Polymorphisms in the promoter region of relaxin-2 and preterm birth: Involvement of relaxin in the etiology of preterm birth

In Vivo

Volumn 23, Issue 6, 2009, Pages 1005-1009

  Vogel, Ida ^a,b   Hollegaard, Mads Vilhelm ^c   Hougaard, David Michael ^c   Thorsen, Poul ^a,d   Grove, Jakob ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

^c STATENS SERUM INSTITUT   (Denmark)

^d EMORY UNIVERSITY   (United States)

Author keywords

Polymorphism; Preterm birth; Preterm delivery; Relaxin 1; Relaxin 2; Relaxin 3; SNP

Indexed keywords

GENOMIC DNA; RELAXIN; RELAXIN 2; UNCLASSIFIED DRUG;

ADULT; ALLELE; ARTICLE; CONFIDENCE INTERVAL; CONTROLLED STUDY; FEMALE; GENE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENOTYPE; HAPLOTYPE; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MOTHER; PREMATURE LABOR; PROMOTER REGION; RISK FACTOR; RLN1 GENE; RLN2 GENE; RLN3 GENE; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 75149166484     PISSN: 0258851X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Treloar SA, Macones GA, Mitchell LE and Martin NG: Genetic influences on premature parturition in an Australian twin sample. Twin Res 3: 80-82, 2000.
2. Clausson B, Lichtenstein P and Cnattingius S: Genetic influence on birthweight and gestational length determined by studies in offspring of twins. BR J Obstet Gynaecol 107: 375-381, 2000.
3. Magnus P, Bakketeig LS and Skjaerven R: Correlations of birth weight and gestational age across generations. Ann Hum Biol 20: 231-238, 1993.
4. Porter TF, Fraser AM, Hunter CY, Ward RH and Varner MW: The risk of preterm birth across generations. Obstet Gynecol 90: 63-67, 1997.
5. Basso O, Olsen J and Christensen K: Study of environmental, social, and paternal factors in preterm delivery using sibs and half sibs. A population-based study in Denmark. J Epidemiol Community Health 53: 20-23, 1999.
6. Plunkett J and Muglia LJ: Genetic contributions to preterm birth: implications from epidemiological and genetic association studies. Ann Med 40: 167-195, 2008.
7. Sherwood OD: Relaxin 2: 861-1009, 1994.
8. Sandager KP, Uldbjerg N, Henriksen TB, Goldsmith L, Thorsen P, Weiss G and Vogel I: Cervical length and relaxin in the prediction of spontaneous preterm birth. Am J Obstet Gynecol, 2009.
9. Vogel I, Salvig JD, Secher NJ and Uldbjerg N: Association between raised s-relaxin during the eighteenth gestational week and very preterm delivery. Am J Obstet Gynecol 184: 390-393,2001.
10. Vogel I, Thorsen P, Hundborg HH, Uldbjerg N: Prediction of preterm delivery using changes in serum relaxin in low risk pregnancies. Eur J Obstet Gynecol Reprod Biol 128: 113-118, 2006.
11. Palejwala S, Stein D, Wojtczuk A, Weiss G and Goldsmith LT: Demonstration of a relaxin receptor and relaxin-stimulated tyrosine phosphorylation in human lower uterine segment fibroblasts. Endocrinology 139: 1208-1212, 1998.
12. Palejwala S, Tseng L, Wojtczuk A, Weiss G and Goldsmith LT: Relaxin gene and protein expression and its regulation of procollagenase and vascular endothelial growth factor in human endometrial cells. Biol Reprod 66: 1743-1748, 2002.
13. Palejwala S, Stein DE, Weiss G, Monia BP, Tortoriello D and Goldsmith LT: Relaxin positively regulates matrix metalloproteinase expression in human lower uterine segment fibroblasts using a tyrosine kinase signaling pathway. Endocrinology 142: 3405-3413,2001.
14. Vogel I, Petersen A, Petersen LK, Helmig RB, Oxlund H and Uldbjerg N: Biphasic effect of relaxin, inhibitable by a collagenase inhibitor, on the strength of human fetal membranes. In Vivo 18: 581-584, 2004.
15. MacLennan AH, Green RC, Bryant-Greenwood GD, Greenwood FC and Seamark RF: Ripening of the human cervix and induction of labour with purified porcine relaxin. Lancet 1: 220-223, 1980.
16. Brennand JE, Calder AA, Leitch CR, Greer IA, Chou MM and MacKenzie IZ: Recombinant human relaxin as a cervical ripening agent. Br J Obstet Gynaecol 104: 775-780, 1997.
17. Vogel I, Glavind-Kristensen M, Thorsen P, Armbruster FP and Uldbjerg N: S-relaxin as a predictor of preterm delivery in women with symptoms of preterm labour. Br J Obstet Gynaecol 109: 977-982, 2002.
18. Olsen J, Melbye M, Olsen SF, Sorensen TI, Aaby P, Andersen AM, Taxbol D, Hansen KD, Juhl M, Schow TB, Sorensen HT, Andresen J, Mortensen EL, Olesen AW and Sondergaard C: The Danish National Birth Cohort - its background, structure and aim. Scand J Public Health 29: 300-307, 2001.
19. Curry AE, Vogel I, Drews C, Schendel D, Skogstrand K, Flanders WD, Hougaard DM, Olsen J and Thorsen P: Midpregnancy maternal plasma levels of interleukin 2, 6, and 12, tumor necrosis factor-alpha, interferon-gamma, and granulocytemacrophage colony-stimulating factor and spontaneous preterm delivery. Acta Obstet Gynecol Scand 86: 1103-1110, 2007.
20. Hollegaard S, Grove J, N0rgaard-Pedersen B and Hougaard DM: High-throughput genotyping on archived dried-blood spot samples, 2008.
21. Westfall PH and Young SS: Resampling-Based Multiple Testing: Examples and Methods for p-value Adjustment, 1993.
22. Lin DY, Zeng D and Millikan R: Maximum likelihood estimation of haplotype effects and haplotype-environment interactions in association studies. Genet Epidemiol 29: 299-312, 2005.
23. Petersen LK, Vogel I, Agger AO, Westergaard J, Milman N and Uldbjerg N: Variations in serum relaxin (hRLX-2) concentrationes during human pregnancy. Acta Obstet Gynecol Scand 74: 251-256, 1995.
24. Weiss G, Goldsmith LT, Sachdev R, Von-Hagen S and Lederer K: Elevated first-trimester serum relaxin concentrations in pregnant women following ovarian stimulation predict prematurity risk and preterm delivery. Obstet Gynecol 82: 821-828,1993.
25. Iams JD, Goldsmith LT and Weiss G: The preterm prediction study: maternal serum relaxin, sonographic cervical length, and spontaneous preterm birth in twins. J Soc Gynecol Investig 8: 39-42,2001.
26. Norman RJ, McLoughlin JW, Borthwick GM, Yohkaichiya T, Matthews CD, MacLennan AH and de-Kretser DM: Inhibin and relaxin concentrations in early singleton, multiple, and failing pregnancy: relationship to gonadotropin and steroid profiles. Fertil Steril 59: 130-137, 1993.
27. Dschietzig T, Bartsch C, Baumann G and Stangl K: Relaxin-a pleiotropic hormone and its emerging role for experimental and clinical therapeutics. Pharmacol Ther 112: 38-56, 2006.
28. Peters CA, Maizels ET, Robertson MC, Shiu RP, Soloff MS and Hunzicker-Dunn M: Induction of relaxin messenger RNA expression in response to prolactin receptor activation requires protein kinase C delta signaling. Mol Endocrinol 14: 576-590,2000.
29. Loeken MR, Channing CP, D'Eletto R and Weiss G: Stimulatory effect of luteinizing hormone upon relaxin secretion by cultured porcine preovulatory granulosa cells. Endocrinology 112: 769-771,1983.
30. Taylor MJ and Clark CL: Basic fibroblast growth factor inhibits basal and stimulated relaxin secretion by cultured porcine luteal cells: analysis by reverse hemolytic plaque assay. Endocrinology 130: 1951-1956, 1992.
31. Quagliarello J, Goldsmith L, Steinetz B, Lustig DS and Weiss G: Induction of relaxin secretion in nonpregnant women by human chorionic gonadotropin. J Clin Endocrinol Metab 51: 74-77,1980.
32. Garibay-Tupas JL, Okazaki KJ, Tashima LS, Yamamoto S and Bryant-Greenwood GD: Regulation of the human relaxin genes H1 and H2 by steroid hormones. Mol Cell Endocrinol 219: 115-125, 2004.