Biphasic effect of relaxin, inhibitable by a collagenase inhibitor, on the strength of human fetal membranes

In Vivo

Volumn 18, Issue 5, 2004, Pages 581-584

  Vogel, Ida ^a,c   Petersen, Astrid ^b   Petersen, Lone Kjeld ^a   Helmig, Rikke Bek ^a   Oxlund, Hans ^c   Uldbjerg, Niels ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b AALBORG UNIVERSITY HOSPITAL   (Denmark)

^c AARHUS UNIVERSITY   (Denmark)

Author keywords

Amnion; Chorion; Collagenase inhibitor; Fetal membranes; H1 relaxin; H2 relaxin; Metalloproteinases; Relaxin; Tissue inhibitor of metalloproteinase

Indexed keywords

COLLAGENASE INHIBITOR; HYDROXYPROLINE; N [3 N (BENZYLOXYCARBONYL)AMINOCARBOXYPROPYL]LEUCYL O METHYLTYROSINE N METHYLAMIDE; RELAXIN; UNCLASSIFIED DRUG;

ARTICLE; BIOMECHANICS; CONTROLLED STUDY; ENZYME INHIBITION; EXPLANT; FEMALE; FETUS; FETUS MEMBRANE; HISTOCHEMISTRY; HORMONE INHIBITION; HUMAN; HUMAN TISSUE; INCUBATION TIME; MATERIALS TESTING; PREMATURE FETUS MEMBRANE RUPTURE;

EID: 6944225305     PISSN: 0258851X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Skinner SJ, Campos GA and Liggins GC: Collagen content of human amniotic membranes: effect of gestation length and premature rupture. Obstet Gynecol 57: 487-489, 1981.
2. Hampson V, Liu D, Billett E and Kirk S: Amniotic membrane collagen content and type distribution in women with preterm premature rupture of the membranes in pregnancy. Br J Obstet Gynaecol 104(9 : 1087-1091, 1997.
3. Skinner SJ and Liggins GC: Glycosaminoglycans and collagen in human amnion from pregnancies with and without premature rupture of the membranes. J Dev Physiol 3(2): 111-121, 1981.
4. Uldbjerg N, Ekman G, Malmstrom A, Olsson K and Ulmsten U: Ripening of the human uterine cervix related to changes in collagen, glycosaminoglycans, and collagenolytic activity. Am J Obstet Gynecol 147: 662-666, 1983.
5. Petersen LK, Skajaa K and Uldbjerg N: Serum relaxin as a potential marker for preterm labour. Br J Obstet Gynaecol 99: 292-295, 1992.
6. Vogel I, Salvig J.D., Secher NJ and Uldbjerg N: Association between raised s-relaxin during the eighteenth gestational week and very preterm delivery. Am J Obstet Gynecol 184(3): 390-393, 2001.
7. Petersen LK, Helmig R, Oxlund H, Vogel I and Uldbjerg N: Relaxin (hRLX-2) induced weakening of human fetal membranes in vitro. Eur J Obstet Gynecol Reprod Biol 57: 123-128, 1994.
8. Koay ES, Too CK, Greenwood FC and Bryant-Greenwood GD: Relaxin stimulates collagenase and plasminogen activator secretion by dispersed human amnion and chorion cells in vitro. J Clin Endocrinol Metab 56: 1332-1334, 1983.
9. Qin X, Chua PK, Ohira RH, and Bryant GG: An autocrine/paracrine role of human decidual relaxin. II. Stromelysin-1 (MMP-3) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1). Biol Reprod 56(4): 812-820, 1997.
10. Qin X, Garibay TJ, Chua PK, Cachola L and Bryant GG: An autocrine/paracrine role of human decidual relaxin. I. Interstitial collagenase (matrix metalloproteinase-1) and tissue plasminogen activator. Biol Reprod 56(4): 800-811, 1997.
11. Delaisse JM, Eeckhout Y, Sear C, Galloway A, McCullagh K and Vaes G: A new synthetic inhibitor of mammalian tissue collagenase inhibits bone resorption in culture. Biochem Biophys Res Commun 133 483-490, 1985.
12. Crawford RJ, Hudson P, Shine J, Niall HD, Eddy RL and Shows TB: Two human relaxin genes are on chromosome 9. EMBO J 3: 2341-2345, 1984.
13. Hansell DJ, Bryant-Greenwood GD and Greenwood FC: Expression of the human relaxin H1 gene in the decidua, trophoblast, and prostate. J Clin Endocrinol Metab 72: 899-904, 1991.
14. Gunnersen JM, Fu P, Roche PJ and Tregear GW: Expression of human relaxin genes: characterization of a novel alternatively-spliced human relaxin mRNA species. Mol Cell Endocrinol 118: 85-94, 1996.
15. Dschietzig T, Richter C, Bartsch C, Laule M, Armbruster FP, Baumann G and Stangl K: The pregnancy hormone relaxin is a player in human heart failure. FASEB J 15(12): 2187-2195, 2001.
16. Garibay Tupas JL, Maaskant RA, Greenwood FC and Bryant-Greenwood GD: Characteristics of the binding of 32P-labelled human relaxins to the human fetal membranes. J Endocrinol 145: 441-448, 1995.
17. Oxlund H, Helmig R, Halaburt JT and Uldbjerg N: Biomechanical analysis of human chorioamniotic membranes. Eur J Obstet Gynecol Reprod Biol 34: 247-255, 1990.
18. Bourne GL: The miscroscopic anatomy of the human amnion and chorion. Am J Obstet Gynecol 79(6): 1070-1073, 1960.
19. Stegemann H and Stalder K: Determination of hydroxyproline. Clin Chim Acta 18: 267-273, 1967.
20. Bigazzi M, Brandi ML, Bani G and Sacchi TB: Relaxin influences the growth of MCF-7 breast cancer cells. Mitogenic and antimitogenic action depends on peptide concentration. Cancer 70: 639-643, 1992.
21. Kuznetsova L, Plesneva S, Derjabina N, Omeljaniuk E and Pertseva M: On the mechanism of relaxin action: the involvement of adenylyl cyclase signalling system. Regul Pept 80(1-2): 33-39, 3-17-1999.
22. Vadillo-Ortega F, Gonzalez-Avila G, Villanueva-Diaz C, Banales JL, Selman-Lama M and Alvarado-Duran A: Human amniotic fluid modulation of collagenase production in cultured fibroblasts. A model of fetal membrane rupture. Am J Obstet Gynecol 164: 664-668, 1991.
23. Masterson R, Hewitson TD, Kelynack K, Martic M, Parry L, Bathgate R, Darby I and Becker G: Relaxin down-regulates renal fibroblast function and promotes matrix remodelling in vitro. Nephrol Dial Transplant 19(3): 544-552, 2004.
24. Palejwala S, Tseng L, Wojtczuk A, Weiss G and Goldsmith LT: Relaxin gene and protein expression and its regulation of procollagenase and vascular endothelial growth factor in human endometrial cells. Biol Reprod 66(6): 1743-1748, 2002.
25. Lenhart JA, Ryan PL, Ohleth KM, Palmer SS and Bagnell CA: Relaxin increases secretion of matrix metalloproteinase-2 and matrix metalloproteinase-9 during uterine and cervical growth and remodeling in the pig. Endocrinology 142(9): 3941-3949, 2001.
26. Weiss G, Goldsmith LT, Sachdev R, Von-Hagen S and Lederer K: Elevated first-trimester serum relaxin concentrations in pregnant women following ovarian stimulation predict prematurity risk and preterm delivery. Obstet Gynecol 82: 821-828, 1993.
27. Petersen LK, Vogel I, Agger AO, Westergaard J, Milman N and Uldbjerg N: Variations in serum relaxin (hRLX-2) concentrationes during human pregnancy. Acta Obstet Gynecol Scand 74: 251-256, 1995.
28. Koay ES, Bagnell CA, Bryant-Greenwood GD, Lord SB, Cruz AC and Larkin LH: Immunocytochemical localization of relaxin in human decidua and placenta. J Clin Endocrinol Metab 60: 859-863, 1985.