Immunoglobulin KM and GM gene polymorphisms modify the clinical presentation of primary Sjögren's syndrome

Journal of Rheumatology

Volumn 31, Issue 11, 2004, Pages 2175-2180

  Pertovaara, Marja ^a   Hurme, Mikko ^a,b   Antonen, Jaakko ^a,b   Pasternack, Amos ^a,b   Pandey, Janardan P ^c  

^a TAMPERE UNIVERSITY HOSPITAL   (Finland)

^b UNIVERSITY OF TAMPERE MEDICAL SCHOOL   (Finland)

^c MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Gene polymorphism; Immunoglobulin; Primary Sj gren's syndrome

Indexed keywords

BETA 2 MICROGLOBULIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G3; IMMUNOGLOBULIN KAPPA CHAIN;

ADULT; AGED; ALLELE; ARTICLE; CLINICAL FEATURE; CLINICAL STUDY; CONTROLLED STUDY; DISEASE SEVERITY; DNA POLYMORPHISM; ERYTHROCYTE SEDIMENTATION RATE; FEMALE; GENETIC SUSCEPTIBILITY; GENOTYPE; HISTOLOGY; HUMAN; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOGLOBULIN GENE; IMMUNOPATHOLOGY; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SALIVARY GLAND; SJOEGREN SYNDROME;

BIOLOGICAL MARKERS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; IMMUNOGLOBULIN GAMMA-CHAINS; IMMUNOGLOBULIN GM ALLOTYPES; IMMUNOGLOBULIN KAPPA-CHAINS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; SALIVARY GLANDS, MINOR; SJOGREN'S SYNDROME;

EID: 7544223329     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Price EJ, Venables PJ. The etiopathogenesis of Sjögren's syndrome. Semin Arthritis Rheum 1995;25:117-33.
2. Pease CT, Charles PJ, Shattles W, Markwick J, Maini RN. Serological and immunogenetic markers of extraglandular primary Sjögren's syndrome. Br J Rheumatol 1993;32:574-7.
3. Hulkkonen J, Pertovaara M, Antonen J, Lahdenpohja N, Pasternack A, Hurme M. Genetic associations between IL-10 promoter region polymorphism and primary Sjögren's syndrome. Arthritis Rheum 2001;44:176-9.
4. Font J, Carcia-Carrasco M, Ramos-Casals M, et al. The role of interleukin-10 promoter polymorphism in the expression of primary Sjögren's syndrome. Rheumatology 2002;41:1025-30.
5. Hulkkonen J, Pertovaara M, Antonen J, Pasternack A, Hurme M. Elevated interleukin-6 plasma levels are regulated by the promoter region polymorphism of IL-6 gene in primary Sjögren's syndrome (pSS) and correlate with clinical manifestations of the disease. Rheumatology 2001;40:656-61.
6. Pertovaara M, Hulkkonen J, Antonen J, et al. Polymorphism of the tumour necrosis factor-alpha gene at position -308 and renal manifestations of primary Sjögren's syndrome. Rheumatology 2004;43:106-7.
7. Gottenberg JE, Busson M, Loiseau P, et al. Association of transforming growth factor B1 and tumor necrosis factor α polymorphisms with anti-SSB/La antibody secretion in patients with primary Sjögren's syndrome. Arthritis Rheum 2004;50:570-80.
8. Dugoujon J, Cambon-Thomsen A. Immunoglobulin allotypes (Gm and Km) and their interactions with HLA-antigens in autoimmune diseases: a review. Autoimmunity 1995;22:245-60.
9. Pandey JP. Immunoglobulin GM and KM allotypes and vaccine immunity. Vaccine 2001;19:613-7.
10. Whittingham S, Propert D, Mackay I. A strong association between the antinuclear antibody anti-La (SS-B) and the kappa light chain allotype Km(1). Immunogenetics 1984;19:295-9.
11. Downie-Doyle S, Lester S, Bardy P, Gordon T, Rischmueller M, Pile K. Immunoglobulin kappa light chain gene alleles are not associated with primary Sjögren's syndrome. Genes Immunity 2002; Suppl 1:S63-S65.
12. Fox RI, Robinson CA, Curd JG, Kozin F, Howell FV. Sjögren's syndrome. Proposed criteria for classification. Arthritis Rheum 1986;29:577-85.
13. Chishom DM, Mason DK. Labial salivary gland biopsy in Sjögren's disease. J Clin Pathol 1968;21:656-60.
14. Vitali C, Bombardieri S, Jonsson R, et al. Classification criteria for Sjögren's syndrome: a revised version of the European criteria proposed by the American-European consensus group. Ann Rheum Dis 2002;61:554-9.
15. Pertovaara M, Korpela M, Kouri T, Pasternack A. The occurrence of renal involvement in primary Sjögren's syndrome: a study of 78 patients. Rheumatology 1999;38:1113-20.
16. Balbin M, Grubb A, de Lange CC, Grubb R. DNA sequences specific for Caucasian G3m(b) and (g) allotypes: Immunogenetics 1994;39:187-93.
17. Balbin M, Grubb A, Abrahamson M, Grubb R. Determination of allotypes Glm(f) and Glm(z) at the genomic level by subclass-specific amplification of DNA and use of allele-specific probes. Exp Clin Immunogenet 1991;8:88-95.
18. Cavalli-Sforza LL, Menozzi P, Piazza A, et al. The history and geography of human genes. Princeton: Princeton University Press; 1994.
19. Cooper LJ, Robertson D, Granzow R, Greenspan NS. Variable domain-identical antibodies exhibit IgG subclass-related differences in affinity and kinetic constants as determined by surface plasmon resonance. Mol Immunol 1994;31:577-84.
20. Pritsch O, Hudry-Clergeon G, Buckle M, et al. Can immunoglobulin C(H)1 constant region domain modulate antigen binding affinity of antibodies? J Clin Invest 1996;98:2235-43.
21. McLean GR, Torres M, Elguezabal N, Nakouzi A, Casadevall A. Isotype can affect the fine specificity of an antibody for a polysaccharide antigen. J Immunol 2002;169:1379-86.
22. Hoffman RW, Sharp GC, Irvin WS, Anderson SK, Hewett JE, Pandey JP. Association of immunoglobulin Km and Gm allotypes with specific antinuclear antibodies and disease susceptibility among connective tissue disease patients. Arthritis Rheum 1991;34:453-8.
23. Pandey JP, Page GP, Silver RM, LeRoy EC, Bona CA. Anti-fibrillin-1 autoantibodies in systemic sclerosis are GM and KM allotype-restricted. Exp Clin Immunogenet 2001;18:123-9.
24. Rider LG, Shamim E, Okada S, et al. Genetic risk and protective factors for idiopathic inflammatory myopathy in Koreans and American whites: a tale of two foci. Arthritis Rheum 1999;42:1285-90.
25. Pandey JP, Prohászka Z, Veres A, Füst G, Hurme M. Epistatic effects of genes encoding immunoglobulin GM allotypes and interleukin-6 on the production of autoantibodies to 60- and 65-kDa heat-shock proteins. Genes Immun 2004;5:68-71.
26. Michalski J, Daniels T, Talal N, Grey H. Beta-2 microglobulin and lymphocytic infiltration in Sjögren's syndrome. N Engl J Med 1975;293:1228-31.
27. Pertovaara M, Pukkala E, Laippala P, Miettinen A, Pasternack A. A longitudinal cohort study of Finnish patients with primary Sjögren's syndrome. Clinical, immunological and epidemiological aspects. Ann Rheum Dis 2001;60:467-72.
28. Nakao Y, Matsumoto H, Miyazaki T, et al. Genetic and clinical studies of serum beta-2 microglobulin in hematologic malignancies. Clin Exp Immunol 1981;46:134-41.
29. Rautonen N, Sarvas H, Julkunen I, Pyhälä R, Mäkelä O. Gm allotypes influence the production of IgG3 but the effect is age-dependent. Hum Immumol 1991;32:72-7.
30. Pandey JP, French MA. GM phenotypes influence the concentrations of the four subclasses of immunoglobulin G in normal human serum. Hum Immunol 1996;51:99-102.
31. Musk AW, Zilko PJ, Manners P, Kay PH, Kamboh ML. Genetic studies in familial fibrosing alveolitis. Possible linkage with immunoglobulin allotypes (Gm). Chest 1986;89:206-10.
32. Luger AM, Komathireddy G, Walker RE, Pandey JP, Hoffman RW Molecular and serologic analysis of HLA-genes and immunoglobulin allotypes in IgA nephropathy. Autoimmunity 1994;19:1-5.
33. Hartung K, Coldewey R, Rother E, et al. Immunoglobulin allotypes are not associated with HLA-antigens, autoantibodies and clinical symptoms in systemic lupus erythematosus. Members of the SLE Study Group. Rheumatol Int 1991;11:179-82.
34. Stenszky V, Kozma L, Szegedi G, Farid NR. Interplay of immunoglobulin G heavy chain markers (Gm) in predisposing to systemic lupus nephritis. J Immunogenet 1985;13:11-7.
35. Sanders PA, de Lange GG, Dyer PA, Grennan DM. Gm and Km allotypes in rheumatoid arthritis. Ann Rheum Dis 1985;44:529-32.
36. Eberhardt K, Grubb R, Johnson U, Pettersson H. HLA-DR antigens, Gm allotypes and anti-allotypes in early rheumatoid arthritis: their relation to disease progression. J Rheumatol 1993;20:1825-9.
37. Pandey JP, Cooper GS, Treadwell EL, Gilkeson GS, St Clair EW, Dooley MA. Immunoglobulin GM and KM allotypes in systemic lupus erythematosus. Exp Clin Immunogenet 2001;18:117-22.
38. Gottenberg JE, Busson M, Loiseau P, et al. In primary Sjögren's syndrome, HLA class II is associated exclusively with autoantibody production and spreading of the autoimmune response. Arthritis Rheum 2003;48:2240-5.