Kidneys of Alb/TGF-β1 transgenic mice are deficient in retinoic acid and exogenous retinoic acid shows dose-dependent toxicity

Nephron - Experimental Nephrology

Volumn 114, Issue 4, 2010, Pages

  Xu, Qihe ^a   Hendry, Bruce M ^a   Maden, Malcolm ^b   Lu, Huiyan ^c   Wong, Yuen Fei ^a   Rankin, Alexandra C ^a   Noor, Mazhar ^a   Kopp, Jeffrey B ^c  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b University of Florida   (United States)

^c NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

All trans retinoic acid; Connective tissue growth factor; Fibrosis; Retinal dehydrogenase 2; Transforming growth factor 1

Indexed keywords

ALBUMIN; COLLAGEN TYPE 1; COLLAGEN TYPE 1 A1; COLLAGEN TYPE 1 A2; COLLAGEN TYPE 4; COLLAGEN TYPE 4 A1; CONNECTIVE TISSUE GROWTH FACTOR; FIBRONECTIN; MESSENGER RNA; PLACEBO; RETINAL DEHYDROGENASE; RETINAL DEHYDROGENASE 2; RETINOIC ACID; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE MODEL; DOSE RESPONSE; DRUG MEGADOSE; GENE EXPRESSION; GENETIC MARKER; GLOMERULOSCLEROSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; KIDNEY FIBROSIS; KIDNEY FUNCTION; LOW DRUG DOSE; MALE; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE; URINARY EXCRETION; WILD TYPE;

ANIMALS; CONNECTIVE TISSUE GROWTH FACTOR; DISEASE MODELS, ANIMAL; FIBROSIS; KIDNEY; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; TRANSFORMING GROWTH FACTOR BETA1; TRETINOIN;

EID: 75149170185     PISSN: 16602129     EISSN: None     Source Type: Journal    
DOI: 10.1159/000276587     Document Type: Article

References (29)

1. Feehally J, Floege J, Johnson RJ: Comprehensive Clinical Nephrology, ed 3, revised. London, Mosby, 2007.
2. Xu Q, Lucio-Cazana J, Kitamura M, Ruan X, Fine LG, Norman J: Retinoids in nephrology: promises and pitfalls. Kidney Int 2004; 66: 2119-2131.
3. Wen X, Li Y, Hu K, Dai C, Liu Y: Hepatocyte growth factor receptor signaling mediates the anti-fibrotic action of 9- cis -retinoic acid in glomerular mesangial cells. Am J Pathol 2005; 167: 947-957.
4. Daly TJ, Weston WL: Retinoid effects on fibroblast proliferation and collagen synthesis in vitro and on fibrotic disease in vivo. J Am Acad Dermatol 1986; 15: 900-902.
5. Redlich CA, Delisser HM, Elias JA: Retinoic acid inhibition of transforming growth factor- β -induced collagen production by human lung fibroblasts. Am J Respir Cell Mol Biol 1995; 12: 287-295.
6. Davis BH, Kramer RT, Davidson NO: Retinoic acid modulates rat Ito cell proliferation, collagen, and transforming growth factor β production. J Clin Invest 1990; 86: 2062-2070.
7. Shindo T, Manabe I, Fukushima Y, Tobe K, Aizawa K, Miyamoto S, Kawai-Kowase K, Moriyama N, Imai Y, Kawakami H, Nishimatsu H, Ishikawa T, Suzuki T, Morita H, Maemura K, Sata M, Hirata Y, Komukai M, Kagechika H, Kadowaki T, Kurabayashi M, Nagai R: Kruppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling. Nat Med 2002; 8: 856-863.
8. Haxsen V, Adam-Stitah S, Ritz E, Wagner J: Retinoids inhibit the actions of angiotensin II on vascular smooth muscle cells. Circ Res 2001; 88: 637-644.
9. Pendaries V, Verrecchia F, Michel S, Mauviel A: Retinoic acid receptors interfere with the TGF- β /Smad signaling pathway in a ligandspecific manner. Oncogene 2003; 22: 8212-8220.
10. Cao Z, Flanders KC, Bertolette D, Lyakh LA, Wurthner JU, Parks WT, Letterio JJ, Ruscetti FW, Roberts AB: Levels of phospho- Smad2/3 are sensors of the interplay between effects of TGF- β and retinoic acid on monocytic and granulocytic differentiation of HL-60 cells. Blood 2003; 101: 498-507.
11. Wu LN, Ishikawa Y, Nie D, Genge BR, Wuthier RE: Retinoic acid stimulates matrix calcification and initiates type I collagen synthesis in primary cultures of avian weightbearing growth plate chondrocytes. J Cell Biochem 1997; 65: 209-230.
12. Federspiel SJ, DiMari SJ, Howe AM, Guerry- Force ML, Haralson MA: Extracellular matrix biosynthesis by cultured fetal rat lung epithelial cells. IV. Effects of chronic exposure to retinoic acid on growth, differentiation, and collagen biosynthesis. Lab Invest 1991; 65: 441-450.
13. La P, Morgan TA, Sykes SM, Mao H, Schnepp RW, Petersen CD, Hua X: Fusion proteins of retinoid receptors antagonize TGF- β -induced growth inhibition of lung epithelial cells. Oncogene 2003; 22: 198-210.
14. Lateef H, Stevens MJ, Varani J: All- trans retinoic acid suppresses matrix metalloproteinase activity and increases collagen synthesis in diabetic human skin in organ culture. Am J Pathol 2004; 165: 167-174.
15. Griffiths CE, Russman AN, Majmudar G, Singer RS, Hamilton TA, Voorhees JJ: Restoration of collagen formation in photodamaged human skin by tretinoin (retinoic acid). N Engl J Med 1993; 329: 530-535.
16. Varani J, Mitra RS, Gibbs D, Phan SH, Dixit VM, Mitra R Jr, Wang T, Siebert KJ, Nickoloff BJ, Voorhees JJ: All- trans retinoic acid stimulates growth and extracellular matrix production in growth-inhibited cultured human skin fibroblasts. J Invest Dermatol 1990; 94: 717-723.
17. Okuno M, Moriwaki H, Imai S, Muto Y, Kawada N, Suzuki Y, Kojima S: Retinoids exacerbate rat liver fibrosis by inducing the activation of latent TGF- β in liver stellate cells. Hepatology 1997; 26: 913-921.
18. Vollmar B, Heckmann C, Richter S, Menger MD: High, but not low, dietary retinoids aggravate manifestation of rat liver fibrosis. J Gastroenterol Hepatol 2002; 17: 791-799.
19. Kopp JB, Factor VM, Mozes M, Nagy P, Sanderson N, Böttinger EP, Klotman PE, Thorgeirsson SS: Transgenic mice with increased plasma levels of TGF- β 1 develop progressive renal disease. Lab Invest 1996; 74: 991-1003.
20. Mozes MM, Bottinger EP, Jacot TA, Kopp JB: Renal expression of fibrotic matrix proteins and of transforming growth factor- β (TGF- β ) isoforms in TGF- β transgenic mice. J Am Soc Nephrol 1999; 10: 271-280.
21. Achkar CC, Derguini F, Blumberg B, Langston A, Levin AA, Speck J, Evans RM, Bolado J Jr, Nakanishi K, Buck J, Gudas LJ: 4-Oxoretinol, a new natural ligand and transactivator of the retinoic acid receptors. Proc Natl Acad Sci USA 1996; 93: 4879-4884.
22. Sinha P, Clements VK, Ostrand-Rosenberg S: Reduction of myeloid-derived suppressor cells and induction of M1 macrophages facilitate the rejection of established metastatic disease. J Immunol 2005; 174: 636-645.
23. Blush J, Lei J, Ju W, Silbiger S, Pullman J, Neugarten J: Estradiol reverses renal injury in Alb/TGF- β 1 transgenic mice. Kidney Int 2004; 66: 2148-2154.
24. Yuen PS, Dunn SR, Miyaji T, Yasuda H, Sharma K, Star RA: A simplified method for HPLC determination of creatinine in mouse serum. Am J Physiol Renal Physiol 2004; 286: F1116-F1119.
25. López-Bermejo A, Buckway CK, Devi GR, Hwa V, Plymate SR, Oh Y, Rosenfeld RG: Characterization of insulin-like growth factor- binding protein-related proteins (IGFBPrPs) 1, 2, and 3 in human prostate epithelial cells: potential roles for IGFBP-rP1 and 2 in senescence of the prostatic epithelium. Endocrinology 2000; 141: 4072-4080.
26. Shimo T, Koyama E, Sugito H, Wu C, Shimo S, Pacifici M: Retinoid signaling regulates CTGF expression in hypertrophic chondrocytes with differential involvement of MAP kinases. J Bone Miner Res 2005; 220: 867-877.
27. Cash DE, Gates PB, Imokawa Y, Brockes JP: Identification of newt connective tissue growth factor as a target of retinoid regulation in limb blastemal cells. Gene 1998; 222: 119-124.
28. Soylu A, Kavukçu S, Sariölu S, Astarciölu H, Türkmen M, Büyükgebiz B: The effect of vitamin A on the course of renal ablation nephropathy. Pediatr Nephrol 2001; 16: 472-476.
29. Morath C, Ratzlaff K, Dechow C, Schwenger V, Schaier M, Zeier B, Peters J, Tsukada M, Zouboulis CC, Waldherr R, Gross ML, Ritz E, Zeier M, Wagner J: Chronic low-dose isotretinoin treatment limits renal damage in subtotally nephrectomized rats. J Mol Med 2009; 87: 53-64.