Trace LC/MS/MS quantitation of 17β-estradiol as a biomarker for selective estrogen receptor modulator activity in the rat brain

Journal of Mass Spectrometry

Volumn 45, Issue 1, 2010, Pages 65-71

  Petucci, Chris ^a   Lloyd, Tom ^a   Harris, Heather A ^a   Zhang, Xiaochun ^a   Chennathukuzhi, Vargheese M ^a,b   Mekonnen, Belew ^a   Cai, Yanxuan ^a  

^a PFIZER INC   (United States)

^b UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

Biomarker; Gene expression; Mass spectrometry; Quantitation; Trace detection

Indexed keywords

BIOLOGICAL HYPOTHESIS; DANSYL CHLORIDE; DERIVATIZATION OF; ESTROGEN RECEPTOR; FEMALE RAT; LC/MS/MS; LIMIT OF QUANTITATIONS; MEDICINAL CHEMISTRY; NEGATIVE FEEDBACK; QUANTITATION; RAT BRAIN; SELECTIVE ESTROGEN RECEPTOR MODULATORS; SMALL MOLECULES; TRACE DETECTION; UP-REGULATION;

BIOACTIVITY; BODY FLUIDS; BRAIN; CHLORINE COMPOUNDS; CUSTOMER SATISFACTION; DERIVATIVES; FEEDBACK; GENE EXPRESSION; MASS SPECTROMETERS; MASS SPECTROMETRY; MODULATORS; TOTAL QUALITY MANAGEMENT; TRACE ANALYSIS;

QUALITY CONTROL;

BIOLOGICAL MARKER; DANSYL CHLORIDE; ESTRADIOL; ESTROGEN RECEPTOR; MESSENGER RNA; SELECTIVE ESTROGEN RECEPTOR MODULATOR;

ACCURACY; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; HYPOTHALAMUS HYPOPHYSIS SYSTEM; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; OVARY HYPERSTIMULATION; PRIORITY JOURNAL; QUALITY CONTROL; QUANTITATIVE ANALYSIS; RAT; UPREGULATION;

ANIMALS; BIOLOGICAL MARKERS; BRAIN CHEMISTRY; CHROMATOGRAPHY, LIQUID; DRUG STABILITY; ESTRADIOL; FEMALE; RADIOIMMUNOASSAY; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SELECTIVE ESTROGEN RECEPTOR MODULATORS; SENSITIVITY AND SPECIFICITY; STEROID 17-ALPHA-HYDROXYLASE; TANDEM MASS SPECTROMETRY;

RATTUS;

EID: 75149189581     PISSN: 10765174     EISSN: 10969888     Source Type: Journal    
DOI: 10.1002/jms.1689     Document Type: Article

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