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Volumn 5, Issue 10, 2009, Pages 1675-1684

Targeted therapy in biliary tract cancer: 2009 Update

Author keywords

Anti EGFR therapy; Antiangiogenic therapy; Biliary tract cancer; Molecular features; Prognostic factors; Targeted therapy

Indexed keywords

BEVACIZUMAB; BORTEZOMIB; CEDIRANIB; CETUXIMAB; CISPLATIN; DEFOROLIMUS; DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR 3; EPIDERMAL GROWTH FACTOR RECEPTOR 4; ERLOTINIB; EVEROLIMUS; FLUOROURACIL; FOLINIC ACID; GEFITINIB; GEMCITABINE; IMATINIB; K RAS PROTEIN; LAPATINIB; N (5 CHLORO 1,3 BENZODIOXOL 4 YL) 7 [2 (4 METHYL 1 PIPERAZINYL)ETHOXY] 5 (TETRAHYDRO 2H PYRAN 4 YLOXY) 4 QUINAZOLINAMINE; OXALIPLATIN; SOMATOMEDIN; SOMATOMEDIN RECEPTOR; SORAFENIB; TEMSIROLIMUS; VASCULOTROPIN A; VASCULOTROPIN B; VASCULOTROPIN E;

EID: 75149140628     PISSN: 14796694     EISSN: 17448301     Source Type: Journal    
DOI: 10.2217/fon.09.130     Document Type: Review
Times cited : (10)

References (78)
  • 2
    • 2942615272 scopus 로고    scopus 로고
    • The epidemiology of cholangiocarcinoma
    • Shaib Y, El-Serag HB: The epidemiology of cholangiocarcinoma. Semin. Liver Dis. 24, 115-125 (2004).
    • (2004) Semin. Liver Dis , vol.24 , pp. 115-125
    • Shaib, Y.1    El-Serag, H.B.2
  • 3
    • 39549101224 scopus 로고    scopus 로고
    • Guidelines for chemotherapy of biliary tract and ampullary carcinomas
    • Comprehensive guidelines regarding the management of patients with biliary tract cancer, ■
    • Furuse J, Takada T, Miyazaki M et al.: Guidelines for chemotherapy of biliary tract and ampullary carcinomas. J. Hepatobiliary Pancreat. Surg. 15, 55-62 (2008). ■ Comprehensive guidelines regarding the management of patients with biliary tract cancer.
    • (2008) J. Hepatobiliary Pancreat. Surg , vol.15 , pp. 55-62
    • Furuse, J.1    Takada, T.2    Miyazaki, M.3
  • 4
    • 0025806249 scopus 로고
    • Role of radiation after operative palliation in cancer of the proximal bile ducts
    • Grove MK, Hermann RE, Vogt DP, Broughan TA: Role of radiation after operative palliation in cancer of the proximal bile ducts. Am. J. Surg. 161, 454-458 (1991).
    • (1991) Am. J. Surg , vol.161 , pp. 454-458
    • Grove, M.K.1    Hermann, R.E.2    Vogt, D.P.3    Broughan, T.A.4
  • 5
    • 43549116605 scopus 로고    scopus 로고
    • Systemic therapy for biliary tract cancer
    • A thorough review about the different treatments for biliary tract cancer patients, ■■
    • Hezel FA, Zhu XA: Systemic therapy for biliary tract cancer. Oncologist 13, 415-423 (2008). ■■ A thorough review about the different treatments for biliary tract cancer patients.
    • (2008) Oncologist , vol.13 , pp. 415-423
    • Hezel, F.A.1    Zhu, X.A.2
  • 6
    • 66149108788 scopus 로고    scopus 로고
    • Tonini G, Fratto M:E, Vincenzi B, Santini D: Classification of biliary tract cancer (BTC): evaluation of all entities. Ann. Oncol. 20, 6 (2009). ■ An interesting letter that underlines the importance of a correct classification of biliary tract cancer for prognosis and treatment strategy.
    • Tonini G, Fratto M:E, Vincenzi B, Santini D: Classification of biliary tract cancer (BTC): evaluation of all entities. Ann. Oncol. 20, 6 (2009). ■ An interesting letter that underlines the importance of a correct classification of biliary tract cancer for prognosis and treatment strategy.
  • 7
    • 38549139744 scopus 로고    scopus 로고
    • Clinicopathological and prognostic significance of EGFR, VEGF, and HER2 expression in cholangiocarcinoma
    • Yoshikawa D, Ojima H, Iwasaki M et al.: Clinicopathological and prognostic significance of EGFR, VEGF, and HER2 expression in cholangiocarcinoma. Br. J. Cancer 98(2), 418-425 (2008).
    • (2008) Br. J. Cancer , vol.98 , Issue.2 , pp. 418-425
    • Yoshikawa, D.1    Ojima, H.2    Iwasaki, M.3
  • 8
    • 2442701289 scopus 로고    scopus 로고
    • The ErbB/HER receptor protein-tyrosine kinases and cancer
    • Roskoski R Jr: The ErbB/HER receptor protein-tyrosine kinases and cancer. Biochem. Biophys. Res. Commun. 319, 1-11 (2004).
    • (2004) Biochem. Biophys. Res. Commun , vol.319 , pp. 1-11
    • Roskoski Jr, R.1
  • 9
    • 18344390418 scopus 로고    scopus 로고
    • ERBB receptors and cancer: The complexity of targeted inhibitors
    • Hynes NE, Lane HA: ERBB receptors and cancer: the complexity of targeted inhibitors. Nat. Rev. Cancer 5, 341-354 (2005).
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 341-354
    • Hynes, N.E.1    Lane, H.A.2
  • 10
    • 18744405139 scopus 로고    scopus 로고
    • The ErbB receptors and their ligands in cancer: An overview
    • Normanno N, Bianco C, Strizzi L et al.: The ErbB receptors and their ligands in cancer: an overview. Curr. Drug Targets 6, 243-257 (2005).
    • (2005) Curr. Drug Targets , vol.6 , pp. 243-257
    • Normanno, N.1    Bianco, C.2    Strizzi, L.3
  • 11
    • 33751328082 scopus 로고    scopus 로고
    • ErbB receptors: New insights on mechanisms and biology
    • Linggi B, Carpenter G: ErbB receptors: new insights on mechanisms and biology. Trends Cell Biol. 16, 649-656 (2006).
    • (2006) Trends Cell Biol , vol.16 , pp. 649-656
    • Linggi, B.1    Carpenter, G.2
  • 14
    • 7244220245 scopus 로고    scopus 로고
    • Enhanced epidermal growth factor receptor activation in human cholangiocarcinoma cells
    • Yoon JH, Gwak GY, Lee HS, Bronk SF, Werneburg NW, Gores GJ: Enhanced epidermal growth factor receptor activation in human cholangiocarcinoma cells. J. Hepatol. 41, 808-814 (2004).
    • (2004) J. Hepatol , vol.41 , pp. 808-814
    • Yoon, J.H.1    Gwak, G.Y.2    Lee, H.S.3    Bronk, S.F.4    Werneburg, N.W.5    Gores, G.J.6
  • 16
    • 21344438897 scopus 로고    scopus 로고
    • Amplification and overexpression of c-erbB-2, epidermal growth factor receptor, and c-met in biliary tract cancers
    • Nakazawa K, Dobashi Y, Suzuki S et al.: Amplification and overexpression of c-erbB-2, epidermal growth factor receptor, and c-met in biliary tract cancers. J. Pathol. 206, 356-365 (2005).
    • (2005) J. Pathol , vol.206 , pp. 356-365
    • Nakazawa, K.1    Dobashi, Y.2    Suzuki, S.3
  • 17
    • 33645689431 scopus 로고    scopus 로고
    • Somatic mutations of epidermal growth factor receptor in bile duct and gall bladder carcinoma
    • Leone F, Cavalloni G, Pignochino Y et al.: Somatic mutations of epidermal growth factor receptor in bile duct and gall bladder carcinoma. Clin. Cancer Res. 12(6), 1680-1685 (2006).
    • (2006) Clin. Cancer Res , vol.12 , Issue.6 , pp. 1680-1685
    • Leone, F.1    Cavalloni, G.2    Pignochino, Y.3
  • 18
    • 0033756536 scopus 로고    scopus 로고
    • Frequency of p16(INK4A) alterations and K-ras mutations in intrahepatic cholangiocarcinoma of the liver
    • Tannapfel A, Benicke M, Katalinic A et al.: Frequency of p16(INK4A) alterations and K-ras mutations in intrahepatic cholangiocarcinoma of the liver. Gut 47(5), 721-727 (2000).
    • (2000) Gut , vol.47 , Issue.5 , pp. 721-727
    • Tannapfel, A.1    Benicke, M.2    Katalinic, A.3
  • 19
    • 0034107937 scopus 로고    scopus 로고
    • Aberrations of the K-ras, p53, and APC genes in extrahepatic bile duct cancer
    • Suto T, Habano W, Sugai T et al.: Aberrations of the K-ras, p53, and APC genes in extrahepatic bile duct cancer. J. Surg. Oncol. 73(3), 158-163 (2000).
    • (2000) J. Surg. Oncol , vol.73 , Issue.3 , pp. 158-163
    • Suto, T.1    Habano, W.2    Sugai, T.3
  • 20
    • 0033965567 scopus 로고    scopus 로고
    • High frequency of K-ras mutations in biliary duct carcinomas of cases with a long common channel in the papilla of Vater
    • Hidaka E, Yanagisawa A, Seki M, Takano K, Setoguchi T, Kato Y: High frequency of K-ras mutations in biliary duct carcinomas of cases with a long common channel in the papilla of Vater. Cancer Res. 60(3), 522-524 (2000).
    • (2000) Cancer Res , vol.60 , Issue.3 , pp. 522-524
    • Hidaka, E.1    Yanagisawa, A.2    Seki, M.3    Takano, K.4    Setoguchi, T.5    Kato, Y.6
  • 21
    • 0036793788 scopus 로고    scopus 로고
    • K-ras mutation, p53 overexpression, and microsatellite instability in biliary tract cancers: A population-based study in China
    • Rashid A, Ueki T, Gao YT et al.: K-ras mutation, p53 overexpression, and microsatellite instability in biliary tract cancers: a population-based study in China. Clin. Cancer Res. 8(10), 3156-3163 (2002).
    • (2002) Clin. Cancer Res , vol.8 , Issue.10 , pp. 3156-3163
    • Rashid, A.1    Ueki, T.2    Gao, Y.T.3
  • 22
    • 33644998898 scopus 로고    scopus 로고
    • Gefitinib, a selective EGFR tyrosine kinase inhibitor, induces apoptosis through activation of Bax in human gall bladder adenocarcinoma cells
    • Ariyama H, Qin B, Baba E et al.: Gefitinib, a selective EGFR tyrosine kinase inhibitor, induces apoptosis through activation of Bax in human gall bladder adenocarcinoma cells. J. Cell Biochem. 97, 724-734 (2006).
    • (2006) J. Cell Biochem , vol.97 , pp. 724-734
    • Ariyama, H.1    Qin, B.2    Baba, E.3
  • 23
    • 33744729984 scopus 로고    scopus 로고
    • The effects of ZD1839 (Iressa), a highly selective EGFR tyrosine kinase inhibitor, as a radiosensitiser in bile duct carcinoma cell lines
    • Miyata H, Sasaki T, Kuwahara K, Serikawa M, Chayama K: The effects of ZD1839 (Iressa), a highly selective EGFR tyrosine kinase inhibitor, as a radiosensitiser in bile duct carcinoma cell lines. Int. J. Oncol. 28, 915-921 (2006).
    • (2006) Int. J. Oncol , vol.28 , pp. 915-921
    • Miyata, H.1    Sasaki, T.2    Kuwahara, K.3    Serikawa, M.4    Chayama, K.5
  • 24
    • 63449116658 scopus 로고    scopus 로고
    • Simultaneous inhibition of ErbB1 and ErbB2 signaling significantly enhances the growth suppression of rat and human cholangiocarcinoma cell lines
    • Zhang Z, Sirica AE: Simultaneous inhibition of ErbB1 and ErbB2 signaling significantly enhances the growth suppression of rat and human cholangiocarcinoma cell lines. FASEB J. 21, A71-A72 (2007).
    • (2007) FASEB J , vol.21
    • Zhang, Z.1    Sirica, A.E.2
  • 25
    • 17144415942 scopus 로고    scopus 로고
    • Epidermal growth factor receptor dynamics influences response to epidermal growth factor receptor targeted agents
    • Jimeno A, Rubio-Viqueira B, Amador ML et al.: Epidermal growth factor receptor dynamics influences response to epidermal growth factor receptor targeted agents. Cancer Res. 65, 3003-3010 (2005).
    • (2005) Cancer Res , vol.65 , pp. 3003-3010
    • Jimeno, A.1    Rubio-Viqueira, B.2    Amador, M.L.3
  • 26
    • 63449110684 scopus 로고    scopus 로고
    • Role of ErbB family receptor tyrosine kinases in intrahepatic cholangiocarcinoma
    • Sirica A: Role of ErbB family receptor tyrosine kinases in intrahepatic cholangiocarcinoma. World J. Gastroenterol. 14(46), 7033-7058 (2008).
    • (2008) World J. Gastroenterol , vol.14 , Issue.46 , pp. 7033-7058
    • Sirica, A.1
  • 27
    • 67649354927 scopus 로고    scopus 로고
    • Simultaneous blockade of the epidermal growth factor receptor/mammalian target of rapamycin pathway by epidermal growth factor receptor inhibitors and rapamycin results in reduced cell growth and survival in biliary tract cancer cells
    • Herberger B, Berger W, Puhalla H et al.: Simultaneous blockade of the epidermal growth factor receptor/mammalian target of rapamycin pathway by epidermal growth factor receptor inhibitors and rapamycin results in reduced cell growth and survival in biliary tract cancer cells. Mol. Cancer Ther. 8(6), 1547-1556 (2008).
    • (2008) Mol. Cancer Ther , vol.8 , Issue.6 , pp. 1547-1556
    • Herberger, B.1    Berger, W.2    Puhalla, H.3
  • 28
    • 33748169241 scopus 로고    scopus 로고
    • Novel targeted approaches to treating biliary tract cancer: The dual epidermal growth factor receptor and ErbB-2 tyrosine kinase inhibitor NVP-AEE788 is more efficient than the epidermal growth factor receptor inhibitors gefitinib and erlotinib
    • Wiedmann M, Feisthammel J, Blüthner T et al.: Novel targeted approaches to treating biliary tract cancer: the dual epidermal growth factor receptor and ErbB-2 tyrosine kinase inhibitor NVP-AEE788 is more efficient than the epidermal growth factor receptor inhibitors gefitinib and erlotinib. Anticancer Drugs 17(7), 783-795 (2006)
    • (2006) Anticancer Drugs , vol.17 , Issue.7 , pp. 783-795
    • Wiedmann, M.1    Feisthammel, J.2    Blüthner, T.3
  • 29
    • 64949187144 scopus 로고    scopus 로고
    • Vandetanib (ZD6474), an inhibitor of VEGFR and EGFR signaling, as a novel molecular-targeted therapy against cholangiocarcinoma
    • Yoshikawa D, Ojima H, Kokubu A et al.: Vandetanib (ZD6474), an inhibitor of VEGFR and EGFR signaling, as a novel molecular-targeted therapy against cholangiocarcinoma. Br. J. Cancer 100(8), 1257-1266 (2009).
    • (2009) Br. J. Cancer , vol.100 , Issue.8 , pp. 1257-1266
    • Yoshikawa, D.1    Ojima, H.2    Kokubu, A.3
  • 30
    • 0037699955 scopus 로고    scopus 로고
    • Angiogenesis in health and disease
    • Carmeliet P: Angiogenesis in health and disease. Nat. Med. 9, 653-660 (2003).
    • (2003) Nat. Med , vol.9 , pp. 653-660
    • Carmeliet, P.1
  • 31
    • 34447310236 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor-1 (VEGFR-1/Flt-1): A dual regulator for angiogenesis
    • Shibuya M: Vascular endothelial growth factor receptor-1 (VEGFR-1/Flt-1): a dual regulator for angiogenesis. Angiogenesis 9, 225-230 (2006).
    • (2006) Angiogenesis , vol.9 , pp. 225-230
    • Shibuya, M.1
  • 32
    • 0037373855 scopus 로고    scopus 로고
    • Transforming growth factor b1 stimulates vascular endothelial growth factor gene transcription in human cholangiocellular carcinoma cells
    • Benckert C, Jonas S, Cramer T et al.: Transforming growth factor b1 stimulates vascular endothelial growth factor gene transcription in human cholangiocellular carcinoma cells. Cancer Res. 63, 1083-1092 (2003).
    • (2003) Cancer Res , vol.63 , pp. 1083-1092
    • Benckert, C.1    Jonas, S.2    Cramer, T.3
  • 33
    • 33645737997 scopus 로고    scopus 로고
    • Angiogenesis in cholangiocellular carcinoma: Expression of vascular endothelial growth factor, angiopoietin-1/2, thrombospondin-1 and clinicopathological significance
    • Tang D, Nagano H, Yamamoto H, Wada H et al.: Angiogenesis in cholangiocellular carcinoma: expression of vascular endothelial growth factor, angiopoietin-1/2, thrombospondin-1 and clinicopathological significance. Oncol. Rep. 15, 525-532 (2006).
    • (2006) Oncol. Rep , vol.15 , pp. 525-532
    • Tang, D.1    Nagano, H.2    Yamamoto, H.3    Wada, H.4
  • 34
    • 0036129705 scopus 로고    scopus 로고
    • The role of thymidine phosphorylase and thrombospondin-1 in angiogenesis and progression of intrahepatic cholangiocarcinoma
    • Aishima S, Taguchi K, Sugimachi K et al.: The role of thymidine phosphorylase and thrombospondin-1 in angiogenesis and progression of intrahepatic cholangiocarcinoma. Int. J. Surg. Pathol. 10, 47-56 (2002).
    • (2002) Int. J. Surg. Pathol , vol.10 , pp. 47-56
    • Aishima, S.1    Taguchi, K.2    Sugimachi, K.3
  • 35
    • 67349268419 scopus 로고    scopus 로고
    • Comparative protein expression profiles of hilar and peripheral hepatic cholangiocarcinomas
    • Guedj N, Zhan Q, Perigny MJ et al.: Comparative protein expression profiles of hilar and peripheral hepatic cholangiocarcinomas. J. Hepatol. 51(1), 93-101 (2009).
    • (2009) J. Hepatol , vol.51 , Issue.1 , pp. 93-101
    • Guedj, N.1    Zhan, Q.2    Perigny, M.J.3
  • 36
    • 0036984640 scopus 로고    scopus 로고
    • Role of angiogenesis in tumor growth and metastasis
    • Folkman J: Role of angiogenesis in tumor growth and metastasis. Semin. Oncol. 29, 15-18 (2002).
    • (2002) Semin. Oncol , vol.29 , pp. 15-18
    • Folkman, J.1
  • 37
    • 38049080992 scopus 로고    scopus 로고
    • Development of sorafenib and other molecularly targeted agents in hepatocellular carcinoma
    • Zhu AX: Development of sorafenib and other molecularly targeted agents in hepatocellular carcinoma. Cancer 112, 250-259 (2008).
    • (2008) Cancer , vol.112 , pp. 250-259
    • Zhu, A.X.1
  • 38
    • 34547681379 scopus 로고    scopus 로고
    • Phase clinical study of AZD2171, an oral vascular endothelial growth factor signaling inhibitor, in patients with advanced solid tumors
    • Drevs J, Siegert P, Medinger M et al.: Phase clinical study of AZD2171, an oral vascular endothelial growth factor signaling inhibitor, in patients with advanced solid tumors. J. Clin. Oncol. 25, 3045-3054 (2007).
    • (2007) J. Clin. Oncol , vol.25 , pp. 3045-3054
    • Drevs, J.1    Siegert, P.2    Medinger, M.3
  • 39
    • 43049178243 scopus 로고    scopus 로고
    • The role of angiogenesis inhibitors in prostate cancer
    • Aragon-Ching JB, Dahut WL: The role of angiogenesis inhibitors in prostate cancer. Cancer J. 14, 20-25 (2008).
    • (2008) Cancer J , vol.14 , pp. 20-25
    • Aragon-Ching, J.B.1    Dahut, W.L.2
  • 40
    • 20144370978 scopus 로고    scopus 로고
    • AZD2171: A highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer
    • Wedge SR, Kendrew J, Hennequin LF et al.: AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer. Cancer Res. 65, 4389-4400 (2005).
    • (2005) Cancer Res , vol.65 , pp. 4389-4400
    • Wedge, S.R.1    Kendrew, J.2    Hennequin, L.F.3
  • 41
    • 33846807433 scopus 로고    scopus 로고
    • Disrupting insulin-like growth factor signaling as a potential cancer therapy
    • Sachdev D, Yee D: Disrupting insulin-like growth factor signaling as a potential cancer therapy. Mol. Cancer Ther. 6, 1-12 (2007).
    • (2007) Mol. Cancer Ther , vol.6 , pp. 1-12
    • Sachdev, D.1    Yee, D.2
  • 42
    • 10344222098 scopus 로고    scopus 로고
    • The therapeutic potential of agents targeting the type I insulin-like growth factor receptor
    • Zhang H, Yee D: The therapeutic potential of agents targeting the type I insulin-like growth factor receptor. Expert Opin. Investig. Drugs 13, 1569-1577 (2004).
    • (2004) Expert Opin. Investig. Drugs , vol.13 , pp. 1569-1577
    • Zhang, H.1    Yee, D.2
  • 43
    • 0037442061 scopus 로고    scopus 로고
    • Expression of IGF-II in early experimental hepatocellular carcinomas and its significance in early diagnosis
    • Wang Z, Ruan YB, Guan Y, Liu SH: Expression of IGF-II in early experimental hepatocellular carcinomas and its significance in early diagnosis. World J. Gastroenterol. 9, 267-227 (2003).
    • (2003) World J. Gastroenterol , vol.9 , pp. 267-227
    • Wang, Z.1    Ruan, Y.B.2    Guan, Y.3    Liu, S.H.4
  • 44
    • 23044493251 scopus 로고    scopus 로고
    • Blocking the insulin-like growth factor-I receptor as a strategy for targeting cancer
    • Hofmann F, Garcia-Echeverria C: Blocking the insulin-like growth factor-I receptor as a strategy for targeting cancer. Drug Discov. Today 10, 1041-1047 (2005).
    • (2005) Drug Discov. Today , vol.10 , pp. 1041-1047
    • Hofmann, F.1    Garcia-Echeverria, C.2
  • 45
    • 33745710682 scopus 로고    scopus 로고
    • Estrogens and insulin-like growth factor 1 modulate neoplastic cell growth in human cholangiocarcinoma
    • Alvaro D, Barbaro B, Franchitto A et al.: Estrogens and insulin-like growth factor 1 modulate neoplastic cell growth in human cholangiocarcinoma. Am. J. Pathol. 169, 877-888 (2006).
    • (2006) Am. J. Pathol , vol.169 , pp. 877-888
    • Alvaro, D.1    Barbaro, B.2    Franchitto, A.3
  • 46
    • 38349035898 scopus 로고    scopus 로고
    • AKT and ERK1/2 signaling in intrahepatic cholangiocarcinoma
    • Schmitz KJ, Lang H, Wohlschlaeger J et al.: AKT and ERK1/2 signaling in intrahepatic cholangiocarcinoma. World J. Gastroenterol. 13, 6470-6477 (2007)
    • (2007) World J. Gastroenterol , vol.13 , pp. 6470-6477
    • Schmitz, K.J.1    Lang, H.2    Wohlschlaeger, J.3
  • 47
    • 34250197654 scopus 로고    scopus 로고
    • New drug development in digestive neuroendocrine tumors
    • Duran I, Salazar R, Casanovas O et al.: New drug development in digestive neuroendocrine tumors. Ann. Oncol. 18, 1307-1313 (2007).
    • (2007) Ann. Oncol , vol.18 , pp. 1307-1313
    • Duran, I.1    Salazar, R.2    Casanovas, O.3
  • 48
    • 75149171363 scopus 로고    scopus 로고
    • Discovery of a small molecule Akt inhibitor with antitumor activity in cancer cells overexpressing Akt
    • Yang L, Dan HC, Sun M et al.: Discovery of a small molecule Akt inhibitor with antitumor activity in cancer cells overexpressing Akt. Proc. Am. Assoc. Cancer Res. 45(Suppl.), 893 (2004).
    • (2004) Proc. Am. Assoc. Cancer Res , vol.45 , Issue.SUPPL. , pp. 893
    • Yang, L.1    Dan, H.C.2    Sun, M.3
  • 49
    • 33846569938 scopus 로고    scopus 로고
    • Targeting mammalian target of rapamycin (mTOR) for health and diseases
    • Tsang CK, Qi H, Liu LF, Zheng XF: Targeting mammalian target of rapamycin (mTOR) for health and diseases. Drug Discov. Today 12, 112-124 (2007).
    • (2007) Drug Discov. Today , vol.12 , pp. 112-124
    • Tsang, C.K.1    Qi, H.2    Liu, L.F.3    Zheng, X.F.4
  • 50
    • 59449109515 scopus 로고    scopus 로고
    • Rapamycin inhibits the growth of cholangiocarcinoma cells in vitro
    • Sawada T, Okada T, Kubota K: Rapamycin inhibits the growth of cholangiocarcinoma cells in vitro. J. Clin. Oncol. 25(Suppl. 18), 15153 (2007).
    • (2007) J. Clin. Oncol , vol.25 , Issue.SUPPL. 18 , pp. 15153
    • Sawada, T.1    Okada, T.2    Kubota, K.3
  • 51
    • 34548085100 scopus 로고    scopus 로고
    • Activated mammalian target of rapamycin is an adverse prognostic factor in patients with biliary tract adenocarcinoma
    • Herberger B, Puhalla H, Lehnert M et al.: Activated mammalian target of rapamycin is an adverse prognostic factor in patients with biliary tract adenocarcinoma. Clin. Cancer Res. 13, 4795-4799 (2007).
    • (2007) Clin. Cancer Res , vol.13 , pp. 4795-4799
    • Herberger, B.1    Puhalla, H.2    Lehnert, M.3
  • 52
    • 0033756536 scopus 로고    scopus 로고
    • Frequency of p16(INK4A) alterations and K-ras mutations in intrahepatic cholangiocarcinoma of the liver
    • Tannapfel A, Benicke M, Katalinic A et al.: Frequency of p16(INK4A) alterations and K-ras mutations in intrahepatic cholangiocarcinoma of the liver. Gut 47,
    • Gut 47
    • Tannapfel, A.1    Benicke, M.2    Katalinic, A.3
  • 53
    • 0034050615 scopus 로고    scopus 로고
    • 721-727 (2000, 53. Tannapfel A, Weinans L, Geissler F et al, Mutations of p53 tumor suppressor gene, apoptosis, and proliferation in intrahepatic cholangiocellular carcinoma of the liver. Dig. Dis. Sci. 45, 317-324 2000
    • 721-727 (2000). 53. Tannapfel A, Weinans L, Geissler F et al.: Mutations of p53 tumor suppressor gene, apoptosis, and proliferation in intrahepatic cholangiocellular carcinoma of the liver. Dig. Dis. Sci. 45, 317-324 (2000).
  • 54
    • 0037624602 scopus 로고    scopus 로고
    • Mutations of the BRAF gene in cholangiocarcinoma but not in hepatocellular carcinoma
    • Tannapfel A, Sommerer F, Benicke M et al.: Mutations of the BRAF gene in cholangiocarcinoma but not in hepatocellular carcinoma. Gut 52, 706-712 (2003).
    • (2003) Gut , vol.52 , pp. 706-712
    • Tannapfel, A.1    Sommerer, F.2    Benicke, M.3
  • 55
    • 4944249117 scopus 로고    scopus 로고
    • BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/ MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    • Wilhelm SM, Carter C, Tang L et al.: BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/ MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 64, 7099-7109 (2004).
    • (2004) Cancer Res , vol.64 , pp. 7099-7109
    • Wilhelm, S.M.1    Carter, C.2    Tang, L.3
  • 56
    • 33947508735 scopus 로고    scopus 로고
    • Sorafenib alone or as combination therapy for growth control of cholangiocarcinoma
    • Huether A, Höpfner M, Baradari V, Schuppan D, Scherubl H: Sorafenib alone or as combination therapy for growth control of cholangiocarcinoma. Biochem. Pharmacol. 73, 1308-1317 (2007).
    • (2007) Biochem. Pharmacol , vol.73 , pp. 1308-1317
    • Huether, A.1    Höpfner, M.2    Baradari, V.3    Schuppan, D.4    Scherubl, H.5
  • 57
    • 63449139679 scopus 로고    scopus 로고
    • Growth inhibition of human cholangiocarcinoma by sorafenib-based mono- and combination treatment
    • Höpfner M, Baradari V, Huether A, Scherübl H: Growth inhibition of human cholangiocarcinoma by sorafenib-based mono- and combination treatment. FASEB J. 22, 1136-1139 (2008).
    • (2008) FASEB J , vol.22 , pp. 1136-1139
    • Höpfner, M.1    Baradari, V.2    Huether, A.3    Scherübl, H.4
  • 58
    • 34548668194 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor MS-275 alone or combined with bortezomib or sorafenib exhibits strong antiproliferative action in human cholangiocarcinoma cells
    • Baradari V, Hopfner M, Huether A, Schuppan D, Scherubl H: Histone deacetylase inhibitor MS-275 alone or combined with bortezomib or sorafenib exhibits strong antiproliferative action in human cholangiocarcinoma cells. World J. Gastroenterol. 13, 4458-4466 (2007).
    • (2007) World J. Gastroenterol , vol.13 , pp. 4458-4466
    • Baradari, V.1    Hopfner, M.2    Huether, A.3    Schuppan, D.4    Scherubl, H.5
  • 61
    • 17644379385 scopus 로고    scopus 로고
    • Pharmacology, pharmacokinetics, and practical applications of bortezomib
    • Schwartz R, Davidson T: Pharmacology, pharmacokinetics, and practical applications of bortezomib. Oncology 18, 14-21 (2004).
    • (2004) Oncology , vol.18 , pp. 14-21
    • Schwartz, R.1    Davidson, T.2
  • 62
    • 33747443493 scopus 로고    scopus 로고
    • Effect of bortezomib on human neuroblastoma cell growth, apoptosis, and angiogenesis
    • Brignole C, Marimpietri D, Pastorino F et al.: Effect of bortezomib on human neuroblastoma cell growth, apoptosis, and angiogenesis. J. Natl Cancer Inst. 98, 1142-1157 (2006).
    • (2006) J. Natl Cancer Inst , vol.98 , pp. 1142-1157
    • Brignole, C.1    Marimpietri, D.2    Pastorino, F.3
  • 63
    • 33947516495 scopus 로고    scopus 로고
    • Proteasome inhibition-induces endoplasmic reticulum dysfunction and cell death of human cholangiocarcinoma cells
    • Ustundag Y, Bronk SF, Gores GJ: Proteasome inhibition-induces endoplasmic reticulum dysfunction and cell death of human cholangiocarcinoma cells. World J. Gastroenterol. 13, 851-857 (2007).
    • (2007) World J. Gastroenterol , vol.13 , pp. 851-857
    • Ustundag, Y.1    Bronk, S.F.2    Gores, G.J.3
  • 64
    • 33745970752 scopus 로고    scopus 로고
    • Phase II study of erlotinib in patients with advanced biliary cancer
    • An important Phase II trial regarding erlotinib in bilary tract cancer, ■
    • Philip PA, Mahoney MR, Allmer C et al.: Phase II study of erlotinib in patients with advanced biliary cancer. J. Clin. Oncol. 24, 3069-3074 (2006). ■ An important Phase II trial regarding erlotinib in bilary tract cancer.
    • (2006) J. Clin. Oncol , vol.24 , pp. 3069-3074
    • Philip, P.A.1    Mahoney, M.R.2    Allmer, C.3
  • 65
    • 33748680142 scopus 로고    scopus 로고
    • Gemcitabine in combination with EGF-receptor antibody (cetuximab) as a treatment of cholangiocarcinoma: A case report
    • Sprinzl MF, Schimanski CC, Moehler M et al.: Gemcitabine in combination with EGF-receptor antibody (cetuximab) as a treatment of cholangiocarcinoma: a case report. BMC Cancer 6, 190 (2006).
    • (2006) BMC Cancer , vol.6 , pp. 190
    • Sprinzl, M.F.1    Schimanski, C.C.2    Moehler, M.3
  • 66
    • 38349077844 scopus 로고    scopus 로고
    • Cetuximab plus gemcitabine/oxaliplatin (GEMOX) for patients with unresectable/ recurrent intrahepatic cholangiocarcinoma refractory to GEMOX
    • Paule B, Bralet M, Herelle M et al.: Cetuximab plus gemcitabine/oxaliplatin (GEMOX) for patients with unresectable/ recurrent intrahepatic cholangiocarcinoma refractory to GEMOX. J. Clin. Oncol. 24(Suppl. 18), 14084 (2007).
    • (2007) J. Clin. Oncol , vol.24 , Issue.SUPPL. 18 , pp. 14084
    • Paule, B.1    Bralet, M.2    Herelle, M.3
  • 67
    • 37049013090 scopus 로고    scopus 로고
    • Cetuximab plus gemcitabine-oxaliplatin (GEMOX) in patients with refractory advanced intrahepatic cholangiocarcinomas
    • Paule B, Herelle MO, Rage E et al.: Cetuximab plus gemcitabine-oxaliplatin (GEMOX) in patients with refractory advanced intrahepatic cholangiocarcinomas. Oncology 72, 105-110 (2007).
    • (2007) Oncology , vol.72 , pp. 105-110
    • Paule, B.1    Herelle, M.O.2    Rage, E.3
  • 68
    • 75149145463 scopus 로고    scopus 로고
    • Malka D, Trarbach T, Fartoux L et al.: A multicenter, randomized Phase II trial of gemcitabine and oxaliplatin (GEMOX) alone or in combination with biweekly cetuximab in the first-line treatment of advanced biliary cancer: Interim ana lysis of the BINGO trial. J. Clin. Oncol. 27, S15 (2009) (Abstract 4520). ■■ The first randomized trial regarding the activity of the combination between cetuximab and gemcitabine-oxaliplatin in biliary tract cancer.
    • Malka D, Trarbach T, Fartoux L et al.: A multicenter, randomized Phase II trial of gemcitabine and oxaliplatin (GEMOX) alone or in combination with biweekly cetuximab in the first-line treatment of advanced biliary cancer: Interim ana lysis of the BINGO trial. J. Clin. Oncol. 27, S15 (2009) (Abstract 4520). ■■ The first randomized trial regarding the activity of the combination between cetuximab and gemcitabine-oxaliplatin in biliary tract cancer.
  • 69
    • 73249116624 scopus 로고    scopus 로고
    • K-ras status and response in patients with advanced or metastatic cholangiocarcinoma treated with cetuximab plus gemcitabine-oxaliplatin (GEMOX): A single center Phase II study
    • Abstract 4586
    • Gruenberger B,Schueller J, Tamandl D et al.: K-ras status and response in patients with advanced or metastatic cholangiocarcinoma treated with cetuximab plus gemcitabine-oxaliplatin (GEMOX): a single center Phase II study. J. Clin. Oncol. 27, S15 (2009) (Abstract 4586).
    • (2009) J. Clin. Oncol , vol.27
    • Gruenberger, B.1    Schueller, J.2    Tamandl, D.3
  • 70
    • 75149190920 scopus 로고    scopus 로고
    • Ramanathan RK, Belani CP, Singh DA et al.: Phase II study of lapatinib, a dual inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase 1 and 2 (Her2/Neu) in patients (pts) with advanced biliary tree cancer (BTC) or hepatocellular cancer (HCC). A California Consortium (CCC-P) Trial. J. Clin. Oncol. 24(Suppl.), S18 (2006) (Abstract 4010).
    • Ramanathan RK, Belani CP, Singh DA et al.: Phase II study of lapatinib, a dual inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase 1 and 2 (Her2/Neu) in patients (pts) with advanced biliary tree cancer (BTC) or hepatocellular cancer (HCC). A California Consortium (CCC-P) Trial. J. Clin. Oncol. 24(Suppl.), S18 (2006) (Abstract 4010).
  • 71
    • 33645664294 scopus 로고    scopus 로고
    • Rapid resolution of liver metastasis from cholangiocarcinoma after bevacizumab with cisplatin and high-dose fluorouracil plus leucovorin
    • Tai CJ, Chiou HY, Wu CH, Pan S, Liu JD: Rapid resolution of liver metastasis from cholangiocarcinoma after bevacizumab with cisplatin and high-dose fluorouracil plus leucovorin. Onkologie 29, 179-180 (2006).
    • (2006) Onkologie , vol.29 , pp. 179-180
    • Tai, C.J.1    Chiou, H.Y.2    Wu, C.H.3    Pan, S.4    Liu, J.D.5
  • 72
    • 75149143443 scopus 로고    scopus 로고
    • Clark JW, Meyerhardt JA, Sahani DV et al.: Phase II study of gemcitabine, oxaliplatin in combination with bevacizumab (GEMOX-B) in patients with unresectable or metastatic biliary tract and gall bladder cancers. J. Clin. Oncol. 25(Suppl.), S18 (2007) (Abstract 4625).
    • Clark JW, Meyerhardt JA, Sahani DV et al.: Phase II study of gemcitabine, oxaliplatin in combination with bevacizumab (GEMOX-B) in patients with unresectable or metastatic biliary tract and gall bladder cancers. J. Clin. Oncol. 25(Suppl.), S18 (2007) (Abstract 4625).
  • 73
    • 75149132733 scopus 로고    scopus 로고
    • Phase II and fluorodeoxyglucose positron emission tomography (FDG-PET) study in patients with advanced biliary tract cancers (BTCs) receiving bevacizumab (B) in combination with gemcitabine (GEM) and oxaliplatin (OX)
    • Abstract 4578
    • Zhu AX, Meyerhardt JA, Blaszkowsky LS et al.: Phase II and fluorodeoxyglucose positron emission tomography (FDG-PET) study in patients with advanced biliary tract cancers (BTCs) receiving bevacizumab (B) in combination with gemcitabine (GEM) and oxaliplatin (OX). J. Clin. Oncol. 27, S15 (2009) (Abstract 4578).
    • (2009) J. Clin. Oncol , vol.27
    • Zhu, A.X.1    Meyerhardt, J.A.2    Blaszkowsky, L.S.3
  • 74
    • 38349043328 scopus 로고    scopus 로고
    • SWOG 0514: A Phase II study of sorafenib (BAY 43-9006) as single agent in patients (pts) with unresectable or metastatic gall bladder cancer or cholangiocarcinomas
    • The first evidence of the activity of sorafenib as a single agent in patients with biliary tract cancer, ■
    • El-Khoueiry AB, Rankin C, Lenz HJ, Philip P, Rivkin SE Blanke CD: SWOG 0514: a Phase II study of sorafenib (BAY 43-9006) as single agent in patients (pts) with unresectable or metastatic gall bladder cancer or cholangiocarcinomas. J. Clin. Oncol. 25(Suppl. 20), 4639 (2007). ■ The first evidence of the activity of sorafenib as a single agent in patients with biliary tract cancer.
    • (2007) J. Clin. Oncol , vol.25 , Issue.SUPPL. 20 , pp. 4639
    • El-Khoueiry, A.B.1    Rankin, C.2    Lenz, H.J.3    Philip, P.4    Rivkin, S.E.5    Blanke, C.D.6
  • 75
    • 75149134287 scopus 로고    scopus 로고
    • Preliminary results of a multicenter Phase II study of imatinib and fluorouracil/leucovorin (FU/LV) in patients with unresectable or metastatic gall bladder or biliary tract cancer
    • Abstract E15502
    • Sprenger K, Moehler M, Kettner E et al.: Preliminary results of a multicenter Phase II study of imatinib and fluorouracil/leucovorin (FU/LV) in patients with unresectable or metastatic gall bladder or biliary tract cancer. J. Clin. Oncol. 27(Suppl.) (2009) (Abstract E15502).
    • (2009) J. Clin. Oncol , Issue.SUPPL. , pp. 27
    • Sprenger, K.1    Moehler, M.2    Kettner, E.3
  • 76
    • 33644785935 scopus 로고    scopus 로고
    • Phase I trial of bortezomib in combination with docetaxel in patients with advanced solid tumors
    • Messersmith WA, Baker SD, Lassiter L et al.: Phase I trial of bortezomib in combination with docetaxel in patients with advanced solid tumors. Clin. Cancer Res. 12, 1270-1275 (2006).
    • (2006) Clin. Cancer Res , vol.12 , pp. 1270-1275
    • Messersmith, W.A.1    Baker, S.D.2    Lassiter, L.3
  • 77
    • 75149192197 scopus 로고    scopus 로고
    • Costello MR, Meropol NJ, Denlinger CS et al.: A Phase II trial of the proteasome inhibitor bortezomib in patients with recurrent or metastatic adenocarcinoma of the bile duct or gall bladder (NCI #6135). J. Clin. Oncol. 27(Suppl.) (2009) (Abstract E15605).
    • Costello MR, Meropol NJ, Denlinger CS et al.: A Phase II trial of the proteasome inhibitor bortezomib in patients with recurrent or metastatic adenocarcinoma of the bile duct or gall bladder (NCI #6135). J. Clin. Oncol. 27(Suppl.) (2009) (Abstract E15605).
  • 78
    • 70350205992 scopus 로고    scopus 로고
    • Gemcitabine with or without cisplatin in patients (pts) with advanced or metastatic biliary tract cancer (ABC): Results of a multicenter, randomized Phase III trial (the UK ABC-02 trial)
    • Abstract 4503
    • Valle JW, Wasan HS, Palmer DD: Gemcitabine with or without cisplatin in patients (pts) with advanced or metastatic biliary tract cancer (ABC): Results of a multicenter, randomized Phase III trial (the UK ABC-02 trial). J. Clin. Oncol. 27, S15 (2009) (Abstract 4503).
    • (2009) J. Clin. Oncol , vol.27
    • Valle, J.W.1    Wasan, H.S.2    Palmer, D.D.3


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