Screening anal dysplasia in HIV-infected Patients: Is there an agreement between anal pap smear and high-resolution anoscopy-guided biopsy?

Diseases of the Colon and Rectum

Volumn 52, Issue 11, 2009, Pages 1854-1860

  Nahas, Caio S R ^a   Da Silva Filho, Edesio V ^a   Segurado, Aluisio A C ^a   Genevcius, Raphael F F ^a   Gerhard, Rene ^a   Gutierrez, Eliana B ^a   Marques, Carlos F S ^a   Cecconello, Ivan ^a   Nahas, Sergio C ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Anal dysplasia; Anal intraepithelial neoplasia; High resolution anoscopy; HIV; Human papillomavirus; Pap smear; Screening; Squamouscell carcinoma

Indexed keywords

ADULT; AGED; ANAL DYSPLASIA; ANUS; ARTICLE; CROSS-SECTIONAL STUDY; CYTOLOGY; DIAGNOSTIC VALUE; DYSPLASIA; FEMALE; HIGH RESOLUTION ANOSCOPY; HISTOLOGY; HISTOPATHOLOGY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; INTESTINE ENDOSCOPY; MAJOR CLINICAL STUDY; MALE; PAPANICOLAOU TEST; PREDICTION; RECTUM BIOPSY; SCREENING TEST; SENSITIVITY AND SPECIFICITY; ANAL CANAL; ANUS DISEASE; BIOPSY; CYTODIAGNOSIS; GASTROINTESTINAL ENDOSCOPY; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; METHODOLOGY; MIDDLE AGED; PATHOLOGY; PREDICTION AND FORECASTING; REPRODUCIBILITY; VIROLOGY;

ADULT; AGED; ANAL CANAL; ANUS DISEASES; BIOPSY; CROSS-SECTIONAL STUDIES; CYTODIAGNOSIS; ENDOSCOPY, GASTROINTESTINAL; FEMALE; HIV SEROPOSITIVITY; HUMANS; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 75349098901     PISSN: 00123706     EISSN: 15300358     Source Type: Journal    
DOI: 10.1007/DCR.0b013e3181b98f36     Document Type: Article

References (22)

1. Daling JR, Weiss NS, Hislop TG, et al. Sexual practices, sexually transmitted diseases, and the incidence of anal cancer. N Engl J Med 1987;317:973-7.
2. Goldstone SE, Winkler B, Ufford LJ, Alt E, Palefsky JM. High prevalence of anal squamous intraepithelial lesions and squamouscell carcinoma in men who have sex with men as seen in a surgical practice. Dis Colon Rectum 2001;44:690 -8.
3. Ryan DP, Compton CC, Mayer RJ. Carcinoma of the anal canal. N Engl J Med 2000;342:792-800.
4. Palefsky JM. Anal squamous intraepithelial lesions: relation to HIV and human papillomavirus infection. J Acquir Immune Defic Syndr 1999;21(Suppl 1):S42-8.
5. Vernon SD, Hart CE, Reeves WC, Icenogle JP. The HIV-1 tat protein enhances E2-dependent human papillomavirus 16 transcription. Virus Res 1993;27:133-45.
6. Chin-Hong PV, Palefsky JM. Natural history and clinical management of anal human papillomavirus disease in men and women infected with human immunodeficiency virus. Clin Infect Dis 2002;35:1127-34.
7. Piketty C, Darragh TM, Heard I, et al. High prevalence of anal squamous intraepithelial lesions in HIV-positive men despite the use of highly active antiretroviral therapy. Sex Transm Dis 2004;31:96-9.
8. Goldie SJ, Kuntz KM, Weinstein MC, Freedberg KA, Welton ML, Palefsky JM. The clinical effectiveness and cost-effectiveness of screening for anal squamous intraepithelial lesions in homosexual and bisexual HIV-positive men. JAMA 1999;281: 1822-9.
9. Palefsky JM, Holly EA, Hogeboom CJ, Berry JM, Jay N, Darragh TM. Anal cytology as a screening tool for anal squamous intraepithelial lesions. J Acquir Immune Defic Syndr Hum Retrovirol 1997;14:415-22.
10. Mathews WC, Sitapati A, Caperna JC, Barber RE, Tugend A, Go U. Measurement characteristics of anal cytology, histopathology, and highresolution anoscopic visual impression in an anal dysplasia screening program. J Acquir Immune Defic Syndr 2004;37:1610-5.
11. Friedlander MA, Stier E, Lin O. Anorectal cytology as a screening tool for anal squamous lesions: cytologic, anoscopic, and histologic correlation. Cancer 2004;102:19-26.
12. Fox PA, Seet JE, Stebbing J, et al. The value of anal cytology and human papillomavirus typing in the detection of anal intraepithelial neoplasia: a review of cases from an anoscopy clinic. Sex Transm Infect 2005;81:142-6.
13. de Ruiter A, Carter P, Katz DR, et al. A comparison between cytology and histology to detect anal intraepithelial neoplasia. Genitourin Med 1994;70:22-5.
14. Solomon D, Davey D, Kurman R, et al. The 2001 Bethesda System: terminology for reporting results of cervical cytology. JAMA 2002;287:2114-9.
15. Mayeaux EJ Jr., Harper MB, Abreo F, Pope JB, Phillips GS. A comparison of the reliability of repeat cervical smears and colposcopy in patients with abnormal cervical cytology. J Fam Pract 1995;40:57-62.
16. Di Bonito L, Falconieri G, Tomasic G, Colautti I, Bonifacio D, Dudine S. Cervical cytopathology: an evaluation ofits accuracy based on cytohistologic comparison. Cancer 1993;72:3002-6.
17. Panther LA, Wagner K, Proper J, et al. High resolution anoscopy findings for men who have sex with men: inaccuracy of anal cytology as a predictor of histologic high-grade anal intraepithelial neoplasia and the impact of HIV serostatus. Clin Infect Dis 2004;38:1490-2.
18. Jay N, Berry JM, HogeboomCJ, Holly EA, DarraghTM, Palefsky JM. Colposcopic appearance of anal squamous intraepithelial lesions: relationship to histopathology. Dis Colon Rectum1997; 40:919-28. (Pubitemid 27355394)
19. Stoler MH, Schiffman M. Interobserver reproducibility of cervical cytologic and histologic interpretations: realistic estimates from the ASCUS-LSIL Triage Study. JAMA 2001;285:1500-5.
20. Willocx F, de Somer ML, Van Roy J. Classification of cervical smears with discordance between the cytologic and/or histologic ratings. Acta Cytol 1987;31:883-6.
21. Colquhoun P, Nogueras JJ, Dipasquale B, Petras R, Wexner SD, Woodhouse S. Interobserver and intraobserver bias exists in the interpretation of anal dysplasia. Dis Colon Rectum 2003;46: 1332-8.
22. Darragh TM, Jay N, Tupkelewicz BA, Hogeboom CJ, Holly EA, Palefsky JM. Comparison of conventional cytologic smears and ThinPrep preparations from the anal canal. Acta Cytol 1997;41: 1167-70.