A comparison of dexmedetomidine versus conventional therapy for sedation and hemodynamic control during carotid endarterectomy performed under regional anesthesia

Anesthesia and Analgesia

Volumn 102, Issue 3, 2006, Pages 668-675

  McCutcheon, Craig A ^a   Orme, Ruari M ^a   Scott, David A ^a   Davies, Michael J ^a   McGlade, Desmond P ^a  

^a ST VINCENT S HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; ANALGESIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; CLONIDINE; DEXMEDETOMIDINE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; FENTANYL; LIDOCAINE; MIDAZOLAM; ROPIVACAINE;

AGED; ANESTHESIOLOGICAL TECHNIQUES; ARTICLE; BLOOD PRESSURE; BRADYCARDIA; BRAIN BLOOD FLOW; CARDIOVASCULAR DISEASE; CAROTID ARTERY DISEASE; CAROTID ENDARTERECTOMY; CLINICAL TRIAL; COMORBIDITY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; HEART RATE; HEMODYNAMIC PARAMETERS; HUMAN; HYPERTENSION; HYPOTENSION; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MALE; POSTOPERATIVE PAIN; PRIORITY JOURNAL; RAMSAY SEDATION SCORE; RANDOMIZED CONTROLLED TRIAL; REGIONAL ANESTHESIA; SCORING SYSTEM; SEDATION; TACHYCARDIA; TREATMENT OUTCOME;

EID: 33644542726     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/01.ane.0000197777.62397.d5     Document Type: Article

References (14)

1. Coursin DB, Maccioli GA. Dexmedetomidine. Curr Opin Crit Care 2001;7:221-6.
2. Shetty G, Heyer EJ, Connolly ES. Dexmedetomidine as primary sedative in CEA patients. J Neurosurg Anesthesiol 2004;16:320-1.
3. Khan Z, Ferguson CN, Jones RM. Alpha-2 and imidazoline receptor agonists: their pharmacology and therapeutic role. Anaesthesia 1999;54:146-65.
4. Venn M. Preliminary UK experience of dexmedetomidine, a novel agent for postoperative sedation in the intensive care unit. Anaesthesia 1999;54:1136-42.
5. Ramsay M. Controlled sedation with alphaxalone-alphadolone. BMJ 1974;2:656-9.
6. Davies M, Silbert BS, Scott DA, et al. Superficial and deep cervical plexus block for carotid artery surgery: a prospective study of 1000 blocks. Reg Anesth 1997;22:442-6.
7. McGlade DP, Murphy PM, Davies MJ, et al. Comparative effects of plain and epinephrine-containing bupivacaine on the hemodynamic response to cervical plexus anesthesia in patients undergoing carotid endarterectomy. J Cardiothorac Vasc Anesth 1996;10:593-7.
8. Bekker AY, Basile J, Gold M, et al. Dexmedetomidine for awake carotid endarterectomy: efficacy, hemodynamic profile, and side effects. J Neurosurg Anesthesiol 2004;16:126-35
9. Talke P, Li J, Jain U, et al. Effects of perioperative dexmedetomidine infusion in patients undergoing vascular surgery. The Study of Perioperative Ischemia Research Group. Anesthesiology 1995;82:620-33.
10. Venn M, Newman J, Grounds M. A phase II study to evaluate the efficacy of dexmedetomidine for sedation in the medical intensive care unit. Intensive Care Med 2003;29:201-7.
11. Venn RM, Karol MD, Grounds RM. Pharmacokinetics of dexmedetomidine infusions for sedation of postoperative patients requiring intensive care. Br J Anaesth 2002;88:669-75.
12. Martin E, Ramsay G, Mantz J, Sum-Ping ST. The role of the alpha 2-adrenoceptor agonist dexmedetomidine in postsurgical sedation in the intensive care unit. J Intensive Care Med 2003;18:29-41.
13. Hall JE. Sedative, amnestic, and analgesic properties of small-dose dexmedetomidine infusions. Anesth Analg 2000;90:699-705.
14. Ebert TJ, Hall JE, Barney JA, et al. The effects of increasing plasma concentrations of dexmedetomidine in humans. Anesthesiology 2000;93:382-94.