Detection of pneumolysin and autolysin genes among antibiotic resistant Streptococcus pneumoniae in invasive infections

Indian Journal of Medical Microbiology

Volumn 28, Issue 1, 2010, Pages 34-39

  Sourav, S ^a   Patricia, A ^b   Sharma, S ^c   Kanungo, R ^b   Jayachandran, S ^a   Prashanth, K ^a  

^a PONDICHERRY UNIVERSITY   (India)

^b PONDICHERRY INSTITUTE OF MEDICAL SCIENCES   (India)

^c L V PRASAD EYE INSTITUTE   (India)

Author keywords

Autolysin; Invasive and ocular infections; Pneumolysin; Streptococcus pneumoniae

Indexed keywords

AMOXICILLIN; AMPICILLIN; ANTIBIOTIC AGENT; AUTOLYSIN; CEFAZOLIN; CEFEPIME; CEFOTAXIME; CEFTAZIDIME; CEFTRIAXONE; CHLORAMPHENICOL; CIPROFLOXACIN; PENICILLIN G; PNEUMOLYSIN; VANCOMYCIN;

ABSCESS; ADOLESCENT; ADULT; AGED; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIUM ISOLATE; BACTERIUM ISOLATION; BRONCHOPNEUMONIA; BROTH DILUTION; CHILD; CONTROLLED STUDY; DACRYOCYSTITIS; DISK DIFFUSION; EAR INFECTION; EYE INFECTION; FEMALE; GENE IDENTIFICATION; HUMAN; INFANT; LOWER RESPIRATORY TRACT INFECTION; LUNG TUBERCULOSIS; MALE; MENINGITIS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PNEUMOCOCCAL INFECTION; PNEUMONIA; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; SCHOOL CHILD; SEPSIS; SINUSITIS; STREPTOCOCCUS PNEUMONIAE;

EID: 75349097193     PISSN: 02550857     EISSN: 19983646     Source Type: Journal    
DOI: 10.4103/0255-0857.58726     Document Type: Article

References (20)

1. Greenwood B. The epidemiology of pneumococcal infection in children in the developing world. Philos. Trans R Soc Lond B Biol Sci 1999;354:777-785
2. Vashishtha VM. Emergence of multidrug resistant pneumococci in India. Br Med J 2000;21:1022-1023
3. Kanungo R, Rajalakshmi B. Serotype distribution and antimicrobial resistance in Streptococcus pneumoniae causing invasive and other infections in South India. Indian J Med Res 2001;114:127-132
4. Song JH, Chang HH, Suh JY, Ko KS, Jung SI, Oh WS, et al. Macrolide resistance and genotypic characterization of Streptococcus pneumoniae in Asian countries: A study of the Asian Network for Surveillance of Resistant Pathogens (ANSORP). J Antimicrob Chemother 2004;53:457-463
5. Mani R, Pradhan S, Nagarathna S, Wasiulla R, Chandramuki A. Bacteriological profile of community acquired acute bacterial meningitis: A ten-year retrospective study in a tertiary neurocare centre in South India. Indian J Med Microbiol 2007;25:108-114
6. Lalitha MK, Pai R, Manoharan A, Appelbaum PC; CMCH Pneumococcal Study Group. Multidrug-resistant Streptococcus pneumoniae from India. Lancet 2002;359:445.
7. Kunimoto DY, Sharma S, Garg P, Gopinathan U, Miller D, Rao GN. Corneal ulceration in the elderly in Hyderabad, South India. Br J Ophthalmol 2000;84:54-59
8. Salo P, Ortqvist A, Leinonen M. Diagnosis of bacteraemic pneumococcal pneumonia by amplification of pneumolysin gene fragment in serum. J Infect Dis 1995;171:479-482
9. Whatmore AM, Efstratiou A, Pickerill AP, Broughton K, Woodard G, Sturgeon D, George R, Dowson CG. Genetic relationships between clinical isolates of Streptococcus pneumoniae, Streptococcus oralis, and Streptococcus mitis: Characterization of "atypical" pneumococci and organisms allied to S. mitis harboring S. pneumoniae virulence factor-encoding genes. Infect Immun 2000;68:1374-1382
10. Murdoch DR, Anderson TP, Beynon KA, Chua A, Fleming AM, Laing RT, et al. Evaluation of a PCR Assay for detection of Streptococcus pneumoniae in respiratory and non-respiratory samples from adults with Community-Acquired Pneumonia. J Clin Microbiol 2003;41:63-66
11. Sheppard CL, Harrison TG, Morris R, Hogan A, George RC. Autolysin-targeted Light Cycler assay including internal process control for detection of Streptococcus pneumoniae DNA in clinical samples. J Med Microbiol 2004;53:189-195
12. Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing, 16th informational supplement, M100-S16. Wayne, PA: CLSI, 2006.
13. Seki M, Yamashita Y, Torigoe H, Tsuda H, Sato S, Maeno M. Loop-mediated isothermal amplification method targeting the lytA gene for detection of Streptococcus pneumoniae. J Clin Microbiol 2005;43:1581-1586
14. Jain A, Kumar P, Awasthi S. High nasopharyngeal carriage of drug resistant Streptococcus pneumoniae and Haemophilus influenzae in North Indian school children. Trop Med Int Health 2005;10:234-239
15. Memish ZA, Osoba AO, Shibl AM, Mokaddas E, Venkatesh S, Rotimi VO. Emergence and trends of penicillin non-susceptible Streptococcus pneumoniae in Saudi Arabia and Kuwait - perspective and outstanding issues. J Chemother 2007;19:471-481
16. Goyal R, Singh NP, Kaur M, Talwar V. Antimicrobial resistance in invasive and colonising Streptococcus pneumoniae in North India. Indian J Med Microbiol 2007;25:256-259
17. García-Rey C, Martín-Herrero JE, Baquero F. Antibiotic consumption and generation of resistance in Streptococcus pneumoniae: The paradoxical impact of quinolones in a complex selective landscape. Clin Microbiol Infect 2006;12:55-66.
18. Ng EW, Costa JR, Samiy N, Ruoff KL, Connolly E, Cousins FV, et al. Contribution of pneumolysin and autolysin to the pathogenesis of experimental pneumococcal endophthalmitis. Retina 2002;22:622-632
19. Sharma S, Kunimoto DY, Garg P, Rao GN. Trends in antibiotic resistance of corneal pathogens: Part II. An analysis of leading bacterial keratitis isolated. Indian J Ophthalmol 1999;47:101-109
20. Paton JC, Berry AM, Lock RA. Molecular analysis of putative pneumococcal virulence proteins. Microb Drug Resist 1988;3:1-10.