The plant-derived natural compound Flavin 7® attenuates oxidative stress in cultured renal proximal tubule cells

In Vivo

Volumn 23, Issue 6, 2009, Pages 975-978

  Ember, Agoston ^a   Clark, Jeb S ^c   Varjas, Timea ^b   Kiss, Istvan ^b   Ember, Istvan ^b   Baliga, Radhakrishna ^c   Arany, Istvan ^c  

^a UNIVERSITY OF PÉCS   (Hungary)

^b UNIVERSITY OF PÉCS   (Hungary)

^c UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

Antioxidant; Bioflavonoid; Oxidative stress; Renal toxicity

Indexed keywords

FLAVIN 7; HYDROGEN PEROXIDE; LACTATE DEHYDROGENASE; NATURAL PRODUCT; PLANT EXTRACT; POLYPHENOL DERIVATIVE; REACTIVE OXYGEN METABOLITE; TRYPAN BLUE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CELL DAMAGE; CONTROLLED STUDY; KIDNEY PROXIMAL TUBULE; MITOCHONDRIAL PERMEABILITY; MOUSE; NEPHROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PLANT PRODUCT;

EID: 75149185412     PISSN: 0258851X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Lau AT, Wang Y and Chiu JF: Reactive oxygen species: current knowledge and applications in cancer research and therapeutic. J Cell Biochem 104: 657-667, 2008.
2. Ushio-Fukai M and Nakamura Y: Reactive oxygen species and angiogenesis: NADPH oxidase as target for cancer therapy. Cancer Lett 266: 37-52, 2008.
3. Storz P: Reactive oxygen species in tumor progression. Front Biosci 10: 1881-1896, 2005.
4. Schrier RW: Cancer therapy and renal injury. J Clin Invest 110: 743-745, 2002.
5. Flombaum CD: Acute renal failure and dialysis in cancer patients. Crit Care Clin 4: 61-79, 1988.
6. Santos NA, Bezerra CS, Martins NM, Curti C, Bianchi ML and Santos AC: Hydroxyl radical scavenger ameliorates cisplatin-induced nephrotoxicity by preventing oxidative stress, redox state unbalance, impairment of energetic metabolism and apoptosis in rat kidney mitochondria. Cancer Chemother Pharmacol 61: 145-155, 2008.
7. Luo J, Tsuji T, Yasuda H, Sun Y, Fujigaki Y and Hishida A: The molecular mechanisms of the attenuation of cisplatin-induced acute renal failure by N-acetylcysteine in rats. Nephrol Dial Transplant 23: 2198-2205, 2008.
8. Do Amaral CL, Francescato HD, Coimbra TM, Costa RS, Darin JD, Antunes LM and Bianchi ML: Resveratrol attenuates cisplatin-induced nephrotoxicity in rats. Arch Toxicol 82: 363-370, 2008.
9. Markman M, Geary S and Howell SB: Nephrotoxicity of high-dose intracavitary cisplatin with intravenous thiosulfate protection. Eur J Cancer Clin Oncol 21: 1015-1018, 1985.
10. Ramiro-Puig E, Casadesus G, Lee HG, Zhu X, McShea A, Perry G, Perez-Cano FJ, Smith MA and Castell M: Neuroprotective effect of cocoa flavonoids on in vitro oxidative stress. Eur J Nutr 48: 54-61, 2009.
11. Rodrigo R and Bosco C: Oxidative stress and protective effects of polyphenols: comparative studies in human and rodent kidney. A review. Comp Biochem Physiol C Toxicol Pharmacol 142: 317-327, 2006.
12. Ernest S and Bello-Reuss E: Expression and function of P-glycoprotein in a mouse kidney cell line. Amn J Physiol 269: C323-333, 1995.
13. Arany I, Faisal A, Nagamine Y and Safirstein RL: p66shc inhibits pro-survival epidermal growth factor receptor/ERK signaling during severe oxidative stress in mouse renal proximal tubule cells. J Biol Chem 283: 6110-6117, 2008.
14. 2 cytotoxicity in mouse renal proximal tubule cells. Kidney Int 65: 1231-1239, 2004.
15. Nadasi E, Ember I and Arany I: Effect of a plant-derived natural compound, Flavin7, on the ERK signaling pathway in immortalized mouse proximal tubule cells. In Vivo 21: 871-875, 2007.
16. Mojzis J, Sarissky M, Pilatova M, Voharova V, Varinska L, Mojzisova G, Ostro A, Urdzik P, Dankovcik R and Mirossay L: In vitro antiproliferative and antiangiogenic effects of Flavin7. Physiol Res 57: 413-420, 2008.
17. Brady NR, Hamacher-Brady A, Westerhoff HV and Gottlieb RA: A wave of reactive oxygen species (ROS)-induced ROS release in a sea of excitable mitochondria. Antioxid Redox Signal 8: 1651-1665, 2006.
18. Honda HM, Korge P and Weiss JN: Mitochondria and ischemia/reperfusion injury. Ann N Y Acad Sci 1047: 248-258, 2005.
19. Modlinger PS, Wilcox CS and Aslam S: Nitric oxide, oxidative stress, and progression of chronic renal failure. Semin Nephrol 24: 354-365, 2004.
20. Singh D, Kaur R, Chander V and Chopra K: Antioxidants in the prevention of renal disease. J Med Food 9: 443-450, 2006.
21. Chatterjee PK: Novel pharmacological approaches to the treatment of renal ischemia-reperfusion injury: a comprehensive review. Naunyn Schmiedebergs Arch Pharmacol 376: 1-43, 2007.
22. Cuzzocrea S, Riley DP, Caputi AP and Salvemini D: Antioxidant therapy: a new pharmacological approach in shock, inflammation, and ischemia/reperfusion injury. Pharmacol Rev 53: 135-159, 2001.
23. Hall AM and Unwin RJ: The not so "mighty chondrion": emergence of renal diseases due to mitochondrial dysfunction. Nephron Physiol 105: 1-10, 2007.
24. Jassem W and Heaton ND: The role of mitochondria in ischemia/reperfusion injury in organ transplantation. Kidney Int 66: 514-517, 2004.
25. Di Lisa F and Bernardi P: Mitochondria and ischemia-reperfusion injury of the heart: fixing a hole. Cardiovasc Res 70: 191-199, 2006.
26. Tsujimoto Y, Nakagawa T and Shimizu S: Mitochondrial membrane permeability transition and cell death. Biochim Biophys Acta 7757: 1297-1300, 2006.