Immunoglobulin kappa light chain gene alleles are not associated with primary Sjögren’s syndrome

Genes and Immunity

Volumn 3, Issue , 2002, Pages S63-S65

  Downie Doyle, S ^a   Lester, S ^a   Bardy, P ^b   Gordon, T ^c   Rischmueller, M ^a   Pile, K ^a  

^a QUEEN ELIZABETH HOSPITAL   (Australia)

^b AUSTRALIAN RED CROSS BLOOD SERVICE   (Australia)

^c FLINDERS MEDICAL CENTRE   (Australia)

Author keywords

Immunoglobulins; Km allotypes; Polymorphism; Sjogren s syndrome

Indexed keywords

IMMUNOGLOBULIN KAPPA CHAIN;

ARTICLE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; HUMAN; IMMUNOLOGY; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SJOEGREN SYNDROME;

GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; IMMUNOGLOBULIN KAPPA-CHAINS; POLYMORPHISM, GENETIC; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; SJOGREN'S SYNDROME;

EID: 34547473674     PISSN: 14664879     EISSN: 14765470     Source Type: Journal    
DOI: 10.1038/sj.gene.6363853     Document Type: Article

References (19)

1. Vitali C, Bombardieri S, Moutsopoulos M et al. Preliminary criteria for the classification of Sjo¨gren’s syndrome. Arthritis Rheum 1993; 36: 340–347.
2. Hinzova E, Ivanyi D, Sula K, Horejs J, Dostal C, Crizhal I. HLADw3 in Sjo¨gren’s syndrome. Tissue Antigens 1977; 37: 10–15.
3. Harley JB, Reichlin M, Arnett FC, Alexander EL, Bias WB, Provost TT. Gene interaction at HLA-DQ enhances autoantibody production in primary Sjo¨gren’s syndrome. Science 1986; 232: 1145–1147.
4. Rischmueller M, Lester S, Chen Z et al. HLA class II phenotype controls diversification of the autoantibody response in primary Sjo¨gren’s syndrome. Clin Exp Immunol 1998; 111: 365–371.
5. Dugoujon J, Cambon-Thomsen A. Immunoglobulin Allotypes (Gm and Km) and their interactions with HLA antigens in autoimmune diseases: a review. Autoimmunity 1995; 22: 245–260.
6. Kurth J, Bowcock A, Erlich H, Nevo S, Cavalli-Sforza L. Km typing with PCR: application to population screening. Am J Hum Genet 1991; 48: 613–620.
7. Moxley G, Gibbs R. Polymerase chain reaction-based genotyping for allotypic markers of immunoglobulin kappa shows allelic association of Km with kappa variable segment. Genomics 1992; 13: 104–108.
8. Pandey J, Fudenberg H, Virella G et al. Association between immunoglobulin allotypes and immune response to Haemophilus influenzae and meningococcus polysaccharides. Lancet 1979; 1: 190–192.
9. Le Petit J, van Loghem E, de Lange G, Berthoux F, Chapuis- Cellier C, Serre J. Gm, Am, Pi and Km markers in mesangial glomerulonephritis. J Immunogenet 1981; 8: 415–418.
10. Brachtel R, Walter H, Beck W, Hilling M. Associations between atopic diseases and the polymorphic systems ABO, Kidd, Inv and red cell acid phosphatase. Hum Genet 1979; 49: 337–348.
11. Hoffman R, Sharp G, Irvin W, Anderson S, Hewett J, Pandey J. Association of immunoglobulin Km and Gm allotypes with specific antinuclear antibodies and disease susceptibility among connective tissue disease patients. Arthritis Rheum 1991; 34: 453–458.
12. Propert D, Wang F, Whittingham S. Immunoglobulin allotypes Gm and Km in Chinese and Malay patients with systemic lupus erythematosus. Am J Hum Genet 1991; 49 (Suppl): 479 (Abstract).
13. Whittingham S, Propert D, Mackay I. A strong association between the antinuclear antibody anti-La (SS-B) and the kappa chain allotype Km(1). Immunogenet 1984; 19: 295–299.
14. Schur P, Pandey J, Fedrick J. Gm allotypes in white patients with systemic lupus erythematosus. Arthritis Rheum 1985; 28: 828–830.
15. Hartung K, Coldewey R, Rother E et al. Immunoglobulin allotypes in systemic lupus erythematosus – results of a central European multicenter study. Exp Clin Immunogenet 1991; 8: 11–15.
16. Pandey J, Cooper G, Treadwell E et al. Immunoglobulin GM and KM allotypes in systemic lupus erythematosus. Exp Clin Immunogenet 2001; 18: 117–122.
17. Schneider S, Kueffer J-M, Roessli D, Excofier L. Arlequin: A software for population genetic data analysis. Ver 1.1. Genetics and Biometry Lab, Department of Anthropology, University of Geneva, 1997.
18. Singh R, Mullinax F, Moxley G. Systemic lupus erythematosus is not associated with allotypic markers of immunoglobulin kappa in caucasians. J Rheumatol 1994; 21: 839–842.
19. Keech C, McClusky J, Gordon T. Transfection and overexpression of the human 60-kDa Ro/SS-A autoantigen in Hep-cells. Clin Immunol Immunopathol 1994; 73: 466–451.