Effects of dexmedetomidine pretreatment on bupivacaine cardiotoxicity in rats

Regional Anesthesia and Pain Medicine

Volumn 34, Issue 6, 2009, Pages 565-568

  Hanci, Volkan ^a   Karakaya, Kemal ^a   Yurtlu, Serhan ^a   Hakimoǧlu, Sedat ^a   Can, Murat ^a   Ayoǧlu, Hilal ^a   Erdoǧan, Gülay ^a   Okyay, Rahşan Dilek ^a   Turan, Işil Özkoçak ^a  

^a ZONGULDAK KARAELMAS UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

BUPIVACAINE; DEXMEDETOMIDINE; KETAMINE; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASYSTOLE; BLOOD PRESSURE MONITORING; CARDIOTOXICITY; CONTROLLED STUDY; DRUG EFFECT; ELECTROCARDIOGRAPHY; HEART ARRHYTHMIA; HEART RATE; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; RAT;

ADRENERGIC ALPHA-AGONISTS; ANESTHETICS, LOCAL; ANIMALS; ARRHYTHMIAS, CARDIAC; BLOOD PRESSURE; BUPIVACAINE; DEXMEDETOMIDINE; ELECTROCARDIOGRAPHY; HEART; HEART RATE; MALE; RANDOM ALLOCATION; RATS; RATS, WISTAR; TREATMENT OUTCOME;

EID: 74549221428     PISSN: 10987339     EISSN: None     Source Type: Journal    
DOI: 10.1097/AAP.0b013e3181bfbe35     Document Type: Article

References (23)

1. Gulec S, Aydin Y, Uzuner K, Yelken B, Senturk Y. Effects of clonidine pre-treatment on bupivacaine and ropivacaine cardiotoxicity in rats. Eur J Anaesthesiol. 2004;21:205-209.
2. 2-adrenoceptor for controlling convulsions. Anesth Analg. 2005;100:687-696.
3. De La Coussaye JE, Bassoul B, Brugada J, et al. Reversal of electrophysiologic and hemodynamic effects induced by high dose of bupivacaine by the combination of clonidine and dobutamine in anesthetized dogs. Anesth Analg. 1992;74:703-711.
4. De Kock M, Le Polain B, Henin D, Vandewalle F, Scholtes JL. Clonidine pre-treatment reduces the systemic toxicity of intravenous bupivacaine in rats. Anesthesiology. 1993;79:282-289.
5. McCutcheon CA, Orme RM, Scott DA, Davies MJ, McGlade DP. A comparison of dexmedetomidine versus conventional therapy for sedation and hemodynamic control during carotid endarterectomy performed under regional anesthesia. Anesth Analg. 2006;102:668-675.
6. Saadawy I, Boker A, Elshahawy MA, et al. Effect of dexmedetomidine on the characteristics of bupivacaine in a caudal block in pediatrics. Acta Anaesthesiol Scand. 2009;53:251-256.
7. Coskuner I, Tekin M, Kati I, Yagmur C, Elcicek K. Effects of dexmedetomidine on the duration of anaesthesia and wakefulness in bupivacaine epidural block. Eur J Anaesthesiol. 2007;24:535-540.
8. Wahlander S, Frumento RJ, Wagener G, et al. A prospective, double-blind, randomized, placebo-controlled study of dexmedetomidine as an adjunct to epidural analgesia after thoracic surgery. J Cardiothorac Vasc Anesth. 2005;19:630-635.
9. Arain SR, Ebert TJ. The efficacy, side effects, and recovery characteristics of dexmedetomidine versus propofol when used for intraoperative sedation. Anesth Analg. 2002;95:461-466.
10. Al-Mustafa MM, Abu-Halaweh SA, Aloweidi AS, et al. Effect of dexmedetomidine added to spinal bupivacaine for urological procedures. Saudi Med J. 2009;30:365-370.
11. Brummett CM, Norat MA, Palmisano JM, Lydic R. Perineural administration of dexmedetomidine in combination with bupivacaine enhances sensory and motor blockade in sciatic nerve block without inducing neurotoxicity in rat. Anesthesiology. 2008;109:502-511.
12. Kanazi GE, Aouad MT, Jabbour-Khoury SI, et al. Effect of low-dose dexmedetomidine or clonidine on the characteristics of bupivacaine spinal block. Acta Anaesthesiol Scand. 2006;50:222-227.
13. de La Coussaye JE, Eledjam JJ, Brugada J, Sassine A. Cardiotoxicity of local anesthetics. Cah Anesthesiol. 1993;41:589-598.
14. Favier JC, Da Conceiçao M, Fassassi M, Allanic L, Steiner T, Pitti R. Successful resuscitation of serious bupivacaine intoxication in a patient with pre-existing heart failure. Can J Anaesth. 2003;50:62-66.
15. Roekaerts PM, Prinzen FW, De Lange S. Beneficial effects of dexmedetomidine on ischaemic myocardium of anaesthetized dogs. Br J Anaesth. 1996;77:427-429.
16. Willigers HM, Prinzen FW, Roekaerts PM, de Lange S, Durieux ME. Dexmedetomidine decreases perioperative myocardial lactate release in dogs. Anesth Analg. 2003;96:657-664.
17. Okada H, Kurita T, Mochizuki T, Morita K, Sato S. The cardioprotective effect of dexmedetomidine on global ischaemia in isolated rat hearts. Resuscitation. 2007;74:538-545.
18. 2 adrenoceptors in halothane-anesthetized dogs. Anesthesiology. 1991;75:113-117.
19. 2-adrenoceptor agonist, dexmedetomidine, in rat focal cerebral ischemia. Eur J Pharmacol. 1999;372:31-36.
20. 2-adrenoreceptor agonist dexmedetomidine in a focal model of cerebral ischemia. Anesthesiology. 1993;79:1-7.
21. Hoffman WE, Kochs E, Werner C, Thomas C, Albrecht RF. Dexmedetomidine improves neurologic outcome from incomplete ischemia in the rat. Anesthesiology. 1991;75:328-332.
22. Can M, Gul S, Bektas S, Hanci V, Acikgoz S. Effects of dexmedetomidine or methylprednisolone on inflammatory responses in spinal cord injury. Acta Anaesthesiol Scand. 2009;53:1068-1072.
23. Rosen MA, Thigpen JW, Shnider SM, Foutz SE, Levinson G, Koike M. Bupivacaine-induced cardiotoxicity in hypoxic and acidotic sheep. Anesth Analg. 1985;64:1089-1096.