Synthesis of 3'-amino-3'-deoxyguanosine and 3'-amino-3'-deoxyxyloguanosine monophosphate hepdirect prodrugs from guanosine

Nucleosides, Nucleotides and Nucleic Acids

Volumn 28, Issue 10, 2009, Pages 969-986

  Bookser, Brett C ^a   Raffaele, Nicholas B ^a   Reddy, K Raja ^a   Fan, Kevin ^a   Huang, Wenjian ^a   Erion, Mark D ^a  

^a Metabasis Therapeutics Inc   (United States)

Author keywords

3' amino 3' deoxyguanosines; HepDirect prodrugs; NTPs

Indexed keywords

3' AMINO 3' DEOXYGUANOSINE; 3' AMINO 3' DEOXYXYLOGUANOSINE PHOSPHATE; 9 (2,5 BIS O TERT BUTYLDIMETHYLSILYL BETA DEXRO RIBOFURANOSYL) 2 N (N,N DIBENZYLFORMAMIDINO)GUANINE; 9 [3 AMINO 5 O [4 (3 CHLOROPHENYL) 1,3 DIOXA 2 OXOPHOSPHORINAN 2 YL] 3 DEOXY BETA DEXTRO RIBOFURANOSYL]GUANINE; 9 [3 AMINO 5 O [4 (3 CHLOROPHENYL) 1,3 DIOXA 2 OXOPHOSPHORINAN 2 YL] BETA DEXTRO XYLOFURANOSYL]GUANINE; GUANINE DERIVATIVE; GUANOSINE; GUANOSINE DERIVATIVE; METHANOL; NUCLEOSIDE TRIPHOSPHATE; PRODRUG; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHEMICAL STRUCTURE; DRUG SYNTHESIS; GLYCOSYLATION; ISOMERIZATION; LIVER CELL; NONHUMAN; RAT; SOLVENT EFFECT; TEMPERATURE SENSITIVITY;

ANIMALS; DEOXYGUANOSINE; HEPATOCYTES; MOLECULAR CONFORMATION; PRODRUGS; RATS;

RATTUS;

EID: 75149169870     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1080/15257770903307151     Document Type: Article

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