Absence of TLR2 influences survival of neutrophils after infection with Candida albicans

Medical Mycology

Volumn 48, Issue 1, 2010, Pages 129-140

  Tessarolli, Venessa ^a   Gasparoto, Thaís Helena ^a   Lima, Hayana Ramos ^a   Figueira, Eduardo Aleixo ^a   Garlet, Thiago Pompermaier ^a   Torres, Sérgio Aparecido ^a   Garlet, Gustavo Pompermaier ^a   Da Silva, João Santana ^a   Campanelli, Ana Paula ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Candida albicans; Innate response; TLR2

Indexed keywords

CHEMOKINE; MYELOPEROXIDASE; NITRIC OXIDE; TOLL LIKE RECEPTOR 2; CYTOKINE; PEROXIDASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANDIDA ALBICANS; CANDIDIASIS; CELL FUNCTION; CELL SURVIVAL; CHEMOTAXIS; CONTROLLED STUDY; ENZYME ACTIVITY; LYMPH NODE; MACROPHAGE; MALE; MOUSE; NEUTROPHIL; NONHUMAN; PATHOGENESIS; PHAGOCYTOSIS; SPLEEN; ANIMAL; BAGG ALBINO MOUSE; CYTOLOGY; DEFICIENCY; DISEASE MODEL; EXUDATE; HUMAN; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; MICROBIOLOGY; PATHOGENICITY; SECRETION (PROCESS);

CANDIDA ALBICANS; MUS;

ANIMALS; CANDIDA ALBICANS; CANDIDIASIS; CELL SURVIVAL; CHEMOTAXIS; CYTOKINES; DISEASE MODELS, ANIMAL; EXUDATES AND TRANSUDATES; HUMANS; LYMPH NODES; MALE; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; NEUTROPHILS; NITRIC OXIDE; PEROXIDASE; PHAGOCYTOSIS; SPLEEN; TOLL-LIKE RECEPTOR 2;

EID: 74949113915     PISSN: 13693786     EISSN: 14602709     Source Type: Journal    
DOI: 10.3109/13693780902964339     Document Type: Article

References (43)

1. Odds F. Candida and Candidosis: A Review and Bibliography. London: Bailliere and Tindcell, 1988.
2. Sharma G, Pai KM, Suhas S, et al. Oral manifestations in HIV/AIDS infected patients from India. Oral Dis 2006; 12: 537-542.
3. Shoham S, Levitz SM. The immune response to fungal infections. Br J Haematol 2005; 129: 569-582.
4. Hu Y, Farah CS, Ashman RB. Effector function of leucocytes from susceptible and resistant mice against distinct isolates of Candida albicans. Immunol Cell Biol 2006; 84: 455-460.
5. Urban CF, Lourido S, Zychlinsky A. How do microbes evade neutrophil killing? Cell Microbiol 2006; 8: 1687-1696.
6. Fidel PL, Jr. Immunity to Candida. Oral Dis 2002; 8 ( Suppl. 2 ): 69-75.
7. Roeder A, Kirschning CJ, Rupec RA, et al. Toll-like receptors as key mediators in innate antifungal immunity. Med Mycol 2004; 42: 485-498. (Pubitemid 40109561)
8. Tada H, Nemoto E, Shimauchi H, et al. Saccharomyces cerevisiae - and Candida albicans -derived mannan induced production of tumor necrosis factor alpha by human monocytes in a CD14- and Toll-like receptor 4-dependent manner. Microbiol Immunol 2002; 46: 503-512.
9. Jouault T, Ibata-Ombetta S, Takeuchi O, et al. Candida albicans phospholipomannan is sensed through toll-like receptors. J Infect Dis 2003; 188: 165-672.
10. Underhill DM, Ozinsky A, Hajjar AM, et al. The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens. Nature 1999; 401: 811-815.
11. Sabroe I, Prince LR, Jones EC, et al. Selective roles for Toll-like receptor (TLR)2 and TLR4 in the regulation of neutrophil activation and life span. J Immunol 2003; 170: 5268-5275.
12. Klotz SA, Gaur NK, Rauceo J, et al. Inhibition of adherence and killing of Candida albicans with a 23-Mer peptide (Fn/23) with dual antifungal properties. Antimicrob Agents Chemother 2004; 48: 4337-4341.
13. Gasparoto TH, Gaziri LC, Burger E, De Almeida RS, Felipe I. Apoptosis of phagocytic cells induced by Candida albicans and production of IL-10. FEMS Immunol Med Microbiol 2004; 42: 219-224.
14. Elahi S, Pang G, Ashman RB, Clancy R. Nitric oxide-enhanced resistance to oral candidiasis. Immunology 2001; 104: 447-454.
15. Garlet GP, Cardoso CR, Campanelli AP, et al. The dual role of p55 tumor necrosis factor-alpha receptor in Actinobacillus actinomycetemcomitans -induced experimental periodontitis: host protection and tissue destruction. Clin Exp Immunol 2007; 147: 128-138.
16. Kobayashi SD, Voyich JM, Buhl CL, Stahl RM, DeLeo FR. Global changes in gene expression by human polymorphonuclear leukocytes during receptor-mediated phagocytosis: cell fate is regulated at the level of gene expression. Proc Natl Acad Sci USA 2002; 99: 6901-6906.
17. Arimilli S, Ferlin W, Solvason N, et al. Chemokines in autoimmune diseases. Immunol Rev 2000; 177: 43-51.
18. Gantner BN, Simmons RM, Canavera SJ, Akira S, Underhill DM. Collaborative induction of infl ammatory responses by dectin-1 and Toll-like receptor 2. J Exp Med 2003; 197: 1107-1117.
19. Villamon E, Gozalbo D, Roig P, et al. Toll-like receptor-2 is essential in murine defenses against Candida albicans infections. Microbes Infect. 2004; 6: 1-7.
20. Blasi E, Mucci A, Neglia R, et al. Biological importance of the two Toll-like receptors, TLR2 and TLR4, in macrophage response to infection with Candida albicans. FEMS Immunol Med Microbiol 2005; 44: 69-79.
21. Jouault T, El Abed-El Behi M, Martinez-Esparza M, et al. Specific recognition of Candida albicans by macrophages requires galectin-3 to discriminate Saccharomyces cerevisiae and needs association with TLR2 for signaling. J Immunol 2006; 177: 4679-4687.
22. Bellocchio S, Montagnoli C, Bozza S, et al. The contribution of the Toll-like/IL-1 receptor superfamily to innate and adaptive immunity to fungal pathogens in vivo. J Immunol 2004; 172: 3059-3069.
23. Underhill DM. Toll-like receptors: networking for success. Eur J Immunol 2003; 33: 1767-1775.
24. Blander JM, Medzhitov R. On regulation of phagosome maturation and antigen presentation. Nat Immunol 2006; 7: 1029-1035.
25. Vazquez-Torres A, Jones-Carson J, Balish E. Peroxynitrite contributes to the candidacidal activity of nitric oxide-producing macrophages. Infect Immun 1996; 64: 3127-3133.
26. Fierro IM, Barja-Fidalgo C, Cunha FQ, Ferreira SH. The involvement of nitric oxide in the anti- Candida albicans activity of rat neutrophils. Immunology 1996; 89: 295-300.
27. Aratani Y, Koyama H, Nyui S, et al. Severe impairment in early host defense against Candida albicans in mice deficient in myeloperoxidase. Infect Immun 1999; 67: 1828-1836.
28. Kilpatrick LE, Sun S, Mackie D, et al. Regulation of TNF mediated antiapoptotic signaling in human neutrophils: role of delta-PKC and ERK1/2. J Leukoc Biol 2006; 80: 1512-1521.
29. Sabroe I, Dower SK, Whyte MK. The role of Toll-like receptors in the regulation of neutrophil migration, activation, and apoptosis. Clin Infect Dis 2005; 41 ( Suppl. 7 ): S421 - 426. (Pubitemid 41598299)
30. Panagio LA, Felipe I, Vidotto MC, Gaziri LC. Early membrane exposure of phosphatidylserine followed by late necrosis in murine macrophages induced by Candida albicans from an HIV-infected individual. J Med Microbiol 2002; 51: 929-936.
31. Renna MS, Correa SG, Porporatto C, et al. Hepatocellular apoptosis during Candida albicans colonization: involvement of TNF-alpha and infi ltrating Fas-L positive lymphocytes. Int Immunol 2006; 18: 1719-1728.
32. Netea MG, van Tits LJ, Curfs JH, et al. Increased susceptibility of TNF-alpha lymphotoxin-alpha double knockout mice to systemic candidiasis through impaired recruitment of neutrophils and phagocytosis of Candida albicans. J Immunol 1999; 163: 1498-1505.
33. Marr KA, Balajee SA, Hawn TR, et al. Differential role of MyD88 in macrophage-mediated responses to opportunistic fungal pathogens. Infect Immun 2003; 71: 5280-5286.
34. Aderem A, Ulevitch RJ. Toll-like receptors in the induction of the innate immune response. Nature 2000; 406: 782-787.
35. Ozinsky A, Underhill DM, Fontenot JD, et al. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors. Proc Natl Acad Sci USA 2000; 97: 13766-13771.
36. Wheeler RT, Fink GR. A drug-sensitive genetic network masks fungi from the immune system. PLoS Pathog 2006; 2: e35.
37. Liu RK, Cao CF, Meng HX, Gao Y. Polymorphonuclear neutrophils and their mediators in gingival tissues from generalized aggressive periodontitis. J Periodontol 2001; 72: 1545-1553.
38. Ashman RB, Papadimitriou JM. Production and function of cytokines in natural and acquired immunity to Candida albicans infection. Microbiol Rev 1995; 59: 646-672.
39. Vonk AG, Netea MG, van Krieken JH, et al. Endogenous interleukin (IL)-1 alpha and IL-1 beta are crucial for host defense against disseminated candidiasis. J Infect Dis 2006; 193: 1419-1426.
40. Torosantucci A, Chiani P, Cassone A. Differential chemokine response of human monocytes to yeast and hyphal forms of Candida albicans and its relation to the beta-1,6 glucan of the fungal cell wall. J Leukoc Biol 2000; 68: 923-932.
41. Rot A, von Andrian UH. Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells. Annu Rev Immunol 2004; 22: 891-928.
42. Gil ML, Gozalbo D. TLR2, but not TLR4, triggers cytokine production by murine cells in response to Candida albicans yeasts and hyphae. Microbes Infect 2006; 8: 2299-2304.
43. Netea MG, Sutmuller R, Hermann C, et al. Toll-like receptor 2 suppresses immunity against Candida albicans through induction of IL-10 and regulatory T cells. J Immunol 2004; 172: 3712-3718.