Blast-related brain injury: imaging for clinical and research applications: report of the 2008 st. louis workshop

Journal of Neurotrauma

Volumn 26, Issue 12, 2009, Pages 2127-2144

  Benzinger, Tammie L S ^a   Brody, David ^a   Cardin, Sylvain ^b,af   Curley, Kenneth C ^b,e,af   Mintun, Mark A ^a   Mun, Seong K ^c   Wong, Kenneth H ^d   Wrathall, Jean R ^d   Armstrong, Regina C ^e   Bayly, Philip V ^f   Bentley, Timothy B ^g   Chavko, Mikulas ^h   Corbetta, Maurizio ^f   Culver, Joseph P ^f   DeWitt, Douglas S ⁱ   Faden, Alan I ^d   Fiskum, Gary ^j   Fitzpatrick, Susan M ^k   Gennarelli, Thomas ^l   Ghajar, Jamshid ^m   Gullapalli, Rao P ^j   Hovda, David ⁿ   Jost, R Gilbert ^a   Kharasch, Evan D ^f   Kharasch, Karen ^a   Kochanek, Patrick ^o   Lammle, Markus ^p   Leggieri Jr , Michael J ^b   Latour, Lawrence L ^q   Little, Deborah M ^r   Mac Donald, Christine L ^f   Macedonia, Christian ^s   Marcus, Daniel ^f   McCabe, Joseph T ^e   McCarron, Richard M ^h   Moore, David ^t   Mukherjee, Pratik ^u   Povlishock, John ^v   Pancrazio, Joseph ^q   Petersen, Steve ^f   Peskind, Elaine R ^w   Pierce, Kathy J ^f   Pineda, Jose A ^f   Raskind, Murray ^x   Riedel, Charles ^y   Ritzel, David ^z   Shimony, Joshua S ^f   Smith, Alice Boyd ^e   Smith, Douglas H ^aa   Smirniotopoulos, James ^e   Song, Victor Sheng Kwei ^f   Sterkel, Barbara B ^ab   Svetlov, Stanislav ^ac   VandeVord, Pamela J ^ad   Young, Alan W ^ae   Zipfel, Gregory ^f   more..

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b U S ARMY MEDICAL RESEARCH AND MATERIEL COMMAND   (United States)

^c VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^d GEORGETOWN UNIVERSITY   (United States)

^e UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^f WASHINGTON UNIVERSITY   (United States)

^g WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^h NAVAL MEDICAL RESEARCH CENTER   (United States)

ⁱ UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^j UNIVERSITY OF MARYLAND   (United States)

^k The James S McDonnell Foundation   (United States)

^l MEDICAL COLLEGE OF WISCONSIN   (United States)

^m WEILL CORNELL MEDICAL COLLEGE   (United States)

ⁿ UNIVERSITY OF CALIFORNIA   (United States)

^o UNIVERSITY OF PITTSBURGH   (United States)

^p VETERANS AFFAIRS MEDICAL CENTER   (United States)

^q NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^r UNIVERSITY OF ILLINOIS   (United States)

^s Office of the Senior Enlisted Advisor to the Chairman of the Joint Chiefs of Staff   (United States)

^t Defense and Veterans Brain Injury Center   (United States)

^u UNIVERSITY OF CALIFORNIA   (United States)

^v VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^w VA PUGET SOUND HEALTH CARE SYSTEM   (United States)

^x UNIVERSITY OF WASHINGTON   (United States)

^y VIRGINIA HOSPITAL CENTER   (United States)

^z Dyn FX Consulting Ltd   (Canada)

^aa UNIVERSITY OF PENNSYLVANIA   (United States)

^ab St Louis Veterens Administration Medical Center   (United States)

^ac BANYAN BIOMARKERS INC   (United States)

^ad WAYNE STATE UNIVERSITY   (United States)

^ae NONE

^af US ARMY INSTITUTE OF SURGICAL RESEARCH   (United States)

more..

Author keywords

Animal models of blast related injury; Blast physics; Blast related traumatic brain injury; Brain imaging; Post traumatic stress disorder

Indexed keywords

BLAST INJURY; CONFERENCE PAPER; DIAGNOSTIC IMAGING; DISEASE MODEL; FUNCTIONAL DISEASE; HUMAN; MEDICAL RESEARCH; NEUROIMAGING; NEUROPATHOLOGY; NONHUMAN; OCCUPATIONAL EXPOSURE; PATHOPHYSIOLOGY; PHYSICS; POSTTRAUMATIC STRESS DISORDER; RISK FACTOR; SLEEP DEPRIVATION; STRESS; SYMPTOM; TRAUMATIC BRAIN INJURY;

ANIMALS; AUTOPSY; BIOMEDICAL RESEARCH; BLAST INJURIES; BRAIN; BRAIN INJURIES; DIAGNOSTIC IMAGING; DIFFUSE AXONAL INJURY; DISEASE MODELS, ANIMAL; HUMANS; INTERDISCIPLINARY COMMUNICATION; MILITARY MEDICINE; PHYSICS; SEVERITY OF ILLNESS INDEX; TRANSLATIONAL RESEARCH; WAR;

EID: 75449110787     PISSN: 08977151     EISSN: None     Source Type: Journal    
DOI: 10.1089/neu.2009.0885     Document Type: Conference Paper

References (77)

1. Alexander, M. (1995). Mild traumatic brain injury: pathophysiology, natural history, and clinical management. Neurology 45, 1253-1260.
2. Armonda, R.A., Bell, R.S., Vo, A.H., Ling, G., DeGraba, T.J., Crandall, B., Ecklund, J., and Campbell, W.W. (2006). Wartime traumatic cerebral vasospasm: recent review of combat casualties. Neurosurgery 59, 1215-1225.
3. Askenasy, J. (1989). Association of intracerebral bone fragments and epilepsy in missile head injuries. Acta Neurol. Scand. 79, 47-52.
4. Benzinger, T. (1950). Physiological effects of blast in air and water, Ch. XIV-B, German Aviation Medicine, World War II, Vol.II. U.S. Government Printing Office: Washington, DC, pps. 1225-1259.
5. Bergsneider, M., Hovda, D., Shalmon, E., Kelly, D., Vespa, P., Martin, N., Phelps, M., McArthur, D., Caron, M., Kraus, J. and Becker, D. (1997). Cerebral hyperglycolysis following severe traumatic brain injury in humans: a positron emission tomography study. J. Neurosurg. 86, 241-251.
6. Bhattacharjee, Y. (2008). Neuroscience. Shell shock revisited: solving the puzzle of blast trauma. Science 319, 406-408.
7. Brenner, T., Freier, M.C., Holshouser, B.A., Burley, T., and Ashwal, S. (2003). Predicting neuropsychologic outcome after traumatic brain injury in children. Ped. Neurol. 28, 104-114.
8. Cernak, I., Wang, Z., Jiang, J., Bian, X., and Savic, J. (2001). Ultrastructural and functional characteristics of blast injuryinduced neurotrauma. J. Trauma 50, 695-706.
9. Chavko, M., Koller, W.A., Prusaczyk, W.K., and McCarron, R.M. (2007). Measurement of blast wave by a miniature fiber optic pressure transducer in the rat brain. J. Neurosci. Meth. 159, 277-281.
10. Chavko, M., Prusaczyk, W.K., and McCarron, R.M. (2008). Protection against blast-induced mortality in rats by hemin. J. Trauma 65, 1140-1145.
11. Clemedson, C.-J. (1956). Shockwave transmission to the central nervous system. Acta Physiologica Scand. 37, 204-214.
12. Condon, B., Oluoch-Olunya, D., Hadley, D., Teasdale, G., and Wagstaff, A. (1998). Early 1H magnetic resonance spectroscopy of acute head injury: four cases. J. Neurotrauma. 15, 563-571.
13. Cooper, G., Maynard, R., Cross, N., and Hill, J. (1983). Casualties from terrorist bombings. J. Trauma 23, 955-967.
14. Cripps, N.P.J., and Cooper, G.J. (1996). The influence of personal blast protection on the distribution and severity of primary blast gut injury. J. Trauma 40, S206-S211.
15. Culver, J., Akers, W., and Achilefu, S. (2008). Multimodality molecular imaging with combined optical and SPECT=PET modalities. J. Nucl. Med. 49, 169-172.
16. Curcio, C.K., Larriva, R.F., and Sullivan, A. (2002). Enhanced blast weapons defensive tactics, techniques, and procedures medical precautions and treatment and threat assessment, CETO Report 004-102, Center for Emerging Threats and Opportunities, Marine Corps Warfighting Laboratory, Quantico, Virginia.
17. Daly, C.M., Doyle, M.E., Radkind, M., Raskind, E., and Daniels, C. (2005). Clinical case series: the use of prazosin for combatrelated recurrent nightmares among Operation Iraqi Freedom combat veterans. Mil. Med. 170, 513-515.
18. DeKosky, S.T., Abrahamson, E.E., Ciallella, J.R., Paljug, W.R., Wisniewski, S.R., Clark, R.S., and Ikonomovic, M.D. (2007). Association of increased cortical soluble abeta42 levels with diffuse plaques after severe brain injury in humans. Arch. Neurol. 64, 541-544.
19. DePalma, R.G., Burris, D.G., Champion, H.R., and Hodgson, M.J. (2005). Blast injuries. N. Engl. J. Med. 352, 1335-1342.
20. Desaga, H. (1943). Experimental Investigation of the Blast Effect, Communications from the Domain of Aeromedicine, Aeromedical Research Institute of the German Air Ministry, Res. Report No. 15.
21. DeWitt, D.S., and Prough, D.S. (2003). Traumatic cerebral vascular injury: the effects of concussive brain injury on the cerebral vasculature. J. Neurotrauma 20, 795-825.
22. Diaz-Arrastia, R., Gong, Y., Fair, S., Scott, K.D., Garcia, M.C., Carlile, M.C., Agostini, M.A., and Van Ness, P.C. (2003). Increased risk of late posttraumatic seizures associated with inheritance of APOE epsilon4 allele. Arch. Neurol. 60, 818-822.
23. Doukas, A.G., McAulliffe, D.J., Lee, S., Venugopalan, V., and Flotte, T.J. (1995). Physical factors involved in stresswave-induced cell injury: the effect of stress gradient. Ultrasound Med. Biol. 21, 961-967.
24. Draeger, R.H., Barr, J.S., Dunbar, J.Y., Sager, W.W., and Shelesnyak, M.C. (1945). A Study of Personnel Injury by 'Solid Blast' and the Design and Evaluation of Protective Devices. Report No. 1, Research Project X-517, Naval Medical Research Institute, National Naval Medical Center, Bethesda, Maryland.
25. Dusick, J.R., Glenn, T.C., Lee, W.N., Vespa, P.M., Kelly, D.F., Lee, S.M., Hovda, D.A., and Martin, N.A. (2007). Increased pentose phosphate pathway flux after clinical traumatic brain injury: a [1,2-13C2]glucose labeling study in humans. J. Cereb. Blood Flow Metab. 27, 1593-1602.
26. Fine, J.E., and Vinci, S.J. (1998). Causes of electromagnetic radiation from detonation of conventional explosives: a literature survey, ARL-TR-1690. Army Research Laboratory, Adelphi, Maryland.
27. Garner, E., Lakes, R., Lee, T., Swan, C., and Brand, R. (2000). Viscoelastic dissipation in compact bone: implications for stress-induced fluid flow in bone. Trans. Amer. Soc. Mech. Eng. 122, 166-172.
28. Garnett, M.R., Blamire, A.M., Corkill, R.G., Cadoux-Hudson, T.A., Rajagopalan, B., and Styles, P. (2000a). Early proton magnetic resonance spectroscopy in normal-appearing brain correlates with outcome in patients following traumatic brain injury. Brain 123, 2046-2054.
29. Garnett, M.R., Blamire, A.M., Rajagopalan, B., Styles, P., and Cadoux-Hudson, T.A. (2000b). Evidence for cellular damage in normal-appearing white matter correlates with injury severity in patients following traumatic brain injury: A magnetic resonance spectroscopy study. Brain 123, 1403-1409. (Pubitemid 30420940)
30. Ghajar, J., and Ivry, R.B. (2008). The predictive brain state: timing deficiency in traumatic brain injury? Neurorehab. Neural Repair 22, 217-227.
31. Gouw, A.A., Seewann, A., Vrenken, H., Van Der Flier, W.M., Rozemuller, J.M., Barkhof, F., Scheltens, P., and Geurts, J.J. (2008). Heterogeneity of white matter hyperintensities in Alzheimer's disease: post-mortem quantitative MRI and neuropathology. Brain 131, 3286-3298.
32. Head, D., Buckner, R.L., Shimony, J.S., Williams, L.E., Akbudak, E., Conturo, T.E., McAvoy, M., Morris, J.C., and Snyder, A.Z. (2004). Differential vulnerability of anterior white matter in nondemented aging with minimal acceleration in dementia of the Alzheimer type: evidence from diffusion tensor imaging. Cereb. Cortex 14, 410-423.
33. He, B.J., Shulman, G.L., Snyder, A.Z., and Corbetta, M. (2007). The role of impaired neuronal communication in neurological disorders. Curr. Opin. Neurol. 20, 655-660.
34. Hoge, C.W., McGurk, D., Thomas, J.L., Cox, A.L., Engel, C.C., and Castro, C.A. (2008). Mild traumatic brain injury in U.S. soldiers returning from Iraq. N. Engl. J Med. 358, 453-463.
35. Hughes, D.G., Jackson, A., Mason, D.L., Berry, E., Hollis, S., and Yates, D.W. (2004). Abnormalities on magnetic resonance imaging seen acutely following mild traumatic brain injury: correlation with neuropsychological tests and delayed recovery. Neuroradiology 46, 550-558.
36. Ikonomovic, M.D., Uryu, K., Abrahamson, E.E., Ciallella, J.R., Trojanowski, J.Q., Lee, V.M., Clark, R.S., Marion, D.W., Wisniewski, S.R., and DeKosky, S.T. (2004). Alzheimer's pathology in human temporal cortex surgically excised after severe brain injury. Exp. Neurol. 190, 192-203.
37. Jellinger, K.A. (2004). Head injury and dementia. Curr. Opin. Neurol. 17, 719-723.
38. Jordan, B.D. (2007). Genetic influences on outcome following traumatic brain injury. Neurochem. Res. 32, 905-915.
39. Kelly, B. (1993). EMP from Chemical Explosions, Group P-14. Los Alamos National Laboratory, Los Alamos, New Mexico.
40. Lee, H., Wintermark, M., Gean, A.D., Ghajar, J., Manley, G.T., and Mukherjee, P. (2008). Focal lesions in acute mild traumatic brain injury and neurocognitive outcome: CT versus 3T MRI. J. Neurotrauma 25, 1049-1056.
41. Leung, L.Y., VandeVord, P.J., Dal Cengio, A.L., Bir, C., Yang, K.H., and King, A.I. (2008). Blast related neurotrauma: a review of cellular injury. Mol. Cell Biomech. 5, 155-168.
42. Longhi, L., Saatman, K.E., Fujimoto, S., Raghupathi, R., Meaney, D.F., Davis, J., McMillan, B.S.A., Conte, V., Laurer, H.L., Stein, S., Stocchetti, N., and McIntosh, T.K. (2005). Temporal window of vulnerability to repetitive experimental concussive brain injury. Neurosurgery 56, 364-374; discussion 364-374.
43. Maas, A.I., Stocchetti, N., and Bullock, R. (2008). Moderate and severe traumatic brain injury in adults. Lancet Neurol. 7, 728-741.
44. Mac Donald, C.L., Dikranian, K., Bayly, P., Holtzman, D., and Brody, D. (2007). Diffusion tensor imaging reliably detects experimental traumatic axonal injury and indicates approximate time of injury. J. Neurosci. 27, 11869-11876.
45. McHugh, G.S., Engel, D.C., Butcher, I., Steyerberg, E.W., Lu, J., Mushkudiani, N., Hernandez, A.V., Marmarou, A., Maas, A.I., and Murray, G.D. (2007). Prognostic value of secondary insults in traumatic brain injury: results from the IMPACT study. J. Neurotrauma 24, 287-293. (Pubitemid 46492150)
46. Morrison, B., Meaney, D.F., Margulies, S.S., and McIntosh, T.K. (2000). Dynamic mechanical stretch of organotypic brain slice cultures induces differential genomic expression: relationship to mechanical parameters. J. Biomech. Eng. 122, 224-230.
47. Nelson, T.J., Wall, D.B., Stedje-Larsen, E.T., Clark, R.T., Chambers, L.W., and Bohman, H.R. (2006). Predictors of mortality in close proximity blast injuries during Operation Iraqi Freedom. J. Am. Coll. Surg. 202, 418-422.
48. Niogi, S.N., Mukherjee, P., Ghajar, J., Johnson, C.E., Kolster, R., Lee, H., Suh, M., Zimmerman, R.D., Manley, G.T., and Candliss, B.D. (2008a). Structural dissociation of attentional control and memory in adults with and without mild traumatic brain injury. Brain 131, 3209-3221.
49. Niogi, S.N., Mukherjee, P., Ghajar, J., Johnson, C., Kolster, R.A., Sarkar, R., Lee, H., Meeker, M., Zimmerman, R.D., Manley, G.T., and McCandliss, B.D. (2008b). Extent of microstructural white matter injury in postconcussive syndrome correlates with impaired cognitive reaction time: a 3T diffusion tensor imaging study of mild traumatic brain injury. Am. J. Neuroradiol. 29, 967-973.
50. Okie, S. (2005). Traumatic brain injury in the war zone. N. Engl. J. Med. 352, 2043-2047.
51. Parizel, P.M., Van Goethem, J.W., Ozsarlak, O., Maes, M., and Phillips, C.D. (2005). New developments in the neuroradiological diagnosis of craniocerebral trauma. Europ. Radiol. 15, 569-581.
52. Peles, E., Barell, V., Boyko, V., Ziv, A., and Kaplan, G. (2001). Traumatic brain injury-the National Trauma Registry. Harefuah 140, 381-385.
53. Phillips, Y., and Richmond, D. (1990). Primary blast injury and basic research: a brief history, in: Textbook of Military Medicine: Conventional Warfare: Ballistic, Blast and Burn Injuries. R.F. Bellamy and R. Zajtchuck (eds), Borden Institute: Washington, D.C., pps. 221-240. Accessible at: http:==www.bordeninstitute .army.mil=published-volumes=conventional-warfare= ch06.pdf
54. Raskind, M.A., Peskind, E.R., Hoff, D.J., Hart, K.L., Holmes, H.A., Warren, D., Shofer, J., O'Connell, J., Taylor, F., Gross, C., Rohde, K., and McFall, M.E. (2007). A parallel group placebo controlled study of prazosin for trauma nightmares and sleep disturbance in combat veterans with post-traumatic stress disorder. Biol. Psychiat. 61, 928-934.
55. Richmond, D.R., and Jenssen, A. (1992). Compendium of the biological effects of complex blast waves. Prepared for the Norwegian Defence Construction Service and HQ Defence Command, Norway Joint Medical Service.
56. Richmond, D.R., Taborelli, R.V., Sherping, F., Wetherbe, M.B., Sanchez, R.T., Goldizen, V.C., and White, C.S. (1959). Shock tube studies of the effects of sharp-rising, long-duration overpressures on biological systems. USAEC Technical Report TID-6056, Office of Technical Services, Department of Commerce, Washington D.C.
57. Saatman, K.E., Duhaime, A.C., Bullock, R., Maas, A.I., Valadka, A., and Manley, G.T. (2008). Classification of traumatic brain injury for targeted therapies. J. Neurotrauma 25, 719-738.
58. Schmierer, K., Wheeler-Kingshott, C.A., Boulby, P.A., Scaravilli, F., Altmann, D.R., Barker, G.J., Tofts, P.S., and Miller, D.H. (2007). Diffusion tensor imaging of post mortem multiple sclerosis brain. Neuroimage 35, 467-477.
59. Schwartz, I., Tsenter, J., Shochina, M., Shiri, S., Kedary, M., Katz-Leurer, M., Meiner, Z. (2007). Rehabilitation outcomes of terror victims with multiple traumas. Arch. Phys. Med. Rehabil 88, 440-448.
60. Shein, N.A., Horowitz, M., and Shohami, E. (2007). Heat acclimation: a unique model of physiologically mediated global preconditioning against traumatic brain injury. Prog. Brain Res. 161, 353-363.
61. Sternberg, H.M., and Hurwitz, H. (1976). Calculated spherical shock waves produced by condensed explosives in air and water. Proc. Sixth Int'l. Symp. Detonation, Coronado, California, August, 24-27, pps. 528-539.
62. Stuhmiller, J. (2008). Blast injury: translating research into operational medicine. W. Santee and K. Friedl (eds), U.S. Army Medical Research and Materiel Command, Ft. Detrick, Maryland, pps. 1-36.
63. Tanielian, T., and Jaycox, L.H. (2008). Invisible wounds of war: psychological and cognitive injuries, their consequences, and services to assist recovery. RAND. Accessed at: http:==www .rand.org=pubs=monographs=MG720=
64. Teasdale, G.M., Murray, G.D., and Nicoll, J.A. (2005). The association between APOE epsilon4, age and outcome after head injury: A prospective cohort study. Brain 128, 2556-2561.
65. Thali, M.J., Jackowski, C., Oesterhelweg, L., Ross, S.G., and Dirnhofer, R. (2007). VIRTOPSY-the Swiss virtual autopsy approach. Leg. Med. (Tokyo) 9, 100-104.
66. Toth, C., and Fletcher, W.A. (2005). Autonomic disorders and the eye. J. Neuroophthalmol. 25, 1-4.
67. Vagnozzi, R., Signoretti, S., Tavazzi, B., Floris, R., Ludovici, A., Marziali, S., Tarascio, G., Amorini, A.M., Di Pietro, V., Delfini, R., and Lazzarino, G. (2008). Temporal window of metabolic brain vulnerability to concussion: a pilot 1H-magnetic resonance spectroscopic study in concussed athletes-part III. Neurosurgery. 62, 1286-1295; discussion 1295-11286
68. Vawter, D.L., Fung, Y.C., and West, J.B. (1978). Elasticity of excised dog lung parenchyma. J. Appl. Physiol. 45, 261-269.
69. Viano, D.C., and Lau, I.V. (1988). A viscous tolerance criterion for soft tissue injury assessment. J. Biomechanics 21, 387-399.
70. Warden, D. (2006). Military TBI during the Iraq and Afghanistan wars. J. Head Trauma Rehabil. 21, 398-402.
71. Weber, J.T. (2007). Experimental models of repetitive brain injuries. Prog. Brain Res. 161, 253-261.
72. White, C.S. (1961). Biological effects of blast. Technical Progress Report No. DASA 1271, Defense Atomic Support Agency, Department of Defense, Washington D.C.
73. White, C.S., Bowen, I.G., and Richmond, D.R. (1964). A comparative analysis of some of the immediate environmental effects at Hiroshima and Nagasaki. Health Physics 10, 89-150.
74. White, C.S., Bowen, I.G., and Richmond, D.R. (1965). Biological tolerance to air blast and related biomedical criteria, CEX-65.4, Civil Effects Test Operations, U.S. Atomic Energy Commission, p. 20.
75. Yoshino, A.,Hovda,D.A., Kawamata, T., Katayama, Y., and Becker, D.P. (1991). Dynamic changes in local cerebral glucose utilization following cerebral conclusion in rats: evidence of a hyper- and subsequent hypometabolic state. Brain Res. 561, 106-119.
76. Young, M. (1945). Mechanics of blast injury. War Med. 8, 73.
77. Zuckerman, S. (1940). Experimental study of blast injuries to the lungs, Lancet ii, 219-224.