IL-6 adsorption dynamics in hemoadsorption beads studied using confocal laser scanning microscopy

Journal of Biomedical Materials Research - Part B Applied Biomaterials

Volumn 92, Issue 2, 2010, Pages 390-396

  Kimmel, Jeremy D ^a,b   Gibson, Gregory A ^c   Watkins, Simon C ^c   Kellum, John A ^c   Federspiel, William J ^a,b,d  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b University of Pittsburgh   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

Adsorption; Blood purification; CLSM; Cytokine; Sepsis

Indexed keywords

ADSORPTION DYNAMICS; ADSORPTION PROFILE; BLOOD PURIFICATION; CLSM; CONFOCAL LASER SCANNING MICROSCOPY; CYTOKINES; EFFECTIVE DIFFUSION COEFFICIENTS; INFLAMMATORY MEDIATORS; INFLAMMATORY RESPONSE; INTENSITY PROFILES; INTRAPARTICLE; LANGMUIR ADSORPTION ISOTHERMS; LARGE DIAMETER; MATRIX; MODEL PARAMETERS; ORGAN FAILURE; SORBENT PARTICLES; SORBENT SURFACE; SURFACE AREA; TIME PERIODS;

BLOOD; CONFOCAL MICROSCOPY; MATHEMATICAL MODELS; PURIFICATION; SORBENTS;

ADSORPTION;

BIOMATERIAL; INTERLEUKIN 6; POLYMER; SORBENT BEAD; UNCLASSIFIED DRUG;

ADSORPTION; ARTICLE; BLOOD VOLUME; CONCENTRATION (PARAMETERS); CONFOCAL LASER MICROSCOPY; DIFFUSION COEFFICIENT; EXTRACORPOREAL CIRCULATION; FLUORESCENCE; HEMADSORPTION; MATHEMATICAL MODEL; SEPSIS;

ADSORPTION; ANIMALS; DATA INTERPRETATION, STATISTICAL; FLUORESCENT DYES; FORECASTING; INTERLEUKIN-6; KINETICS; MICROSCOPY, CONFOCAL; MICROSPHERES; MODELS, STATISTICAL; POLYSTYRENES; POROSITY; RATS; RECOMBINANT PROTEINS;

EID: 74749094633     PISSN: 15524973     EISSN: 15524981     Source Type: Journal    
DOI: 10.1002/jbm.b.31527     Document Type: Article

References (30)

1. Angus D, Linde-Zwirble W, Lidicker J, Clermont G, Carcillo J, Pinsky M. Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001;29:1303-1310.
2. Baillie JK. Activated protein C: Controversy and hope in the treatment of sepsis. Curr Opin Invest Drugs 2007;8:933-938.
3. Abraham E, Wunderink R, Silverman H, Perl T, Nasraway S, Levy H, Bone R, Wenzel R, Balk R, Allred R. Efficacy and safety of monoclonal antibody to human necrosis factor α in patients with sepsis syndrome. A randomized, controlled, double-blind, multicenter clinical trial. TNF-α mAb sepsis study group. J Am Med Assoc 1995;273:934-941.
4. Fisher C, Dhainaut J, Opal S, Pribble J, Balk R, Slotman G, Iberti T, Rackow E, Shapiro M, Greenman R. Recombinant human interleukin 1 receptor antagonist in the treatment of patients with sepsis syndrome. Results from a randomized, double-blind, placebo-controlled trial. Phase III rhIL-1ra sepsis syndrome study group. J Am Med Assoc 1994;271:1836-1843.
5. Ziegler E, Fisher C, Sprung C, Straube R, Sadoff J, Foulke G, Wortel C, Fink M, Dellinger R, Teng N. Treatment of Gramnegative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin. A randomized, double-blind, placebo-controlled trial. The HA-1A sepsis study group. N Engl J Med 1991;324:429-436.
6. Kellum JA, Song M, Venkataraman R. Hemoadsorption removes tumor necrosis factor, interleukin-6, and interleukin-10, reduces nuclear factor-(B DNA binding, and improves short-term survival in lethal endotoxemia. Crit Care Med 2004;32:801-805.
7. Casey LC. Immunologic response to infection and its role in septic shock. Crit Care Clin 2000;16:193-213.
8. Kellum JA, Kong L, Fink MP, Weissfeld LA, Yealy DM, Pinsky MR, Fine J, Krichevsky A, Delude RL, Angus DC. Understanding the inflammatory cytokine response in pneumonia and sepsis: Results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study. Arch Intern Med 2007;167:1655-1663.
9. Venkataraman R, Subramanian S, Kellum JA. Clinical review: Extracorporeal blood purification in severe sepsis. Crit Care 2003;7:139-145.
10. DiLeo MV, Kellum JA, Federspiel WJ. A simple mathematical model of cytokine capture using a hemoadsorption device. Ann Biomed Eng 2009;37:222-229.
11. Ljunglof A, Hjorth R. Confocal microscopy as a tool for studying protein adsorption to chromatographic matrices. J Chromatogr A 1996;743:75-83.
12. Hubbuch J, Linden T, Knieps E, Ljunglof A, Thommes J, Kula MR. Mechanism and kinetics of protein transport in chromatographic media studied by confocal laser scanning microscopy. I. The interplay of sorbent structure and fluid phase conditions. J Chromatogr A 2003;1021:93-104.
13. Ljunglof A, Bergvall P, Bhikhabhai R, Hjorth R. Direct visualisation of plasmid DNA in individual chromatography adsorbent particles by confocal scanning laser microscopy. J Chromatogr A 1999;844:129-135.
14. Zhou X-P, Li W, Shi Q-H, Sun Y. Analysis of mass transport models for protein adsorption to cation exchanger by visualization with confocal laser scanning microscopy. J Chromatogr A 2006;1103:110-117.
15. Ljunglof A, Thommes J. Visualising intraparticle protein transport in porous adsorbents by confocal microscopy. J Chromatogr A 1998;813:387-395.
16. Harinarayan C, Mueller J, Ljunglof A, Fahrner R, van Alstine J, van Reis R. An exclusion mechanism in ion exchange chromatography. Biotechnol Bioeng 2006;95:775-787.
17. Kasche V, de Boer M, Lazo C, Gad M. Direct observation of intraparticle equilibration and the rate-limiting step in adsorption of proteins in chromatographic adsorbents with confocal laser scanning microscopy. J Chromatogr B 2003;790:115-129.
18. Yang K, Shi Q-H, Sun Y. Modeling and simulation of protein uptake in cation exchanger visualized by confocal laser scanning microscopy. J Chromatogr A 2006;1136:19-28.
19. Hubbuch J, Linden T, Knieps E, Thommes J, Kula MR. Dynamics of protein uptake within the adsorbent particle during packed bed chromatography. Biotechnol Bioeng 2002;80:359-368.
20. Hubbuch J, Kula MR. Confocal laser scanning microscopy as an analytical tool in chromatographic research. Bioprocess Biosyst Eng 2008;31:241-259.
21. Lundberg E, Sundberg M, Graslund T, Uhlen M, Svahn HA. A novel method for reproducible fluorescent labeling of small amounts of antibodies on solid phase. J Immunol Methods 2007;322:40-49.
22. Song M, Winchester J, Albright R, Capponi V, Choquette M, Kellum JA. Cytokine removal with a novel adsorbent polymer. Blood Purif 2004;22:428-434.
23. Dileo MV, Fisher JD, Federspiel WJ. Experimental validation of a theoretical model of cytokine capture using a hemoadsorption device. Ann Biomed Eng 2009; Aug 14 [Epub ahead of print].
24. Schroder M, von Lieres E, Hubbuch J. Direct quantification of intraparticle protein diffusion in chromatographic media. J Phys Chem B 2006;110:1429-1436.
25. Sharma U, Carbeck JD. Hydrodynamic radius ladders of proteins. Electrophoresis 2005;26:2086-2091.
26. Bassingthwaighte JB. A practical extension of hydrodynamic theory of porous transport for hydrophilic solutes. Microcirculation 2006;13:111-118.
27. Beck R, Schultz J. Hindered diffusion in microporous membranes with known pore geometry. Science 1970;170:1302-1305.
28. Renkin EM. Filtration, diffusion, and molecular sieving through porous cellulose membranes. J Gen Physiol 1954;38:225-243.
29. Susanto A, Herrmann T, Hubbuch J. Short-cut method for the correction of light attenuation influences in the experimental data obtained from confocal laser scanning microscopy. J Chromatogr A 2006;1136:29-36.
30. Linden T, Ljunglof A, Hagel L, Kula MR, Thommes J. Visualizing patterns of protein uptake to porous media using confocal laser scanning microscopy. Sep Sci Technol 2002;37:1-32.