Inhibitory effects of dauricine on early afterdepolarizations and L-type calcium current

Canadian Journal of Physiology and Pharmacology

Volumn 87, Issue 11, 2009, Pages 954-962

  Liu, Qiang Ni ^a   Zhang, Li ^a   Gong, Pei Li ^a   Yang, Xiao Yan ^a   Zeng, Fan Dian ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Dauricine; Dofetilide; Early afterdepolarization; Hypertrophy; Hypokalemia; L type calcium current; Triangulation

Indexed keywords

CALCIUM CHANNEL L TYPE; DAURICINE; DOFETILIDE;

ACTION POTENTIAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA COARCTATION; ARTICLE; CALCIUM CURRENT; CONCENTRATION RESPONSE; CONTROLLED STUDY; FEMALE; HEART DEPOLARIZATION; HEART MUSCLE CELL; HEART PAPILLARY MUSCLE; HEART REPOLARIZATION; HEART VENTRICLE HYPERTROPHY; HYPOKALEMIA; HYPOMAGNESEMIA; MALE; MICROELECTRODE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; STEADY STATE;

ACTION POTENTIALS; ANIMALS; ANTI-ARRHYTHMIA AGENTS; BENZYLISOQUINOLINES; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HYPERTROPHY, LEFT VENTRICULAR; LONG QT SYNDROME; MAGNESIUM; MALE; MYOCYTES, CARDIAC; NEUROMUSCULAR DEPOLARIZING AGENTS; PAPILLARY MUSCLES; PATCH-CLAMP TECHNIQUES; PHENETHYLAMINES; POTASSIUM; POTASSIUM CHANNEL BLOCKERS; RABBITS; SULFONAMIDES; TETRAHYDROISOQUINOLINES;

EID: 74849127153     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/Y09-090     Document Type: Article

References (23)

1. Antzelevitch, C., El-Sherif, N., Rosenbaum, D., and Vos, M. 2003. Cellular mechanisms underlying the long QT syndrome. J. Cardiovasc. Electrophysiol. 14(1): 114-115. doi:10.1046/j.1540-8167.2003.02480-1.x. PMID:12625624.
2. Belardinelli, L., Antzelevitch, C., and Vos, M.A. 2003. Assessing predictors of drug-induced torsade de pointes. Trends Pharmacol. Sci. 24(12): 619-625. doi:10.1016/j.tips.2003.10.002. PMID:14654302.
3. Camm, A.J., Janse, M.J., Roden, D.M., Rosen, M.R., Cinca, J., and Cobbe, S.M. 2000. Congenital and acquired long QT syndrome. Eur. Heart J. 21(15): 1232-1237. doi:10.1053/euhj.2000.2222. PMID:10924312.
4. Dhein, S., Perlitz, F., and Mohr, F.W. 2008. An in vitro model for assessment of drug-induced torsade de pointes arrhythmia: effects of haloperidol and dofetilide on potential duration, repolarization inhomogeneities, and torsade de pointes arrhythmia. Naunyn Schmiedebergs Arch Pharmacol. 378(6): 631-644. doi:10.1007/s00210-008-0329-0. PMID:18648775.
5. Eckardt, L., Haverkamp, W., Johna, R., Böcker, D., Deng, M.C., Breithardt, G., and Borggrefe, M. 2000. Arrhythmias in heart failure: current concepts of mechanisms and therapy. J. Cardiovasc. Electrophysiol. 11(1): 106-117. doi:10.1111/j.1540-8167.2000.tb00746.x. PMID:10695472.
6. Gillis, A. M., Geonzon, R. A., Mathison, H. J., Kulisz, E., Lester, W. M., and Duff, H. J. 1998. The effects of barium, dofetilide and 4-aminopyridine (4-AP) on ventricular repolarization in normal and hypertrophied rabbit heart. J. Pharmacol. Exp. Ther. 285: 262-270. PMID- 9536020.
7. Guo, D.L., Zeng, F.D., and Hu, C.J. 1997a. Effects of dauricine, quinidine, and sotalol on action potential duration of papillary muscles in vitro. Zhongguo Yao Li Xue Bao, 18(4): 348-350. PMID:10072920.
8. Guo, D.L., Zhou, Z.N., Zeng, F.D., and Hu, C.J. 1997b. Dauricine inhibited L-type calcium current in single cardiomyocyte of guinea pig. Zhongguo Yao Li Xue Bao, 18(5): 419-421. PMID:10322931.
9. Guo, D.L., Zhao, X., Wu, Y., Liu, T., Kowey, P.R., and Yan, G.X. 2007. L-type calcium current reactivation contributes to arrhythmogenesis associated with action potential triangulation. J. Cardiovasc. Electrophysiol. 18(2): 196-203. doi:10.1111/j.1540-8167.2006.00698.x. PMID:17212595.
10. Hondeghem, L.M., Carlsson, L., and Duker, G. 2001a. Instability and triangulation of the action potential predict serious proarrhythmia, but action potential duration prolongation is antiarrhythmic. Circulation, 103(15): 2004-2013. PMID:11306531.
11. Hondeghem, L.M., Dujardin, K., and De Clerck, F. 2001b. Phase 2 prolongation, in the absence of instability and triangulation, antagonizes class III proarrhythmia. Cardiovasc. Res. 50(2): 345-353. doi:10.1016/S0008- 6363(01)00259-0. PMID:11334838.
12. Huang, Z.J., Dai, D.Z., Li, N., Na, T., Ji, M., and Dai, Y. 2007. Calcium antagonist property of CPU228, a dofetilide derivative, contributes to its low incidence of torsades de pointes in rabbits. Clin. Exp. Pharmacol. Physiol. 34(4): 310-317. doi:10.1111/j.1440-1681.2007.04555.x. PMID:17324143.
13. 2+ current. Circ. Res. 64(5): 977-990. PMID:2468430.
14. Li, Q., Yin, J.X., and He, R.R. 2002. Effect of agmatine on L-type calcium current in rat ventricular myocytes. Acta Pharmacol. Sin. 23(3): 219-224. PMID:11918845.
15. Lu, H.R., Vlaminckx, E., Van Ammel, K., and De Clerck, F. 2002. Drug-induced long QT in isolated rabbit Purkinje fibers: importance of action potential duration, triangulation and early afterdepolarizations. Eur. J. Pharmacol. 452(2): 183-192. doi:10.1016/S0014-2999(02)02246-X. PMID:12354568.
16. Milberg, P., Eckardt, L., Bruns, H.J., Biertz, J., Ramtin, S., Reinsch, N., et al. 2002. Divergent proarrhythmic potential of macrolide antibiotics despite similar QT prolongation: fast phase 3 repolarization prevents early afterdepolarizations and torsade de pointes. J. Pharmacol. Exp. Ther. 303(1): 218-225. doi:10.1124/jpet.102.037911. PMID:12235254.
17. Redfern, W.S., Carlsson, L., Davis, A.S., Lynch, W.G., MacKenzie, I., Palethorpe, S., et al. 2003. Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development. Cardiovasc. Res. 58(1): 32-45. doi:10.1016/S0008-6363(02) 00846-5. PMID:12667944.
18. Tsujimae, K., Suzuki, S., Yamada, M., and Kurachi, Y. 2004. Comparison of kinetic properties of quinidine and dofetilide block of HERG channels. Eur. J. Pharmacol. 493(1-3): 29-40. doi:10.1016/j.ejphar.2004.04.015. PMID:15189761.
19. Valentin, J.P., Hoffmann, P., De Clerck, F., Hammond, T.G., and Hondeghem, L. 2004. Review of the predictive value of the Langendorff heart model (Screenit system) in assessing the proarrhythmic potential of drugs. J. Pharmacol. Toxicol. Methods, 49(3): 171-181. doi:10.1016/j.vascn.2004.03. 008. PMID:15172013.
20. van Opstal, J.M., Schoenmakers, M., Verduyn, S.C., de Groot, S.H., Leunissen, J.D., van Der Hulst, F.F., et al. 2001. Chronic amiodarone evokes no torsade de pointes arrhythmias despite QT lengthening in an animal model of acquired long-QT syndrome. Circulation, 104(22): 2722-2727. doi:10.1161/hc4701.099579. PMID:11723026.
21. Xia, J.S., Tu, H., Li, Z., and Zeng, F.D. 1999. Dauricine suppressed CsCl-induced early afterdepolarizations and triggered arrhythmias in rabbit heart in vivo. Zhongguo Yao Li Xue Bao, 20(6): 513-516. PMID:10678143.
22. Yan, G.X., Wu, Y., Liu, T., Wang, J., Marinchak, R.A., and Kowey, P.R. 2001. Phase 2 early afterdepolarization as a trigger of polymorphic ventricular tachycardia in acquired long-QT syndrome: direct evidence from intracellular recordings in the intact left ventricular wall. Circulation, 103(23): 2851-2856. PMID:11401944.
23. Yan, G.X., Joshi, A., Guo, D., Hlaing, T., Martin, J., Xu, X., and Kowey, P.R. 2004. Phase 2 reentry as a trigger to initiate ventricular fibrillation during early acute myocardial ischemia. Circulation, 110(9): 1036-1041. doi:10.1161/01.CIR.0000140258.09964.19. PMID:15302777.