In vivo bone biocompatibility and degradation of porous fumarate-based polymer/alumoxane nanocomposites for bone tissue engineering

Journal of Biomedical Materials Research - Part A

Volumn 92, Issue 2, 2010, Pages 451-462

  Mistry, Amit S ^a   Pham, Quynh P ^a   Schouten, Corinne ^b   Yeh, Tiffany ^a   Christenson, Elizabeth M ^a   Mikos, Antonios G ^a   Jansen, John A ^b  

^a Rice University   (United States)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Biocompatibility; Bone tissue engineering; Micro computed tomography; Nanobiomaterials; Nanocomposite

Indexed keywords

ALUMOXANE; BONE CONTACTS; BONE INGROWTH; BONE TISSUE; BONE TISSUE ENGINEERING; DEGRADABILITY; DIRECT CONTACT; FEMORAL CONDYLES; FUMARATES; HISTOLOGICAL ANALYSIS; IN-VIVO; LOW-MOLECULAR WEIGHT; MACROCOMPOSITE; MICRO-PARTICLES; MICROCOMPUTED TOMOGRAPHY; NANOBIOMATERIALS; POLY(PROPYLENE FUMARATE); POROUS SCAFFOLD; SOFT TISSUE; SURFACE-MODIFIED;

BIOCOMPATIBILITY; BIODEGRADABLE POLYMERS; BONE; COMPUTERIZED TOMOGRAPHY; CONTROL SURFACES; DEGRADATION; NANOCOMPOSITES; NANOPARTICLES; PROPYLENE; TISSUE ENGINEERING;

SCAFFOLDS;

ALUMINUM OXIDE; ALUMOXANE; BIOMATERIAL; FUMARIC ACID; NANOCOMPOSITE; POLY(PROPYLENE FUMARATE); POLYMER; PROPYLENE FUMARATE DIACRYLATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOCOMPATIBILITY; BONE GROWTH; BONE TISSUE; CONTROLLED STUDY; DEGRADATION; FEMUR CONDYLE; IN VIVO STUDY; MICRO-COMPUTED TOMOGRAPHY; MICROPARTICLE ENZYME IMMUNOASSAY; NONHUMAN; TISSUE ENGINEERING;

ABSORBABLE IMPLANTS; ACRYLIC RESINS; ALUMINUM OXIDE; ANALYSIS OF VARIANCE; ANIMALS; BIOCOMPATIBLE MATERIALS; BONE AND BONES; BONE DEVELOPMENT; CROSS-LINKING REAGENTS; FUMARATES; GELS; GOATS; MATERIALS TESTING; MOLECULAR WEIGHT; NANOTECHNOLOGY; POLYMERS; POLYPROPYLENES; POROSITY; PROSTHESES AND IMPLANTS; TISSUE ENGINEERING; TISSUE SCAFFOLDS; TOMOGRAPHY, X-RAY COMPUTED;

EID: 75149166969     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.32371     Document Type: Article

References (26)

1. Mistry AS, Mikos AG. Tissue engineering strategies for bone regeneration. Adv Biochem Eng Biotechnol 2005;94:1-22.
2. He S, Timmer MD, Yaszemski MJ, Yasko AW, Engel PS, Mikos AG. Synthesis of biodegradable poly(propylene fumarate) networks with poly(propylene fumarate)-diacrylate macromers as crosslinking agents and characterization of their degradation products. Polymer 2000;42:1251-1260.
3. Timmer MD, Ambrose CG, Mikos AG. In vitro degradation of polymeric networks of poly(propylene fumarate) and the crosslinking macromer poly(propylene fumarate)-diacrylate. Biomaterials 2003;24:571-577.
4. Timmer MD, Ambrose CG, Mikos AG. Evaluation of thermaland photo-crosslinked biodegradable poly(propylene fumarate)-based networks. J Biomed Mater Res A 2003;66:811-818.
5. Timmer MD, Horch RA, Ambrose CG, Mikos AG. Effect of physiological temperature on the mechanical properties and network structure of biodegradable poly(propylene fumarate)-based networks. J Biomater Sci Polym Ed 2003;14:369-382.
6. Fisher JP, Vehof JW, Dean D, van der Waerden JP, Holland TA, Mikos AG, Jansen JA. Soft and hard tissue response to photocrosslinked poly(propylene fumarate) scaffolds in a rabbit model. J Biomed Mater Res 2002;59:547-556.
7. Hedberg EL, Kroese-Deutman HC, Shih CK, Crowther RS, Carney DH, Mikos AG, Jansen JA. Effect of varied release kinetics of the osteogenic thrombin peptide TP508 from biodegradable, polymeric scaffolds on bone formation in vivo. J Biomed Mater Res A 2005;72:343-353.
8. Horch RA, Shahid N, Mistry AS, Timmer MD, Mikos AG, Barron AR. Nanoreinforcement of poly(propylene fumarate)-based networks with surface modified alumoxane nanoparticles for bone tissue engineering. Biomacromolecules 2004;5:1990-1998.
9. Mistry AS, Mikos AG, Jansen JA. Degradation and biocompatibility of a poly(propylene fumarate)-based/alumoxane nanocomposite for bone tissue engineering. J Biomed Mater Res A 2007;83:940-953.
10. Mistry AS, Cheng SH, Yeh T, Christenson E, Jansen JA, Mikos AG. Fabrication and in vitro degradation of porous fumarate-based polymer/alumoxane nanocomposite scaffolds for bone tissue engineering. J Biomed Mater Res A 2009;89:68-79.
11. Shung AK, Timmer MD, Jo S, Engel PS, Mikos AG. Kinetics of poly(propylene fumarate) synthesis by step polymerization of diethyl fumarate and propylene glycol using zinc chloride as a catalyst. J Biomater Sci Polym Ed 2002;13:95-108.
12. Mendenhall HV. Animal selection. In: Recum AFV, editor. Handbook of Biomaterials Evaluation: Scientific, Technical, and Clinical Testing of Implant Materials. Philadelphia: Taylor and Francis; 1999. p 475-479.
13. Bernhardt R, van den Dolder J, Bierbaum S, Beutner R, Scharnweber D, Jansen J, Beckmann F, Worch H. Osteoconductive modifications of Ti-implants in a goat defect model: Characterization of bone growth with SR lCT and histology. Biomaterials 2005;26:3009-3019.
14. Jansen JA, Dhert WJ, van der Waerden JP, von Recum AF. Semi-quantitative and qualitative histologic analysis method for the evaluation of implant biocompatibility. J Invest Surg 1994;7:123-134.
15. Hedberg EL, Kroese-Deutman HC, Shih CK, Crowther RS, Carney DH, Mikos AG, Jansen JA. In vivo degradation of porous poly(propylene fumarate)/poly(DL-lactic-co-glycolic acid) composite scaffolds. Biomaterials 2005;26:4616-4623.
16. De Jong WH, Eelco Bergsma J, Robinson JE, Bos RR. Tissue response to partially in vitro predegraded poly-L-lactide implants. Biomaterials 2005;26:1781-1791.
17. Fisher JP, Holland TA, Dean D, Mikos AG. Photoinitiated cross-linking of the biodegradable polyester poly(propylene fumarate). II. In vitro degradation. Biomacromolecules 2003;4:1335-1342.
18. Hedberg EL, Shih CK, Lemoine JJ, Timmer MD, Liebschner MA, Jansen JA, Mikos AG. In vitro degradation of porous poly(propylene fumarate)/poly( DL-lactic-co-glycolic acid) composite scaffolds. Biomaterials 2005;26:3215-3225.
19. Hedberg EL, Kroese-Deutman HC, Shih CK, Lemoine JJ, Liebschner MA, Miller MJ, Yasko AW, Crowther RS, Carney DH, Mikos AG, Jansen JA. Methods: A comparative analysis of radiography, microcomputed tomography, and histology for bone tissue engineering. Tissue Eng 2005;11:1356-1367.
20. Webster TJ, Ergun C, Doremus RH, Siegel RW, Bizios R. Enhanced functions of osteoblasts on nanophase ceramics. Biomaterials 2000;21:1803-1810.
21. Lewandrowski KU, Bondre SP, Wise DL, Trantolo DJ. Enhanced bioactivity of a poly(propylene fumarate) bone graft substitute by augmentation with nano-hydroxyapatite. Biomed Mater Eng 2003;13:115-124.
22. Ishaug SL, Crane GM, Miller MJ, Yasko AW, Yaszemski MJ, Mikos AG. Bone formation by three-dimensional stromal osteoblast culture in biodegradable polymer scaffolds. J Biomed Mater Res 1997;36:17-28.
23. Ishaug-Riley SL, Crane-Kruger GM, Yaszemski MJ, Mikos AG. Three-dimensional culture of rat calvarial osteoblasts in porous biodegradable polymers. Biomaterials 1998;19:1405-1412.
24. Burdick JA, Frankel D, Dernell WS, Anseth KS. An initial investigation of photocurable three-dimensional lactic acid based scaffolds in a critical-sized cranial defect. Biomaterials 2003;24:1613-1620.
25. Peter SJ, Lu L, Kim DJ, Mikos AG. Marrow stromal osteoblast function on a poly(propylene fumarate)/β-tricalcium phosphate biodegradable orthopaedic composite. Biomaterials 2000;21:1207-1213.
26. Vehof JW, Fisher JP, Dean D, van der Waerden JP, Spauwen PH, Mikos AG, Jansen JA. Bone formation in transforming growth factor β-1-coated porous poly(propylene fumarate) scaffolds. J Biomed Mater Res 2002;60:241-251.