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Volumn 33, Issue 1, 2010, Pages 4-9

Dyslipidemia in the elderly: Should it be treated?

Author keywords

[No Author keywords available]

Indexed keywords

ANTILIPEMIC AGENT; ATORVASTATIN; EZETIMIBE; FENOFIBRATE; GEMFIBROZIL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MEVINOLIN; NICOTINIC ACID; PLACEBO; PRAVASTATIN; ROSUVASTATIN; SIMVASTATIN; TRIACYLGLYCEROL;

EID: 74949120830     PISSN: 01609289     EISSN: 19328737     Source Type: Journal    
DOI: 10.1002/clc.20702     Document Type: Article
Times cited : (46)

References (41)
  • 1
    • 33644849222 scopus 로고    scopus 로고
    • Heart disease and stroke statistics - 2006 update: A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee
    • Thom T, Haase N, Rosamond W, et al. Heart disease and stroke statistics - 2006 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2006;113(6):e85-e151.
    • (2006) Circulation , vol.113 , Issue.6
    • Thom, T.1    Haase, N.2    Rosamond, W.3
  • 2
    • 0035897696 scopus 로고    scopus 로고
    • Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III)
    • Expert Panel on Detection
    • Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA. 2001;285(19):2486-2497.
    • (2001) JAMA , vol.285 , Issue.19 , pp. 2486-2497
  • 3
    • 3142729178 scopus 로고    scopus 로고
    • Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines
    • Grundy SM, Cleeman JI, Merz CN, et al. Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines. Circulation. 2004;110(2):227-239.
    • (2004) Circulation , vol.110 , Issue.2 , pp. 227-239
    • Grundy, S.M.1    Cleeman, J.I.2    Merz, C.N.3
  • 4
    • 0028849929 scopus 로고
    • Physiological predictors of increasing total and central adiposity in aging men and women
    • Poehlman ET, Toth MJ, Bunyard LB, et al. Physiological predictors of increasing total and central adiposity in aging men and women. Arch Intern Med. 1995;155(22):2443-2448.
    • (1995) Arch Intern Med , vol.155 , Issue.22 , pp. 2443-2448
    • Poehlman, E.T.1    Toth, M.J.2    Bunyard, L.B.3
  • 5
    • 0030465875 scopus 로고    scopus 로고
    • Fat and carbohydrate metabolism during exercise in elderly and young subjects
    • Sial S, Coggan AR, Carroll R, et al. Fat and carbohydrate metabolism during exercise in elderly and young subjects. Am J Physiol. 1996;271(6 Pt 1):E983-E989.
    • (1996) Am J Physiol , vol.271 , Issue.6 PART 1
    • Sial, S.1    Coggan, A.R.2    Carroll, R.3
  • 6
    • 0025255188 scopus 로고
    • Role of triglyceride-fatty acid cycle in controlling fat metabolism in humans during and after exercise
    • Wolfe RR, Klein S, Carraro F, Weber JM. Role of triglyceride-fatty acid cycle in controlling fat metabolism in humans during and after exercise. Am J Physiol. 1990;258(2 Pt 1):E382-E389.
    • (1990) Am J Physiol , vol.258 , Issue.2 PART 1
    • Wolfe, R.R.1    Klein, S.2    Carraro, F.3    Weber, J.M.4
  • 7
    • 0028342686 scopus 로고
    • Mechanisms of fatty acid-induced inhibition of glucose uptake
    • Boden G, Chen X, Ruiz J, et al. Mechanisms of fatty acid-induced inhibition of glucose uptake. J Clin Invest. 1994;93(6):2438-2446.
    • (1994) J Clin Invest , vol.93 , Issue.6 , pp. 2438-2446
    • Boden, G.1    Chen, X.2    Ruiz, J.3
  • 8
    • 0016433018 scopus 로고
    • Plasma-high-density-lipoprotein concentration and development of ischaemic heart-disease
    • Miller GJ, Miller NE. Plasma-high-density-lipoprotein concentration and development of ischaemic heart-disease. Lancet. 1975;1(7897):16-19.
    • (1975) Lancet , vol.1 , Issue.7897 , pp. 16-19
    • Miller, G.J.1    Miller, N.E.2
  • 9
    • 0017384270 scopus 로고
    • High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study
    • Gordon T, Castelli WP, Hjortland MC, et al. High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study. Am J Med. 1977;62(5):707-714.
    • (1977) Am J Med , vol.62 , Issue.5 , pp. 707-714
    • Gordon, T.1    Castelli, W.P.2    Hjortland, M.C.3
  • 10
    • 0032572086 scopus 로고    scopus 로고
    • Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: Results of AFCAPS/TexCAPS. Air Force/Texas Coronary Atherosclerosis Prevention Study
    • Downs JR, Clearfield M, Weis S, et al. Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPS. Air Force/Texas Coronary Atherosclerosis Prevention Study. JAMA. 1998;279(20):1615-1622.
    • (1998) JAMA , vol.279 , Issue.20 , pp. 1615-1622
    • Downs, J.R.1    Clearfield, M.2    Weis, S.3
  • 11
    • 4344683381 scopus 로고    scopus 로고
    • Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): Multicentre randomised placebo-controlled trial
    • Colhoun HM, Betteridge DJ, Durrington PN, et al. Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial. Lancet. 2004;364(9435):685-696.
    • (2004) Lancet , vol.364 , Issue.9435 , pp. 685-696
    • Colhoun, H.M.1    Betteridge, D.J.2    Durrington, P.N.3
  • 12
    • 33845493715 scopus 로고    scopus 로고
    • Analysis of efficacy and safety in patients aged 65-75 years at randomization: Collaborative Atorvastatin Diabetes Study (CARDS)
    • Neil HA, DeMicco DA, Luo D, et al. Analysis of efficacy and safety in patients aged 65-75 years at randomization: Collaborative Atorvastatin Diabetes Study (CARDS). Diabetes Care. 2006;29(11):2378-2384.
    • (2006) Diabetes Care , vol.29 , Issue.11 , pp. 2378-2384
    • Neil, H.A.1    DeMicco, D.A.2    Luo, D.3
  • 13
    • 0037166649 scopus 로고    scopus 로고
    • Therapy with hydroxymethylglutaryl coenzyme a reductase inhibitors (statins) and associated risk of incident cardiovascular events in older adults: Evidence from the Cardiovascular Health Study
    • Lemaitre RN, Psaty BM, Heckbert SR, et al. Therapy with hydroxymethylglutaryl coenzyme a reductase inhibitors (statins) and associated risk of incident cardiovascular events in older adults: evidence from the Cardiovascular Health Study. Arch Intern Med. 2002;162(12):1395-1400.
    • (2002) Arch Intern Med , vol.162 , Issue.12 , pp. 1395-1400
    • Lemaitre, R.N.1    Psaty, B.M.2    Heckbert, S.R.3
  • 14
    • 0037164314 scopus 로고    scopus 로고
    • Pravastatin in elderly individuals at risk of vascular disease (PROSPER): A randomised controlled trial
    • Shepherd J, Blauw GJ, Murphy MB, et al. Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial. Lancet. 2002;360(9346):1623-1630.
    • (2002) Lancet , vol.360 , Issue.9346 , pp. 1623-1630
    • Shepherd, J.1    Blauw, G.J.2    Murphy, M.B.3
  • 15
    • 56749106312 scopus 로고    scopus 로고
    • Rosuvastatin to prevent vascular events inmen and women with elevated C-reactive protein
    • Ridker PM, Danielson E, Fonseca FA, et al. Rosuvastatin to prevent vascular events inmen and women with elevated C-reactive protein. N Engl J Med. 2008;359(21):2195-2207.
    • (2008) N Engl J Med , vol.359 , Issue.21 , pp. 2195-2207
    • Ridker, P.M.1    Danielson, E.2    Fonseca, F.A.3
  • 16
    • 0344653659 scopus 로고    scopus 로고
    • Cholesterol-lowering therapy in women and elderly patients with myocardial infarction or angina pectoris: Findings from the Scandinavian Simvastatin Survival Study (4S)
    • Miettinen TA, Pyorala K, Olsson AG, et al. Cholesterol-lowering therapy in women and elderly patients with myocardial infarction or angina pectoris: findings from the Scandinavian Simvastatin Survival Study (4S). Circulation. 1997;96(12):4211-4218.
    • (1997) Circulation , vol.96 , Issue.12 , pp. 4211-4218
    • Miettinen, T.A.1    Pyorala, K.2    Olsson, A.G.3
  • 17
    • 0037031061 scopus 로고    scopus 로고
    • MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20 536 high-risk individuals: A randomised placebo-controlled trial
    • Heart Protection Study Collaborative Group
    • Heart Protection Study Collaborative Group. MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20 536 high-risk individuals: a randomised placebo-controlled trial. Lancet. 2002;360(9326):7-22.
    • (2002) Lancet , vol.360 , Issue.9326 , pp. 7-22
  • 18
    • 0342981862 scopus 로고    scopus 로고
    • The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events Trial investigators
    • Sacks FM, Pfeffer MA, Moye LA, et al. The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events Trial investigators. N Engl J Med. 1996;335(14):1001-1009.
    • (1996) N Engl J Med , vol.335 , Issue.14 , pp. 1001-1009
    • Sacks, F.M.1    Pfeffer, M.A.2    Moye, L.A.3
  • 19
    • 14444271787 scopus 로고    scopus 로고
    • Effect of pravastatin on cardiovascular events in older patients with myocardial infarction and cholesterol levels in the average range. Results of the Cholesterol and Recurrent Events (CARE) trial
    • Lewis SJ, Moye LA, Sacks FM, et al. Effect of pravastatin on cardiovascular events in older patients with myocardial infarction and cholesterol levels in the average range. Results of the Cholesterol and Recurrent Events (CARE) trial. Ann Intern Med. 1998;129(9):681-689.
    • (1998) Ann Intern Med , vol.129 , Issue.9 , pp. 681-689
    • Lewis, S.J.1    Moye, L.A.2    Sacks, F.M.3
  • 20
    • 0035873251 scopus 로고    scopus 로고
    • Benefits of pravastatin on cardiovascular events and mortality in older patients with coronary heart disease are equal to or exceed those seen in younger patients: Results from the LIPID trial
    • Hunt D, Young P, Simes J, et al. Benefits of pravastatin on cardiovascular events and mortality in older patients with coronary heart disease are equal to or exceed those seen in younger patients: Results from the LIPID trial. Ann Intern Med. 2001;134(10):931-940.
    • (2001) Ann Intern Med , vol.134 , Issue.10 , pp. 931-940
    • Hunt, D.1    Young, P.2    Simes, J.3
  • 21
    • 0032487931 scopus 로고    scopus 로고
    • Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group. N Engl J Med. 1998;339(19):1349-1357
    • Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group. N Engl J Med. 1998;339(19):1349-1357.
  • 22
    • 0035804846 scopus 로고    scopus 로고
    • Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes: The MIRACL study: a randomized controlled trial
    • Schwartz GG, Olsson AG, Ezekowitz MD, et al. Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes: the MIRACL study: a randomized controlled trial. JAMA. 2001;285(13):1711-1718.
    • (2001) JAMA , vol.285 , Issue.13 , pp. 1711-1718
    • Schwartz, G.G.1    Olsson, A.G.2    Ezekowitz, M.D.3
  • 23
    • 33847012971 scopus 로고    scopus 로고
    • Effects of high-dose atorvastatin in patients ≥65 years of age with acute coronary syndrome (from the myocardial ischemia reduction with aggressive cholesterol lowering [MIRACL] study)
    • Olsson AG, Schwartz GG, Szarek M, et al. Effects of high-dose atorvastatin in patients ≥65 years of age with acute coronary syndrome (from the myocardial ischemia reduction with aggressive cholesterol lowering [MIRACL] study). Am J Cardiol. 2007;99(5):632-635.
    • (2007) Am J Cardiol , vol.99 , Issue.5 , pp. 632-635
    • Olsson, A.G.1    Schwartz, G.G.2    Szarek, M.3
  • 24
    • 15944410609 scopus 로고    scopus 로고
    • Intensive lipid lowering with atorvastatin in patients with stable coronary disease
    • LaRosa JC, Grundy SM, Waters DD, et al. Intensive lipid lowering with atorvastatin in patients with stable coronary disease.N Engl J Med. 2005;352(14):1425-1435.
    • (2005) N Engl J Med , vol.352 , Issue.14 , pp. 1425-1435
    • LaRosa, J.C.1    Grundy, S.M.2    Waters, D.D.3
  • 25
    • 34447274822 scopus 로고    scopus 로고
    • Treating to New Targets Study Steering Committee and Investigators. Outcomes of using high- or low-dose atorvastatin in patients 65 years of age or older with stable coronary heart disease
    • Wenger NK, Lewis SJ, Herrington DM, et al. Treating to New Targets Study Steering Committee and Investigators. Outcomes of using high- or low-dose atorvastatin in patients 65 years of age or older with stable coronary heart disease. Ann Intern Med. 2007;147(1):1-9.
    • (2007) Ann Intern Med , vol.147 , Issue.1 , pp. 1-9
    • Wenger, N.K.1    Lewis, S.J.2    Herrington, D.M.3
  • 26
    • 33847171482 scopus 로고    scopus 로고
    • Effects of intensive versus moderate lipid-lowering therapy on myocardial ischemia in older patients with coronary heart disease: Results of the Study Assessing Goals in the Elderly (SAGE)
    • Deedwania P, Stone PH, Bairey Merz CN, et al. Effects of intensive versus moderate lipid-lowering therapy on myocardial ischemia in older patients with coronary heart disease: results of the Study Assessing Goals in the Elderly (SAGE). Circulation. 2007;115(6):700-707.
    • (2007) Circulation , vol.115 , Issue.6 , pp. 700-707
    • Deedwania, P.1    Stone, P.H.2    Bairey Merz, C.N.3
  • 27
    • 45549106669 scopus 로고    scopus 로고
    • Efficacy and safety of intensive statin therapy in the elderly
    • Maroo BP, Lavie CJ, Milani RV. Efficacy and safety of intensive statin therapy in the elderly. Am J Geriatr Cardiol. 2008;17(2):92-100.
    • (2008) Am J Geriatr Cardiol , vol.17 , Issue.2 , pp. 92-100
    • Maroo, B.P.1    Lavie, C.J.2    Milani, R.V.3
  • 28
    • 29944446607 scopus 로고    scopus 로고
    • Statins and cancer risk: A meta-analysis
    • Dale KM, Coleman CI, Henyan NN, et al. Statins and cancer risk: a meta-analysis. JAMA. 2006;295(1):74-80.
    • (2006) JAMA , vol.295 , Issue.1 , pp. 74-80
    • Dale, K.M.1    Coleman, C.I.2    Henyan, N.N.3
  • 29
    • 26244432388 scopus 로고    scopus 로고
    • Efficacy and safety of cholesterol-lowering treatment: Prospective meta-analysis of data from 90 056 participants in 14 randomised trials of statins
    • Baigent C, Keech A, Kearney PM, et al. Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90 056 participants in 14 randomised trials of statins. Lancet. 2005;366(9493):1267-1278.
    • (2005) Lancet , vol.366 , Issue.9493 , pp. 1267-1278
    • Baigent, C.1    Keech, A.2    Kearney, P.M.3
  • 30
    • 27644511663 scopus 로고    scopus 로고
    • Statins and cognitive function in the elderly: The Cardiovascular Health Study
    • Bernick C, Katz R, Smith NL, et al. Statins and cognitive function in the elderly: the Cardiovascular Health Study. Neurology. 2005;65(9):1388-1394.
    • (2005) Neurology , vol.65 , Issue.9 , pp. 1388-1394
    • Bernick, C.1    Katz, R.2    Smith, N.L.3
  • 31
    • 0034638746 scopus 로고    scopus 로고
    • Statins and the risk of dementia
    • Jick H, Zornberg GL, Jick SS, et al. Statins and the risk of dementia. Lancet. 2000;356(9242):1627-1631.
    • (2000) Lancet , vol.356 , Issue.9242 , pp. 1627-1631
    • Jick, H.1    Zornberg, G.L.2    Jick, S.S.3
  • 32
    • 0036126850 scopus 로고    scopus 로고
    • Use of lipid-lowering agents, indication bias, and the risk of dementia in community-dwelling elderly people
    • Rockwood K, Kirkland S, Hogan DB, et al. Use of lipid-lowering agents, indication bias, and the risk of dementia in community-dwelling elderly people. Arch Neurol. 2002;59(2):223-227.
    • (2002) Arch Neurol , vol.59 , Issue.2 , pp. 223-227
    • Rockwood, K.1    Kirkland, S.2    Hogan, D.B.3
  • 33
    • 13244295723 scopus 로고    scopus 로고
    • Do statins reduce risk of incident dementia and Alzheimer disease? The Cache County Study
    • Zandi PP, Sparks DL, Khachaturian AS, et al. Do statins reduce risk of incident dementia and Alzheimer disease? The Cache County Study. Arch Gen Psychiatry. 2005;62(2):217-224.
    • (2005) Arch Gen Psychiatry , vol.62 , Issue.2 , pp. 217-224
    • Zandi, P.P.1    Sparks, D.L.2    Khachaturian, A.S.3
  • 34
    • 0032568552 scopus 로고    scopus 로고
    • Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons
    • Simons M, Keller P, De Strooper B, et al. Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons. Proc Natl Acad Sci USA. 1998;95(11):6460-6464.
    • (1998) Proc Natl Acad Sci USA , vol.95 , Issue.11 , pp. 6460-6464
    • Simons, M.1    Keller, P.2    De Strooper, B.3
  • 35
    • 0026021035 scopus 로고
    • Coronary drug project: Experience with niacin. Coronary Drug Project Research Group
    • 40(Suppl. 1suppl 1):S
    • Berge KG, Canner PL. Coronary drug project: experience with niacin. Coronary Drug Project Research Group. Eur J Clin Pharmacol. 1991;40(Suppl. 1suppl 1):S49-S51.
    • (1991) Eur J Clin Pharmacol
    • Berge, K.G.1    Canner, P.L.2
  • 36
    • 20244370323 scopus 로고
    • Rationale and design of a secondary prevention trial of increasing serum high-density lipoprotein cholesterol and reducing triglycerides in patients with clinically manifest atherosclerotic heart disease (the Bezafibrate Infarction Prevention Trial)
    • Goldbourt U, Behar S, Reicher-Reiss H, et al. Rationale and design of a secondary prevention trial of increasing serum high-density lipoprotein cholesterol and reducing triglycerides in patients with clinically manifest atherosclerotic heart disease (the Bezafibrate Infarction Prevention Trial). Am J Cardiol. 1993;71(11):909-915.
    • (1993) Am J Cardiol , vol.71 , Issue.11 , pp. 909-915
    • Goldbourt, U.1    Behar, S.2    Reicher-Reiss, H.3
  • 37
    • 26844579239 scopus 로고    scopus 로고
    • Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study: Baseline characteristics and short-term effects of fenofibrate [ISRCTN64783481]
    • Scott R, Best J, Forder P, et al. Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study: baseline characteristics and short-term effects of fenofibrate [ISRCTN64783481]. Cardiovasc Diabetol. 2005;4:13.
    • (2005) Cardiovasc Diabetol , vol.4 , pp. 13
    • Scott, R.1    Best, J.2    Forder, P.3
  • 38
    • 34250785602 scopus 로고    scopus 로고
    • ACCORD Study Group. Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial: Design and methods
    • Buse JB, Bigger JT, Byington RP, et al; ACCORD Study Group. Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial: design and methods. Am J Cardiol. 2007;99(12A):21i-33i.
    • (2007) Am J Cardiol , vol.99 , Issue.12 A
    • Buse, J.B.1    Bigger, J.T.2    Byington, R.P.3
  • 39
    • 11344285421 scopus 로고    scopus 로고
    • Efficacy and safety of coadministration of ezetimibe and statins in elderly patients with primary hypercholesterolaemia
    • Lipka L, Sager P, Strony J, et al. Efficacy and safety of coadministration of ezetimibe and statins in elderly patients with primary hypercholesterolaemia. Drugs Aging. 2004;21(15):1025-1032.
    • (2004) Drugs Aging , vol.21 , Issue.15 , pp. 1025-1032
    • Lipka, L.1    Sager, P.2    Strony, J.3
  • 40
    • 4544368258 scopus 로고    scopus 로고
    • Mediterranean diet, lifestyle factors, and 10-year mortality in elderly European men and women: The HALE project
    • Knoops KT, de Groot LC, Kromhout D, et al. Mediterranean diet, lifestyle factors, and 10-year mortality in elderly European men and women: the HALE project. JAMA. 2004;292(12):1433-1439.
    • (2004) JAMA , vol.292 , Issue.12 , pp. 1433-1439
    • Knoops, K.T.1    de Groot, L.C.2    Kromhout, D.3
  • 41
    • 0004324213 scopus 로고    scopus 로고
    • Statement on exercise: Benefits and recommendations for physical activity programs for all Americans. A statement for health professionals by the Committee on Exercise and Cardiac Rehabilitation of the Council on Clinical Cardiology, American Heart Association
    • Fletcher GF, Balady G, Blair SN, et al. Statement on exercise: benefits and recommendations for physical activity programs for all Americans. A statement for health professionals by the Committee on Exercise and Cardiac Rehabilitation of the Council on Clinical Cardiology, American Heart Association. Circulation. 1996;94(4):857-862.
    • (1996) Circulation , vol.94 , Issue.4 , pp. 857-862
    • Fletcher, G.F.1    Balady, G.2    Blair, S.N.3


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