Muscarinic acetylcholine receptor subtypes in the male reproductive tract : EExpression and function in rat efferent ductules and epididymis

Journal of Molecular Neuroscience

Volumn 40, Issue 1-2, 2010, Pages 127-134

  Avellar, Maria Christina W ^a   Siu, Erica R ^a   Yasuhara, Fabiana ^a   Maróstica, Elisabeth ^b   Porto, Catarina S ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b FLUMINENSE FEDERAL UNIVERSITY   (Brazil)

Author keywords

Acetylcholine; Efferent ductules; Epididymis; Male reproductive tract; Muscarinic acetylcholine receptor

Indexed keywords

ACETYLCHOLINE; MUSCARINIC RECEPTOR; RECEPTOR SUBTYPE; SIGNAL PEPTIDE;

ANIMAL EXPERIMENT; CHOLINERGIC SYSTEM; CONFERENCE PAPER; DESENSITIZATION; EPIDIDYMIS; MALE FERTILITY; MALE GENITAL SYSTEM; MOLECULAR BIOLOGY; MOTOR SYSTEM; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ACETYLCHOLINE; ANDROGENS; ANIMALS; EPIDIDYMIS; EPITHELIAL CELLS; MALE; MUSCLE, SMOOTH; PROTEIN BIOSYNTHESIS; PROTEIN SUBUNITS; RATS; RECEPTORS, MUSCARINIC; SPERMATOGENESIS; TESTIS;

MAMMALIA; RATTUS;

EID: 75049085549     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12031-009-9268-6     Document Type: Conference Paper

References (73)

1. Y Ban T Sato T Nakatsuka M Kemi K Samura H Matsumoto MA Cukierski MJ van Zwieten 2002 Impairment of male fertility induced by muscarinic receptor antagonists in rats Reproductive Toxicology 16 757 765 10.1016/S0890-6238(02) 00050-3 1:CAS:528:DC%2BD38XotVChsLo%3D 12401503 (Pubitemid 35278496)
2. HG Baumgarten B Falck AF Holstein C Owman T Owman 1968 Adrenergic innervation of the human testis, epididymis, ductus deferens and prostate: a fluorescence microscopic and fluorometric study Z. Zellforsch 90 81 95 10.1007/BF00496704 1:CAS:528:DyaF1MXjsFKrtw%3D%3D 5722959
3. MR Bishop BV Sastry DE Schmidt RD Harbison 1976 Occurrence of choline acetyltransferase and acetylcholine and other quaternary ammonium compounds in mammalian spermatozoa Biochemical Pharmacology 25 1617 1622 10.1016/0006- 2952(76)90473-1 1:CAS:528:DyaE2sXhsVehtg%3D%3D 945986
4. TI Bonner NJ Buckley AC Young MR Brann 1987 Identification of a family of muscarinic acetylcholine receptor genes Science 237 527 532 10.1126/science.3037705 1:CAS:528:DyaL2sXltFSgsbo%3D 3037705
5. MO Borges ML Abreu CS Porto MCW Avellar 2001 Characterization of muscarinic acetylcholine receptor in rat Sertoli cells Endocrinology 142 4701 4710 10.1210/en.142.11.4701 1:CAS:528:DC%2BD3MXnslGqtLc%3D 11606435 (Pubitemid 33022345)
6. DE Brooks 1981 Secretion of proteins and glycoprotiens by the rat epididymis: regional differences, anfrogen-dependence and effects of proteins inhibitors, procaine and tunicamycin Biology of Reproduction 25 1099 1117 10.1095/biolreprod25.5.1099 1:CAS:528:DyaL38XkvFGrtQ%3D%3D 7326301
7. H Bruschini RA Schmidt EA Tanagho 1978 Neurologic control of prostatic secretion in the dog Investigative Urology 15 288 290 1:STN:280: DyaE1c7gvVyitQ%3D%3D 627473
8. MP Caulfield NJM Birdsall 1998 International Union of Pharmacology. XVII. Classification of muscarinic acetylcholine receptors Pharmacological Reviews 50 279 290 1:CAS:528:DyaK1cXksFCltrw%3D 9647869
9. TG Cooper 1995 Role of the epididymis in mediating changes in the male gamete during maturation Advances in Experimental Medicine and Biology 377 87 101 1:CAS:528:DyaK2MXptl2gs7c%3D 7484449
10. TG Cooper 1998 Interactions between epididymal secretions and spermatozoa Journal of Reproduction and Fertility. Supplement 53 119 136 1:CAS:528:DyaK1MXitVekurY%3D 10645272
11. JL Dacheux S Castella JL Gatti F Dacheux 2005 Epididymal cell secretory activities and the role of proteins in boar sperm maturation Theriogenology 63 319 341 10.1016/j.theriogenology.2004.09.015 1:CAS:528:DC%2BD2MXjsVSh 15626402 (Pubitemid 40033959)
12. JY Du WL Zuo MH Chen H Xiang WL Zhou 2006 Involvement of muscarinic acetylcholine receptors in chloride secretion by cultured rat epididymal epithelium Cell Biology International 30 741 746 10.1016/j.cellbi.2006.05.008 1:CAS:528:DC%2BD28XpsVOmtbY%3D 16814576 (Pubitemid 44331632)
13. C Dwivedi NJ Long 1989 Effect of cholinergic agents on human spermatozoa motility.Biochem Med. Metab. Biol. 42 66 70 10.1016/0885-4505(89)90042-X 1:CAS:528:DyaL1MXlsVOgsrs%3D (Pubitemid 19237759)
14. RM Eglen 2006 Muscarinic receptor subtype in neuronal and non-neuronal cholinergic function Auton. Autacoid Pharmacol. 6 219 233 10.1111/j.1474-8673. 2006.00368.x (Pubitemid 43898622)
15. A El-Badawi EA Schenk 1967 The distribution of cholinergic and adrenergic nerves in the mammalian epididymis. A comparative histochemical study American Journal of Anatomy 121 1 14 10.1002/aja.1001210102 1:STN:280: DyaF1c%2FkvVyqsw%3D%3D 6069971
16. I Ehrén NO Sjöstrand M Hammarström NP Wiklund 1997 Is glandular formation of nitric oxide a prerequisite for muscarinic secretion of fructose in the guinea-pig seminal vesicle? Urological Research 25 433 438 10.1007/BF01268862 9443654 (Pubitemid 28005212)
17. HM Florman BT Storey 1982 Mouse gamete interactions: the zona pellucida is the site of the acrosome reaction leading to fertilization in vitro Developmental Biology 91 121 130 10.1016/0012-1606(82)90015-X 1:STN:280:DyaL383js1GqsA%3D%3D 7201425
18. JL Gatti S Castella F Daucheux H Ecroyd S Métayer V Thimon JL Dacheux 2004 Posttesticular sperm enviroment and fertility Animal Reproduction Science 82-83 321 339 10.1016/j.anireprosci.2004.05.011 15271463 (Pubitemid 39027069)
19. I Gerendai IE Tóth K Kocsis Z Boldogkoi M Rusvai B Haláz 2001 Identification of CNS neurons involved in the innervation of the epididymis: a viral transneuronal tracing study Auton. Neurosci. 92 1120 1126
20. D Goodman R Harbison 1981 Characterization of enzymatic acetylcholine synthesis by mouse brain, rat sperm, and purified carnitine acetyltransferase Biochemical Pharmacology 30 1521 1528 10.1016/0006-2952(81)90376-2 1:CAS:528:DyaL3MXlsVOlu70%3D 7271845 (Pubitemid 11072280)
21. D Goodman F Adatsi R Harbison 1984 Evidence for the extreme overestimation of choline acetyltransferase in human sperm, human seminal plasma and rat heart: a case of mistaking carnitine acetyltransferase for choline acetyltransferase Chemico-Biological Interactions 49 39 53 10.1016/0009-2797(84) 90051-6 1:CAS:528:DyaL2cXksFSmsLs%3D 6722939
22. SA Grando 1997 Biological functions of keratinocyte cholinergic receptors Journal of Investigative Dermatology Symposium Proceedings 2 41 48 1:CAS:528:DyaK2sXlsFCqu7Y%3D
23. M Hamamura E Maróstica MCW Avellar CS Porto 2006 Muscarinic acetylcholine receptor subtypes in the rat seminal vesicle Molecular and Cellular Endocrinology 247 192 198 10.1016/j.mce.2006.01.004 1:CAS:528:DC%2BD28XhvVWkt74%3D 16481100 (Pubitemid 43279692)
24. LA Hansen F Dacheux SY Man J Clulow RC Jones 2004 Fluid reabsorption by the ductuli efferentes testis of the rat is dependent on both sodium and chlorine Biology of Reproduction 71 410 416 10.1095/biolreprod.104.027490 1:CAS:528:DC%2BD2cXmtFWgtLw%3D 15056565 (Pubitemid 38970513)
25. N Hodson 1965 Sympathetic nerves and reproductive organs in the male rabbit Journal of Reproduction and Fertility 10 209 220 1:STN:280: DyaF28%2FitVahsA%3D%3D 5836268
26. Hodson, N. (1970). The nerves of the testis, epididymis and scrotum. In A. D. Johnson, W. R. Gomes & N. L. Vandemark (Eds.), The Testis, Vol I (pp. 47-99). New York: Academic.
27. Hinton, B. T., Lan, Z. J., Lye, R. J., & Labus, J. C. (2000). Regulation of epididymal function by testicular factors: the lumicrine hypothesis. In E. Goldberg (Ed.), The Testis: From Stem Cell to Sperm Function (pp. 63-173). Massachusetts, NJ: Norwell.
28. EC Hulme NJM Birdsall NJ Buckley 1990 Muscarinic receptor subtypes Annual Review of Pharmacology and Toxicology 30 633 673 10.1146/annurev.pa.30.040190. 003221 1:CAS:528:DyaK3MXhslGqsA%3D%3D 2188581
29. CF Ibanez M Pelto-Huikko O Soder EM Ritzen LB Hersh T Hokfelt H Persson 1991 Expression of choline acetyltransferase mRNA in spermatogenic cells results in an accumulation of the enzyme in the postacrosomal region of mature spermatozoa Proceedings of the National Academy of Sciences of the United States of America 88 3676 3680 10.1073/pnas.88.9.3676 1:CAS:528:DyaK3MXkt1aqsLk%3D 2023918
30. KY Ilio RA Hess 1994 Structure and function of the ductuli efferentes: a review Microscopy Research and Technique 29 432 467 10.1002/jemt.1070290604 1:STN:280:DyaK2M7nvVOnuw%3D%3D 7873793 (Pubitemid 24368794)
31. F Jimenez-Trejo M Tapia-Rodriguez DBC Queiróz P Padilla MCW Avellar PR Manzano G Manjarrez-Gutierrez G Gutierrez-Ospina 2007 Serotonin concentration, synthesis, cell origin, and targets in the rat caput epididymis during sexual maturation and variations associated with adult mating status: morphological and biochemical studies Journal of Andrology 28 136 149 10.2164/jandrol.106.000653 1:CAS:528:DC%2BD2sXhtleqsLw%3D 16988324 (Pubitemid 46048086)
32. Karczmar, A. G. (1963). Ontogenesis of cholinesterases. In G. B. Koelle (Ed.), Cholinesterases and Anticholinesterase Agents. Hanbck. of Exper. Pharmacol., Erganzangswk., vol. 15 (pp. 129-186). Berlin: Springer.
33. T Kumazawa K Mizumura J Sato 1987 Response properties of polymodal receptors studied using in vitro testis superior spermatic nerve preparations of dogs Journal of Neurophysiology 57 702 711 1:STN:280:DyaL2s7mvVKguw%3D%3D 3559698
34. EM Kinghorn AS Bate SJ Higgins 1987 Growth of rat seminal vesicle epithelial cells in culture: neurotransmitters are required for androgen-regulated synthesis of tissue-specific secretory proteins Endocrinology 121 1678 1688 10.1210/endo-121-5-1678 1:CAS:528:DyaL2sXmt12qsbg%3D 3665841
35. L Laitinen A Talo 1981 Effects of adrenergic and cholinergic drugs on electrical and mechanical activities of the rat cauda epididymis in vitro Journal of Reproduction and Fertility 63 205 209 1:CAS:528:DyaL3MXlsVyju7s%3D 6115943 (Pubitemid 12195706)
36. WAK Lau JN Pennefather 1998 Muscarinic receptor subtypes in the rat prostate gland European Journal of Pharmacology 343 151 156 10.1016/S0014- 2999(97)01535-5 1:CAS:528:DyaK1cXhsFejtL8%3D 9570462 (Pubitemid 28138597)
37. WAK Lau JN Pennefather FJ Mitchelson 2000 Cholinergic facilitation of neurotransmission to the smooth muscle of the guinea-pig prostate gland British Journal of Pharmacology 130 1013 1020 10.1038/sj.bjp.0703409 1:CAS:528:DC%2BD3cXlt1SlurY%3D 10882385
38. DH Lockwood HG Williams-Ashman 1971 Cholinergic-stimulated alkaline phosphatase secretion and phospholipid synthesis in guinea pig seminal vesicles Journal of Cellular Physiology 77 7 15 10.1002/jcp.1040770103 1:CAS:528:DyaE3MXhtV2qtL8%3D 4323201
39. PA Longhurst TP Brotcke 1989 Effects of castration and diabetes mellitus on cholinergic responsiveness and muscarinic receptors in the rat vas deferens Journal of Urology 141 1225 1229 1:STN:280:DyaL1M3hslWgtg%3D%3D 2709516
40. TF Lucas MCW Avellar CS Porto 2004 Effects of carbachol on rat Sertoli cell proliferation and muscarinic acetylcholine receptors regulation: an in vitro study Life Sciences 75 1761 1773 10.1016/j.lfs.2004.05.006 1:CAS:528:DC%2BD2cXmtVWhtr4%3D 15268975 (Pubitemid 38961799)
41. TFG Lucas ER Siu C Royer CS Trindade HB Nader MFM Lazari CS Porto 2008 Muscarinic acetylcholine receptors: relevance to infertility and male contraception Immun. Endoc. & Metab. Agents in Med. Chem. 8 42 50 1:CAS:528:DC%2BD1cXisFSntLY%3D
42. GR Luthin P Wang H Zhou D Dhanasekaran MR Ruggieri 1997 Role of m1 receptor G-protein coupling in cell proliferation in the prostate Life Sciences 60 963 968 10.1016/S0024-3205(97)00035-0 1:CAS:528:DyaK2sXhvFShsb8%3D 9121362 (Pubitemid 27165563)
43. E Maróstica EF Guaze MCW Avellar CS Porto 2001 Characterization of muscarinic acetylcholine receptors in rat epididymis Biology of Reproduction 65 1120 1126 10.1095/biolreprod65.4.1120 11566733
44. E Maróstica MCW Avellar CS Porto 2005 Effects of testosterone on muscarinic acetylcholine receptors in the rat epididymis Life Sciences 77 656 669 10.1016/j.lfs.2004.12.031 15921997 (Pubitemid 40726353)
45. S Meizel JH Son 2005 Studies of sperm from mutant mice suggesting that two neurotransmitter receptors are important to the zona pellucida-initiated acrosome reaction Molecular Reproduction and Development 72 250 258 10.1002/mrd.20336 1:CAS:528:DC%2BD2MXnt1ynsro%3D 15948184 (Pubitemid 41099414)
46. HF Miranda E Duran D Bustamante C Paeile G Pinardi 1994 Pre- and postjunctional muscarinic receptor subtypes in the vas deferens of rat General Pharmacology 25 1643 1647 1:CAS:528:DyaK2MXjsFers7Y%3D 7721040
47. HF Miranda E Duran E Fernandez G Pinardi 1995 Muscarinic receptor subtypes in the bisected vas deferens of the rat General Pharmacology 26 387 391 10.1016/0306-3623(94)00185-P 1:CAS:528:DyaK2MXkvVSjsL0%3D 7590092
48. I Nadelhaft 2003 Cholinergic axons in the rat prostate and neurons in the pelvic ganglion Brain Research 989 52 57 10.1016/S0006-8993(03)03353-5 1:CAS:528:DC%2BD3sXnslSkt7Y%3D 14519511 (Pubitemid 37281401)
49. NM Nathanson 2008 Synthesis, trafficking and localization of muscarinic acetylcholine receptors Pharmacology and Therapeutics 119 33 43 10.1016/j.pharmthera.2008.04.006 1:CAS:528:DC%2BD1cXotlaitrw%3D 18558434
50. Y Nouhouayi I Negulesco 1985 Adrenergic innervation of the smooth muscle cells of the cauda epididymis of the mouse Acta Anatomica 121 59 62 1:STN:280:DyaL2M7hvVWntQ%3D%3D 3969824
51. MC Orgebin-Crist N Jahad LH Hoffman 1976 The effects of testosterone, 5-alpha- dihydrotestosterone, 3alpha-androstanediol, and 3beta-androstanediol on the maturation of rabbit epididymal spermatozoa in organ culture Cell and Tissue Research 167 515 525 10.1007/BF00215181 1:CAS:528:DyaE28XksVWhsbw%3D 1268923
52. JN Pennefather WA Lau F Mitchelson S Ventura 2000 The autonomic and sensory innervation of the smooth muscle of the prostate gland: a review of pharmacological and histological studies Journal of Autonomic Pharmacology 20 193 206 10.1046/j.1365-2680.2000.00195.x 1:CAS:528:DC%2BD3MXit1Onsr4%3D 11260358 (Pubitemid 34211031)
53. C Pholpramool N Triphrom 1984 Effects of cholinergic and adrenergic drugs on intraluminal pressures and contractility of the rat testis and epididymis in vivo Journal of Reproduction and Fertility 71 181 188 1:CAS:528: DyaL2cXktFyjurc%3D 6144794
54. ZP Picarelli N Hyppolito JR Valle 1962 Synergistic effect of 5-hydroxytriptamine on response of rat seminal vesicle to adrenaline and noradrenaline Archives Internationales de Pharmacodynamie 138 354 363 1:CAS:528:DyaF3sXktlSq
55. BJ Proskocil HS Sekhon Y Jia V Savchenko RD Blakely J Lindstrom ER Spindel 2004 Acetylcholine is an autocrine or paracrine hormone synthesized and secreted by airway bronchial epithelial cells Endocrinology 145 2498 506 10.1210/en.2003-1728 1:CAS:528:DC%2BD2cXjsV2jsLY%3D 14764638 (Pubitemid 38535077)
56. DD Ricker 1998 The autonomic innervation of the epididymis: its effects on epididymal function and fertility Journal of Andrology 19 1 4 1:CAS:528:DyaK1cXhs1aisLY%3D 9537285
57. Robaire, B., & Hermo, L. (1988). Efferent Ducts, Epididymis, and Vas Deferens: Structure Functions, and their Regulation. In E. Knobil & J. D. Neill (Eds.), The Physiology of Reproduction, vol. 1 (pp. 999-1080). New York, NY: Raven.
58. T Sato Y Ban M Uchida E Gondo M Yamamoto Y Sekiguchi A Sakaue M Kemi T Nakatsuka 2005 Atropine-induced inhibition of sperm and semen transport impairs fertility in male rats Journal of Toxicological Sciences 30 207 212 10.2131/jts.30.207 1:CAS:528:DC%2BD2MXht1aiurrO 16141654 (Pubitemid 41305778)
59. Setchell, B. P., Maddocks, S., & Brooks, D. E. (1994). Anatomy, Vasculature, Innervation, and Fluids of the Male Reproductive Tract. In E. Knobil & J. Neill (Eds.), The Physiology of Reproduction (2nd ed., pp. 1063-1175). New York: Raven.
60. E Shapiro AR Miller H Lepor 1985 Down-regulation of the muscarinic cholinergic receptor of the rat prostate following castration Journal of Urology 134 179 182 1:CAS:528:DyaL2MXkvVWqur0%3D 4009819
61. AM Silva DBC Queiróz EF Castro Neto MG Naffah-Mazzacoratti RO Godinho CS Porto G Gutierrez-Ospina MCW Avellar 2002 Segment-specific decrease of both catecholamine concentration and acetylcholinesterase activity are accompanied by nerve refinement in the rat cauda epididymis during sexual maturation Journal of Andrology 23 374 383 1:CAS:528:DC%2BD38XjvVKmtLw%3D 12002439
62. ER Siu F Yasuhara E Maróstica MCW Avellar CS Porto 2006 Expression and localization of muscarinic acetylcholine receptor subtypes in the rat efferent ductules and epididymis Cell and Tissue Research 323 157 166 10.1007/s00441-005-0054-7 1:CAS:528:DC%2BD2MXht1CqtLzK 16160857 (Pubitemid 41677694)
63. TA Stewart IT Forrester 1978 Acetylcholinesterase and choline acetyltransferase in ram spermatozoa Biology of Reproduction 19 271 279 10.1095/biolreprod19.2.271 1:CAS:528:DyaE1cXmtFSqu78%3D 719088
64. S Ventura JN Pennefather 1991 Sympathetic co-transmission to the cauda epididymis of the rat: characterization of postjunctional adrenoceptors and purinoceptors British Journal of Pharmacology 102 540 544 1:CAS:528: DyaK3MXhtlKnu7c%3D 1849774
65. S Ventura J Pennefather F Mitchelson 2002 Cholinergic innervation and function in the prostate gland Pharmacology and Therapeutics 94 93 112 10.1016/S0163-7258(02)00174-2 1:CAS:528:DC%2BD38XksVSgsr8%3D 12191596 (Pubitemid 34615960)
66. JT Vreeburg MK Holland MC Orgebin-Crist 1992 Binding of epididymal proteins to rat spermatozoa in vivo Biology of Reproduction 47 588 597 10.1095/biolreprod47.4.588 1:CAS:528:DyaK38XmtV2msLw%3D 1391346
67. JM Wang KE McKenna KT McVary C Lee 1991 Requirement of innervation for maintenance of structural and functional integrity in the rat prostate Biology of Reproduction 44 1171 1176 10.1095/biolreprod44.6.1171 1:STN:280: DyaK3MzjvVahug%3D%3D 1873391
68. JM Wang KE McKenna C Lee 1991 Determination of prostatic secretion in rats: effect of neurotransmitters and testosterone Prostate 18 289 301 10.1002/pros.2990180403 1:CAS:528:DyaK3MXlslGksrY%3D 1676157
69. J Wess 2004 Muscarinic acetylcholine receptor knockout mice: novel phenotypes and clinical implications Annual Review of Pharmacology and Toxicology 44 423 450 10.1146/annurev.pharmtox.44.101802.121622 1:CAS:528:DC%2BD2cXhvVCktLY%3D 14744253 (Pubitemid 38263848)
70. J Wess RM Eglen D Gautam 2007 Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development Nature Reviews 6 721 728 10.1038/nrd2379 1:CAS:528:DC%2BD2sXpslaks7c%3D 17762886 (Pubitemid 47342315)
71. I Wessler CJ Kirkpatric 2008 Acetylcholine beyond neurons: the non-neuronal cholinergic system in humans British Journal of Pharmacology 154 1558 1571 10.1038/bjp.2008.185 1:CAS:528:DC%2BD1cXps1Grurg%3D 18500366
72. I Wessler CJ Kirkpatrick K Racke 1998 Non-neuronal acetylcholine, a locally acting molecule, widely distributed in biological systems: expression and function in humans Pharmacology and Therapeutics 77 59 79 10.1016/S0163-7258(97)00085-5 1:CAS:528:DyaK1cXmtFKltw%3D%3D 9500159 (Pubitemid 28059940)
73. RJ Young JC Laing 1991 The binding characteristics of cholinergic sites in rabbit spermatozoa Molecular Reproduction and Development 28 55 61 10.1002/mrd.1080280109 1:CAS:528:DyaK3MXkt1artL8%3D 1994980