Pathogenicity variations of susceptibility and resistance to Leishmania major MRHO/IR/75/ER strain in BALB/c and C57BL/6 mice

Iranian Journal of Parasitology

Volumn 3, Issue 4, 2008, Pages 51-59

  Amini, Marzieh ^a   Nahrevanian, Hossein ^b   Farahmand, Mahin ^b  

^a PAYAME NOOR UNIVERSITY   (Iran)

^b PASTEUR INSTITUTE OF IRAN   (Iran)

Author keywords

Balb c; C57bl 6; Iran; Leishmania major; MRHO IR 75 ER; Pathogenicity

Indexed keywords

EID: 74549201494     PISSN: 17357020     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Herwaldt BL. Leishmaniasis. Lancet. 1999;354:1191-1199.
2. Scott P, Artis D, Uzonna J, Zaph C. The development of effectors and memory T cells in cutaneous leishmaniasis: the implications for vaccine development. Immunol Rev. 2004;201:318-338.
3. Davies CR, Kaye P, Croft SL, Sundar S. Leishmaniasis: new approaches to disease control. BMJ. 2003;326:377-82.
4. Esther VS. Immunology of cutaneous leishmaniasis: the role of mast cells, phagocytes and dendritic cells for protective immunity. Eur J Dermatol. 2007;17:115-122.
5. Sacks D, Noben-Trauth N. The immunology of susceptibility and resistance to Leishmania major in mice. Nat Rev Immunol. 2002;2:845-858.
6. Wei XQ, Charles IG, Smith A, Ure J, Feng GJ, Huang FP, Xu D, Muiler W, Moncada S, Liew FY. Altered immune responses in mice lacking inducible nitric oxide synthase. Nature. 1995;375:408-411.
7. Bosca L, Zeini M, Traves PG, Hortelano, S. Nitric oxide and cell viability in inflammatory cells: a role for NO in macrophages function and fate. Toxicology. 2005;208: 249-258.
8. Allenbach C, Zufferey C, Perez C, Launois P, Mueller C, Tacchini-Cottier F. Macrophages induce neutrophil apoptosis through membrane TNF, a process amplified by Leishmania major. J Immunol. 2006; 176:6656-64.
9. Lipoldova MM, Svobodova M, Krulova H, Havelkova H, Badalova J, Nohynkova E, Holan V, Hart AAM, Volf P, Demant P. Susceptibility to Leishmania major infection in mice: multiple loci and heterogeneity of immunopathological phenotypes. Genes Immun. 2000;1(3):200-206.
10. Locksley RM, Heinzel FP, Sadick MD, Holaday BJ, Gardner KD Jr. Murine cutaneous leishmaniasis: susceptibility correlates with differential expansion of helper T-cell subsets. Ann. Inst. Pasteur Immunol. 1987;138:744-749.
11. Biedermann TS, Zimmermann H, Himmelrich A, Gumy A, Egeter O, Sackrauski AK et al. IL-4 instructs TH1 responses and resistance to Leishmania major in susceptible BALB/c mice. Nat. Immunol. 2001;2:1054-1060.
12. Solbach W, Laskay T. The host response to Leishmania infection. Adv. Immunol. 2000;74:275-317.
13. Scott P, Natovitz P, Coffman RL, Pearce E, Sher A. Immuno regulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens. J Exp Med. 1988;168:1675-1684.
14. Heinzel FP, Sadick MD, Holaday, BJ, Coffman RL, Locksley RM. Reciprocal expression of interferon gamma or interleukin-4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets. J Exp Med. 1989;169:59-72.
15. Kavoosi G, Ardestani SK, Kariminia A, Tavakoli Z. Production of nitric oxide by murine macrophages induced by lipophosphoglycan of Leishmania major. Korean J Parasitol. 2006;44:35-41.
16. Nahrevanian H, Farahmand, M, Aghighi Z, Amirkhani A. Pharmacological evaluation of anti-leishmanial activity by in vivo nitric oxide modulation in Balb/c mice infected with Leishmania major MRHO/IR/75/ER: An Iranian strain of cutaneous leishmaniasis. Exp Parasitol. 2007;116: 191-198.
17. Rolao N, Cortes S, Pereira SG, Campino L. Leishmania infantum: Mixed T-helper-1/T-helper-2 immune response in experimentally infected Balb/c mice. Exp Parasitol. 2006;115:270-276.
18. Gantt KR, Schultz-Cherry S, Rodriguez N, Jeronimo SM, Nascimento ET, Goldman TL, Recker TJ, Miller MA, Wilson ME. Activation of TGF-β by Leishmania chagasi: importance for survival in macrophages. J Immunol. 2003;170:2613-620.
19. Walteraud JB, Meinardus-Hager G, Neugebauer DC, Sorg C. Differences in the onset of the inflammatory response to cutaneous leishmaniasis in resistant and susceptible mice. Leukoc Biol. 1992;52: 135-142.
20. Aguilar TF, Glaichenhaus N, Laman JD, Carlier Y. T-cell responses to immuno dominant LACK antigen do not play a critical role in determining susceptibility of BALB/c mice to Leishmania mexicana. Infec. Immun. 2001;69:617-621.
21. Davies EV, Singleton AM, Blackwell JM. Differences in Lsh gene control over systemic Leishmania major and Leishmania donovani or Leishmania mexicana infections are caused by differential targeting to infiltrating and resident liver macrophage populations. Infect. Immun. 1988; 56:1128-1134.
22. Roberts M, Alexander J, Blackwell JM. Genetic analysis of Leishmania mexicana infection in mice: single gene (Scl-2) controlled predisposition to cutaneous lesion development. J Immunogenet. 1990; 17:89-100.
23. Vladimirov V, Badalova J, Svobodova M, Hvelkova H, Hart AA, Blazkova H, Demant P, Lipoldova M. Different genetic control of cutaneous and visceral disease after Leishmania major infection in mice. Infect Immun. 2003;71:2041-2046.
24. Demant P, Lipoldova M, Svobodova M. Resistance to Leishmania major in mice. Science. 1996;274:1392-1393.
25. Belkaid Y, Mendez S, Lira R, Kadambi N, Milon G, Sacks D. Natural model of Leishmania major infection reveals a prolonged "Silent" phase of parasite amplification in the skin before the onset of lesion formation and immunity. J Immunol. 2000;165:969-977.