Maternal separation alters maternal care, but has minor effects on behavior and brain opioid peptides in adult offspring

Developmental Psychobiology

Volumn 45, Issue 3, 2004, Pages 140-152

  Marmendal, Maarit ^a   Roman, Erika ^b   Eriksson, C J Peter ^c   Nylander, Ingrid ^b   Fahlke, Claudia ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

^c NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

Author keywords

Corticosterone; Dynorphin B; Emotionality; Ethanol intake; Maternal care; Maternal separation; Met enkefalin Arg6Phe7

Indexed keywords

ALCOHOL; AMPHETAMINE; CORTICOSTERONE; ENDORPHIN; OPIATE PEPTIDE;

ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BEHAVIOR; COMPETITIVE BEHAVIOR; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; DRUG ABUSE; EMOTIONALITY; EXPLORATORY BEHAVIOR; FEMALE; IMMUNOREACTIVITY; LOCOMOTION; MALE; MATERNAL BEHAVIOR; MATERNAL CARE; MATERNAL DEPRIVATION; MENTAL DISEASE; NONHUMAN; PERINATAL PERIOD; PROGENY; RAT; RAT STRAIN;

ANIMALS; BRAIN; CORTICOSTERONE; DYNORPHINS; EMOTIONS; ENDORPHINS; ENKEPHALIN, METHIONINE; FEMALE; MALE; MATERNAL BEHAVIOR; MATERNAL DEPRIVATION; MOTOR ACTIVITY; NESTING BEHAVIOR; RATS; REFERENCE VALUES; SOCIAL BEHAVIOR;

RATTUS NORVEGICUS;

EID: 7544244252     PISSN: 00121630     EISSN: None     Source Type: Journal    
DOI: 10.1002/dev.20027     Document Type: Article

References (51)

1. Albert, D. J., Dyson, E. M., & Walsh, M. L. (1987). Competitive behavior: Intact male rats but not hyperdefensive males with medial hypothalamic lesions share water with females. Physiology & Behavior, 41, 549-553.
2. Caldji, C., Francis, D., Sharma, S., Plotsky, P. M., & Meaney, M. J. (2000). The effects of early rearing environment on the development of GABAA and central benzodiazepine receptor levels and novelty-induced fearfulness in the rat. Neuropsychopharmacology, 22, 219-229.
3. Caldji, C., Tannenbaum, B., Sharma, S., Francis, D., Plotsky, P. M., & Meaney, M. J. (1998). Maternal care during infancy regulates the development of neural systems mediating the expression of fearfulness in the rat. Proceedings of the National Academy of Sciences, USA, 95, 5335-5340.
4. Chretien, P., & Gratton, A. (2002, November). Long term effects of early maternal separation on cocaine-seeking in the adult rat. Paper presented at the meeting of the Society for Neuroscience, Washington, DC.
5. Christensson-Nylander, I., Nyberg, F., Ragnarsson, U., & Terenius, L. (1985). A general procedure for analysis of proenkephalin B derived opioid peptides. Regulatory Peptides, 11, 65-76.
6. Fahlke, C., Hård, E., Eriksson, C. J., Engel, J. A., & Hansen, S. (1995a). Amphetamine-induced hyperactivity: Differences between rats with high or low preference for alcohol. Alcohol, 12, 363-367.
7. Fahlke, C., Hård, E., Eriksson, C. J., Engel, J. A., & Hansen, S. (1995b). Consequence of long-term exposure to corticosterone or dexamethasone on ethanol consumption in the adrenalectomized rat, and the effect of type I and type II corticosteroid receptor antagonists. Psychopharmacology (Berlin), 117, 216-224.
8. Fahlke, C., Lorenz, J. G., Long, J., Champoux, M., Suomi, S. J., & Higley, J. D. (2000). Rearing experiences and stress-induced plasma cortisol as early risk factors for excessive alcohol consumption in nonhuman primates. Alcoholism, Clinical and Experimental Research, 24, 644-650.
9. File, S. E., & Wardill, A. G. (1975). Validity of head-dipping as a measure of exploration in a modified hole-board. Psychopharmacologia, 44, 53-59.
10. Francis, D. D., Caldji, C., Champagne, F., Plotsky, P. M., & Meaney, M. J. (1999). The role of corticotropin-releasing factor - Norepinephrine systems in mediating the effects of early experience on the development of behavioral and endocrine responses to stress. Biological Psychiatry, 46, 1153-1166.
11. Hall, F. S. (1998). Social deprivation of neonatal, adolescent, and adult rats has distinct neurochemical and behavioral consequences. Critical Reviews in Neurobiology, 12, 129-162.
12. Hansen, S., Fahlke, C., Hård, E., & Engel, J. A. (1994). Adrenal corticosteroids modulate the consumption of ethanol in the rat. In T. Palomo & T. Archer (Eds.), Strategies for studying brain disorders: Depressive, anxiety, and abuse disorders (pp. 465-479). London: Farrand Press.
13. Hansen, S., & Hård, E. (1980). Ontogeny of the audiogenic immobility reaction in the rat. Biology of Behavior, 5, 163-168.
14. Heim, C., & Nemeroff, C. B. (2001). The role of childhood trauma in the neurobiology of mood and anxiety disorders: Preclinical and clinical studies. Biological Psychiatry, 49, 1023-1039.
15. Henry, J. P., & Wang, S. (1998). Effects of early stress on adult affiliative behavior. Psychoneuroendocrinology, 23, 863-875.
16. Higley, J. D., & Bennett, A. J. (1999). Central nervous system serotonin and personality as variables contributing to excessive alcohol consumption in non-human primates. Alcohol and Alcoholism, 34, 402-418.
17. Higley, J. D., Hasert, M. F., Suomi, S. J., & Linnoila, M. (1991). Nonhuman primate model of alcohol abuse: Effects of early experience, personality, and stress on alcohol consumption. Proceedings of the National Academy of Sciences, USA, 88, 7261-7265.
18. Huot, R. L., Thrivikraman, K. V., Meaney, M. J., & Plotsky, P. M. (2001). Development of adult ethanol preference and anxiety as a consequence of neonatal maternal separation in Long-Evans rats and reversal with antidepressant treatment. Psychopharmacology (Berlin), 158, 366-373.
19. Hård, E., & Larsson, K. (1975). Development of air righting in rats. Brain Behavior and Evolution, 11, 53-59.
20. Hård, E., Musi, B., Dahlgren, I. L., Engel, J., Larsson, K., Liljequist, S., & Lindh, A. S. (1985). Impaired maternal behaviour and altered central serotonergic activity in the adult offspring of chronically ethanol treated dams. Acta Pharmacologica et Toxicologica (Copenhagen), 56, 347-353.
21. Johansson, A. K., & Hansen, S. (2001). Increased novelty seeking and decreased harm avoidance in rats showing Type 2-like behaviour following basal forebrain neuronal loss. Alcohol and Alcoholism, 36, 520-524.
22. Kalinichev, M., Easterling, K. W., Plotsky, P. M., & Holtzman, S. G. (2002). Long-lasting changes in stress-induced corticosterone response and anxiety-like behaviors as a consequence of neonatal maternal separation in Long-Evans rats. Pharmacology Biochemistry & Behavior, 73, 131-140.
23. Kendler, K. S., Bulik, C. M., Silberg, J., Hettema, J. M., Myers, J., & Prescott, C. A. (2000). Childhood sexual abuse and adult psychiatric and substance use disorders in women: An epidemiological and cotwin control analysis. Archives in General Psychiatry, 57, 953-959.
24. Koob, G. F. (1992). Drugs of abuse: Anatomy, pharmacology and function of reward pathways. Trends in Pharmacology Science, 13, 177-184.
25. Ladd, C. O., Huot, R. L., Thrivikraman, K. V., Nemeroff, C. B., Meaney, M. J., & Plotsky, P. M. (2000). Long-term behavioral and neuroendocrine adaptations to adverse early experience. Progress in Brain Research, 122, 81-103.
26. Lancaster, F. E. (1998). Sex differences in voluntary drinking by Long-Evans rats following early stress. Alcoholism, Clinical and Experimental Research, 22, 830-836.
27. Lehmann, J., & Feldon, J. (2000). Long-term biobehavioral effects of maternal separation in the rat: Consistent or confusing? Reviews in the Neurosciences, 11, 383-408.
28. Lehmann, J., Pryce, C. R., & Feldon, J. (2000). Lack of effect of an early stressful life event on sensorimotor gating in adult rats. Schizophrenia Research, 41, 365-371.
29. Liu, D., Diorio, J., Tannenbaum, B., Caldji, C., Francis, D., Freedman, A., Sharma, S., Pearson, D., Plotsky, P. M., Meaney, M. J. (1997, September). Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary- adrenal responses to stress. Science, 277, 1659-1662.
30. Matthews, K., Hall, F. S., Wilkinson, L. S., & Robbins, T. W. (1996). Retarded acquisition and reduced expression of conditioned locomotor activity in adult rats following repeated early maternal separation: Effects of prefeeding, d-amphetamine, dopamine antagonists and clonidine. Psychopharmacology (Berlin), 126, 75-84.
31. Matthews, K., & Robbins, T. W. (2003). Early experience as a determinant of adult behavioural responses to reward: The effects of repeated maternal separation in the rat. Neuroscience and Biobehavioral Reviews, 27, 45-55.
32. Matthews, K., Robbins, T. W., Everitt, B. J., & Caine, S. B. (1999). Repeated neonatal maternal separation alters intravenous cocaine self-administration in adult rats. Psychopharmacology (Berlin), 141, 123-134.
33. Matthews, K., Wilkinson, L. S., & Robbins, T. W. (1996). Repeated maternal separation of preweanling rats attenuates behavioral responses to primary and conditioned incentives in adulthood. Physiology & Behavior, 59, 99-107.
34. Maughan, B., & McCarthy, G. (1997). Childhood adversities and psychosocial disorders. British Medical Bulletin, 53, 156-169.
35. Meaney, M. J., Brake, W., & Gratton, A. (2002). Environmental regulation of the development of mesolimbic dopamine systems: A neurobiological mechanism for vulnerability to drug abuse? Psychoneuroendocrinology, 27, 127-138.
36. Nylander, I., Stenfors, C., Tan-No, K., Mathe, A. A., & Terenius, L. (1997). A comparison between microwave irradiation and decapitation: Basal levels of dynorphin and enkephalin and the effect of chronic morphine treatment on dynorphin peptides. Neuropeptides, 31, 357-365.
37. Paxinos, G., & Watson, C. (1997). The rat brain in stereotaxic coordinates (Compact 3rd ed.) San Diego, CA: Academic Press.
38. Ploj, K., Roman, E., Gustavsson, L., & Nylander, I. (2000). Basal levels and alcohol-induced changes in nociceptin/orphanin FQ, dynorphin, and enkephalin levels in C57BL/6J mice. Brain Research Bulletin, 53, 219-226.
39. Ploj, K., Roman, E., & Nylander, I. (2002). Effects of maternal separation on brain nociceptin/orphanin FQ peptide levels in male Wistar rats. Pharmacology Biochemistry & Behavior, 73, 123-129.
40. Ploj, K., Roman, E., & Nylander, I. (2003a). Long-term effects of maternal separation on ethanol intake and brain opioid and dopamine receptors in male Wistar rats. Neuroscience, 121, 787-799.
41. Ploj, K., Roman, E., & Nylander, I. (2003b). Long-term effects of short and long periods of maternal separation on brain opioid peptide levels in male Wistar rats. Neuropeptides, 37, 149-156.
42. Pohorecky, L. A. (1990). Interaction of ethanol and stress: Research with experimental animals - An update. Alcohol and Alcoholism, 25, 263-276.
43. Pryce, C. R., Bettschen, D., & Feldon, J. (2001). Comparison of the effects of early handling and early deprivation on maternal care in the rat. Developmental Psychobiology, 38, 239-251.
44. Pryce, C. R., & Feldon, J. (2003). Long-term neurobehavioural impact of the postnatal environment in rats: Manipulations, effects and mediating mechanisms. Neuroscience and Biobehavioral Reviews, 27, 57-71.
45. Roman, E., Hyytiä, P., & Nylander, I. (2003). Maternal separation alters acquisition of ethanol intake in male ethanol-preferring AA rats. Alcoholism, Clinical and Experimental Research, 27, 31-37.
46. Scimonelli, T., Marucco, M., & Celis, M. E. (1999). Age-related changes in grooming behavior and motor activity in female rats. Physiology & Behavior, 66, 481-484.
47. Shalev, U., & Kafkafi, N. (2002). Repeated maternal separation does not alter sucrose-reinforced and open-field behaviors. Pharmacology Biochemistry & Behavior, 73, 115-122.
48. Siegel, S., & Castellan, N. J. (1988). Nonparametric statistics for the behavioral sciences (2nd ed.) New York: McGraw-Hill.
49. Vazquez, D. M., Eskandari, R., Zimmer, C. A., Levine, S., & Lopez, J. F. (2002). Brain 5-HT receptor system in the stressed infant rat: Implications for vulnerability to substance abuse. Psychoneuroendocrinology, 27, 245-272.
50. von Hoersten, S., Dimitrijevic, M., Markovic, B. M., & Jankovic, B. D. (1993). Effect of early experience on behavior and immune response in the rat. Physiology & Behavior, 54, 931-940.
51. Wigger, A., & Neumann, I. D. (1999). Periodic maternal deprivation induces gender-dependent alterations in behavioral and neuroendocrine responses to emotional stress in adult rats. Physiology & Behavior, 66, 293-302.