Methylglyoxal causes dysfunction of thioredoxin and thioredoxin reductase in endothelial cells

Journal of Pharmacological Sciences

Volumn 111, Issue 4, 2009, Pages 426-432

  Tatsunami, Ryosuke ^a   Oba, Tatsuya ^a   Takahashi, Kyohei ^a   Tampo, Yoshiko ^a  

^a HOKKAIDO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

Endothelial cell; Methylglyoxal; Peroxiredoxin; Thioredoxin; Thioredoxin reductase

Indexed keywords

CARBONYL DERIVATIVE; GLUTAREDOXIN; METHYLGLYOXAL; PEROXIREDOXIN; THIOREDOXIN; THIOREDOXIN REDUCTASE;

ANIMAL CELL; AORTA; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; COW; DEFENSE MECHANISM; ENDOTHELIUM CELL; ENZYME ACTIVITY; NONHUMAN; OXIDATION; OXIDATIVE STRESS; WESTERN BLOTTING;

EID: 74849111826     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.09131FP     Document Type: Article

References (36)

1. Mukohda M, Yamawaki H, Nomura H, Okada M, Hara Y. Methylglyoxal inhibits smooth muscle contraction in isolated blood vessels. J Pharmacol Sci. 2009;109:305-310.
2. Kalapos MP. Methylglyoxal and glucose metabolism: a historical perspective and future avenues for research. Drug Metabol Drug Interact. 2008;23:69-91.
3. Thornalley PJ, Langborg A, Minhas HS. Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose. Biochem J. 1999;344:109-116.
4. McLellan AC, Thornalley PJ, Benn J, Sonksen PH. Glyoxalase system in clinical diabetes mellitus and correlation with diabetic complications. Clin Sci (Lond). 1994;87:21-29.
5. Cantero AV, Portero-Otín M, Ayala V, Auge N, Sanson M, Elbaz M, et al. Methylglyoxal induces advanced glycation end product (AGEs) formation and dysfunction of PDGF receptor-beta: implications for diabetic atherosclerosis. FASEB J. 2007;21:3096-3106.
6. Sakurai K, Sawamura T. Stress and vascular responses: endothelial dysfunction via lectin-like oxidized low-density lipoprotein receptor-1: close relationships with oxidative stress. J Pharmacol Sci. 2003;91:182-186.
7. Kimura S, Zhang GX, Abe Y. Malfunction of vascular control in lifestyle-related diseases: oxidative stress of angiotensin II-induced hypertension: mitogen-activated protein kinases and blood pressure regulation. J Pharmacol Sci. 2004;96:406-410.
8. Jabeen R, Mohammad AA, Elefano EC, Petersen JR, Saleemuddin M. Antibodies and Fab fragments protect Cu, Zn-SOD against methylglyoxal-induced inactivation. Biochim Biophys Acta. 2006;1760:1167-1174.
9. Park YS, Koh YH, Takahashi M, Miyamoto Y, Suzuki K, Dohmae N, et al. Identification of the binding site of methylglyoxal on glutathione peroxidase: methylglyoxal inhibits glutathione peroxidase activity via binding to glutathione binding sites Arg 184 and 185. Free Radic Res. 2003;37:205-211.
10. Mori A, Saigo O, Hanada M, Nakahara T, Ishii K. Hyperglycemia accelerates impairment of vasodilator responses to acetylcholine of retinal blood vessels in rats. J Pharmacol Sci. 2009;110:160-168.
11. de Cavanagh EM, Inserra F, Toblli J, Stella I, Fraga CG, Ferder L. Enalapril attenuates oxidative stress in diabetic rats. Hypertension. 2001;38:1130-1136.
12. Bidasee KR, Nallani K, Besch HR Jr, Dincer UD. Streptozotocin-induced diabetes increases disulfide bond formation on cardiac ryanodine receptor (RyR2). J Pharmacol Exp Ther. 2003;305:989-998.
13. Berndt C, Lillig CH, Holmgren A. Thiol-based mechanisms of the thioredoxin and glutaredoxin systems: implications for diseases in the cardiovascular system. Am J Physiol Heart Circ Physiol. 2007;292:H1227-H1236.
14. Ceriello A, Bortolotti N, Falleti E, Taboga C, Tonutti L, Crescentini A, et al. Total radical-trapping antioxidant parameter in NIDDM patients. Diabetes Care. 1997;20:194-197.
15. Yamawaki H, Haendeler J, Berk BC. Thioredoxin: a key regulator of cardiovascular homeostasis. Circ Res. 2003;93:1029-1033.
16. Myers CR, Myers JM. The effects of acrolein on peroxiredoxins, thioredoxins, and thioredoxin reductase in human bronchial epithelial cells. Toxicology. 2009;257:95-104.
17. Schulze PC, Yoshioka J, Takahashi T, He Z, King GL, Lee RT. Hyperglycemia promotes oxidative stress through inhibition of thioredoxin function by thioredoxin-interacting protein. J Biol Chem. 2004;279:30369-30374.
18. Parthasarathy S, Barnett J, Fong LG. High density lipoprotein inhibits the oxidative modification of low density lipoprotein. Biochim Biophys Acta. 1990;1044:275-283.
19. Connolly DT, Knight MB, Harakas NK, Wittwer AJ, Feder, J. Determination of the number of endothelial cells in culture using an acid phosphatase assay. Anal Biochem. 1986;152:136-140.
20. Holmgren A, Björnstedt M. Thioredoxin and thioredoxin reductase. Methods Enzymol. 1995;252:199-208.
21. Mieyal JJ, Starke DW, Gravina SA, Dothey C, Chung JS. Thioltransferase in human red blood cells: purification and properties. Biochemistry. 1991;30:6088-6097.
22. Cox AG, Pullar JM, Hughes G, Ledgerwood EC, Hampton MB. Oxidation of mitochondrial peroxiredoxin 3 during the initiation of receptor-mediated apoptosis. Free Radic Biol Med. 2008;44:1001-1009.
23. Chevion M, Berenshtein E, Stadtman ER. Human studies related to protein oxidation: protein carbonyl content as a marker of damage. Free Radic Res. 2000;33:S99-S108.
24. Takahashi K, Shibata T, Oba T, Ishikawa T, Yoshikawa M, Tatsunami R, et al. Multidrug-resistance-associated protein plays a protective role in menadione-induced oxidative stress in endothelial cells. Life Sci. 2009;84:211-217.
25. Wood ZA, Schroder E, Robin Harris J, Poole LB. Structure, mechanism and regulation of peroxiredoxins. Trends Biochem Sci. 2003;28:32-40.
26. Barranco-Medina S, Lazaro JJ, Dietz KJ. The oligomeric conformation of peroxiredoxins links redox state to function. FEBS Lett. 2009;583:1809-1816.
27. Takahashi K, Tatsunami R, Tampo Y. [Methylglyoxal-induced apoptosis of endothelial cells.] Yakugaku Zasshi. 2008;128:1443-1448. (text in Japanese with English abstract)
28. Tatsunami R, Takahashi K, Oba T, Tampo Y. [Methylglyoxal-induced superoxide anion production in endothelial cells.] Yakugaku Zasshi. 2009;129:147-153. (text in Japanese with English abstract)
29. Chang T, Wu L. Methylglyoxal, oxidative stress, and hypertension. Can J Physiol Pharmacol. 2006;84:1229-1238.
30. Mirza MA, Kandhro AJ, Memon SQ, Khuhawar MY, Arain R. Determination of glyoxal and methylglyoxal in the serum of diabetic patients by MEKC using stilbenediamine as derivatizing reagent. Electrophoresis. 2007;28:3940-3947.
31. Odani H, Shinzato T, Matsumoto Y, Usami J, Maeda K. Increase in three α,β-dicarbonyl compound levels in human uremic plasma: specific in vivo determination of intermediates in advanced Maillard reaction. Biochem Biophys Res Commun. 1999;256:89-93.
32. Che W, Asahi M, Takahashi M, Kaneto H, Okado A, Higashiyama S, et al. Selective induction of heparin-binding epidermal growth factor-like growth factor by methylglyoxal and 3-deoxyglucosone in rat aortic smooth muscle cells. The involvement of reactive oxygen species formation and a possible implication for atherogenesis in diabetes. J Biol Chem. 1997;272:18453-18459.
33. Chaplen FW, Fahl WE, Cameron DC. Evidence of high levels of methylglyoxal in cultured Chinese hamster ovary cells. Proc Natl Acad Sci U S A. 1998;95:5533-5538.
34. Fukunaga M, Miyata S, Liu BF, Miyazaki H, Hirota Y, Higo S, et al. Methylglyoxal induces apoptosis through activation of p38 MAPK in rat Schwann cells. Biochem Biophys Res Commun. 2004;320:689-695.
35. Du J, Suzuki H, Nagase F, Akhand AA, Yokoyama T, Miyata T, et al. Methylglyoxal induces apoptosis in Jurkat leukemia T cells by activating c-Jun N-terminal kinase. J Cell Biochem. 2000;77:333-344.
36. Saitoh M, Nishitoh H, Fujii M, Takeda K, Tobiume K, Sawada Y, et al. Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1. EMBO J. 1998;17:2596-2606.