Design and synthesis of DPP-4 inhibitor for the treatment of type 2 diabetes

Chinese Chemical Letters

Volumn 21, Issue 3, 2010, Pages 253-256

  Tang, Peng Cho ^a   Lin, Zhi Gang ^a   Wang, Yang ^a   Yang, Fang Long ^a   Wang, Qian ^a   Fu, Jian Hong ^a   Zhang, Lei ^a   Gong, Ai Shen ^a   Luo, Jing Jing ^a   Dai, Jun ^a   She, Gao Hong ^a   Si, Dan Dan ^a   Feng, Jun ^a  

^a Shanghai Hengrui Pharmaceuticals Co Ltd   (China)

Author keywords

2 Cyano pyrrolidine alpha amino amide derivative; Aza bicyclo 3.2.0 heptane scaffold; DPP 4 inhibitor; Synthesis; Type 2 diabetes

Indexed keywords

EID: 74649085040     PISSN: 10018417     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cclet.2009.11.014     Document Type: Article

References (11)

1. Gautier J.F., Fetita S., Sobngwi E., et al. Diabetes Metab. 31 (2005) 233
2. Zander M., Madsbad S., and Madsen J.L. Lancet 359 (2002) 824
3. Gwaltney S.L., and Stafford J.A. Annu. Rep. Med. Chem. 40 (2005) 149
4. Villhauer E.B., Brinkman J.A., Naderi G.B., et al. J. Med. Chem. 46 (2003) 2774
5. Peters J.U. Curr. Top. Med. Chem. 7 (2007) 579
6. Magnin D.R., Robl J.A., Sulsky R.B., et al. J. Med. Chem. 47 (2004) 2587
7. Augeri D.J., Robl J.A., Betebenner D.A., et al. J. Med. Chem. 48 (2005) 5025
8. João Carlos L.A., Regina Helena de A.S., and Carlos R.D.C. J. Braz. Chem. Soc. 14 (2003) 27
9. + 366.4.
10. Lankas G.R., Leiting B., Roy R.S., et al. Diabetes 54 (2005) 2988
11. Rosenblum J.S., and Kozarich J.W. Curr. Opin. Chem. Biol. 7 (2003) 496