Proteinase-activated receptor-2 activation evokes oesophageal longitudinal smooth muscle contraction via a capsaicin-sensitive and neurokinin-2 receptor-dependent pathway

Neurogastroenterology and Motility

Volumn 22, Issue 2, 2010, Pages

  Liu, H ^a   Miller, D V ^a   Lourenssen, S ^a   Wells, R W ^a   Blennerhassett, M G ^a,b   Paterson, W G ^a,b  

^a QUEEN S UNIVERSITY   (Canada)

^b QUEEN S UNIVERSITY   (Canada)

Author keywords

Capsaicin sensitive neurons; Esophagitis; Mast cells; Neurokinin; Substance P

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; CAPSAICIN; NEUROKININ 2 RECEPTOR; PROTEINASE ACTIVATED RECEPTOR 2; SUBSTANCE P; TRYPSIN;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ESOPHAGITIS; ESOPHAGUS MOTILITY; ESOPHAGUS MUSCLE; ESOPHAGUS PAIN; HIATUS HERNIA; MAST CELL; NERVE CELL; NONHUMAN; OPOSSUM; PRIORITY JOURNAL; SMOOTH MUSCLE CONTRACTION;

ANIMALS; AXONS; CALCITONIN GENE-RELATED PEPTIDE; CAPSAICIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ESOPHAGUS; FEMALE; IMMUNOHISTOCHEMISTRY; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; NEUROKININ A; OPOSSUMS; PEPTIDE FRAGMENTS; RECEPTOR, PAR-2; RECEPTORS, NEUROKININ-2; SIGNAL TRANSDUCTION; SUBSTANCE P; TRYPSIN;

EID: 74549164764     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/j.1365-2982.2009.01394.x     Document Type: Article

References (26)

1. Balaban DH, Yamamoto Y, Liu J et al. Sustained esophageal contraction: a marker of esophageal chest pain identified by intraluminal ultrasonography. Gastroenterology 1999 116 : 29 37.
2. Pouderoux P, Lin S, Kahrilas PJ. Timing, propagation, coordination, and effect of esophageal shortening during peristalsis. Gastroenterology 1997 112 : 1147 1154.
3. Paterson WG, Kolyn DM. Esophageal shortening induced by short-term intraluminal acid perfusion in opossum: a cause for hiatus hernia? Gastroenterology 1994 107 : 1736 1740.
4. Paterson WG. Role of mast cell-derived mediators in acid-induced shortening of the esophagus. Am J Physiol Gastrointest Liver Physiol 1998 274 : G385 8.
5. White RJ, Zhang Y, Morris GP, Paterson WG. Esophagitis-related esophageal shortening in opossum is associated with longitudinal muscle hyperresponsiveness. Am J Physiol Gastrointest Liver Physiol 2001 280 : G463 9.
6. Paterson WG, Miller DV, Dilworth N, Assini JB, Lourenssen S, Blennerhassett MB. Intraluminal acid induces oesophageal shortening via capsaicin-sensitive neurokinin neurons. Gut 2007 56 : 1347 1352.
7. Shirazi S, Schulze-Delrieu K, Custer-Hagen T, Brown CK, Ren J. Motility changes in opossum esophagus from experimental esophagitis. Dig Dis Sci 1989 34 : 1668 1676.
8. Zhang X, Geboes K, Depoortere I, Tack J, Janssens J, Sifrim D. Effect of repeated cycles of acute esophagitis and healing on esophageal peristalsis, tone and length. Am J Physiol Gastrointest Liver Physiol 2005 288 : G1339 46.
9. Dunne DP, Paterson WG. Acid-induced esophageal shortening in humans: a cause of hiatus hernia? Can J Gastroenterol 2000 14 : 847 850.
10. Barclay RL, Dinda PK, Morris GP, Paterson WG. Morphological evidence of mast cell degranulation in an animal model of acid-induced esophageal mucosal injury. Dig Dis Sci 1995 40 : 1651 1658.
11. Steinhoff M, Vergnolle N, Young SH et al. Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism. Nat Med 2000 6 : 151 158.
12. Liu H, Miller DV, Lourenssen S, Wells RW, Blennerhassett MG, Paterson WG. Proteinase-activated receptor-2 (PAR-2) activation evokes esophageal longitudinal smooth muscle (LSM) contraction via a capsaicin-sensitive and neurokinin-2 (NK-2) receptor-dependent pathway. Neurogastroenterol Motil 2006 18 : 669.
13. Wells RW, Morris GP, Blennerhassett MG, Paterson WG. Effects of acid-induced esophagitis on esophageal smooth muscle. Can J Physiol Pharmacol 2003 81 : 451 458.
14. Corvera CU, Dery O, McConalogue K et al. Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor 2. J Clin Invest 1997 100 : 1383 1393.
15. Kahrilas PJ, Dodds WJ, Hogan WJ, Kern M, Arndorfer RC, Reece A. Esophageal peristaltic dysfunction in peptic esophagitis. Gastroenterology 1986 91 : 897 904.
16. Biancani P, Harnett KM. Signal transduction in lower esophageal sphincter circular muscle. GI Motility Online 2006 doi : (http://www.nature.com/gimo/ contents/pt1/full/gimo24.html)
17. Kerr RM. Hiatal hernia and mucosal prolapse. In : Castell DO, ed. The Esophagus. Boston : Little, Brown and Co, 1992 : 759 780.
18. Mittal RK, Lange RC, McCallum RW. Identification and mechanism of delayed esophageal acid clearance in subjects with hiatus hernia. Gastroenterology 1987 92 : 130 135.
19. Pehlivanov N, Liu J, Mittal RK. Sustained oesophageal contraction: a motor correlate of heartburn symptom. Am J Physiol Gastrointest Liver Physiol 2001 281 : G743 51.
20. Ying LTJ, Hurlbut DJ, Paterson WG. Human mucosal mast cell number and relationship to vasculature in acid-induced inflammatory conditions of the oesophagus. Can J Gastroenterol 1996 10 (Suppl. A 51A.
21. Patton D, O'Reilly M, Vanner S. Sensory peptide neurotransmitters mediating mucosal and distention evoked neural vasodilator reflexes in guinea pig ileum. Am J Physiol Gastrointest Liver Physiol 2005 289 : G785 90.
22. Al-Ani B, Saifeddine M, Wijesuriya SJ, Hollenberg MD. Modified proteinase-activated receptor-1 and -2 derived peptides inhibit proteinase-activated receptor-2 activation by trypsin. J Pharmacol Exp Ther 2002 300 : 702 708.
23. Corvera CU, Dery O, McConalogue K et al. Thrombin and mast cell tryptase regulate guinea-pig myenteric neurons through proteinase-activated receptors-1 and -2. J Physiol 1999 517 : 741 756.
24. Reed DE, Barajas-Lopez C, Cottrell G et al. Mast cell tryptase and proteinase-activated receptor 2 induce hyperexcitability of guinea-pig submucosal neurons. J Physiol 2003 547 : 531 542.
25. D'Andrea MR, Derian CK, Leturcq D et al. Characterization of protease-activated receptor-2 immunoreactivity in normal human tissues. J Histochem Cytochem 1998 46 : 157 164.
26. Mikkelsen TS, Wakefield MJ, Aken B et al. Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences. Nature 2007 10 447 : 167 177.