Analgesic ω-conotoxins CVIE and CVIF selectively and voltage-dependently block recombinant and native N-type calcium channels

Molecular Pharmacology

Volumn 77, Issue 2, 2010, Pages 139-148

  Berecki, G ^a,d   Motin, L ^a   Haythornthwaite, A ^a   Vink, S ^a   Bansal, P ^a   Drinkwater, R ^b   Wang, C I ^a   Moretta, M ^c   Lewis, R J ^a   Alewood, P F ^a   Christie, M J ^c   Adams, D J ^a,e  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b Xenome Ltd   (Australia)

^c UNIVERSITY OF SYDNEY   (Australia)

^d UNIVERSITY OF CALGARY   (Canada)

^e RMIT UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANALGESIC AGENT; BARIUM ION; CALCIUM CHANNEL N TYPE; CALCIUM CHANNEL T TYPE; IODINE 125; OMEGA CONOTOXIN; OMEGA CONOTOXIN CVIE; OMEGA CONOTOXIN CVIF; OMEGA CONOTOXIN GVIA; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL;

ALLODYNIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BETA CHAIN; BINDING AFFINITY; BRAIN MEMBRANE; CONTROLLED STUDY; CONUS SNAIL; DEPOLARIZATION; DISEASE MODEL; DNA LIBRARY; DRUG BINDING; DRUG BINDING SITE; DRUG EFFECT; DRUG INACTIVATION; DRUG POTENCY; DRUG SELECTIVITY; ELECTRIC ACTIVITY; HYPERPOLARIZATION; ION CURRENT; MALE; MOLECULAR INTERACTION; MOLECULAR MODEL; MUSCLE SPINDLE AFFERENT NERVE; NERVE LIGATION; NEUROPATHIC PAIN; NONHUMAN; OOCYTE; PRIORITY JOURNAL; RAT; SENSORY NERVE CELL; SPINAL CORD; SPINAL CORD DORSAL HORN; SPINAL GANGLION; SYNAPTIC TRANSMISSION; TISSUE SLICE; TREATMENT OUTCOME; XENOPUS LAEVIS;

AMINO ACID SEQUENCE; ANALGESICS, NON-NARCOTIC; ANIMALS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, N-TYPE; CELLS, CULTURED; CONUS SNAIL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GANGLIA, SPINAL; MALE; MOLECULAR SEQUENCE DATA; OMEGA-CONOTOXINS; PATCH-CLAMP TECHNIQUES; PROTEIN STRUCTURE, TERTIARY; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; RECOMBINANT PROTEINS; XENOPUS LAEVIS;

EID: 74549151229     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.109.058834     Document Type: Article

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