Purification and comparative neurotoxicity of the trichothecenes satratoxin g and roridin l2 from stachybotrys chartarum

Journal of Toxicology and Environmental Health - Part A: Current Issues

Volumn 72, Issue 20, 2009, Pages 1242-1251

  Islam, Zahidul ^a,b   Shinozuka, Junko ^b,d   Harkema, Jack R ^b,c   Pestka, James J ^a,b  

^a Department of Food Science and Human Nutrition ^*  (United States)

^b Center for Integrative Toxicology   (United States)

^c MICHIGAN STATE UNIVERSITY   (United States)

^d MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

MACROCYCLIC COMPOUND; RORIDIN L2; SATRATOXIN G; TRICHOTHECENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BRAIN; CELL STRAIN; CELL VIABILITY; CONTROLLED STUDY; FEMALE; MOUSE; NERVE CELL CULTURE; NEUROTOXICITY; NONHUMAN; NOSE; OLFACTORY EPITHELIUM; PRIORITY JOURNAL; PURIFICATION; SENSORY NERVE CELL; STACHYBOTRYS CHARTARUM;

ANIMALS; CENTRAL NERVOUS SYSTEM DISEASES; DNA FRAGMENTATION; FEMALE; MICE; MICE, INBRED STRAINS; MOLECULAR STRUCTURE; NOSE; PC12 CELLS; RATS; RESPIRATORY MUCOSA; STACHYBOTRYS; TRICHOTHECENES;

MUS; STACHYBOTRYS CHARTARUM;

EID: 75149120561     PISSN: 15287394     EISSN: 10872620     Source Type: Journal    
DOI: 10.1080/15287390903129234     Document Type: Article

References (31)

1. Andersen, B., Nielsen, K. F., and Jarvis, B. B. 2002. Characterization of Stachybotrys from water-damaged buildings based on meorphology, growth, and metabolite production. Mycologia 94:392-403.
2. Bamburg, J. R. 1983. Biological and biochemical actions of trichothecene mycotoxins. Prog. Mol. Subcell. Biol. 8:41-110.
3. Brasel, T. L., Martin, J. M., Carriker, C. G., Wilson, S. C., and Straus, D. C. 2005. Detection of airborne Stachybotrys chartarum macrocyclic trichothecene mycotoxins in the indoor environment. Appl. Environ. Microbiol. 71:7376-7388.
4. Chung, Y. J., Zhou, H. R., and Pestka, J. J. 2003. Transcriptional and posttranscriptional roles for p38 mitogen-activated protein kinase in upregulation of TNF-alpha expression by deoxynivalenol (vomitoxin). Toxicol. Appl. Pharmacol. 193:188-201.
5. Demarquay, G., Ryviln, P., and Royet, J. P. 2007. Olfaction and neurological diseases: A review of the literature. Rev. Neurol. 163:155-167.
6. Grove, J. F. 1988. Non-macrocyclic trichothecenes. Nat. Prod. Rep. 5:187-209.
7. Grove, J. F. 1993. Macrocyclic trichothecenes. Nat. Prod. Rep. 10:429-448.
8. Grove, J. F. 2000. Non-macrocyclic trichothecenes. Part 2. Prod. Chem. Org. Nat. Prod. 69:1-70.
9. Grove, J. F. 2007. The trichothecenes and their biosynthesis. Fortschr. Chem. Org. Naturst. 88:63-130.
10. Hawkes, C. 2003. Olfaction in neurodegenerative disorders. Movement Disorders 18:364-372.
11. Hinkley, S. F., and Jarvis, B. B. 2001. Chromatographic method for Stachybotrys toxins. Meth. Mol. Biol. 157:173-194.
12. Institute of Medicine. 2004. Damp indoor spaces and health. Washington, DC: National Academies Press.
13. Islam, Z., Amuzie, C. J., Harkema, J. R., and Pestka, J. J. 2007. Neurotoxicity and inflammation in the nasal airways of mice exposed to the macrocyclic trichothecene mycotoxin roridin A: Kinetics and potentiation by bacterial lipopolysaccharide co-exposure. Toxicol. Sci. 98:526-541.
14. Islam, Z., Harkema, J. R., and Pestka, J. J. 2006. Satratoxin G from the black mold Stachybotrys chartarum evokes olfactory sensory neuron loss and inflammation in the murine nose and brain. Environ. Health Perspect. 114:1099-1107.
15. Islam, Z., Hegg, C. C., and Pestka, J. J. 2008. Satratoxin G-induced apoptosis in PC-12 neuronal cells is mediated by PKR and caspase-independent. Toxicol. Sci. 105:142-152.
16. Islam, Z., Moon, Y. S., Zhou, H. R., King, L. E., Fraker, P. J., and Pestka, J. J. 2002. Endotoxin potentiation of trichothecene-induced lymphocyte apoptosis is mediated by up-regulation of glucocorticoids. Toxicol. Appl. Pharmacol. 180:43-55.
17. Jarvis, B. B., Sorenson, W. G., Hintikka, E. L., Nikulin, M., Zhou, Y., Jiang, J., Wang, S., Hinkley, S., Etzel, R. A., and Dearborn, D. 1998. Study of toxin production by isolates of Stachybotrys chartarum and Memnoniella echinata isolated during a study of pulmonary hemosiderosis in infants. Appl. Environ. Microbiol. 64:3620-3625.
18. Mery, S., Gross, E. A., Joyner, D. R., Godo, M., and Morgan, K. T. 1994. Nasal diagrams: a tool for recording the distribution of nasal lesions in rats and mice. Toxicol. Pathol. 22:353-372.
19. Nielsen, F. K. 2002. Mold growth on building materials. Secondary metabolites, mycotoxins and biomarkers. PhD thesis, Technical University of Denmark. (http://www.sbi.dk/download/pdf/phd-kfn.pdf).
20. Nielsen, K. F., Huttunen, K., Hyvarinen, A., Andersen, B., Jarvis, B. B., and Hirvonen, M. R. 2002. Metabolite profiles of Stachybotrys isolates from water-damaged buildings and their induction of inflammatory mediators and cytotoxicity in macrophages. Mycopathologia 154:201-205.
21. Pestka, J. J. 2008. Mechanisms of deoxynivalenol-induced gene expression and apoptosis. Food. Addit. Contam. 24:1-13.
22. Pestka, J. J., and Forsell, J. H. 1988. Inhibition of human lymphocyte transformation by the macrocyclic trichothecenes roridin A and verrucarin A. Toxicol. Lett. 41:215-222.
23. Pestka, J. J., Yike, I., Dearborn, D. G., Ward, M. D., and Harkema, J. R. 2008. Stachybotrys chartarum, trichothecene mycotoxins, and damp buildingrelated illness: new insights into a public health enigma. Toxicol. Sci. 104:4-26.
24. Schneider, D. J., Marasas, W. F., le Kuys, J. C., Kriek, N. P., and Van Schalkwyk, G. C. 1979. A field outbreak of suspected stachybotryotoxicosis in sheep. J. S. Afr. Vet. Assoc. 50:73-81.
25. Takeda, A., Kikuchi, A., Matsuzaki-Kobayashi, M., Sugeno, N., and Itoyama, Y. 2007. Olfactory dysfunction in Parkinson's disease. J. Neurol. 254:2-7.
26. Thompson, W. L., and Wannemacher, R. W., Jr. 1986. Structure-function relationships of 12,13-epoxytrichothecene mycotoxins in cell culture: Comparison to whole animal lethality. Toxicon 24:985-994.
27. Tuomi, T., Saarinen, L., and Reijula, K. 1998. Detection of polar and macrocyclic trichothecene mycotoxins from indoor environments. Analyst 123:1835-1841.
28. Ueno, Y. 1984. Toxicological features of T-2 toxin and related trichothecenes. Fundam. Appl. Toxicol. 4:S124-S132.
29. Wong, S. S., Zhou, H. R., Marin-Martinez, M. L., Brooks, K., and Pestka, J. J. 1998. Modulation of IL-1beta, IL-6 and TNF-alpha secretion and mRNA expression by the trichothecene vomitoxin in the RAW 264.7 murine macrophage cell line. Food Chem. Toxicol. 36:409-419.
30. Young, J. T. 1981. Histopathologic examination of the rat nasal cavity. Fundam. Appl. Toxicol. 1:309-312.
31. Zhou, H. R., Islam, Z., and Pestka, J. J. 2005. Induction of competing apoptotic and survival signaling pathways in the macrophage by the ribotoxic trichothecene deoxynivalenol. Toxicol. Sci. 87:113-122.