The effect of human neural stem cells on neural regeneration according to transplantation timing: A rat spinal cord injury model

Neurosurgery Quarterly

Volumn 19, Issue 4, 2009, Pages 228-234

  Song, Kyung Jin ^a   Taghavi, Cyrus E ^b   Lee, Kwang Bok ^b,c   Wang, Jeffrey C ^b   Chung, Kwang Hoon ^c   Park, Yong Geun ^c   Nam, Uk ^c  

^a Chonbuk National University Medical School   (South Korea)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Jeju National University   (South Korea)

Author keywords

Neural recovery; Neural stem cell; Spinal cord injury

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CONVALESCENCE; FEMALE; GLIA CELL; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; NERVE REGENERATION; NEURAL STEM CELL TRANSPLANTATION; NONHUMAN; PRIORITY JOURNAL; PSEUDORABIES; PSEUDORABIES HERPETOVIRUS; RAT; SPINAL CORD INJURY;

EID: 74949141084     PISSN: 10506438     EISSN: None     Source Type: Journal    
DOI: 10.1097/WNQ.0b013e3181b0cea8     Document Type: Article

References (22)

1. Myckatyn TM, Mackinnon SE, McDonald JW. Stem cell transplantation and other novel techniques for promoting recovery from spinal cord injury. Transpl Immunol. 2004;12:343-358.
2. McDonald JW, Sadowsky C. Spinal cord injury. Lancet. 2002; 359:417-425.
3. Blesch A, Lu P, TuszynskiMH. Neurotrophic factors, gene therapy, and neural stem cells for spinal cord repair. Brain Res Bull. 2002;57:833-838.
4. Diers-Fenger M, Kirchhoff F, Kettenmann H, et al. AN2/NG2 protein-expressing glial progenitor cells in the murine CNS: isolation, differentiation, and association with radial glia. Glia. 2001;34:213-228.
5. Galvin K, Jones DG. Adult human neural stem cells for cell replacement therapies in the central nervous system. Med J Aust. 2002;177:316-318.
6. Liu S, Qu Y, Stewart TJ, et al. Embryonic stem cells differentiate into oligodendrocytes and myelinate in culture and after spinal cord transplantation. Proc Natl Acad Sci USA. 2000;97:6126-6131.
7. Lu P, Jones LL, Snyder EY, et al. Neural stem cells constitutively secrete neurotrophic factors and promote extensive host axonal growth after spinal cord injury. Exp Neurol. 2003;181:115-129.
8. Shihabuddin LS, Horner PJ, Ray J, et al. Adult spinal cord stem cells generate neurons after transplantation in the adult dentate gyrus. J Neurosci. 2000;20:8727-8735.
9. Cho T, Bae JH, Choi HB, et al. Human neural stem cells: electrophysiologic properties of voltage-gated ion channels. Neuroreport. 2002;13:1447-1452.
10. Flax JD, Aurora S, Yang C, et al. Engraftable human neural stem cells respond to developmental cues, replace neurons, and express foreign genes. Nat Biotechnol. 1998;16:1033-1039.
11. Chu K, Kim M, Jeong SW, et al. Human neural stem cells can migrate, differentiate, and integrate after intravenous transplantation in adult rats with transient forebrain ischemia. Neurosci Lett. 2003;343:129-133.
12. Lee EM, Kim JY, Cho BR, et al. Down-regulation of MHC class I expression in human neuronal stem cells using viral stealth mechanism. Biochem Biophys Res Commun. 2005;326: 825-835.
13. De Castro R, Tajrishi R, Claros J, et al. Differential responses of spinal axons to transection: influence of the NG2 proteoglycan. Exp Neurol. 2005;192:299-309.
14. Ankeny DP, McTigue DM, Jakeman LB. Bone marrow transplants provide tissue protection and directional guidance for axons after contusive spinal cord injury in rats. Exp Neurol. 2004; 190:17-31.
15. Caggiano AO, Zimber MP, Ganguly A, et al. Chondroitinase ABCI improves locomotion and bladder function following contusion injury of the rat spinal cord. J Neurotrauma. 2005;22:226-239.
16. Lu P, Jones LL, Tuszynski MH. BDNF-expressing marrow stromal cells support extensive axonal growth at sites of spinal cord injury. Exp Neurol. 2005;191:344-360.
17. Card JP, Rinaman L, Schwaber JS, et al. Neurotropic properties of pseudorabies virus: uptake and transneuronal passage in the rat central nervous system. J Neurosci. 1990;10:1976-1994.
18. Ko MH, Oh MY, Noh HS, et al. CNS cholinergic innervation to the hippocampus in the rat using pseudorabies virus as a neurotracer. J Korean Med Sci. 2001;16:209-213.
19. Byun DS, Sin SY, Seo JE, et al. Location of CNS labeled neurons innervating the rat thymus using the pseudorabies virus. Korean J Phys Anthropol. 1999;12:123-137.
20. Park HB, Koh M, Cho SH, et al. Mapping the rat somatosensory pathway from the anterior cruciate ligament nerve endings to the cerebrum. J Orthop Res. 2005;23:1419-1424.
21. Gerendai I, Toth IE, Boldogkoi Z, et al. CNS structures presumably involved in vagal control of ovarian function. J Auton Nerv Syst. 2000;80:40-45.
22. Basso DM, Beattie MS, Bresnahan JC. A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma. 1995;12:1-21.