Structural stabilization of a rigid β-sheet cluster of fucosylated proteinase inhibitor PMPC (Pars intercerebralis major peptide C) against thermal denaturation: An unfolding molecular dynamics simulation study

Journal of Molecular Graphics and Modelling

Volumn 28, Issue 6, 2010, Pages 487-494

  Choi, Youngjin ^a   Kim, Hyunmyung ^b   Lee, Jong Hyun ^b   Park, Sungjun ^a   Jeong, Karpjoo ^b   Jung, Seunho ^b  

^a Hoseo University   (South Korea)

^b Konkuk University   (South Korea)

Author keywords

Conformational analysis; Denatured conformation; Fucose; Glycosylation; Non local interaction; Unfolding MD simulations

Indexed keywords

CONFORMATIONAL ANALYSIS; DENATURED CONFORMATION; FUCOSYLATION; GLYCOSYLATED; HIGH TEMPERATURE; HYDROGEN BOND NETWORKS; MD SIMULATION; MOLECULAR DYNAMICS SIMULATIONS; NON-LOCAL INTERACTIONS; NONLOCAL; PROTEIN STRUCTURES; PROTEINASE INHIBITORS; STRUCTURAL STABILIZATION; THEORETICAL BASIS; THERMAL DENATURATIONS;

CONFORMATIONS; DENATURATION; ESTERIFICATION; GLYCOSYLATION; HYDROGEN; HYDROGEN BONDS; MOLECULAR DYNAMICS; PEPTIDES; PYROLYSIS; STABILIZATION;

COMPUTER SIMULATION;

FUCOSE; MONOMER; PARS INTERCEREBRALIS MAJOR PEPTIDE C; PROTEINASE INHIBITOR; THREONINE; UNCLASSIFIED DRUG;

ARTICLE; BETA SHEET; FUCOSYLATION; HIGH TEMPERATURE; HYDROGEN BOND; MOLECULAR DYNAMICS; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; SIMULATION; THERMODYNAMICS;

FUCOSE; HYDROGEN BONDING; INSECT PROTEINS; MOLECULAR DYNAMICS SIMULATION; PEPTIDES; PROTEASE INHIBITORS; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN STABILITY; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; TEMPERATURE; TIME FACTORS;

EID: 74649083611     PISSN: 10933263     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmgm.2009.11.003     Document Type: Article

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