Interventions for cutaneous molluscum contagiosum

Cochrane Database of Systematic Reviews

Volumn 2009, Issue 4, 2009, Pages

  van der Wouden, Johannes C ^a   van der Sande, Renske ^a   van Suijlekom Smit, Lisette Wa ^b   Berger, Marjolein ^a   Butler, Christopher C ^c   Koning, Sander ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b SOPHIA CHILDREN S HOSPITAL   (Netherlands)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CIMETIDINE; HYDROXIDE; POTASSIUM DERIVATIVE; POVIDONE IODINE; SALICYLIC ACID; SODIUM NITRITE; TOPICAL ANTIINFECTIVE AGENT;

HUMAN; META ANALYSIS; METHODOLOGY; MOLLUSCUM CONTAGIOSUM; PHYTOTHERAPY; RANDOMIZED CONTROLLED TRIAL; REMISSION; REVIEW;

ANTI-INFECTIVE AGENTS, LOCAL; CIMETIDINE; HUMANS; HYDROXIDES; MOLLUSCUM CONTAGIOSUM; PHYTOTHERAPY; POTASSIUM COMPOUNDS; POVIDONE-IODINE; RANDOMIZED CONTROLLED TRIALS AS TOPIC; REMISSION, SPONTANEOUS; SALICYLIC ACID; SODIUM NITRITE;

EID: 75349089350     PISSN: None     EISSN: 1469493X     Source Type: Journal    
DOI: 10.1002/14651858.CD004767.pub3     Document Type: Review

References (102)

1. Antony F, Cliff S, Ahmad A, Holden C. Double-blind placebo-controlled study of oral cimetidine treatment for molluscum contagiosum (conference abstract). British Journal of Dermatology 2001;145 Suppl 59:126.
2. Bazza MA, Ryatt KS. Sterile normal 0.9% saline as a effective 5% potassium hydroxide in treatment of molluscum contagiosum, and safer. unpublished manuscript received May 2007.
3. Burke BE, Baillie J-E, Olson RD. Essential oil of Australian lemon myrtle (Backhousia citriodora) in the treatment of molluscum contagiosum in children. Biomedicine & Pharmacotherapy 2004;58:245-7.
4. Hanna D, Hatami A, Powell J, Marcoux D, Maari C, Savard P, et al. A prospective randomized trial comparing the efficacy and adverse effects of four recognized treatments of molluscum contagiosum in children. Pediatric Dermatology 2006;23(6):574-9.
5. McCuaig CC, Hatami A, Powell J, Maari C, Marcoux D, Thibeault H. Mollusca contagiosa: what treatment to use when? (conference abstract). Journal of the European Academy of Dermatology & Venereology 2005;19(Suppl 2):8.
6. Leslie KS, Dootson G, Sterling J. Does treatment of molluscum contagiosum affect clearance? [conference abstract of ongoing study]. British Journal of Dermatology 2004;151(suppl 68):67.
7. Leslie KS, Dootson G, Sterling JC. Topical salicylic acid gel as a treatment for molluscum contagiosum in children. Journal of Dermatological Treatment 2005;16(5-6):336-40.
8. Manchanda RK, Mehan N, Nahl R, Atey R. Double blind placebo controlled clinical trials of homeopathic medicines in warts and molluscum contagiosum. Central Council for Research in Homeopathy Quarterly Bulletin 1997;19:25-9.
9. Ohkuma M. Molluscum contagiosum treated with iodine solution and salicylic acid plaster. International Journal of Dermatology 1990;29(6):443-5.
10. Ormerod AD, White MI, Shah SA, Benjamin N. Molluscum contagiosum effectively treated with a topical acidified nitrite, nitric oxide liberating cream. British Journal of Dermatology 1999;141(6):1051-3.
11. th World Congress on Pediatric Dermatology. Pediatric Dermatology 2004;21(3):399.
12. Short KA, Fuller LC, Higgins EM. Double-blind randomized placebo-controlled trial of the use of topical potassium hydroxide in the treatment of molluscum contagiosum. British Journal of Dermatology 2002;147 Suppl 62:95 (abstract).
13. Short KA, Fuller LC, Higgins EM. Double-blind, randomised, placebo-controlled trial of the use of topical 10% potassium hydroxide solution of molluscum contagiosum. Unpublished manuscript.
14. Short KA, Fuller LC, Higgins EM. Double-blind, randomized, placebo-controlled trial of the use of topical 10% potassium hydroxide solution in the treatment of molluscum contagiosum. Pediatric Dermatology 2006;23:279-81.
15. Theos AU, Cummins R, Silverberg NB, Paller AS. Effectiveness of imiquimod cream 5% for treating childhood molluscum contagiosum in a double-blind, randomized pilot trial. Cutis 2004;74:134-8, 141-2.
16. Barton SE, Chard S. Facial molluscum: treatment with cryotherapy and podophyllotoxin. International Journal of STD & AIDS 2002;13(4):277-8.
17. Caballero Martinez F, Plaza Nohales C, Perez Canal C, Lucena Martin MJ. Cutaneous cryosurgery in family medicine: dimethyl ether-propane spray versus liquid nitrogen. Atencion Primaria 1996;18(5):211-6.
18. Chatproedrai S, Kamol S, Wananukul S, Theamboonlers A, Poovorawan Y. Efficacy of pulsed dye laser (585 nm) in the treatment of molluscum contagiosum subtype 1. Southeast Asian Journal of Tropical Medicine & Public Health 2007;38(5):849-54.
19. de Waard-van der Spek FB, Oranje AP, Lillieborg S, Hop WC, Stolz E. Treatment of molluscum contagiosum using a lidocaine/prilocaine cream (EMLA) for analgesia. Journal of the American Academy of Dermatology 1990;Oct(4 Pt 1):685-8.
20. He H, Lu JY, Fang J, et al. Observation on effect of four kinds of therapy for molluscum contagiosum (Chinese). Chinese Journal of Dermatovenereology 2001;15(5):308-9.
21. Juhlin L, Evers H, Broberg F. A lidocaine-prilocaine cream for superficial skin surgery and painful lesions. Acta Dermato-Venereologica (Stockholm) 1980;60(6):544-6.
22. Manchanda RK, Mehan N, Bahl R, Atey R. Double blind placebo controlled trials of homeopathic medicines in warts and molluscum contagiosum. Central Council for Research in Homeopathy Quarterly Bulletin 1997; Vol. 19 (3&4):25-30.
23. Rosdahl I, Edmar B, Gisslén H, Nordin P, Lillieborg S. Curettage of molluscum contagiosum in children: analgesia by topical application of lidocaine/prilocaine cream (EMLA). Acta Dermato-Venereologica (Stockholm) 1988;68:149-53.
24. Salmanpour R. Treatment of molluscum contagiosum with griseofulvin or cryotherapy. Iranian Journal of Dermatology 2006;9(1):5.
25. Syed TA, Lundin S, Ahmad M. Topical 0.3% and 0.5% podophyllotoxin cream for self-treatment of molluscum contagiosum in males. A placebo-controlled, double-blind study. Dermatology 1994;189(1):65-8.
26. Syed TA, Goswami J, Ahmadpour OA, Ahmad SA. Treatment of molluscum contagiosum in males with an analog of imiquimod 1% in cream: a placebo-controlled, double-blind study. Journal of Dermatology 1998;25(5):309-13.
27. Weller R, O'Callaghan CJ, MacSween RM, White MI. Scarring in molluscum contagiosum: comparison of physical expression and phenol ablation. BMJ 1999;319(7224):1540.
28. Yabut-Catalasan RO, Paliza AC. 10% Potassium Hydroxide as treatment for molluscum contagiosum: a double-blind, placebo-controlled study. Journal of the Philippine Dermatological Society 2003;12(1):28-35.
29. NCT00667225 Efficacy of cantharidin in molluscum contagiosum. ClinicalTrials.Gov/ct2/show/NCT00667225 (accessed 18 February 2009).
30. Cochrane Back Review Group. Sources of risk of bias. http://www.cochrane.iwh.on.ca/pdfs/RoBassessform_June2008.rtf (accessed 3 February 2009).
31. Barba AR, Kapoor S, Berman B. An open label safety study of topical imiquimod 5% cream in the treatment of molluscum contagiosum in children. Dermatology online 2001;7(1):20.
32. Bath-Hextall FJ, Perkins W, Bong J, Williams HC. Interventions for basal cell carcinoma of the skin. Cochrane Database of Systematic Reviews 2007, Issue 1. Art. No.: CD003412.
33. Bayerl C, Feller G, Goerdt S. Experience in treating molluscum contagiosum in children with imiquimod 5% cream. British Journal of Dermatology 2003;149 Suppl 66:25-9.
34. Beaulieu Ph, Pepin E, Aboucaya P, Bennassy I, Blaise F, Blechaye-Butaye F, et al. Molluscum contagiosum. Epidemiological study of 452 cases in private practice [Molluscum contagiosum. Etude épidémiologique de 452 observations en pratique libérale]. Nouvelle Dermatologique 2000;19:231.
35. Behl PN, Bhatia BK. Clinical trial of milkweed (Asclepius Curussavica) in the treatment of warts. Indian Journal of Dermatology 1970;15(2):49-50.
36. Berger TG, Tappero JW. Human immunodeficiency virus infection and the cutaneous complications of immunosuppression. In: Arndt KA, et al. editor(s). Cutaneous medicine and surgery. Vol. 2, Chapter 25, Philadelphia: WB Saunders, 1996:1098-9.
37. Brandrup F, Asschenfeldt P. Molluscum contagiosum-induced comedo and secondary abscess formation. Pediatric Dermatology 1989;6:118-21.
38. Braue A, Ross G, Varigos G, Kelly H. Epidemiology and impact of childhood molluscum contagiosum: a case series and critical review of the literature. Pediatric Dermatology 2005;22:287-94.
39. Cope LF. A case of molluscum contagiosum cured by X rays. Lancet 1915;185(4788):1179.
40. Cunningham BB, Paller AS. Inefficacy of oral cimetidine for non-atopic children. Pediatric Dermatology 1998;15(1):1-72.
41. Davies EG. Topical cidofovir for severe molluscum contagiosum. Lancet 1999;353(9169):2042.
42. Davis AE. Report of a case of molluscum contagiosum which got well under the use of yellow oxide of mercury ointment. Annals of Ophthalmology and Otology 1896;5:404.
43. De Oreo GA, Johnson HH, Binkley GW. An eczematous reaction associated with molluscum contagiosum. Archives of Dermatology 1956;74:344-8.
44. Dohil M, Prendiville MB. Treatment of molluscum contagiosum with oral cimetidine. Pediatric Dermatology 1996;13(4):310-2.
45. Friedman M, Gal D. Keloid scars as a result of CO2 laser for molluscum contagiosum. Obstetrics and Gynecology 1987;70:394-6.
46. Funt TR. Canthadirin treatment of molluscum contagiosum. Archives of Dermatology 1961;83:186-7.
47. Funt TR, Mehr KA. Cantharidin: a valuable office treatment of molluscum contagiosum. Southern Medical Journal 1979;72:1019.
48. Gibbs S, Harvey I. Topical treatments for cutaneous warts. Cochrane Database of Systematic Reviews 2006, Issue 3. Art. No.: CD001781.
49. González U, Pinart M, Reveiz L, Alvar J. Interventions for Old World cutaneous leishmaniasis. Cochrane Database of Systematic Reviews 2008, Issue 4. Art. No.: CD005067.
50. Gottlieb SL. Molluscum contagiosum. International Journal of Dermatology 1994;33(7):453-61.
51. Gräfe A, Fischer S, Bohn M, Neumann Ch, Kölmel K. Treatment of warts with NO releasing ointment [Die Behandlung von Dellwarzen mit einer NO-freisetzenden Creme (5% Natriumnitrit and 5% Zitronensäure in Basiscreme DAC)]. Zeitschrift für Hautkrankheiten 2000;75:492.
52. Haellmigk C. Keratoconjunctivitis in molluscum contagiosum of the eyelids [Keratokonjunktivitis bei Molluscum contagiosum der Lider]. Klinische Monatsblatter fur Augenheilkunde 1966;148:87-91.
53. Hammes S, Greve B, Raulin C. Molluscum contagiosum: treatment with pulsed dye laser (German). Zeitschrift fur Hautkrankheiten 2001;52(1):38-42.
54. Hawley TG. The natural history of molluscum contagiosum in Fijian children. Journal of Hygiene 1970;68:631-2.
55. Hengge UR, Cusini M. Topical immunomodulators for the treatment of external genital warts, cutaneous warts and molluscum contagiosum. British Journal of Dermatology 2003;149 Suppl 66:15-19.
56. Higgins JPT, Green S, editors. Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.1 [updated September 2008]. The Cochrane Collaboration www.cochrane-handbook.org. Chichester, UK: John Wiley & Sons, Ltd, 2008.
57. Hira SK, Wadhawan D, Kamanga J. Cutaneous manifestations of human immunodeficiency virus in Lusaka, Zambia. Journal of the American Academy of Dermatology 1988;19(3):451-6.
58. Hund G. Vitamin A-acid therapy of molluscum contagiosa in Hemophilia A [Vitamin-A-Säure-Therapie von Mollusca contagiosa bei Haemophilie A]. Z Hautkr 1975;50:291-2.
59. Husak R, Garbe C, Orfanos CE. Molluscum contagiosum in HIV-Infection (German). Der Hautarzt; Zeitschrift fur Dermatologie, Venerologic, und verwandte Gebiete 1997;48:103-7.
60. Kang SH, Lee D, Park, JH, Cho, SH, Lee SS, Park SW. Treatment of molluscum contagiosum with topical diphencyprone therapy. Acta Dermatato-Venereologica 2005;85(6):529-30.
61. Koning S, Bruijnzeels MA, van Suijlekom-Smit LWA, van der Wouden JC. Molluscum contagiosum in Dutch general practice. British Journal of General Practice 1994;44:417-9.
62. Kyu Han K, Koo Il S, Jin Ho C, Kyung Chan P, Hee Chul E. The effect of diphenylcyclopropenone immunotherapy on molluscum contagiosum. Annals of Dermatology 1993;5(2):79-82.
63. Liota E, Smith KJ, Buckley R, Menon P, Skelton H. Imiquimod therapy for molluscum contagiosum. Journal of Cutaneous Medical Surgery 2000;4(2):76-82.
64. Liveing R. Molluscum contagiosum. Lancet 1878;112(2875):494.
65. Lowy DR. Molluscum contagiosum. In: Fitzpatrick TB, Freedberg IM editor(s). Fitzpatrick's Dematology in general medicine. 5th Edition. Vol. 2, New York: McGraw-Hill, 1999:2478-81.
66. Markos AR. The successful treatment of molluscum contagiosum with podophyllotoxin (0.5%) self-application. Current Opinion in Infectious Diseases 2001;12 (12):833.
67. Mason AR, Mason J, Cork M, Dooley G, Edwards G. Topical treatments for chronic plaque psoriasis. Cochrane Database of Systematic Reviews 2009, Issue 2. Art. No.: CD005028.
68. Matis WL, Triana A, Shapiro R, Eldred PAC, Polk BF, Hood AF. Dermatologic findings associated with human immunodeficiency virus infection. Journal of the American Academy of Dermatology 1987;17:746-51.
69. Molino AC, Fleischer AB, Feldman SR. Patient demographics and utilization of health care services for molluscum contagiosum. Pediatric Dermatology 2004;21:628-32.
70. Niizeki K, Kano O, Kondo Y. An epidemic study of molluscum contagiosum. Relationship to swimming. Dermatologica 1984;169:197-8.
71. Niizeki K, Hahimoto K. Treatment of molluscum contagiosum with silver nitrate paste. Pediatric Dermatology 1999;16:395-7.
72. Ordoukhanian E. Warts and molluscum contagiosum: beware of treatments worse than the disease. Postgraduate Medicine 1997;101(2):223-32.
73. Orlow SJ, Paller A. Cimetidine therapy for multiple viral warts in children. Journal of the American Academy of Dermatology 1993;28:794-6.
74. Overfield TM, Brody JA. An epidemiologic study of molluscum contagiosum in Anchorage, Alaska. The Journal of Pediatrics 1966;4:640-2.
75. Postlethwaite R, Watt JA, Hawley TG, Simpson I, Adam H. Features of molluscum contagiosum in the northeast of Scotland and in Fijian village settlements. The Journal of Hygiene 1967;65:281-91.
76. Quan LT. Surgical pearl: curetting with a punch. Journal of the American Academy of Dermatology 2000;43:854-5.
77. Redmond RM. Molluscum contagiosum is not always benign. BMJ 2004;329:403.
78. Relyveld J, Bergink AH, Nijhuis HGJ. Epidemiological notes. Leg ulcers, warts and dying circumstances [Epidemiologische notities. Ulcus cruris, wratten en sterfsituatie]. Huisarts en Wetenschap 1988;31:266-7.
79. Rogers M, Barnetson RSC. Diseases of the skin. In: Campbell AGM, McIntosh N, et al. editor(s). Forfar and Arneil's Textbook of Pediatrics. 5th Edition. New York: Churchill Livingstone, 1998:1633-5.
80. Romiti R. Treatment of molluscum contagiosum with potassium hydroxide: a clinical approach in 35 children. Pediatric Dermatology 1999;16(3):228-30.
81. Romiti R, Ribeiro AP, Romiti N. Evaluation of the effectiveness of 5% potassium hydroxide for the treatment of molluscum contagiosum. Pediatric Dermatology 2000;17(6):495.
82. Rosdahl I, Edmar B, Gisslen H, Nordin P, Lillieborg S. Curettage of molluscum contagiosum in children: analgesia by topical application of a lidocaine/ prilocaine cream (EMLA). Acta Dermato-Venereologica 1988;68:149-53.
83. Ross GL, Orchard DC. Combination topical treatment of molluscum contagiosum with cantharidin and imiquimod 5% in children: a case series of 16 patients. The Australasian Journal of Dermatology 2004;45:100-102.
84. Schmitt J, Diepgen TL. Molluscum contagiosum. In: Williams H, Bigby M, Diepgen T, Herxheimer A, Naldi L, Rzany B editor(s). Evidence-based dermatology. 2nd Edition. Oxford: Blackwell, 2008:Web chapter, accessed 18 February 2009.
85. Sharma AK. Cimetidine therapy for multiple molluscum contagiosum lesions. Dermatology 1998;197 (2):194-5.
86. Shelley M, Wilt T, Coles B, Mason M. Cryotherapy for localised prostate cancer. Cochrane Database of Systematic Reviews 2007, Issue 3. Art. No.: CD005010.
87. Silverberg NB, Sidbury R, Mancini AJ. Childhood molluscum contagiosum: experience with cantharidin therapy in 300 patients. Journal of the American Academy of Dermatology 2000;43(3):503-7.
88. Singh OP, Kanwar AJ. Griseofulvin therapy in molluscum contagiosum. Archives of Dermatology 1977;113:1615.
89. Skinner RB. Treatment of molluscum contagiosum with imiquimod 5% cream. Journal of the American Academy of Dermatology 2002;47 Suppl 4:221-4.
90. Sterling JC, Kurtz JB. Viral infections. In: Champion RH, Burton JL, Ebling FJG editor(s). Rook/Wilkinson/Ebling. Textbook of Dermatology. 6th Edition. Oxford: Blackwell, 1998:1005-8.
91. Sturt RJ, Muller HK, Francis GD. Molluscum contagiosum in villages of the West Sepik district of New Guinea. The Medical Journal of Australia 1971;2:751-4.
92. Takemura T, Ohkuma K, Nagai, H, Saito T. The natural history of molluscum contagiosum. Examination and treatment of dermatological diseases (Japanese) 1983;5(7):667-70.
93. Teilla-Hamel D, Roux A, Loeb G. Pharmacokinetics and safety profile of topical podophyllotoxin (0.5% solution) on molluscum contagiosum in children. European Journal of Dermatology 1996;6:437-40.
94. Torfs M, Lambelin G. Considerations on Molluscum Contagiosum in the tropics [Considerations sur le Molluscum Contagiosum en milieu tropical]. Annales de la Societe Belge de Medecine Tropicale 1959;39:703-9.
95. Toro JR, Wood LV, Patel NK, Turner ML. Topical cidofovir: a novel treatment for recalcitrant molluscum contagiosum in children infected with human immunodeficiency virus. Archives of Dermatology 2000;136 (8):983-5.
96. Vasily DB, Bhatia Sg. Erythema annulare centrifugum and molluscum contagiosum. Archives of Dermatology 1978;114:1853.
97. Whitaker SB. Intraoral molluscum contagiosum. Oral Surgery, Oral Medicine, Oral Pathology 1991;72(3):334-6.
98. Wieringa JW, Ketel AG, van Houten MA. Coma in a child after treatment with the 'magic salve' lidocaine-prilocaine cream [Coma bij een peuter na behandeling met de 'toverzalf' lidocaine-prilocainecreme]. Nederlands Tijdschrift voor Geneeskunde 2006;150:1805-7.
99. Wishart J. The local treatment of psoriasis and molluscum contagiosum. Lancet 1903;161(4154):1030-1.
100. Yasher SS, Shamiri B. Oral cimetidine treatment of molluscum contagiosum. Pediatric Dermatology 1999;16:493.
101. Yusuf S, Peto R, Lewis J, Collins R, Sleight P. Beta blockade during and after myocardial infarction: An overview of the randomised trials. Progress in Cardiovascular Diseases 1985;27(5):335-71.
102. Zabawski EJ Jr, Cockerell CJ. Topical cidofovir for molluscum contagiosum in children. Pediatric Dermatology 1999;16:414-5.