Topical delivery of silymarin constituents via the skin route

Acta Pharmacologica Sinica

Volumn 31, Issue 1, 2010, Pages 118-126

  Hung, Chi Feng ^a   Lin, Yin Ku ^b   Zhang, Li Wen ^c   Chang, Ching Hsien ^b   Fang, Jia You ^c  

^a FU JEN CATHOLIC UNIVERSITY   (Taiwan)

^b CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^c CHANG GUNG UNIVERSITY   (Taiwan)

Author keywords

Absorption; Permeation; Silibinin; Silymarin; Skin; Topical delivery; Ultraviolet B

Indexed keywords

SILIBININ; SILICRISTIN; SILIDIANIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG PENETRATION; DRUG TISSUE LEVEL; DRUG UPTAKE; ERYTHEMA; FEMALE; LIPOPHILICITY; MOUSE; NONHUMAN; PH; SKIN IRRITATION; SKIN PERMEABILITY; THERMODYNAMICS; ULTRAVIOLET B RADIATION;

ADMINISTRATION, CUTANEOUS; ANIMALS; ANTIOXIDANTS; DIFFUSION CHAMBERS, CULTURE; FEMALE; HYDROGEN-ION CONCENTRATION; HYDROPHOBICITY; MICE; MICE, NUDE; PERMEABILITY; SILYMARIN; SKIN ABSORPTION; SKIN IRRITANCY TESTS; THERMODYNAMICS; TIME FACTORS;

EID: 74549212480     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2009.186     Document Type: Article

References (35)

1. Meeran SM, Katiyar S, Elmets CA, Katiyar SK. Silymarin inhibits UV radiation-induced immunosuppression through augmentation of interleukin-12 in mice. Mol Cancer Ther 2006; 5: 1660-1668
2. Dhanalakshmi S, Mallikarjuna GU, Singh RP, Agarwal R. Dual efficacy of silibinin in protecting or enhancing ultraviolet B radiationcaused apoptosis in HaCaT human immortalized keratinocytes. Carcinogenesis 2004; 25: 99-106.
3. Leiter U, Garbe C. Epidemiology of melanoma and nonmelanoma skin cancer - the role of sunlight. Adv Exp Med Biol 2008; 624: 89-103.
4. Ramos J, Villa J, Ruiz A, Armstrong R, Matta J. UV dose determines key characteristics of nonmelanoma skin cancer. Cancer Epidemiol Biomarkers Prev 2004; 13: 2006-2011
5. Afaq F, Adhami VM, Mukhtar H. Photochemoprevention of ultraviolet B signaling and photocarcinogenesis. Mutat Res 2005; 571: 153-173
6. Gažák R, Walterová D, Křen V. Silybin and silymarin - new and emerging applications in medicine. Curr Med Chem 2007; 14: 315-338
7. Singh RP, Agarwal R. Flavonoid antioxidant silymarin and skin cancer. Antioxid Redox Signal 2002; 4: 655-663
8. Pinnel SR. Cutaneous photodamage, oxidative stress, and topical antioxidant protection. J Am Acad Dermatol 2003; 48: 1-22.
9. Yang B, Kotani A, Arai K, Kusu F. Estimation of the antioxidant activities of flavonoids from their oxidation potentials. Anal Sci 2001; 17: 599-604.
10. Zielinska-Przyjemska M, Wiktorowicz K. An in vitro study of the protective effect of the flavonoid silydianin against reactive oxygen species. Phytother Res 2006; 20: 115-119
11. Gu M, Singh RP, Dhanalakshmi S, Agarwal C, Agarwal R. Silibinin inhibits inflammatory and angiogenic attributes in photo carcinogenesis in SKH-1 hairless mice. Cancer Res 2007; 67: 3483-3491
12. Svobodová A, Zdařilová A, Mališková J, Mikulková H, Walterová D, Vostalová J. Attenuation of UVA-induced damage to human keratinocytes by silymarin. J Dermatol Sci 2007; 46: 21-30.
13. Zhao J, Agarwal R. Tissue distribution of silibinin, the major active constituent of silymarin, in mice and its association with enhancement of phase II enzymes: implications in cancer chemoprevention. Carcinogenesis 1999; 20: 2101-2108
14. Moore JO, Palep SR, Saladi RN, Gao D, Wang Y, Phelps RG, et al. Effects of ultraviolet B exposure on the expression of proliferating cell nuclear antigen in murine skin. Photochem Photobiol 2004; 80: 587-595
15. Godin B, Touitou E. Transdermal skin delivery: predictions for humans from in vivo, ex vivo and animal models. Adv Drug Deliv Rev 2007; 59: 1152-1161
16. Catz P, Friend D. Transdermal delivery of levonorgestrel: VIII. Effect of enhancers on rat skin, hairless mouse skin, hairless guinea pig skin, and human skin. Int J Pharm 1990; 58: 93-102.
17. Fang JY, Fang CL, Sung KC, Chen HY. Effect of low frequency ultrasound on the in vitro percutaneous absorption of clobetasol 17- propionate. Int J Pharm 1999; 191: 33-42.
18. Sloan KB, Wasdo S. Designing for topical delivery: prodrugs can make the difference. Med Res Rev 2003; 23: 763-793
19. Cole L, Heard C. Skin permeation enhancement potential of aloe vera and a proposed mechanism of action based upon size exclusion and pull effect. Int J Pharm 2006; 333: 10-16
20. Huang ZR, Hung CF, Lin YK, Fang JY. In vitro and in vivo evaluation of topical delivery and potential dermal use of soy isofl avones genistein and daidzein. Int J Pharm 2008; 364: 36-44.
21. Shin SC, Kim HJ, Oh IJ, Cho CW, Yang KH. Development of tretinoin gels for enhanced transdermal delivery. Eur J Pharm Biopharm 2005; 60: 67-71.
22. Hung CF, Lin YK, Huang ZR, Fang JY. Delivery of resveratrol, a red wine polyphenol, from solutions and hydrogels via the skin. Biol Pharm Bull 2008; 31: 955-962
23. Meloun M, Burko ňová D, Syrový T, Vrána A. Thermodynamic dissociation constants of silychristin, silybin, silydianin and mycophenolate by the regression analysis of spectrophotometric data. Anal Chim Acta 2003; 486: 125-141
24. Vávrová K, Lorencová K, Klimentová J, Novotný J, Holý A, Hrabálek A. Transdermal and dermal delivery of adefovir: effects of pH and permeation enhancers. Eur J Pharm Biopharm 2008; 69: 597-604.
25. Jain AK, Thomas NS, Panchagnula R. Transdermal drug delivery of imipramine hydrochloride. I. Effect of terpenes. J Control Release 2002; 79: 93-101.
26. Panchagnula R, Desu H, Jain A, Kriandarilli S. Effect of lipid bilayer alteration on transdermal delivery of a high-molecular-weight and lipophilic drug: studies with paclitaxel. J Pharm Sci 2004; 93: 2177-2183
27. Touitou E, Godin B, Karl Y, Bujanover S, Becker Y. Oleic acid, a skin penetration enhancer, affects Langerhans cells and corneocytes. J Control Release 2002; 80: 1-7.
28. Marti-Mestres G, Mestres JP, Bres J, Martin S, Ramos J, Vian L. The "in vitro" percutaneous penetration of three antioxidant compounds. Int J Pharm 2007; 331: 139-144
29. Batchelder RJ, Calder RJ, Thomas CP, Heard CM. In vitro transdermal delivery of the major catechins and caffeine from extract of Camellia sinensis. Int J Pharm 2004; 283: 45-51.
30. Chang HW, Lai YC, Cheng CY, Ho JL, Ding ST, Liu YC. UV inducibility of rat proliferating cell nuclear antigen gene promoter. J Cell Biochem 1999; 73: 423-432
31. Athar M, An KP, Morel KD, Kim AL, Aszterbaum M, Longley J, et al. Ultraviolet B (UVB)-induced COX-2 expression in murine skin: an immunohistochemical study. Biochem Biophys Res Commun 2001; 280: 1042-1047
32. Lu C, Lu Y, Chen J, Zhang W, Wu W. Synchronized and sustained release of multiple components in silymarin from erodible glyceryl monostearate matrix system. Eur J Pharm Biopharm 2007; 66: 210-219
33. Stratton SP, Bangert JL, Alberts DS, Dorr RT. Dermal toxicity of topical (-)epigallocatechin-3-gallate in BALB/c and SKH1 mice. Cancer Lett 2000; 158: 47-52.
34. Bedi MK, Shenefelt PD. Herbal therapy in dermatology. Arch Dermatol 2002; 138: 232-242
35. Gu M, Dhanalakshmi S, Mohan S, Singh RP, Agarwal R. Silibinin inhibits ultraviolet B radiation-induced mitogenic and survival signaling, and associated biological responses in SKH-1 mouse skin. Carcinogenesis 2005; 26: 1404-1413