N6-cyclopentyl-3'-substituted-xylofuranosyladenosines: A new class of non-xanthine adenosine A1 receptor antagonists

Journal of Medicinal Chemistry

Volumn 40, Issue 23, 1997, Pages 3765-3772

  Van Calenbergh, Serge ^a   Von Frijtag Drabbe Künzel, Jacobien K ^b   Blaton, Norbert M ^c   Peeters, Oswald M ^c   Rozenski, Jef ^d   Van Aerschot, Arthur ^d   De Bruyn, Andre ^d   De Keukeleire, Denis ^a   Ijzerman, Adriaan P ^b   Herdewijn, Piet ^a,d  

^a GHENT UNIVERSITY   (Belgium)

^b LEIDEN UNIVERSITY   (Netherlands)

^c UNIVERSITY OF LEUVEN   (Belgium)

^d REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

9 [3 DEOXY 3 (3,4 DIMETHYLBENZAMIDO) BETA D XYLOFURANOSYL N6 CYCLOPENTYLADENINE; ADENINE DERIVATIVE; ADENOSINE A1 RECEPTOR; ADENOSINE RECEPTOR BLOCKING AGENT; N6 CYCLOPENTYLADENINE DERIVATIVE; UNCLASSIFIED DRUG; ADENOSINE; ADENOSINE RECEPTOR; DRUG DERIVATIVE; N(6) CYCLOPENTYLADENOSINE; N(6)-CYCLOPENTYLADENOSINE; XANTHINE DERIVATIVE;

ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CORPUS STRIATUM; DRUG CONFORMATION; DRUG RECEPTOR BINDING; NONHUMAN; RAT; RECEPTOR AFFINITY; RECEPTOR DENSITY; STRUCTURE ACTIVITY RELATION; ANIMAL; BINDING SITE; DRUG ANTAGONISM; METABOLISM; RADIOASSAY; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

ADENOSINE; ANIMALS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; RADIOLIGAND ASSAY; RATS; RECEPTORS, PURINERGIC P1; XANTHINES;

EID: 0031558658     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970176k     Document Type: Article

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