Crystal structures of Toxoplasma gondii adenosine kinase reveal a novel catalytic mechanism prodrug binding

Journal of Molecular Biology

Volumn 298, Issue 5, 2000, Pages 875-893

  Schumacher, Maria A ^a,b   Scott, Daniel M ^a   Mathews, Iripam I ^c   Ealick, Steven E ^c   Roos, David S ^d   Ullman, Buddy ^a   Brennan, Richard G ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c Department of Obstetrics Gynecology   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Adenosine kinase; Drug design; Macromolecular crystallography; Purine; Toxoplasma gondii

Indexed keywords

7 IODOTUBERCIDIN; ADENOSINE; ADENOSINE KINASE; ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; DIPEPTIDE; GLYCINE; NUCLEOTIDE; PRODRUG; TUBERCIDIN DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; DRUG BINDING; DRUG DESIGN; ENZYME BINDING; ENZYME CONFORMATION; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; TOXOPLASMA GONDII;

TOXOPLASMA GONDII;

EID: 0034685603     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2000.3753     Document Type: Article

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