Phosphorylated derivatives that activate or inhibit mammalian adenosine kinase provide insights into the role of pentavalent ions in AK catalysis

Protein Journal

Volumn 23, Issue 2, 2004, Pages 167-177

  Park, Jae ^a   Singh, Bhag ^a   Maj, Mary C ^a,b   Gupta, Radhey S ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Adenosine kinase; Enzyme activators; Inhibitors; Pentavalent ion dependency; Reaction mechanism; Structure activity studies

Indexed keywords

2 CARBOXYETHYL PHOSPHONIC ACID; ACETIC ACID DERIVATIVE; ADENOSINE; ADENOSINE KINASE; ADENOSINE TRIPHOSPHATE; ARSENIC ACID; CREATINE PHOSPHATE; ENZYME ACTIVATOR; ENZYME INHIBITOR; FOSCARNET; GLYCINE DERIVATIVE; N PHOSPHONOMETHYL GLYCINE; N PHOSPHONOMETHYL IMINODIACETIC ACID; PHOSPHATE; PHOSPHOENOLPYRUVATE; PHOSPHONIC ACID DERIVATIVE; PHOSPHONOACETIC ACID; PHOSPHORIBOSYL PYROPHOSPHATE; PHOSPHOROUS ACID; PYROPHOSPHATE; UNCLASSIFIED DRUG; VANADIC ACID; ANION; ARSENIC ACID DERIVATIVE; CATION;

ARTICLE; CATALYSIS; CHEMICAL INTERACTION; CHEMICAL STRUCTURE; CONCENTRATION RESPONSE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; ENZYME PURIFICATION; PHOSPHORYLATION; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION; ANIMAL; BINDING SITE; CHEMICAL MODEL; CHEMISTRY; CHO CELL; DRUG ANTAGONISM; ENZYME SPECIFICITY; ENZYMOLOGY; HAMSTER; KINETICS; METABOLISM;

MAMMALIA;

ADENOSINE KINASE; ANIMALS; ANIONS; ARSENATES; BINDING SITES; CATALYSIS; CATIONS; CHO CELLS; CRICETINAE; KINETICS; MODELS, CHEMICAL; MOLECULAR STRUCTURE; PHOSPHATES; PHOSPHORYLATION; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; VANADATES;

EID: 7444271937     PISSN: 15723887     EISSN: 18758355     Source Type: Journal    
DOI: 10.1023/B:JOPC.0000020083.81718.55     Document Type: Article

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