Degradation and biocompatibility of a poly(propylene fumarate)-based/ alumoxane nanocomposite for bone tissue engineering

Journal of Biomedical Materials Research - Part A

Volumn 83, Issue 4, 2007, Pages 940-953

  Mistry, A S ^a   Mikos, A G ^a   Jansen, J A ^b  

^a Rice University   (United States)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Accelerated degradation; Goat model; Inflammatory response; Nanobiomaterials; Nanoparticles

Indexed keywords

ACCELERATED DEGRADATION; GOAT MODELS; INFLAMMATORY RESPONSE; NANOBIOMATERIALS;

BIOCOMPATIBILITY; BIODEGRADABILITY; BONE; NANOPARTICLES; POLYPROPYLENES; TISSUE ENGINEERING;

NANOCOMPOSITES;

ALUMOXANE; FUMARIC ACID DERIVATIVE; NANOCOMPOSITE; NANOPARTICLE; POLY(PROPYLENE FUMARATE); POLYMER; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOCOMPATIBILITY; BIOLOGY; BIOMECHANICS; BONE TISSUE; CYTOTOXICITY; DEGRADATION; FEMALE; FIBROBLAST CULTURE; FRAGMENTATION REACTION; GOAT; IN VITRO STUDY; IN VIVO STUDY; MASS; NONHUMAN; PARTICLE SIZE; RAT; SAMPLE; SOFT TISSUE; TISSUE ENGINEERING; TISSUE REACTION;

ALUMINUM COMPOUNDS; ANIMALS; BIOCOMPATIBLE MATERIALS; CELL LINE; FEMALE; FUMARATES; GOATS; NANOCOMPOSITES; POLYPROPYLENES; RATS; TISSUE ENGINEERING;

EID: 36849058159     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.31280     Document Type: Article

References (26)

1. Mistry AS, Mikos AG. Tissue engineering strategies for bone regeneration. Adv Biochem Eng Biotechnol 2005;94:1-22.
2. Kozak LJ, DeFrances CJ, Hall MJ. National Hospital Discharge Survey: 2004 annual summary with detailed diagnosis and procedure data. National Center for Health Statistics. Vital Health Stat 2006;13(162).
3. Thomson RC, Ishaug SL, Mikos AG, Langer R. Polymers for biological systems. In: Meyers RA, editor. Molecular Biology and Biotechnology. New York: VCH Publishers; 1995. p 717-724.
4. He S, Timmer MD, Yaszemski MJ, Yasko AW, Engel PS, Mikos AG. Synthesis of biodegradable poly(propylene fumarate) networks with poly(propylene fumarate)-diacrylate macromers as crosslinking agents and characterization of their degradation products. Polymer 2000;42:1251-1260.
5. Timmer MD, Jo S, Wang C, Ambrose CG, Mikos AG. Characterization of the cross-linked structure of fumarate-based degradable polymer networks. Macromolecules 2002;35:4373-4379.
6. Timmer MD, Shin H, Horch RA, Ambrose CG, Mikos AG. In vitro cytotoxicity of injectable and biodegradable poly(propylene fumarate)-based networks: Unreacted macromers, cross-linked networks, and degradation products. Biomacromolecules 2003;4:1026-1033.
7. Peter SJ, Miller ST, Zhu G, Yasko AW, Mikos AG. In vivo degradation of a poly(propylene fumarate)/beta-tricalcium phosphate injectable composite scaffold. J Biomed Mater Res 1998;41:1-7.
8. Fisher JP, Vehof JW, Dean D, van der Waerden JP, Holland TA, Mikos AG, Jansen JA. Soft and hard tissue response to photocrosslinked poly(propylene fumarate) scaffolds in a rabbit model. J Biomed Mater Res 2002;59:547-556.
9. Mistry AS, Shi X, Mikos AG. Nanocomposite scaffolds for tissue engineering. In: Bronzino J, editor. The Biomedical Engineering Handbook, 3rd ed. - Tissue Engineering and Artificial Organs. Boca Raton: CRC Press; 2006. p 40-1-40-11.
10. Webster TJ, Ergun C, Doremus RH, Siegel RW, Bizios R. Enhanced functions of osteoblasts on nanophase ceramics. Biomaterials 2000;21:1803-1810.
11. Horch RA, Shahid N, Mistry AS, Timmer MD, Mikos AG, Barron AR. Nanoreinforcement of poly(propylene fumarate)-based networks with surface modified alumoxane nanoparticles for bone tissue engineering. Biomacromolecules 2004;5:1990-1998.
12. Shung AK, Timmer MD, Jo S, Engel PS, Mikos AG. Kinetics of poly(propylene fumarate) synthesis by step polymerization of diethyl fumarate and propylene glycol using zinc chloride as a catalyst. J Biomater Sci Polym Ed 2002;13:95-108.
13. Timmer MD, Horch RA, Ambrose CG, Mikos AG. Effect of physiological temperature on the mechanical properties and network structure of biodegradable poly(propylene fumarate)-based networks. J Biomater Sci Polym Ed 2003;14:369-382.
14. Morrison RT, Boyd RN. Organic Chemistry. Englewood Cliffs: Prentice Hall; 1992.
15. Jansen JA, Dhert WJ, van der Waerden JP, von Recum AF. Semi-quantitative and qualitative histologic analysis method for the evaluation of implant biocompatibility. J Invest Surg 1994;7:123-134.
16. De Jong WH, Eelco Bergsma J, Robinson JE, Bos RR. Tissue response to partially in vitro predegraded poly-L-lactide implants. Biomaterials 2005;26:1781-1791.
17. Timmer MD, Ambrose CG, Mikos AG. In vitro degradation of polymeric networks of poly(propylene fumarate) and the crosslinking macromer poly(propylene fumarate)-diacrylate. Biomaterials 2003;24:571-577.
18. Declercq HA, Verbeeck RM, De Ridder LI, Schacht EH, Cornelissen MJ. Calcification as an indicator of osteoinductive capacity of biomaterials in osteoblastic cell cultures. Biomaterials 2005;26:4964-4974.
19. Giachelli CM. Ectopic calcification: Gathering hard facts about soft tissue mineralization. Am J Pathol 1999;154:671-675.
20. Jansen JA, de Ruijter JE, Janssen PT, Paquay YG. Histological evaluation of a biodegradable polyactive/hydroxyapatite membrane. Biomaterials 1995;16:819-827.
21. Kong L, Gao Y, Cao W, Gong Y, Zhao N, Zhang X. Preparation and characterization of nano-hydroxyapatite/chitosan composite scaffolds. J Biomed Mater Res A 2005;75:275-282.
22. Zhang SM, Cui FZ, Liao SS, Zhu Y, Han L. Synthesis and biocompatibility of porous nanohydroxyapatite/collagen/alginate composite. J Mater Sci Mater Med 2003;14:641-645.
23. Du C, Cui FZ, Feng QL, Zhu XD, de Groot K. Tissue response to nano-hydroxyapatite/collagen composite implants in marrow cavity. J Biomed Mater Res 1998;42:540-548.
24. Kikuchi M, Itoh S, Ichinose S, Shinomiya K, Tanaka J. Self-organization mechanism in a bone-like hydroxyapatite/collagen nanocomposite synthesized in vitro and its biological reaction in vivo. Biomaterials 2001;22:1705-1711.
25. Peter SJ, Kim P, Yasko AW, Yaszemski MJ, Mikos AG. Crosslinking characteristics of an injectable poly(propylene fumarate)/β-tricalcium phosphate paste and mechanical properties of the crosslinked composite for use as a biodegradable bone cement. J Biomed Mater Res 1999;44:314-321.
26. Timmer MD, Ambrose CG, Mikos AG. Evaluation of thermal-and photo-crosslinked biodegradable poly(propylene fumarate)-based networks. J Biomed Mater Res A 2003;66:811-818.