Reg IV Regulates Normal Intestinal and Colorectal Cancer Cell Susceptibility to Radiation-Induced Apoptosis

Gastroenterology

Volumn 138, Issue 2, 2010, Pages

  Bishnupuri, Kumar S ^a   Luo, Qizhi ^a   Sainathan, Satheesh K ^a   Kikuchi, Kento ^a   Sureban, Sripathi M ^b,c   Sabarinathan, Mekala ^a   Gross, Jennifer H ^a   Aden, Konrad ^d   May, Randal ^b,c   Houchen, Courtney W ^b,c   Anant, Shrikant ^b   Dieckgraefe, Brian K ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d UNIVERSITY OF KIEL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; MONOCLONAL ANTIBODY; PROTEIN BCL XL; PROTEIN BNIP3; PROTEIN REG IV; RECOMBINANT PROTEIN; SMALL INTERFERING RNA; SURVIVIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER INHIBITION; CANCER RADIOTHERAPY; CELL DEATH; COLORECTAL CANCER; CONTROLLED STUDY; GENE; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; NUDE MOUSE; PRIORITY JOURNAL; RADIOSENSITIVITY; REG IV GENE; RNA INTERFERENCE; TUMOR XENOGRAFT;

EID: 75149140907     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2009.10.050     Document Type: Article

References (30)

1. Chakraborty C., Katsumata N., Myal Y., et al. Age-related changes in peptide-23/pancreatitis-associated protein and pancreatic stone protein/reg gene expression in the rat and regulation by growth hormone-releasing hormone. Endocrinology 136 (1995) 1843-1849
2. Laurine E., Manival X., Montgelard C., et al. PAP IB, a new member of the Reg gene family: cloning, expression, structural properties, and evolution by gene duplication. Biochim Biophys Acta 1727 (2005) 177-187
3. Dieckgraefe B.K., Crimmins D.L., Landt V., et al. Expression of the regenerating gene family in inflammatory bowel disease mucosa: Reg Ialpha upregulation, processing, and antiapoptotic activity. J Investig Med 50 (2002) 421-434
4. Lasserre C., Simon M.T., Ishikawa H., et al. Structural organization and chromosomal localization of a human gene (HIP/PAP) encoding a C-type lectin overexpressed in primary liver cancer. Eur J Biochem 224 (1994) 29-38
5. Hartupee J.C., Zhang H., Bonaldo M.F., et al. Isolation and characterization of a cDNA encoding a novel member of the human regenerating protein family: Reg IV. Biochim Biophys Acta 1518 (2001) 287-293
6. Bishnupuri K.S., Luo Q., Korzenik J.R., et al. Dysregulation of Reg gene expression occurs early in gastrointestinal tumorigenesis and regulates anti-apoptotic genes. Cancer Biol Ther 5 (2006) 1714-1720
7. Dieckgraefe B.K., Stenson W.F., Korzenik J.R., et al. Analysis of mucosal gene expression in inflammatory bowel disease by parallel oligonucleotide arrays. Physiol Genomics 4 (2000) 1-11
8. Zenilman M.E., Kim S., Levine B.A., et al. Ectopic expression of reg protein: A marker of colorectal mucosa at risk for neoplasia. J Gastrointest Surg 1 (1997) 194-201 discussion 201-202
9. Zhang Y., Lai M., Gu X., et al. Reg IV, a differentially expressed gene in colorectal adenoma. Chin Med J (Engl) 116 (2003) 918-922
10. Violette S., Festor E., Pandrea-Vasile I., et al. Reg IV, a new member of the regenerating gene family, is overexpressed in colorectal carcinomas. Int J Cancer 103 (2003) 185-193
11. Oue N., Kuniyasu H., Noguchi T., et al. Serum concentration of Reg IV in patients with colorectal cancer: overexpression and high serum levels of Reg IV are associated with liver metastasis. Oncology 72 (2007) 371-380
12. Bishnupuri K.S., Luo Q., Murmu N., et al. Reg IV activates the epidermal growth factor receptor/Akt/AP-1 signaling pathway in colon adenocarcinomas. Gastroenterology 130 (2006) 137-149
13. Li A., Crimmins D.L., Luo Q., et al. Expression of a novel regenerating gene product, Reg IV, by high density fermentation in Pichia pastoris: production, purification, and characterization. Protein Expr Purif 31 (2003) 197-206
14. May R., Riehl T.E., Hunt C., et al. Identification of a novel putative gastrointestinal stem cell and adenoma stem cell marker, doublecortin and CaM kinase-like-1, following radiation injury and in adenomatous polyposis coli/multiple intestinal neoplasia mice. Stem Cells 26 (2008) 630-637
15. Sureban S.M., May R., Ramalingam S., et al. Selective blockade of DCAMKL-1 results in tumor growth arrest by a Let-7a MicroRNA-dependent mechanism. Gastroenterology 137 (2009) 649-659
16. Reed J.C. Bcl-2 and the regulation of programmed cell death. J Cell Biol 124 (1994) 1-6
17. Reed J.C., Miyashita T., Takayama S., et al. BCL-2 family proteins: regulators of cell death involved in the pathogenesis of cancer and resistance to therapy. J Cell Biochem 60 (1996) 23-32
18. Ogura E., Senzaki H., Yamamoto D., et al. Prognostic significance of Bcl-2, Bcl-xL/S, Bax and Bak expressions in colorectal carcinomas. Oncol Rep 6 (1999) 365-369
19. Maurer C.A., Friess H., Buhler S.S., et al. Apoptosis inhibiting factor Bcl-xL might be the crucial member of the Bcl-2 gene family in colorectal cancer. Dig Dis Sci 43 (1998) 2641-2648
20. Huang Z. Bcl-2 family proteins as targets for anticancer drug design. Oncogene 19 (2000) 6627-6631
21. Watanabe J., Kushihata F., Honda K., et al. Prognostic significance of Bcl-xL in human hepatocellular carcinoma. Surgery 135 (2004) 604-612
22. Sarela A.I., Macadam R.C., Farmery S.M., et al. Expression of the antiapoptosis gene, survivin, predicts death from recurrent colorectal carcinoma. Gut 46 (2000) 645-650
23. Potten C.S., and Loeffler M. Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt. Development 110 (1990) 1001-1020
24. Gordon J.I., and Hermiston M.L. Differentiation and self-renewal in the mouse gastrointestinal epithelium. Curr Opin Cell Biol 6 (1994) 795-803
25. Potten C.S., Booth C., and Pritchard D.M. The intestinal epithelial stem cell: the mucosal governor. Int J Exp Pathol 78 (1997) 219-243
26. Moore K.A., and Lemischka I.R. Stem cells and their niches. Science 311 (2006) 1880-1885
27. Radtke F., and Clevers H. Self-renewal and cancer of the gut: two sides of a coin. Science 307 (2005) 1904-1909
28. Hickman J.A. Apoptosis induced by anticancer drugs. Cancer Metastasis Rev 11 (1992) 121-139
29. Kerr J.F., Winterford C.M., and Harmon B.V. Apoptosis. Its significance in cancer and cancer therapy. Cancer 73 (1994) 2013-2026
30. Steller H. Mechanisms and genes of cellular suicide. Science 267 (1995) 1445-1449