Low free testosterone levels are associated with prevalence and incidence of depressive symptoms in older men

Clinical Endocrinology

Volumn 72, Issue 2, 2010, Pages 232-240

  Joshi, Devina ^a   Van Schoor, Natasja M ^a   De Ronde, Willem ^a   Schaap, Laura A ^a   Comijs, Hannie C ^a   Beekman, Aartjan T F ^a   Lips, Paul ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

TESTOSTERONE;

AGED; ARTICLE; CENTER FOR EPIDEMIOLOGICAL STUDIES DEPRESSION SCALE; CONTROLLED STUDY; DEPRESSION; HUMAN; INCIDENCE; INCIDENTAL FINDING; LIFESTYLE; MAJOR CLINICAL STUDY; MALE; PREVALENCE; PRIORITY JOURNAL; RISK ASSESSMENT;

AGED; AGED, 80 AND OVER; DEPRESSION; HUMANS; INCIDENCE; LINEAR MODELS; LONGITUDINAL STUDIES; MALE; PREVALENCE; TESTOSTERONE;

EID: 74549116339     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2009.03641.x     Document Type: Article

References (51)

1. Steunenberg, B., Beekman, A.T.F., Deeg, D.J.H. et al. (2006) Personality and the onset of depression in late life. Journal of Affective Disorders, 92, 243 251.
2. Seidman, S.N. Walsh, B.T. (1999) Testosterone and depression in aging men. American Journal of Geriatric Psychiatry, 7, 18 33.
3. Seidman, S.N., Araujo, A.B., Roose, S.P. et al. (2001) Testosterone level, androgen receptor polymorphism, and depressive symptoms in middle-aged men: The Massachusetts Male Aging Study. Biological Psychiatry, 50, 371 376.
4. Moffat, S.D., Zonderman, A.B., Metter, E.J. et al. (2002) Longitudinal assessment of serum free testosterone concentration predicts memory performance and cognitive status in elderly men. Journal of Clinical Endocrinology & Metabolism, 87, 5001 5007.
5. Schaap, L.A., Pluijm, S.M., Smit, J.H. et al. (2005) The association of sex hormone levels with poor mobility, low muscle strength and incidence of falls among older men and women. The Longitudinal Aging Study Amsterdam. Clinical Endocrinology, 63, 152 160.
6. Montagnier, D., Barberger-Gateau, P., Jacqmin-Gadda, H. et al. (2006) Evolution of prevalence of depressive symptoms and antidepressant use between 1988 and 1999 in a large sample of older French people: Results from the personnes agees quid study. Journal of the American Geriatrics Society, 54, 1839 1845.
7. Amiaz, R. Seidman, S.N. (2008) Testosterone and depression in men. Current Opinion in Endocrinology, Diabetes and Obesity, 15, 278 283.
8. Schweiger, U., Deuschle, M., Weber, B. et al. (1999) Testosterone, gonadotropin, and cortisol secretion in male patients with male patients with major depression. Psychosomatic Medicine, 61, 292 296.
9. Burris, A.S., Banks, S.M., Carter, C.S. et al. (1992) A long-term prospective study of the physiologic and behavioural effects of hormone replacement in untreated hypogonadal men. Journal of Andrology, 13, 297 304.
10. Wang, C., Swerdloff, R.S., Iranmanesh, A. et al. (2000) Transdermal testosterone gel improves sexual function, mood, muscle strength and body composition parameters in hypogonadal men. Journal of Clinical Endocrinology and Metabolism, 85, 2839 2853.
11. O'Connor, D.B., Archer, J. Wu, F.C.W. (2004) Effects of testosterone on mood, aggression, and sexual behavior in young men: a double-blind, placebo-controlled, cross-over study. Journal of Clinical Endocrinology and Metabolism 89, 2837 2845.
12. McEwen, B.S. (1991) Non-genomic and genomic effects of steroids on neural activity. Trends in Pharmacological Sciences, 12, 141 147.
13. Summers, C.H., Larson, E.T., Ronan, P.J. et al. (2000) Serotonergic responses to corticosterone and testosterone in the limbic system. General & Comparative Endocrinology, 117, 151 159.
14. Fink, G., Sumner, B.E., McQueen, J.K. et al. (1998) Sex steroid control of mood, mental state and memory. Clinical & Experimental Pharmacology & Physiology, 25, 764 775.
15. Barrett-Connor, E., von Muhlen, D.G. Kritz-Silverstein, D. (1999) Bioavailable testosterone and depressed mood in older men: The Rancho Bernardo Study. Journal of Clinical Endocrinology and Metabolism, 84, 573 577.
16. Laughlin, G.A., Barrett-Connor, E. Bergstrom, J. (2008) Low testosterone and mortality in older men. The Rancho Bernardo Study. Journal of Clinical Endocrinology and Metabolism, 93, 63 75.
17. Almeida, O.P., Yeap, B.B., Hankey, G.J. et al. (2008) Low free testosterone concentration as a potentially treatable cause of depressive symptoms in older men: Health in Men Study. Archives of General Psychiatry, 65, 283 289.
18. Morsink, L.F.J., Vogelzangs, N., Nicklas, B.J. et al. (2007) Associations between sex steroid hormone levels and depressive symptoms in elderly men and women: Results from the Health ABC study. Psychoneuroendocrinology, 32, 874 883.
19. Travison, T.G., Araujo, A.B., Kupelian, V. et al. (2007) The relative contributions of aging, health and lifestyle factors to serum testosterone decline in men. The Massachusetts Male Aging Study. Journal of Clinical Endocrinology and Metabolism, 92, 549 555.
20. Shores, M.M., Sloan, K.L., Matsumoto, A.M. et al. (2004) Increased incidence of diagnosed depressive illness in hypogonadal older men. Archives of General Psychiatry, 61, 162 167.
21. Shores, M.M., Moceri, V.M., Sloan, K.L. et al. (2005) Low testosterone levels predict incident depressive illness in older men: effects of age and medical morbidity. Journal of Clinical Psychiatry, 66, 7 14.
22. T'Sjoen, G.G., De Vos, S., Goemaere, S. et al. (2005) Sex steroid level, androgen receptor polymorphism, and depressive symptoms in healthy elderly men. Journal of the American Geriatrics Society, 53, 636 642.
23. Diver, M.J., Imitiaz, K.E., Ahmad, A.M. et al. (2003) Diurnal rhythms of serum total, free and bioavailable testosterone and of SHBG in middle-aged men compared with those in young men. Clinical Endocrinology, 58, 710 717.
24. Deeg, D.J.H., Knipscheer, C.P.M. van Tilberg, W. (1993) Autonomy and Well Being in the Aging Population: Concepts and Design of the Longitudinal Aging Study Amsterdam. Netherlands Institute of Gerontology, Bunnick, the Netherlands, 24, 172 183.
25. Deeg, D.J., van Tilberg, T., Smit, J.H. et al. (2002) Attrition in the Longitudinal Aging Study Amsterdam: the effect of differential inclusion in side studies. Journal of Clinical Epidemiology, 55, 319 328.
26. Vermuelen, A., Verdonck, L. Kaufman, J.M. (1999) A critical evaluation of simple methods for the estimation of free testosterone in serum. Journal of Clinical Endocrinology and Metabolism, 84, 3666 3672.
27. Schaap, L.A., Pluijm, S.M.F., Deeg, D.J.H. et al. (2008) Low testosterone levels and decline in physical performance and muscle strength in older men: findings from two prospective cohort studies. Clinical Endocrinology, 68, 42 50.
28. Radloff, L.S. (1977) The CES-D scale: a self-report depression scale for research in the general population. Applied Psychological Measurement, 1, 385 401.
29. Beekman, A.T.F., Deeg, D.J.H., Van Limbeek, J. et al. (1997) Criterion validity of the Center for Epidemiologic Studies Depression scale (CES-D): results from a community-based sample of older subjects in The Netherlands. Psychological Medicine, 27, 231 235.
30. Berkman, L.F., Berkman, C.S., Kasl, S. et al. (1986) Depressive symptoms in relation to physical health and functioning in the elderly. American Journal of Epidemiology, 124, 372 388.
31. Bierman, E.J.M., Comijs, H.C., Jonker, C. et al. (2007) Symptoms of anxiety and depression in the course of cognitive decline. Dementia and Geriatric Cognitive Disorders, 24, 213 219.
32. Kriegsman, D.M., Deeg, D.J. Stalman, W.A. (2004) Comorbidity of somatic chronic diseases and decline in physical functioning; the Longitudinal Aging Study Amsterdam. Journal of Clinical Epidemiology, 57, 55 65.
33. Kruger, T.H., Brink, P., Goebel, M.U. et al. (2006) Endocrine alterations during a detoxification treatment with carbamazepine in male alcoholics. Addiction Biology, 11, 175 183.
34. Laaksonen, D.E., Niskanen, L., Punnonen, K. et al. (2005) The metabolic syndrome and smoking in relation to hypogonadism in middle-aged men: a prospective cohort study. Journal of Clinical Endocrinology & Metabolism. 90, 712 719.
35. Folstein, M.F., Folstein, S.E. McHugh, P.R. (1975) Mini-mental state: a practical method for grading the cognitive state of patients for a clinician. Journal of Psychiatric Research, 12, 189 198.
36. Comijs, H.C., Jonker, C., Beekman, A.T. et al. (2001) The association between depressive symptoms and cognitive decline in community-dwelling elderly persons. International Journal of Geriatric Psychiatry. 16, 361 367.
37. Garretsen, H.F.L., Bongers, I.M.B., van Oers, J.A.M. et al. (1999) The development of alcohol consumption and problem in Rotterdam 1980-1994: more problem drinking among the young and middle-aged. Alcohol and Alcoholism. 34, 733 740.
38. Stel, V.S., Smit, J.H., Pluijm, S.M. et al. (2004) Comparison of the LASA physical activity questionnaire with a 7-day diary and pedometer. Journal of Clinical Epidemiology. 57, 252 258.
39. Beck, A.T., Ward, C.H., Mendelson, M. et al. (1961) An inventory for measuring depression. Archives of General Psychiatry, 4, 561 571.
40. Wang, C., Catlin, D.H., Starcevic, B. et al. (2004) Testosterone metabolic clearance and production rates determined by stable isotope dilution/tandem mass spectrometry in normal men: influence of ethnicity and age. Journal of Clinical Endocrinology & Metabolism, 89, 2936 2941.
41. Rosner, W. (2001) An extraordinarily inaccurate assay for free testosterone is still with us. Journal of Clinical Endocrinology & Metabolism, 86, 2903.
42. de Ronde, W., van der Schouw, Y.T., Pols, H.A.P. et al. (2006) Calculation of bioavailable and free testosterone in men: a comparison of 5 Published Algorithms. Clinical Chemistry, 52, 1777 1784.
43. Södergard, R., Bäckström, T., Shanbhag, V. et al. (1982) Calculation of free and bound fractions of testosterone and estradiol-17β to human plasma proteins at body temperature. Journal of Steroid Biochemistry, 16, 801 810.
44. van Uytfanghe, K., Stockl, D., Kaufman, J.M. et al. (2005) Validation of 5 routine assays for serum free testosterone with a candidate reference measurement procedure based on ultrafiltration and isotope dilution-gas chromatography-mass spectrometry. Clinical Biochemistry, 38, 253 261.
45. Brambilla, D.J., McKinlay, S.M., McKinlay, J.B. et al. (1996) Does collecting repeated samples from each subject improve the precision of estimated steroid hormone levels? Journal of Clinical Epidemiology, 49, 345 350.
46. Plymate, S.R., Tenover, J.S. Bremner, W.J. (1989) Circadian variation in testosterone, sex hormone-binding globulin, and calculated non-sex hormone-binding globulin bound testosterone in healthy young and elderly men. Journal of Andrology, 10, 366 371.
47. Boyd, J.H., Weissman, M.M., Thompson, W.D. et al. (1982) Screening for depression in a community sample: understanding the discrepancies between depression symptom and diagnostic scales. Archives of General Psychiatry, 39, 1195 1200.
48. American Psychiatric Association (2000) Diagnostic and Statistical Manual of Mental Disorders, DSM-IV-TR Text Revision. American Psychiatric Association, Washington, DC, USA.
49. Zitzmann, M., Brune, M., Kornmann, B. et al. (2001) The CAG repeat polymorphism in the androgen receptor gene affects bone density and bone metabolism in healthy males. Clinical Endocrinology 55, 649 657.
50. Brill, K.T., Weltman, A.L., Gentili, A. et al. (2002) Single and combined effects of growth hormone and testosterone administration of measures of body composition, physical performance, mood, sexual function, bone turnover and muscle gene expression in healthy older men. Journal of Clinical Endocrinology and Metabolism, 87, 5649 5657.
51. Sih, R., Morley, J.E., Kaiser, F.E. et al. (1997) Testosterone replacement in older hypogonadal men: a 12 month randomised control trial. Journal of Clinical Endocrinology and Metabolism, 82, 1661 1667.