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Volumn 21, Issue 1, 2007, Pages 143-150

Prognostic and biological implications of genetic abnormalities in multiple myeloma undergoing autologous stem cell transplantation: t(4;14) is the most relevant adverse prognostic factor, whereas RB deletion as a unique abnormality is not associated with adverse prognosis

(18)  Gutierrez N C a   Castellanos, M V a   Martin M L b   Mateos, M V a   Hernandez J M a   Fernandez M b   Carrera, D c   Rosinol L d   Ribera, J M e   Ojanguren, J M f   Palomera, L g   Gardella, S h   Escoda, L i   Hernandez Boluda J C j   Bello, J L k   de la Rubia, J l   Lahuerta, J J b   San Miguel, J F a  


Author keywords

[No Author keywords available]

Indexed keywords

BENCE JONES PROTEIN; BLEOMYCIN; CARMUSTINE; CYCLOPHOSPHAMIDE; DACARBAZINE; DOXORUBICIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; IMMUNOGLOBULIN G; IMMUNOGLOBULIN HEAVY CHAIN; MELPHALAN; PREDNISONE; PROTEIN P53; RETINOBLASTOMA PROTEIN; VINBLASTINE; VINCRISTINE;

EID: 33845546906     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/sj.leu.2404413     Document Type: Article
Times cited : (167)

References (29)
  • 2
    • 0028880424 scopus 로고
    • Poor prognosis in multiple myeloma is associated only with partial or complete deletions of chromosome 13 or abnormalities involving 11q and not with other karyotype abnormalities
    • Tricot G, Barlogie B, Jagannath S, Bracy D, Mattox S, Vesole DH et al. Poor prognosis in multiple myeloma is associated only with partial or complete deletions of chromosome 13 or abnormalities involving 11q and not with other karyotype abnormalities. Blood 1995; 86: 4250-4256.
    • (1995) Blood , vol.86 , pp. 4250-4256
    • Tricot, G.1    Barlogie, B.2    Jagannath, S.3    Bracy, D.4    Mattox, S.5    Vesole, D.H.6
  • 3
    • 0036721371 scopus 로고    scopus 로고
    • Recurrent 14q32 translocations determine the prognosis of multiple myeloma, especially in patients receiving intensive chemotherapy
    • Moreau P, Facon T, Leleu X, Morineau N, Huyghe P, Harousseau JL et al. Recurrent 14q32 translocations determine the prognosis of multiple myeloma, especially in patients receiving intensive chemotherapy. Blood 2002; 100: 1579-1583.
    • (2002) Blood , vol.100 , pp. 1579-1583
    • Moreau, P.1    Facon, T.2    Leleu, X.3    Morineau, N.4    Huyghe, P.5    Harousseau, J.L.6
  • 4
    • 0038142356 scopus 로고    scopus 로고
    • Clinical and biologic implications of recurrent genomic aberrations in myeloma
    • Fonseca R, Blood E, Rue M, Harrington D, Oken MM, Kyle RA et al. Clinical and biologic implications of recurrent genomic aberrations in myeloma. Blood 2003; 101: 4569-4575.
    • (2003) Blood , vol.101 , pp. 4569-4575
    • Fonseca, R.1    Blood, E.2    Rue, M.3    Harrington, D.4    Oken, M.M.5    Kyle, R.A.6
  • 5
    • 0037217603 scopus 로고    scopus 로고
    • Prognostic impact of cytogenetic and interphase fluorescence in situ hybridization-defined chromosome 13 deletion in multiple myeloma: Early results of total therapy II
    • Shaughnessy Jr J, Tian E, Sawyer J, McCoy J, Tricot G, Jacobson J et al. Prognostic impact of cytogenetic and interphase fluorescence in situ hybridization-defined chromosome 13 deletion in multiple myeloma: Early results of total therapy II. Br J Haematol 2003; 120: 44-52.
    • (2003) Br J Haematol , vol.120 , pp. 44-52
    • Shaughnessy Jr., J.1    Tian, E.2    Sawyer, J.3    McCoy, J.4    Tricot, G.5    Jacobson, J.6
  • 6
    • 0030922231 scopus 로고    scopus 로고
    • Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3
    • Chesi M, Nardini E, Brents LA, Schrock E, Ried T, Kuehl WM et al. Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3. Nat Genet 1997; 16: 260-264.
    • (1997) Nat Genet , vol.16 , pp. 260-264
    • Chesi, M.1    Nardini, E.2    Brents, L.A.3    Schrock, E.4    Ried, T.5    Kuehl, W.M.6
  • 7
    • 0031839633 scopus 로고    scopus 로고
    • Frequent dysregulation of the c-maf proto-oncogene at 16q23 by translocation to an Ig locus in multiple myeloma
    • Chesi M, Bergsagel PL, Shonukan OO, Martelli ML, Brents LA, Chen T et al. Frequent dysregulation of the c-maf proto-oncogene at 16q23 by translocation to an Ig locus in multiple myeloma. Blood 1998; 91: 4457-4463.
    • (1998) Blood , vol.91 , pp. 4457-4463
    • Chesi, M.1    Bergsagel, P.L.2    Shonukan, O.O.3    Martelli, M.L.4    Brents, L.A.5    Chen, T.6
  • 8
    • 0032402134 scopus 로고    scopus 로고
    • Identification of new nonrandom translocations in multiple myeloma with multicolor spectral karyotyping
    • Sawyer JR, Lukacs JL, Munshi N, Desikan KR, Singhal S, Mehta J et al. Identification of new nonrandom translocations in multiple myeloma with multicolor spectral karyotyping. Blood 1998; 92: 4269-4278.
    • (1998) Blood , vol.92 , pp. 4269-4278
    • Sawyer, J.R.1    Lukacs, J.L.2    Munshi, N.3    Desikan, K.R.4    Singhal, S.5    Mehta, J.6
  • 9
    • 27144441760 scopus 로고    scopus 로고
    • Clinical implications of t(11;14)(q13;q32), t(4;14)(p16.3;q32), and -17p13 in myeloma patients treated with high-dose therapy
    • Gertz MA, Lacy MQ, Dispenzieri A, Greipp PR, Litzow MR, Henderson KJ et al. Clinical implications of t(11;14)(q13;q32), t(4;14)(p16.3;q32), and -17p13 in myeloma patients treated with high-dose therapy. Blood 2005; 106: 2837-2840.
    • (2005) Blood , vol.106 , pp. 2837-2840
    • Gertz, M.A.1    Lacy, M.Q.2    Dispenzieri, A.3    Greipp, P.R.4    Litzow, M.R.5    Henderson, K.J.6
  • 11
    • 0036468246 scopus 로고    scopus 로고
    • Biological and prognostic significance of interphase fluorescence in situ hybridization detection of chromosome 13 abnormalities (delta13) in multiple myeloma: An eastern cooperative oncology group study
    • Fonseca R, Harrington D, Oken MM, Dewald GW, Bailey RJ, Van Wier SA et al. Biological and prognostic significance of interphase fluorescence in situ hybridization detection of chromosome 13 abnormalities (delta13) in multiple myeloma: An eastern cooperative oncology group study. Cancer Res 2002; 62: 715-720.
    • (2002) Cancer Res , vol.62 , pp. 715-720
    • Fonseca, R.1    Harrington, D.2    Oken, M.M.3    Dewald, G.W.4    Bailey, R.J.5    Van Wier, S.A.6
  • 12
    • 0035496928 scopus 로고    scopus 로고
    • Hypodiploidy is a major prognostic factor in multiple myeloma
    • Smadja NV, Bastard C, Brigaudeau C, Leroux D, Fruchart C. Hypodiploidy is a major prognostic factor in multiple myeloma. Blood 2001; 98: 2229-2238.
    • (2001) Blood , vol.98 , pp. 2229-2238
    • Smadja, N.V.1    Bastard, C.2    Brigaudeau, C.3    Leroux, D.4    Fruchart, C.5
  • 13
    • 12944332087 scopus 로고    scopus 로고
    • Detection of inv(16) and t(16;16) by fluorescence in situ hybridization in acute myeloid leukemia M4Eo
    • Hernández JM, González MB, Granada I, Gutierrez N, Chillon C, Ramos F et al. Detection of inv(16) and t(16;16) by fluorescence in situ hybridization in acute myeloid leukemia M4Eo. Haematologica 2000; 85: 481-485.
    • (2000) Haematologica , vol.85 , pp. 481-485
    • Hernández, J.M.1    González, M.B.2    Granada, I.3    Gutierrez, N.4    Chillon, C.5    Ramos, F.6
  • 15
    • 0031035918 scopus 로고    scopus 로고
    • Cytogenetic analysis of 280 patients with multiple myeloma and related disorders: Primary breakpoints and clinical correlations
    • Calasanz MJ, Cigudosa JC, Odero MD, Ferreira C, Ardanaz MT, Fraile A et al. Cytogenetic analysis of 280 patients with multiple myeloma and related disorders: Primary breakpoints and clinical correlations. Genes Chromosomes Cancer 1997; 18: 84-93.
    • (1997) Genes Chromosomes Cancer , vol.18 , pp. 84-93
    • Calasanz, M.J.1    Cigudosa, J.C.2    Odero, M.D.3    Ferreira, C.4    Ardanaz, M.T.5    Fraile, A.6
  • 17
    • 17144433568 scopus 로고    scopus 로고
    • Unique role of cytogenetics in the prognosis of patients with myeloma receiving high-dose therapy and autotransplants
    • Tricot G, Sawyer JR, Jagannath S, Desikan KR, Siegel D, Naucke S et al. Unique role of cytogenetics in the prognosis of patients with myeloma receiving high-dose therapy and autotransplants. J Clin Oncol 1997; 15: 2659-2666.
    • (1997) J Clin Oncol , vol.15 , pp. 2659-2666
    • Tricot, G.1    Sawyer, J.R.2    Jagannath, S.3    Desikan, K.R.4    Siegel, D.5    Naucke, S.6
  • 18
    • 0141481984 scopus 로고    scopus 로고
    • The recurrent IgH translocations are highly associated with nonhyperdiploid variant multiple myeloma
    • Fonseca R, Debes-Marun CS, Picken EB, Dewald GW, Bryant SC, Winkler JM et al. The recurrent IgH translocations are highly associated with nonhyperdiploid variant multiple myeloma. Blood 2003; 102: 2562-2567.
    • (2003) Blood , vol.102 , pp. 2562-2567
    • Fonseca, R.1    Debes-Marun, C.S.2    Picken, E.B.3    Dewald, G.W.4    Bryant, S.C.5    Winkler, J.M.6
  • 19
    • 0037085787 scopus 로고    scopus 로고
    • Oncogenesis of multiple myeloma: 14q32 and 13q chromosomal abnormalities are not randomly distributed, but correlate with natural history, immunological features, and clinical presentation
    • Avet-Loiseau H, Facon T, Grosbois B, Magrangeas F, Rapp MJ, Harousseau JL et al. Oncogenesis of multiple myeloma: 14q32 and 13q chromosomal abnormalities are not randomly distributed, but correlate with natural history, immunological features, and clinical presentation. Blood 2002; 99: 2185-2191.
    • (2002) Blood , vol.99 , pp. 2185-2191
    • Avet-Loiseau, H.1    Facon, T.2    Grosbois, B.3    Magrangeas, F.4    Rapp, M.J.5    Harousseau, J.L.6
  • 20
    • 11144219996 scopus 로고    scopus 로고
    • p53 gene deletion detected by fluorescence in situ hybridization is an adverse prognostic factor for patients with multiple myeloma following autologous stem cell transplantation
    • Chang H, Qi C, Yi QL, Reece D, Stewart AK. p53 gene deletion detected by fluorescence in situ hybridization is an adverse prognostic factor for patients with multiple myeloma following autologous stem cell transplantation. Blood 2005; 105: 358-360.
    • (2005) Blood , vol.105 , pp. 358-360
    • Chang, H.1    Qi, C.2    Yi, Q.L.3    Reece, D.4    Stewart, A.K.5
  • 21
    • 2542499695 scopus 로고    scopus 로고
    • Deletion of chromosome band 13q14 as detected by fluorescence in situ hybridization is a prognostic factor in patients with multiple myeloma who are receiving allogeneic dose-reduced stem cell transplantation
    • Kroger N, Schilling G, Einsele H, Liebisch P, Shimoni A, Nagler A et al. Deletion of chromosome band 13q14 as detected by fluorescence in situ hybridization is a prognostic factor in patients with multiple myeloma who are receiving allogeneic dose-reduced stem cell transplantation. Blood 2004; 103: 4056-4061.
    • (2004) Blood , vol.103 , pp. 4056-4061
    • Kroger, N.1    Schilling, G.2    Einsele, H.3    Liebisch, P.4    Shimoni, A.5    Nagler, A.6
  • 22
    • 17344395438 scopus 로고    scopus 로고
    • Deletion of 13q14 remains an independent adverse prognostic variable in multiple myeloma despite its frequent detection by interphase fluorescence in situ hybridization
    • Zojer N, Konigsberg R, Ackermann J, Fritz E, Dallinger S, Kromer E et al. Deletion of 13q14 remains an independent adverse prognostic variable in multiple myeloma despite its frequent detection by interphase fluorescence in situ hybridization. Blood 2000; 95: 1925-1930.
    • (2000) Blood , vol.95 , pp. 1925-1930
    • Zojer, N.1    Konigsberg, R.2    Ackermann, J.3    Fritz, E.4    Dallinger, S.5    Kromer, E.6
  • 23
    • 33748287079 scopus 로고    scopus 로고
    • Bortezomib plus melphalan and prednisone in elderly untreated patients with multiple myeloma: Results of a multicenter phase I/II study
    • E-pub ahead of print
    • Mateos MV, Hernández JM, Hernández MT, Gutiérrez NC, Palomera L, Fuertes M et al. Bortezomib plus melphalan and prednisone in elderly untreated patients with multiple myeloma: Results of a multicenter phase I/II study. Blood 2006, E-pub ahead of print.
    • (2006) Blood
    • Mateos, M.V.1    Hernández, J.M.2    Hernández, M.T.3    Gutiérrez, N.C.4    Palomera, L.5    Fuertes, M.6
  • 25
    • 27744568383 scopus 로고    scopus 로고
    • Relationship of patient survival and chromosome anomalies detected in metaphase and/or interphase cells at diagnosis of myeloma
    • Dewald GW, Therneau T, Larson D, Lee YK, Fink S, Smoley S et al. Relationship of patient survival and chromosome anomalies detected in metaphase and/or interphase cells at diagnosis of myeloma. Blood 2005; 106: 3553-3558.
    • (2005) Blood , vol.106 , pp. 3553-3558
    • Dewald, G.W.1    Therneau, T.2    Larson, D.3    Lee, Y.K.4    Fink, S.5    Smoley, S.6
  • 26
    • 18544409610 scopus 로고    scopus 로고
    • Results of high-dose therapy for 1000 patients with multiple myeloma: Durable complete remissions and superior survival in the absence of chromosome 13 abnormalities
    • Desikan R, Barlogie B, Sawyer J, Ayers D, Tricot G, Badros A et al. Results of high-dose therapy for 1000 patients with multiple myeloma: durable complete remissions and superior survival in the absence of chromosome 13 abnormalities. Blood 2000; 95: 4008-4010.
    • (2000) Blood , vol.95 , pp. 4008-4010
    • Desikan, R.1    Barlogie, B.2    Sawyer, J.3    Ayers, D.4    Tricot, G.5    Badros, A.6
  • 27
    • 0035869257 scopus 로고    scopus 로고
    • Chromosome 13 abnormalities identified by FISH analysis and serum beta2-microglobulin produce a powerful myeloma staging system for patients receiving high-dose therapy
    • Facon T, Avet-Loiseau H, Guillerm G, Moreau P, Genevieve F, Zandecki M et al. Chromosome 13 abnormalities identified by FISH analysis and serum beta2-microglobulin produce a powerful myeloma staging system for patients receiving high-dose therapy. Blood 2001; 97: 1566-1571.
    • (2001) Blood , vol.97 , pp. 1566-1571
    • Facon, T.1    Avet-Loiseau, H.2    Guillerm, G.3    Moreau, P.4    Genevieve, F.5    Zandecki, M.6
  • 28
    • 2642617778 scopus 로고    scopus 로고
    • Prognostic value of numerical chromosome aberrations in multiple myeloma: A FISH analysis of 15 different chromosomes
    • Pérez-Simón JA, García-Sanz R, Tabernero MD, Almeida J, Gonzalez M, Fernandez-Calvo J et al. Prognostic value of numerical chromosome aberrations in multiple myeloma: A FISH analysis of 15 different chromosomes. Blood 1998; 91: 3366-3371.
    • (1998) Blood , vol.91 , pp. 3366-3371
    • Pérez-Simón, J.A.1    García-Sanz, R.2    Tabernero, M.D.3    Almeida, J.4    Gonzalez, M.5    Fernandez-Calvo, J.6
  • 29
    • 0032147210 scopus 로고    scopus 로고
    • Presence of a p53 gene deletion in patients with multiple myeloma predicts for short survival after conventional-dose chemotherapy
    • Drach J, Ackermann J, Fritz E, Kromer E, Schuster R, Gisslinger H et al. Presence of a p53 gene deletion in patients with multiple myeloma predicts for short survival after conventional-dose chemotherapy. Blood 1998; 92: 802-809.
    • (1998) Blood , vol.92 , pp. 802-809
    • Drach, J.1    Ackermann, J.2    Fritz, E.3    Kromer, E.4    Schuster, R.5    Gisslinger, H.6


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