Molluscum contagiosum effectively treated with a topical acidified nitrite, nitric oxide liberating cream

British Journal of Dermatology

Volumn 141, Issue 6, 1999, Pages 1051-1053

  Ormerod, A D ^a   White, M I ^a   Shah, S A A ^a   Benjamin, N ^b  

^a ABERDEEN ROYAL INFIRMARY   (United Kingdom)

^b ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

Author keywords

Acidified nitrite; Antiviral; Molluscum contagiosum; Nitric oxide

Indexed keywords

SALICYLIC ACID; SODIUM NITRITE;

ARTICLE; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; HUMAN; MOLLUSCUM CONTAGIOSUM; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SKIN IRRITATION;

ADMINISTRATION, CUTANEOUS; ANTIVIRAL AGENTS; CHILD; CHILD, PRESCHOOL; DOUBLE-BLIND METHOD; DRUG COMBINATIONS; FEMALE; HUMANS; INFANT; MALE; MOLLUSCUM CONTAGIOSUM; NITRIC OXIDE DONORS; SALICYLIC ACID; SODIUM NITRITE; TREATMENT OUTCOME;

EID: 0033388052     PISSN: 00070963     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2133.1999.03204.x     Document Type: Article

References (22)

1. 1 Martin-Gallardo A, Moratilla M, Funes JM et al. Sequence analysis of a molluscum contagiosum virus DNA region which includes the gene encoding protein kinase 2 and other genes with unique organization. Virus Genes 1996; 13: 19-29.
2. 2 Douglass NJ, Blake NW, Cream JJ et al. Similarity in genome organization between molluscum contagiosum virus (MCV) and vaccinia virus (VV): identification of MCV homologues of the VV genes for protein kinase 2, structural protein VP8, RNA polymerase 35 kDa subunit and 3beta-hydroxysteroid dehydrogenase. J Gen Virol 1996; 77: 3113-20.
3. 3 Mannick JB. The antiviral role of nitric oxide. Res Immunol 1995; 146: 693-7.
4. 4 Reiss CS, Komatsu T. Does nitric oxide play a critical role in viral infections? J Virol 1998; 72: 4547-51.
5. 5 Croen KD. Evidence for an antiviral effect of nitric oxide, inhibition of herpes simplex type 1 replication. J Clin Invest 1993; 91: 2446-52.
6. 6 Karupiah G, Xie Q, Buller ML et al. Inhibition of viral replication by interferon gamma induced nitric oxide synthase. Science 1993; 261: 1445-8.
7. 7 Lane TE, Paoletti AD, Buchmeier MJ. Disassociation between the in vitro and in vivo effects of nitric oxide on a neurotropic murine coronavirus. J Virol 1997; 71: 2202-10.
8. 8 Pertile TL, Karaca K, Sharma JM, Walser MM. An antiviral effect of nitric oxide: inhibition of reovirus replication. Avian Dis 1996; 40: 342-8.
9. 9 Kreil TR, Eibl MM. Nitric oxide and viral infection: No antiviral activity against a flavivirus in vitro, and evidence for contribution to pathogenesis in experimental infection in vivo. Virology 1996; 219: 304-6.
10. 10 Weller R, Ormerod AD, Hobson R, Benjamin N. A randomised trial of acidified nitrite cream in the treatment of tinea pedis. J Am Acad Dermatol 1998; 38: 559-63.
11. 11 Shelley WB, Burmeister V. Demonstration of a unique viral structure: the molluscum viral colony sac. Br J Dermatol 1986; 115: 557-62.
12. 12 Heng MC, Steuer ME, Levy A et al. Lack of host cellular immune response in eruptive molluscum contagiosum. Am J Dermatopathol 1989; 11: 248-54.
13. 13 White MI, Weller R, Diack P. Molluscum contagiosum in children - evidence based treatment. Clin Exp Dermatol 1997; 22: 51.
14. 14 Rosdahl I, Edmar B, Gisslen H et al. Curettage of molluscum contagiosum in children: analgesia by topical application of a Iidocaine/prilocaine cream (Emla). Acta Derm Venereol (Stockh) 1988; 68: 149-53.
15. 15 Ohkuma M. Molluscum contagiosum treated with iodine solution and salicylic acid plaster. Int J Dermatol 1990; 29: 443-5.
16. 16 Syed TA, Lundin S, Ahmad M. Topical 0.3% and 0.5% podophyllotoxin cream for self-treatment of molluscum contagiosum in males. A placebo-controlled, double-blind study. Dermatology 1994; 189: 65-8.
17. 17 Ficarra G, Cortes S, Rubino I, Romagnoli P. Facial and perioral molluscum contagiosum in patients with HIV infection. A report of eight cases. Oral Surg Oral Med Oral Pathol 1994; 78: 621-6.
18. 18 Meadows KP, Tyring SK, Pavia AT, Rallis TM. Resolution of recalcitrant molluscum contagiosum virus lesions in human immunodeficiency virus-infected patients treated with cidofovir. Arch Dermatol 1997; 133: 987-90.
19. 19 Pocock SJ. Monitoring trial progress. In: Clinical Trials: A Practical Approach. Chichester: Wiley, 1983: 147-51.
20. 20 Block SH. The association of molluscum contagiosum and infantile eczema. Med J Aust 1972; 2: 626-7.
21. 21 Block SH. Eczema and molluscum contagiosum. JAMA 1973; 223: 195.
22. 22 Ormerod AD, Copeland P, Hay I et al. The inflammatory and cytotoxic effects of nitric oxide releasing cream on normal skin. J Invest Dermatol 1999; 113: 392-7.