^a TULANE NATIONAL PRIMATE RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; VIRUS RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL KINETICS; CONTROLLED STUDY; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; INOCULATION; INTESTINE INFECTION; INTESTINE LYMPHATIC TISSUE; INTESTINE MUCOSA; MACACA; MALE; NONHUMAN; PERIPHERAL LYMPHOCYTE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SIMIAN IMMUNODEFICIENCY VIRUS; T LYMPHOCYTE; VIRUS INFECTION; VIRUS REPLICATION;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; GENE PRODUCTS, GAG; INTESTINES; KINETICS; MACACA; MALE; PEPTIDE FRAGMENTS; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; SIMIAN IMMUNODEFICIENCY VIRUS;

EID: 0034791052     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.21.10515-10519.2001     Document Type: Article

References (39)

1. Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary viremia
2. Induction of AIDS virus-specific CTL activity in fresh, unstimulated peripheral blood lymphocytes from rhesus macaques vaccinated with a DNA prime/modified vaccinia virus Ankara boost regimen
3. Phenotypic analysis of antigen-specific T lymphocytes
4. Antiviral pressure exerted by HIV-I specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus
5. Direct ex vivo simian immunodeficiency virus (SIV)-specific cytotoxic T cell activity detected from small intestine intraepithelial lymphocytes of SIV-infected macaques at an advanced stage of infection
6. Use of major histocompatibility complex class I/peptide/beta2M tetramers to quantitate CD8(+) cytotoxic T lymphocytes specific for dominant and nondominant viral epitopes in simian-human immunodeficiency virus-infected rhesus monkeys
7. Early changes in peripheral blood T cells during primary infection of rhesus macaques with a pathogenic SIV
8. Definition of five new simian immunodeficincy virus cytotoxic T-lymphocyte epitopes and their restricting major histocompatibility complex class I molecules: Evidence for an influence on disease progression
9. Gut intraepithelial T lymphocytes
10. Carboxyl-terminal and central regions of human immunodeficiency virus-1 NEF recognized by cytotoxic T lymphocytes from lymphoid organs. An in vitro limiting dilution analysis
11. Detection of a vigorous HIV-1-specific cytotoxic T lymphocyte response in cerebrospinal fluid from infected persons with AIDS dementia complex
12. Dramatic rise in plasma viremia after CD8(+) T cell depletion in simian immunodeficiency virus-infected macaques
13. Rapid mucosal CD4+ T-cell depletion and enteropathy in simian immunodeficiency virus-infected rhesus macaques
14. A high frequency of Mamu-A1/2z.ast;01 in the rhesus macaque detected by polymerase chain reaction with sequence-specific primers and direct sequencing
15. Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome
16. Emergence of CTL coincides with clearance of virus during primary simian immunodeficiency virus infection in rhesus monkeys
17. Comparative analysis of cytotoxic T lymphocytes in lymph nodes and peripheral blood of simian immunodeficiency virus-infected rhesus monkeys
18. Simian immunodeficiency virus-specific cytotoxic T lymphocytes and cell-associated viral RNA levels in distinct lymphoid compartments of SIV mac-infected monkeys
19. Progress in the development of an HIV-1 vaccine
20. Antiviral cytotoxic T lymphocytes in vaginal mucosa of simian immunodeficiency virus-infected rhesus macaques
21. Administration of an anti-CD8 monoclonal antibody interferes with the clearance of chimeric simian/human immunodeficiency virus during primary infections of rhesus macaques
22. The anatomical basis of intestinal immunity
23. Selective induction of protective MHC class I-restricted CTL in the intestinal lamina propria of rhesus monkeys by transient SIV infection of the colonic mucosa
24. Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA
25. The qualitative nature of the primary immune response to HIV infection is a prognosticator of disease progression independent of the initial level of plasma viremia
26. Major expansion of CD8+ T cells with a predominant V beta usage during the primary immune response to HIV
27. AIDS virus-specific cytotoxic T lymphocytes in lung disorders
28. Induction of lymphocyte proliferation and severe gastrointestinal disease in macaques by a nef gene variant of SIVmac239
29. Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes
30. Simian immunodeficiency virus (SIV)-specific CTL are present in large numbers in livers of SIV-infected rhesus monkeys
31. Phenotypic heterogeneity of cerebrospinal fluid-derived HIV-specific and HLA-restricted cytotoxic T-cell clones
32. Gastrointestinal T lymphocytes retain high potential for cytokine responses but have severe CD4+ T-cell depletion at all stages of simian immunodeficiency virus infection compared to peripheral lymphocytes
33. Retrospective analysis of viral load and SIV antibody responses in rhesus macaques infected with pathogenic SIV: Predictive value for disease progression
34. Plasma SIV RNA viral load determination by real-time quantification of product generation in reverse transcriptase-polymerase chain reaction. AIDS Res
35. Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection
36. Dynamics of CCR5 expression by CD4+ T cells in lymphoid tissues during simian immunodeficiency virus infection
37. Identifying the target cell in primary simian immunodeficiency virus (SIV) infection: Highly activated memory CD4(+) T cells are rapidly eliminated in early SIV infection in vivo
38. Direct visualization of HIV-l-specific cytotoxic T lymphocytes during primary infection
39. Simian immunodeficiency virus-specific cytotoxic T lymphocytes are present in the AIDS-associated skin rash in rhesus monkeys