Retarded acquisition and reduced expression of conditioned locomotor activity in adult rats following repeated early maternal separation: Effects of prefeeding, d-amphetamine, dopamine antagonists and clonidine

Psychopharmacology

Volumn 126, Issue 1, 1996, Pages 75-84

  Matthews, Keith ^a   Hall, F Scott ^a,b   Wilkinson, Lawrence S ^a   Robbins, Trevor W ^a  

^a UK   (United Kingdom)

^b NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

Author keywords

Amphetamine; Clonidine; Conditioned incentive stimuli; Conditioned locomotor activity; Maternal separation; Mesolimbic dopamine; Rat; SCH 23390; Sulpiride

Indexed keywords

8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; CLONIDINE; DEXAMPHETAMINE; DOPAMINE RECEPTOR BLOCKING AGENT; SULPIRIDE;

AFFECT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICIPATION; APPETITE; ARTICLE; ATTENUATION; CONDITIONING; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; DOSE RESPONSE; FEEDING; FEMALE; HYPERACTIVITY; LIMBIC SYSTEM; LOCOMOTION; MALE; MATERNAL DEPRIVATION; NONHUMAN; NORADRENERGIC SYSTEM; PRIORITY JOURNAL; RAT; WEIGHT GAIN;

(R)-2,3,4,5-TETRAHYDRO-8-CHLORO-3-METHYL-5-PHENYL-1H-3-BENZAZEPIN-7-OL; ADRENERGIC ALPHA-AGONISTS; AMPHETAMINE; ANALYSIS OF VARIANCE; ANIMALS; ANXIETY, SEPARATION; BEHAVIOR, ANIMAL; BODY WEIGHT; CENTRAL NERVOUS SYSTEM STIMULANTS; CLONIDINE; CONDITIONING, OPERANT; DOPAMINE ANTAGONISTS; FEEDING BEHAVIOR; FEMALE; MALE; MOTOR ACTIVITY; RATS; REWARD; SEX FACTORS; SULPIRIDE;

EID: 0029903065     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02246414     Document Type: Article

References (49)

1. Beninger RJ, Hahn BL (1983) Pimozide blocks the establishment but not expression of amphetamine-produced environment-specific conditioning. Science 220: 1304-1306
2. Beninger RJ, Herz RS (1986)Pimozide blocks the establishment but not the expression of cocaine-produced environment-specific conditioning. Life Sci 38: 1425-1431
3. Blackburn JR, Phillips AG, Fibiger HC (1987) Dopamine and preparatory behavior I. Effects of pimozide. Behav Neurosci 101: 352-360
4. Blackburn JR, Phillips AG, Jakubovic A, Fibiger HC (1989) Dopamine and preparatory behavior II. A neurochemical analysis. Behav Neurosci 103: 15-23
5. Bowlby J (1960) Grief and mourning in early infancy. Psychoanal Study Child 15: 9-52
6. Brown GW, Harris TO (1978) The social origins of depression. Tavistock Press, London
7. Butler SR, Schanberg SM (1977) Effect of maternal deprivation on polyamine metabolism in preweanling rat brain and heart. Life Sci 21: 877-884
8. Camp LL, Rudy JW (1987) Behavioral activation in infant rats: pharmacological evidence for dopaminergic mediation. Psychobiology 15: 317-328
9. Camp LL, Rudy JW (1988) Changes in the categorisation of appetitive and aversive events during postnatal development of the rat. Dev Psychobiol 21: 25-42
10. Cirruli F, Gottlieb SL, Rosenfeld P, Levine S (1992) Maternal factors regulate stress responsiveness in the neonatal rat. Psychobiology 20: 143-152
11. Cochran WG, Cox GM (1957) Experimental designs, 2nd edn. Wiley, New York
12. Cramer CP (1988) Experience during suckling increases weight and volume of rat hippocampus. Dev Brain Res 42: 151-155
13. Creese I, Iversen SD (1973) Blockage of amphetamine-induced motor stimulation and stereotypy in the adult rat following neonatal treatment with 6-hydroxy-dopamine. Brain Res 55: 369-382
14. Diaz-Veliz G, Baeza R, Benavente F, Dussaubat N, Mora S (1994) Influence of the oestrous cycle and estradiol on the behavioral effects of amphetamine and apomorphine in rats. Pharmacol Biochem Behav 49: 819-825
15. Fibiger HC (1993) Mesolimbic dopamine: an analysis of its role in motivated behavior. Semin Neurosci 5: 321-327
16. Gold LH , Swerdlow NR, Koob GF (1988) The role of mesolimbic dopamine in conditioned locomotion produced by amphetamine. Behav Neurosci 102: 544-552
17. Grant SJ, Redmond DE (1981) The neuroanacomy and pharmacology of the locus coerulens. In: Lal H & Fielding S. (eds) Psychopharmacology of clonidine. A.R. Liss, New York, pp 5-27
18. Herz RS, Beninger RJ (1987) Comparison of the ability of (+)-amphetamine and caffeine to produce environment-specific conditioning. Psychopharmacology 92: 365-370
19. Hinde RA, Spencer-Booth Y (1971) Effects of brief separations from mothers on rhesus monkeys. Science 173: 117-118
20. Hofer M (1994) Early relationships as regulators of infant physiology and behavior. Acta Paediatr Suppl 397: 9-18
21. Jacobson M (1991) Dependence of the developing nervous system on nutrition and hormones. In: Jacobson M (ed) Developmental neurobiology, 3rd edn. Plenum Press, New York, pp 285-310
22. Jones GH, Robbins TW (1992) Differential effects of mesocortical, mesolimbic and mesostriatal dopamine depletion on spontaneous, conditioned and drug-induced locomotor activity. Pharmacol Biochem Behav 43: 887-895
23. Jones GH, Marsden CA, Robbins TW (1990) Increased sensitivity to amphetamine and reward-related stimuli following social isolation in rats: possible disruption of dopamine-dependent mechanisms of the nucleus accumbens. Psychopharmacology 102: 364-372
24. Kaneko WM, Riley EP, Ehlers CL (1994) Behavioral and electrophysiological effects of early repeated maternal separation. Depression 2: 43-53
25. Konorski J (1967) Integrative activity of the brain: an interdisciplinary approach. University of Chicago Press, Chicago
26. Kuhn CM, Butler SR, Schanberg SM (1978) Selective depression of serum growth hormone during maternal deprivation in rat pups. Science 201: 1034-1036
27. Kuhn CM, Evoniuk G, Schanberg SM (1979) Loss of tissue sensitivity to growth hormone during maternal deprivation in rats. Life Sci 25: 2089-2097
28. Kuhn CM, Pauk J, Schanberg SM (1990) Endocrine responses to mother-infant separation in developing rats. Dev Psychohiol 23: 395-410
29. Kullback S (1968) Information theory and statistics. Dover New York
30. Lau C, Cameron AM, Antolick LL, Stanton ME (1992) Repeated maternal separation in the neonatal rat: cellular mechanisms contributing to brain growth sparing. J Dev Physiol 17: 265-276
31. Levine S, Huchton DM, Weiner SG, Rosenfeld P (1991) Time course of the effect of material deprivation on the hypothalamic-pituitary-adrenal axis in the infant. Dev Psychobiol 24: 547-558
32. Matthews K, Wilkinson LS, Robbins TW (1996) Repeated maternal separation of preweanling rats attenuates behavioural responses to primary and conditioned incentives in adulthood. Physiol Behav 59: 99-107
33. Mazurski EJ, Beninger RJ (1988) Scopolamine produces environment-specific conditioned activity that is not blocked by pimozide in rats. Psychopharmacology 96: 375-380
34. 2 receptors on conditioned locomotion in rats. Psychopharmacology 105: 107-112
35. McCullough LD, Salamone JD (1992) Involvement of nucleus accumbens dopamine in the motor activity induced by periodic food presentation: a microdialysis and behavioral study. Brain Res 592: 29-36
36. McKinney WT, Suomi SJ, Harlow HF (1971) Depression in primates. Am J Psychiatry 127: 49-56
37. Mitome M, Honma S, Yoshihara T, Honma K (1994) Prefeeding increase in paraventricular NE release is regulated by a feeding-associated rhythm in rats. Am J Physiol 266 [Endocrinol Metab 29]: E606-611
38. Ogawa T, Mikuni M, Kuroda Y, Muneoka K, Mori KJ, Takahashi K (1994) Periodic maternal deprivation alters stress response in adult offspring: Potentiates the negative feedback regulation of restraint stress-induced adrenocortical response and reduces the frequencies of open field-induced behaviors. Pharmacol Biochem Behav 49: 961-967
39. Paykel ES, Hollyman JA (1984) Life events and depression - a psychiatric view. Trends Neurol Sci 12: 478-481
40. Plotsky PM, Meaney MJ (1993) Early postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content and stress induced release in adult rats. Mol Brain Res 18: 195-200
41. Poncelet M, Dangoumau L, Soubrie P, Simon P (1987) Effects of neuroleptic drugs, clonidine and lithium on the expression of conditioned behavioral excitation in rats. Psychopharmacology 92: 393-397
42. Post RM, Lockfeld A, Squillace KM, Contel NR (1981) Drug environment interaction: Context dependency of cocaine induced behavioural sensitisation. Life Sci 28: 755-760
43. Radhakishun FS, van Ree JM, Westerink BHC (1988) Scheduled eating increases dopamine release in the nucleus accumbens of food-deprived rats as assessed with on-line brain dialysis. Neurosci Lett 85: 351-356
44. Rutter M (1972) Maternal deprivation reassessed, 2nd edn. Penguin Books, London
45. Scallert T, Pendergrass M, Farrar SB (1982) Cholecystokinin-octapeptide effects on eating elicited by 'external' versus 'internal' cues in rats. Appetite 3: 81-90
46. Stanton ME, Levine S (1988) Maternal modulation of infant glucocorticoid stress responses: Role of age and maternal deprivation. Psychobiology 16: 223-228
47. Suchecki D, Rosenfeld P, Levine S (1993) Maternal regulation of hypothalamic-pituitary-adrenal axis in the infant rat: the role of feeding and stroking. Dev Brain Res 75: 185-192
48. Wilson C, Nomikos GG, Collu M, Fibiger HC (1995) Dopaminergic correlates of motivated behavior: importance of drive. J Neurosci 15[7]: 5169-5178
49. Winer BJ (1971) Statistical principles in experimental design, 2nd edn. McGraw-Hill, New York