Viral activation of coagulation: Implications for thrombosis and atherosclerosis

Annals of the New York Academy of Sciences

Volumn 811, Issue , 1997, Pages 155-167

  Hajjar, David P ^a   Nicholson, Andrew C ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATHEROSCLEROSIS; BLOOD CLOTTING; CONFERENCE PAPER; HEMOSTASIS; INFLAMMATORY CELL; PATHOPHYSIOLOGY; THROMBOSIS; VASCULAR ENDOTHELIUM; VIRUS INFECTION;

EID: 0030793635     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1997.tb51998.x     Document Type: Conference Paper

References (68)

1. POMERANTZ, K. & D. HAJJAR. 1992. Signal transduction in atherosclerosis: integration of cytokines and the eicosanoid network. FASEB J. 6: 2933-2941.
2. IGNARRO, L. 1989. Endothelium-derived nitric oxide: actions and properties. FASEB J. 3: 31-36.
3. ESMON, C. 1994. The regulation of natural anticoagulant pathways. Science 235: 1348-1352.
4. TANAKA, K. & K. SUEISHI. 1994. The coagulation and fibrinolysis systems and atherosclerosis. Lab. Invest. 69: 5-18.
5. COSGRIFF, T. 1989. Viruses and hemostasis. Rev. Infect. Dis. 11: 5672-5688.
6. FRIEDMAN, H., E. MACARAK, R. MACGREGOR, J. WOLFE & N. KEFALIDES. 1981. Virus infection of endothelial cells. J. Infect. Dis. 143: 266-273.
7. HO, D. D., T. R. ROTA, C. A. ANDREWS & M. S. HIRSCH. 1984. Replication of cytomegalovirus in endothelial cells. J. Infect. Dis. 150: 956-957.
8. TUMILOWICZ, J. J., M. E. GAWLIK, B. POWELL & J. TRENTON. 1985. Replication of cytomegalovirus in human arterial smooth muscle cells. J. Virol. 56: 839-845.
9. NAHMIAS, A. & K. JOSEY. 1978. Epidemiology of herpes simplex 1 and 2. In Viral Infection of Humans - Epidemiology and Control. :253-271. Plenum Medical Book Co. New York.
10. JOHNSON, R., A. NAHMIAS, L. MAGDER, F. LEE, C. BROOKS & M. SNOWDEN. 1986. A seroepidemiologic survey of the prevalence of herpes simplex virus type 2 in the United States. N. Engl. J. Med. 321: 7-12.
11. MARSHALL, G., G. RABALAIS, J. STEWART & J. DOBBINS. 1993. Cytomegalovirus seroprevalence in women bearing children in Jefferson County, Kentucky. Am. J. Med. Sci. 305: 292-296.
12. BENDITT, E., T. BARRETT & J. MCDOUGALL. 1983. Viruses in the etiology of atherosclerosis. Proc. Natl. Acad. Sci. USA 80: 6386-6389.
13. GYORKEY, F., J. MELNICK, G. GUINN, P. GYORKEY & M. DEBAKEY. 1984. Herpes viridae in endothelial cells of the proximal aorta of atherosclerotic patients. Expt. Mol. Pathol. 40: 328-339.
14. YAMASHIROYA, H., L. GHOSH, R. YANG & A. ROBERTSON. 1988. Herpesviridae in the coronary arteries and aorta of young trauma victims. Am. J. Pathol. 130: 71-79.
15. MYERSON, D., R. HACKMAN, J. NELSON, D. WARD & J. MCDOUGALL. 1984. Widespread occurrence of histologically occult cytomegalovirus. Hum. Pathol. 15: 430-439.
16. MELNICK, J., G. DREESMAN, C. MCCOLLUM, B. PETRIE, J. BUREK & M. DEBAKEY. 1983. Cytomegalovirus antigen within human arterial smooth muscle cells. Lancet 2: 644-646.
17. HENDRIX, M., M. SALIMANS, C. VAN BOVEN & C. BRUGGEMAN. 1990. High prevalence of latently present cytomegalovirus in artery walls of patients suffering grade III atherosclerosis. Am. J. Pathol. 136: 23-28.
18. HENDRIX, M., P. DORMANS, P. KITSLAAR, F. BOSMAN & C. BRUGGEMAN. 1989. The presence of CMV nucleic acids in arterial walls of atherosclerotic and non-atherosclerotic patients. Am. J. Pathol. 134: 1151-1157.
19. PETRIE, B., J. MELNICK, E. ADAM, J. BUREK, C. MCCOLLUM & M. DEBAKEY. 1987. Nucleic acid sequence of cytomegalovirus in cells cultured from human arterial tissue. J. Infect. Dis. 155: 158-159.
20. MCSORLEY, J., L. SHAPIRO, M. BROWNSTEIN & K. HSU. 1974. Herpes simplex virus and varicella-zoster: comparative histology of 77 cases. Int. J. Dermatol. 13: 69-75.
21. KANER, R., R. IOZZO, Z. ZIAIE & N. KEFALIDES. 1990. Inhibition of proteoglycan synthesis in human endothelial cells after infection with herpes simplex virus type 1 in vitro. Am. J. Resp. Cell Mol. Biol. 2: 423-431.
22. KEY, N., G. VERCELLOTTI, J. WINKELMANN, C. MOLDOW, J. GOODMAN, N. ESMON, C. ESMON & H. JACOB. 1990. Infection of vascular endothelial cells with herpes simplex virus enhances tissue factor activity and reduces thrombomodulin expression. Proc. Natl. Acad. Sci. USA 87: 7095-7097.
23. VISSER, M., P. TRACY, G. VERCELLOTTI, J. GOODMAN, J. WHITE & H. JACOB. 1988. Enhanced thrombin generation and platelet binding on herpes simplex virus-infected endothelium. Proc. Natl. Acad. Sci. USA 85: 8227-8230.
24. BEVILACQUA, M., J. POBER, M. WHEELER, R. COTRAN & M. GIMBRONE. 1985. Interleukin-1 activation of vascular endothelium. Effects on procoagulant activity and leukocyte adhesion. Am. J. Pathol. 121: 393-403.
25. ADAMS, D. H., L. R. WYNER & M. J. KARNOVSKY. 1993. Experimental graft arteriosclerosis. 2. immunocytochemical analysis of lesion development. Transplantation 56: 794-799.
26. KEY, N., R. BACH, G. VERCELLOTTI & C. MOLDOW. 1993. Herpes simplex virus type I does not require productive infection to induce tissue factor in human umbilical vein endothelial cells. Lab. Invest. 68: 645-651.
27. VAN DAM-MIERAS, M., A. MULLER, V. VAN HINSBERGH, W. MULLERS, P. BOMANS & C. BRUGGEMAN. 1992. The procoagulant response of cytomegalovirus infected endothelial cells. Thromb. Haemostasis 68: 364-370.
28. ETINGIN, O., R. SILVERSTEIN & D. HAJJAR. 1993. von Willeband factor mediates platelet adhesion to virally infected endothelial cells. Proc. Natl. Acad. Sci. USA 90: 5153-5156.
29. STORN, L., R. SHI, D. SILVERMAN & V. MARDER. 1991. Rickettsia rickettsia infection of cultured endothelial cells induces release of large von Willebrand factor multimers from Weibel-Palade bodies. Blood 78: 2595-2602.
30. SCHORER, A., C. MOLDOW & M. RICK. 1987. Interleukin 1 or endotoxin increases the release of von Willebrand factor from human endothelial cells. Br. J. Hematol. 67: 193-197.
31. BRUGGEMAN, C., W. DEBIE, A. MULLER, B. SCHUTTE & M. VAN DAM-MIERAS. 1988. Cytomegalovirus alters the von Willebrand factor content in human endothelial cells. Thromb. Haemostasis 59: 264-268.
32. ETINGIN, O., R. SILVERSTEIN, H. FRIEDMAN & D. HAJJAR. 1990. Viral activation of the coagulation cascade: molecular interactions at the surface of the infected endothelial cell. Cell 61: 657-662.
33. ALTIERI, D., O. ETINGIN, D. FAIR, T. BRUNCK, J. GELTOSKY, D. HAJJAR & T. EDGINGTON. 1991. Structural homogolous ligand binding of integrin mac-1 and viral glycoprotein C receptors. Science 254: 1200-1203.
34. CINES, D. B., A. P. LYSS, M. BINA, R. CORKEY & N. A. KEFALIDES. 1982. Fc and C3 receptors induced by Herpes simplex virus infection in cultured endothelial cells. J. Clin. Invest. 69: 123.
35. MACGREGOR, R. R., H. M. FRIEDMAN, E. J. MACARAK & N. A. KEFALIDES. 1980. Virus infection of endothelial cells increases granulocyte adherence. J. Clin. Invest. 65: 1469-1477.
36. ZAJAC, B., K. O'NEILL, H. FRIEDMAN & R. MACGREGOR. 1988. Increased adherence of human granulocytes to herpes simplex type 1 infected endothelial cells. In Vitro Cell. Dev. Biol. 24: 321-325.
37. VISSER, M., H. JACOB, J. GOODMAN, J. MCCARTHY, L. FURCHT & G. VERCELLOTTI. 1989. Granulocyte-mediated injury to herpes simplex virus-infected human endothelium. Lab. Invest. 60: 296-304.
38. SPAN, A., C. VAN BOVEN & C. BRUGGEMAN. 1989. The effect of cytomegalovirus infection on the adherence of polymorphonuclear leukocytes to endothelial cells. Eur. J. Clin. Invest. 19: 542-548.
39. SPAN, A., J. ENDERT, C. VAN BOVEN & C. BRUGGEMAN. 1989. Virus induced adherence of monocytes to endothelial cells. FEMS Microbiol. Immunol. 47: 237-244.
40. MCEVER, R. 1991. GMP-140: A receptor for neutrophils and monocytes on activated platelets and endothelium. J. Cell Biochem. 45: 156-161.
41. HATTORI, R., K. HAMILTON, R. FUGATE, R. MCEVER & P. SIMS. 1989. Stimulated secretion of endothelial cell von Willebrand factor is accompanied by rapid distribution of the intracellular granule membrane protein, GMP-140. J. Cell. Biochem. 264: 7768-7771.
42. ETINGIN, O., R. SILVERSTEIN & D. HAJJAR. 1991. Identification of a monocyte receptor on herpesvirus-infected endothelial cells. Proc. Natl. Acad. Sci. USA 88: 7200-7203.
43. SCHORER, A., M. KAPLAN, G. RAO & C. MOLDOW. 1986. Interleukin 1 stimulates endothelial cell tissue factor production and expression by a prostaglandin-independent mechanism. Thomb. Haemostasis 56: 256-259.
44. ALTIERI, D. 1994. Molecular cloning of effector cell protease-1, a novel cell surface receptor for the protease factor Xa. J. Biol. Chem. 269: 3139-3142.
45. ALTIERI, D. 1994. Splicing of effector cell protease receptor-1 mRNA is modulated by an unusual retained intron. Biochem. 33: 13848-13855.
46. ALTIERI, D. & T. EDGINGTON. 1990. Identification of effector cell protease-1. A leukocyte-distributed receptor for the serine protease factor Xa. J. Immunol. 145: 246-253.
47. COUGHLIN, S. R. 1993. Thrombin receptor structure and function. Thromb. Haemostasis 70: 184-187.
48. VU, T. K. H., D. HUNG, V. WHEATON & S. COUGHLIN. 1991. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 64: 1057-1068.
49. CHEN, L., N. TENG & J. BUCHANAN. 1976. Mitogenicity of thrombin and surface alterations on mouse splenocytes. Exp. Cell Res. 101: 41-46.
50. CHEN, L. & J. BUCHANAN. 1975. Mitogenic activity of blood components. I. Thrombin and prothrombin. Proc. Natl. Acad. Sci. USA 72: 131-135.
51. BAR-SHAVIT, R., A. KAHN, G. WILNER & J. FENTON. 1983. Monocyte chemotaxis: stimulation by specific exosite region in thrombin. Science 220: 728-731.
52. GAJDUSEK, C., S. CARBON, R. Ross, P. NAWROTH & D. STERN. 1986. Activation of coagulation releases endothelial cell mitogens. J. Cell Biol. 103: 419-428.
53. DANIEL, T., V. GIBBS, D. MILFRAY, M. GAROVOY & L. WILLIAMS. 1986. Thrombin stimulates c-sis gene expression in microvascular endothelial cells. J. Biol. Chem. 260: 9579-9582.
54. DOI, T., K. HIGASHINO, Y. KURIHARI, Y. WADA, T. MIYAZAKI, H. NAKAMURA, S. UESUGI, T. IMANISHI, Y. KAWABE, H. ITAKURA, Y. YAZAKI, A. MATSUMOTO & T. KODAMA. 1994. Charged collagen structure mediates the recognition of negatively charged macromolecules by macrophage scavenger receptors. J. Biol. Chem. 268: 2126-2133.
55. GASIC, G., C. ARENAS & T. GASIC. 1992. Coagulation factors X, Xa, and protein S as potent mitogens of cultured aortic smooth muscle cells. Proc. Natl. Acad. Sci. USA 89: 2317-2320.
56. HAJJAR, D. 1991. Viral pathogenesis of atherosclerosis: impact of molecular mimicry and viral genes. Am. J. Pathol. 139: 1195-1211.
57. MACDONALD, K., T. RECTOR, E. BRAUNLAN, S. COUBO & M. OLIVARI. 1989. Association of coronary artery disease in cardiac transplant recipients with cytomegalovirus infection. Am. J. Pathol. 64: 359-362.
58. FABRICANT, C. G., J. FABRICANT, M. LITRENTA & C. MINICK. 1978. Virus induced atherosclerosis. J. Exp. Med. 148: 335-340.
59. MINICK, C. R., C. G. FABRICANT, J. FABRICANT & M. M. LITRENTA. 1978. Atheroarteriosclerosis induced by infection by herpesvirus. Am. J. Pathol. 96: 673-706.
60. HAJJAR, D., C. FABRICANT, C. MINICK & J. FABRICANT. 1986. Virus-induced atherosclerosis. Herpesvirus infection alters arterial cholesterol metabolism and accumulation. Am. J. Pathol. 122: 62-70.
61. HAJJAR, D., D. FALCONE, C. FABRICANT & J. FABRICANT. 1985. Altered cholesteryl ester cycle is associated with lipid accumulation in herpesvirus-infected arterial smooth muscle cells. J. Biol. Chem. 260: 6124-6128.
62. HAJJAR, D. 1986. Herpesvirus infection prevents activation of cytoplasmic cholesteryl esterase in arterial smooth muscle cells. J. Biol. Chem. 261: 7611-7614.
63. HAJJAR, D., A. NICHOLSON, K. HAJJAR, G. SANDO & B. SUMMERS. 1989. Decreased messenger RNA translation in herpesvirus-infected arterial cells: effects on cholesteryl ester hydrolase. Proc. Natl. Acad. Sci. USA 86: 3366-3370.
64. SPEIR, E., R. MODALI, E. HUANG, M. LEON, F. SHAWL, T. FINKEL & S. EPSTEIN. 1994. Potential role of human cytomegalovirus and p53 interaction in coronary atherosclerosis. Science 265: 391-394.
65. LEMSTROM, K., J. BRUNING, C. BRUGGEMAN, I. LAUTENSCHLAGER & P. HAYRY. 1993. Cytomegalovirus infection enhances smooth muscle cell proliferation and intimai thickening of rat aortic allografts. J. Clin. Invest. 92: 549-558.
66. LEMSTROM, K., P. AHO, C. BRUGGEMAN & P. HAYRY. 1994. Cytomegalovirus infection enhances mRNA expression of platelet derived growth factor-BB and transforming growth factor-beta 1 in rat aortic allografts. Arterioscler. Thromb. 14: 2043-2052.
67. PERSOONS, M., M. DAEMEN, J. BRUNING & C. BRUGGEMAN. 1994. Active cytomegalovirus infection of arterial smooth muscle cells in immunocompromised rats. A clue to herpes virus associated atherosclerosis. Circ. Res. 75: 214-220.
68. KANER, R. J., J. MEDINA, A. C. NICHOLSON, R. URSEA, S. M. SCHWARTZ & D. P. HAJJAR. 1993. Developmentally regulated herpesvirus plaque formation in arterial smooth muscle cells. Circ. Res. 73: 10-14.