PET-derived biodistribution and dosimetry of the benzodiazepine receptor-binding radioligand 11C-(R)-PK11195 in children and adults

Journal of Nuclear Medicine

Volumn 51, Issue 1, 2010, Pages 139-144

  Kumar, Ajay ^a,b   Muzik, Otto ^a,b   Chugani, Diane ^a   Chakraborty, Pulak ^a,b   Chugani, Harry T ^a,b  

^a CHILDREN'S HOSPITAL OF MICHIGAN   (United States)

^b WAYNE STATE UNIVERSITY   (United States)

Author keywords

11C PK11195; Biodistribution; Children; Dosimetry; PET

Indexed keywords

N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE C 11; RADIOLIGAND;

ADOLESCENT; ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DOSIMETRY; ENCEPHALITIS; FEMALE; HEPATOBILIARY SYSTEM; HUMAN; MALE; POSITRON EMISSION TOMOGRAPHY; PRESCHOOL CHILD; PRIORITY JOURNAL; RADIATION DOSE; RADIATION DOSE DISTRIBUTION; RADIOASSAY; SCHOOL CHILD;

ADOLESCENT; ADULT; AGING; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; ISOQUINOLINES; MALE; ORGAN SPECIFICITY; POSITRON-EMISSION TOMOGRAPHY; RADIOMETRY; RADIOPHARMACEUTICALS; RECEPTORS, GABA-A; TISSUE DISTRIBUTION; WHOLE BODY IMAGING; YOUNG ADULT;

EID: 75149116681     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.109.066472     Document Type: Article

References (25)

1. Banati RB. Neuropathological imaging: in vivo detection of glial activation as a measure of disease and adaptive change in the brain. Br Med Bull. 2003;65:121-131.
2. Weissman BA, Bolger GT, Isaac L, Paul SM, Skolnick P. Characterization of the binding of [3H]Ro 5-4864, a convulsant benzodiazepine, to guinea pig brain. J Neurochem. 1984;42:969-975.
3. Banati RB, Myers R, Kreutzberg GW. PK ('peripheral benzodiazepine')- binding sites in the CNS indicate early and discrete brain lesions: microautoradiographic detection of [3H]PK11195 binding to activated microglia. J Neurocytol. 1997;26:77-82.
4. Bribes E, Carriere D, Goubet C, Galiegue S, Casellas P, Simony-Lafontaine J. Immunohistochemical assessment of the peripheral benzodiazepine receptor in human tissues. J Histochem Cytochem. 2004;52:19-28.
5. Garnier M, Boujrad N, Oke BO, et al. Diazepam binding inhibitor is a paracrine/autocrine regulator of Leydig cell proliferation and steroidogenesis: action via peripheral-type benzodiazepine receptor and independent mechanisms. Endocrinology. 1993;132:444-458.
6. 11C]PK11195 [abstract]. J Nucl Med. 2006; 47(suppl 1):522P.
7. Radiation dose to patients from radiopharmaceuticals: a report of a Task Group of Committee 2 of the International Commission on Radiological Protection. Ann ICRP. 1987;18:1-377.
8. Stabin MG, Sparks RB, Crowe E. OLINDA/EXM: the second-generation personal computer software for internal dose assessment in nuclear medicine. J Nucl Med. 2005;46:1023-1027.
9. 123I]iodo-PK11195: a possible single-photon emission tomography tracer for visualization of inflammation. Eur J Nucl Med. 1999;26:194-200.
10. 18F]PK14105 as markers for neuronal damage. J Neurochem. 1990;55:175-185.
11. 11C]1-(2- chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinoline carboxamide in mouse plasma and tissue and in human plasma. J Chromatogr B Biomed Sci Appl. 1999;736: 61-66.
12. 11C]PK11195] and its metabolites in humans. Nucl Med Biol. 2005;32:307-312.
13. Huminiecki L, Lloyd AT, Wolfe KH. Congruence of tissue expression profiles from Gene Expression Atlas, SAGEmap and TissueInfo databases. BMC Genomics. 2003;4:31.
14. Skrabanek L, Campagne F. TissueInfo: high-throughput identification of tissue expression profiles and specificity. Nucleic Acids Res. 2001;29:E102.
15. 11C](R)-1-(2-chlorophenyl)- N-(1-methylpropyl)-3-isoquinolinecarb oxamide in humans; an imaging agent for in vivo assessment of peripheral benzodiazepine receptor activity with positron emission tomography. Eur J Nucl Med Mol Imaging. 2009;36:671-682.
16. 123I]iodo-PK 11195: a potential agent for SPET imaging of the peripheral benzodiazepine receptor. Eur J Nucl Med. 2000;27:1326-1333.
17. 123I]-iodo-PK11195 for mapping peripheral-type benzodiazepine receptors (omega 3) in heart. Nucl Med Biol. 1996;23:23-28.
18. 11C-PBR28: a PET radioligand to image inflammation. J Nucl Med. 2007;48:2072-2079.
19. Cappelli A, Matarrese M, Moresco RM, et al. Synthesis, labeling, and biological evaluation of halogenated 2-quinolinecarboxamides as potential radioligands for the visualization of peripheral benzodiazepine receptors. Bioorg Med Chem. 2006;14:4055-4066.
20. 18F]pyrazolo[1,5-a]pyrimidines for the study of the peripheral benzodiazepine receptor using positron emission tomography. J Med Chem. 2008;51:3700-3712.
21. 11C-PK 11195 for in vivo study of peripheral-type benzodiazepine receptors using positron emission tomography. Ann Nucl Med. 1989;3:63-71.
22. Imaizumi M, Briard E, Zoghbi SS, et al. Kinetic evaluation in nonhuman primates of two new PET ligands for peripheral benzodiazepine receptors in brain. Synapse. 2007;61:595-605.
23. 11C]methylated quinoline-2-carboxamides as potential radioligands for visualization of peripheral benzodiazepine receptors. J Med Chem. 2001;44:579-585.
24. Fujita M, Imaizumi M, Zoghbi SS, et al. Kinetic analysis in healthy humans of a novel positron emission tomography radioligand to image the peripheral benzodiazepine receptor, a potential biomarker for inflammation. Neuroimage. 2008;40:43-52.
25. Beurdeley-Thomas A, Miccoli L, Oudard S, Dutrillaux B, Poupon MF. The peripheral benzodiazepine receptors: a review. J Neurooncol. 2000;46:45-56.