Ex vivo hepatocyte gene therapy: Increased biosafety protocol for transduction in suspension with lentiviral vectors and immediate transplantation (SLIT)
Biosafety in ex vivo gene therapy and conditional ablation of lentivirally transduced hepatocytes in nonhuman primates
Menzel O, Birraux J, Wildhaber BE, et al. Biosafety in ex vivo gene therapy and conditional ablation of lentivirally transduced hepatocytes in nonhuman primates. Mol Ther 2009; 17: 1754.
A step toward liver gene therapy: Efficient correction of the genetic defect of hepatocytes isolated from a patient with Crigler-Najjar syndrome type 1 with lentiviral vectors
Birraux J, Menzel O, Wildhaber B, et al. A step toward liver gene therapy: Efficient correction of the genetic defect of hepatocytes isolated from a patient with Crigler-Najjar syndrome type 1 with lentiviral vectors. Transplantation 2009; 87: 1006.
Site-directed mu-tagenesis ofhepatocyte nuclear factor (HNF) binding sites in the mouse transthyretin (TTR) promoter reveal synergistic interactions with its enhancer region
Costa RH, Grayson DR. Site-directed mu-tagenesis ofhepatocyte nuclear factor (HNF) binding sites in the mouse transthyretin (TTR) promoter reveal synergistic interactions with its enhancer region. Nucleic Acids Res 1991; 19: 4139.
Prolonged adherence of human immunodeficiency virus-derived vector particles to hematopoietic target cells leads to secondary transduction in vitro and in vivo
Pan YW, Scarlett JM, Luoh TT, et al. Prolonged adherence of human immunodeficiency virus-derived vector particles to hematopoietic target cells leads to secondary transduction in vitro and in vivo. J Virol 2007; 81: 639.
VSV-G pseudotyped lentiviral vector particles produced in human cells are inactivated by human serum
DePolo NJ, Reed JD, Sheridan PL, et al. VSV-G pseudotyped lentiviral vector particles produced in human cells are inactivated by human serum. Mol Ther 2000; 2: 218.
Long-term correction of bilirubin UDPglucuronyl-transferase deficiency in rats by in utero lenti-viral gene transfer
Seppen J, van der Rijt R, Looije N, et al. Long-term correction of bilirubin UDPglucuronyl-transferase deficiency in rats by in utero lenti-viral gene transfer. Mol Ther 2003; 8: 593.
Ex vivo lentivirus transduction and immediate transplantation of uncultured hepatocytes for treating hyperbilirubinemic Gunn rat
Nguyen TH, Birraux J, Wildhaber B, et al. Ex vivo lentivirus transduction and immediate transplantation of uncultured hepatocytes for treating hyperbilirubinemic Gunn rat. Transplantation 2006; 82: 794.